Immunization with a recombinant C-terminal fragment of Plasmodium yoelii merozoite surface protein 1 protects mice against homologous but not heterologous P. yoelii sporozoite challenge

Infection and Immunity

Volumn 65, Issue 11, 1997, Pages 4419-4423

  Rénia, Laurent ^a,d   Ling, Irene T ^b   Marussig, Myriam ^a   Miltgen, François ^c   Holder, Anthony A ^b   Mazier, Dominique ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b Centre Alexandre Koyré Centre de Recherches en Histoire des Sciences et des Techniques   (France)

^c NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^d INSTITUT COCHIN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ANTIBODY; EPIDERMAL GROWTH FACTOR; FREUND ADJUVANT; MEMBRANE PROTEIN; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; ANIMAL MODEL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GENETIC POLYMORPHISM; IMMUNIZATION; IMMUNOFLUORESCENCE; MALARIA; MEROZOITE; MOUSE; NONHUMAN; PLASMODIUM YOELII; PRIORITY JOURNAL; SCHIZONT; SPOROZOITE;

EID: 1842374388     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.65.11.4419-4423.1997     Document Type: Article

References (43)

1. Aley, S. B., J. W. Barnwell, M. D. Bates, W. E. Collins, and M. R. Hollingdale. 1987. Plasmodium vivax: exoerythrocytic schizonts recognized by monoclonal antibodies against blood-stage schizonts. Exp. Parasitol. 64:188-194.
2. Audibert, M., and L. D. Lise. 1993. Adjuvants: current status, clinical perspectives and future prospects. Immunol. Today 14:281-284.
3. Blackman, M. J., H. G. Heidrich, S. Donachie, J. S. McBride, and A. A. Holder. 1990. A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasioninhibiting antibodies. J. Exp. Med. 172:273-278.
4. Blackman, M. J., I. T. Ling, S. C. Nicholls, and A. A. Holder. 1991. Proteolytic processing of the Plasmodium falciparum merozoite surface protein-1 produces a membrane-bound fragment containing two epidermal growth factor-like domains. Mol. Biochem. Parasitol. 49:29-34.
5. Blackman, M. J., T. J. Scott-Finnigan, S. Shai, and A. A. Holder. 1994. Antibodies inhibit the protease-mediated processing of a malaria merozoite surface protein. J. Exp. Med. 180:389-393.
6. Boubaroun-Tayoun, H., P. Attanath, A. Sabchareon, T. Chongsuphajaisiddhi, and P. Druilhe. 1990. Antibodies that protect humans against Plasmodium falciparum blood stages do not on their own inhibit parasite growth and invasion in vitro, but act in cooperation with monocytes. J. Exp. Med. 172: 1633-1641.
7. Burghaus, P. A., B. T. Wellde, T. Hall, R. L. Richards, A. F. Egan, E. M. Riley, W. R. Ballou, and A. A. Holder. 1996. Immunization of Aotus nancymai with recombinant C terminus of Plasmodium falcipamm merozoite surface protein 1 in liposomes and alum adjuvant does not induce protection against a challenge infection. Infect. Immun. 64:3614-3619.
8. Burns, J. A., L. A. Parke, T. M. Daly, L. A. Cavacini, W. P. Weidanz, and C. A. Long. 1989. A protective monoclonal antibody recognizes a variant-specific epitope in the precursor of the major merozoite surface antigen of the rodent malarial parasite Plasmodium yoelii. J. Immunol. 142:2835-2840.
9. Burns, J. M., W. R. Majarian, J. F. Young, T. M. Daly, and C. A. Long. 1989. A protective monoclonal antibody recognizes an epitope in the carboxylterminal cysteine-rich domain in the precursor of the major merozoite surface antigen of the rodent malarial parasite, Plasmodium yoelii. J. Immunol. 143:2670-2676.
10. Calvo, P. A., T. M. Daly, and C. A. Long. 1996. Plasmodium yoelii: the role of the individual epidermal growth factor-like domains of the merozoite surface protein-1 in protection from malaria. Exp. Parasitol. 82:54-64.
11. Chang, S. P., H. L, Gibson, C. T. Lee, P. J. Barr, and G. S. N. Hui. 1992. A carboxyl-terminal fragment of Plasmodium falciparum gp195 expressed by recombinant baculovirus induces antibodies that completely inhibit parasite growth. J. Immunol. 149:548-555.
12. Cooper, J. A. 1993. Merozoite surface antigen-1 of Plasmodium. Parasitol. Today 9:50-54.
13. Daly, T., and C. A. Long. 1993. A recombinant 15-kilodalton carboxyl-terminal fragment of Plasmodium yoelii 17XL merozoite surface protein 1 induces a protective immune response in mice. Infect. Immun. 61:2462-2467.
14. Daly, T., and C. A. Long. 1995. Humoral response to a carboxyl-terminal region of the merozoite surface protein-1 plays a predominant role in controlling blood-stage infection in rodent malaria. J. Immunol. 155:236-243.
15. Daly, T. M., J. M. Bums, and C. A. Long. 1992. Comparison of the carboxyterminal, cysteine-rich domain of the merozoite surface protein-1 from several strains of Plasmodium yoelii. Mol. Biochem. Parasitol. 52:279-282.
16. Egan, A. F., J. Morris, G. Barnish, S. Allen, B. M. Greenwood, D. C. Kaslow, A. A. Holder, and E. M. Riley. 1996. Clinical immunity to Plasmodium falciparum malaria is associated with serum antibodies to the 19kDa Clerminal fragment of the merozoitc surface antigen, PfMSP-1. J. Infect. Dis. 173:765-769.
17. Ferreira, A., L. Schofield, V. Enea, H. Schellekens, P. Van der Meide, W. E. Collins, R. S. Nussenzweig, and V. Nussenzweig. 1986. Inhibition of development of exoerythrocytic forms of malaria parasites by gamma Interferon. Science 232:881-883.
18. Holder, A. A., and R. R. Freeman. 1982. Biosynthesis and processing of a Plasmodium falciparum schizont antigen recognized by immune serum and a monoclonal antibody. J. Exp. Med. 156:1528-1538.
19. Holder, A. A., and M. J. Blackman. 1994. What is the function of MSP-I on the malaria merozoite. Parasitol. Today 10:182-184.
20. Jongjutiwes, S., K. Tanabe, and H. Kanbara. 1993. Sequence conservation in the C-terminal part of the precursor of the major merozoite surface proteins (MSP-1) of Plasmodium falciparum from field isolates. Mol. Biochem. Parasitol. 59:95-100.
21. Kang, Y., and C. A. Long. 1995. Sequence heterogeneity of ihe C-terminal, Cys-rich region of the merozoite surface protein-1 (MSP-1) in field samples of Plasmodium falciparum. Mol. Biochem. Parasitol. 73:103-110.
22. Kumar, S., A. Yadava, D. B. Keister, J. H. Tian, M. Ohl, K. A. Perdue-Greenfield, L. H. Miller, and D. C. Kaslow. 1995. Immunogenicity and in vivo efficacy of recombinant Plasmodium falciparum merozoite surface protein-1 in Aotus monkeys. Mol. Med. 1:1-8.
23. Lewis, A. P. 1989. Cloning and analysis of the gene encoding the 230kilodalton merozoite surface antigen of Plasmodium yoelii. Mol. Biochem. Parasitol. 36:271-282.
24. Ling, I. T., S. A. Ogun, and A. A. Holder. 1994. Immunization against malaria with a recombinant protein. Parasite Immunol. 16:63-67.
25. Ling, I. T., S. A. Ogun, and A. A. Holder. 1995. The combined epidermal growth factor-like modules of Plasmodium yoelii merozoite surface protein-1 are required for a protective immune response. Parasite Immunol. 17:425-433.
26. Ling, I. T., S. A. Ogun, P. Momin, R. L. Richards, N. Garçon, J. Cohen, W. R. Ballou, and A. A. Holder. Immunization against Plasmodium yoelii malaria using a recombinant protein with adjuvants developed for clinical use. Vaccine, in press.
27. Lyon, J. A., A. W. Thomas, T. Hall and J. D. Chulay. 1989. Specificities of antibodies that inhibit merozoite dispersal from malaria-infected erythrocytes. Mol. Biochcm. Parasitol. 36:77-85.
28. Majarian, W. R., T. M. Daly, W. P. Weidanz, and C. A. Long. 1984. Passive immunization against murine malaria with an IgG3 monoclonal antibody. J. Immunol. 132:3131-3137.
29. Mazier, D., L. Re∼nia, A. Nüssler, S. Pied, M. Marussig, J. Goma, D. Grillot, F. Miltgen, J. C. Drapier, G. Corradin, G. Del Giudice, and G. E. Grau. 1990. Hepatic phase of malaria parasite is the target of cellular mechanisms induced by the previous and the subsequent stage. A crucial role for the liver non-parenchymal cells. Immunol. Lett. 25:65-70.
30. Mellouk, S., R. K. Maheshwari, A. Rhodes-Feuilletes, R. L. Beaudoin, N. Berbiguier, H. Matile, F. Miltgen, I. Landau, S. Pied, J. P. Chigot, R. M. Friedman, and D. Mazier. 1987. Inhibitory activity of interferons and interleukin 1 on the development of Plasmodium falciparum in human hepatocyte cultures. J. Immunol. 139:4192-4197.
31. Motard, A., M. Marussig, L. Rénia, D. Baccam, I. Landau, D. Mattel, G. A. T. Targett, and D. Mazier. 1995. Immunization with the malaria heat shock like protein Hsp70-l enhances transmission to the mosquito. Int. Immunol. 7:147-150.
32. Nüssler, A., J. C. Drapier, L. Renia, S. Pied, F. Miltgen, M. Genlilini, and D. Mazier. 1991. Destruction of intrahcpatic malaria parasite by L-arginine-dependent effector mechanism in response to TNF and/or IL-6 stimulation. Eur. J. Immunol. 21:227-231.
33. Nüssler, A., S. Pied, J. Goma, L. Rénia, F. Miltgen, M. Gentilini, G. E. Grau, and D. Mazier. 1991. TNF inhibits malaria hepatic stages in vitro via IL-6 liver synthesis. Int Immunol. 3:317-321.
34. Nussler, A. K., L. Renia, V. Pasquetto, F. Miltgen, H. Matile, and D. Mazier. 1993. In vivo induction of the nitric oxide pathway in hepatocytes after injection with irradiated malaria sporozoites, malaria blood parasites or adjuvants. Eur. J. Immunol. 23:882-887.
35. Palacios, M., R. G. Knowles, and S. Moncada. 1992. Enhancers of nonspecific immunity induce nitric oxide synthase: induction docs not correlate with toxicity or adjuvanticity. Eur. J. Immunol. 22:2303-2307.
36. Pied, S., L. Rénia, A. Nüssler, F. Miltgen, and D. Mazier. 1991. Inhibitory activity of IL-6 on malaria hepatic stages. Parasite Immunol. 13:211-214.
37. Rénia, L, D. Mattei, J. Goma, S. Pied, P. Dubois, F. Miltgen, A. Nüssler, F. Ménégaux, M. Gentilini, and D. Mazier. 1990. A malaria heat-shock like determinant expressed on the infected hepatocyte surface is the target of antibody-dependent cell-mediated cytotoxic mechanisms by nonparenchymal cells. Eur. J. Immunol. 20:1445-1449.
38. Riley, E. M., S. J. Allen, J. G. Wheeler, M. J. Blackman, S. Bennet, B. Takacs, H.-J. Schonfeld, A. A. Holder, and B. M. Greenwood. 1992. Naturally acquired cellular and humoral immune responses to the major merozoite surface antigen (PfMSP1) of Plasmodium falciparum are associated with reduced malaria morbidity. Parasite Immunol. 14:321-337.
39. Suhrbier, A., A. A. Holder, M. F. Wiser, J. Nicholas, and R. Sinden. 1989. Expressions of the precursors of the major merozoite surface antigen during the hepatic stage of malaria. Am. J. Trop. Med. Hyg. 40:351-355.
40. Szarfman, A., D. Walliker, J. S. McBride, J. A. Lyon, I. A. Quakvi, and R. Carter. 1988. Allelic forms of gp195, a major blood stage antigen of Plasmodium falciparum, are expressed in the liver stages. J. Exp. Med. 167:231-236.
41. Tolle, R., H. Bujard, and J. A. Cooper. 1995. Plasmodium falciparum: variations within the C-terminal region of merozoite surface antigen-1. Exp. Parasitol. 81:47-54.
42. Voller, A., and P. O'Neil. 1971. Immunofluorescence method suitable for large scale application to malaria. Bull. W. H. O. 45:524-529.
43. Warren, H. S., F. R. Vogel, and L. A. Chedid. 1986. Current status of immunological adjuvants. Annu. Rev. Immunol. 4:369-388.