Non-random chromosomal deletion clustering at 20q in waldenstrom macroglobulinemia

Hematology

Volumn 16, Issue 3, 2011, Pages 139-142

  Kitahara, Toshihiko ^a   Umezu, Tomohiro ^a   Ando, Keiko ^a   Kodama, Atsushi ^b   Ohyashiki, Junko H ^a   Ohyashiki, Kazuma ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

^b TOKYO MEDICAL UNIVERSITY HOSPITAL   (Japan)

Author keywords

20q deletion; FISH; Waldenstrom macroglobulinemia

Indexed keywords

ADULT; AGED; ARTICLE; BONE MARROW CELL; CHROMOSOME 20Q; CHROMOSOME BREAKAGE; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE CLUSTER; GENETIC LINKAGE; HEMATOPOIETIC CELL; HUMAN; INTERPHASE; INTERSTITIAL CHROMOSOME DELETION; MALE; PRIORITY JOURNAL; WALDENSTROEM MACROGLOBULINEMIA; Y CHROMOSOME;

AGED; AGED, 80 AND OVER; CHROMOSOME BANDING; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 20; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; MALE; MIDDLE AGED; WALDENSTROM MACROGLOBULINEMIA;

EID: 79958715742     PISSN: 10245332     EISSN: 16078454     Source Type: Journal    
DOI: 10.1179/102453311X12953015767338     Document Type: Article

References (15)

1. Vijay A, Gertz MA. Waldenström macroglobulinemia. Blood 2007;109:5096-5103.
2. San-Miguel J, Mateos MV, Gutierrez NC. Risk stratification in the era of novel therapies. Cancer J 2009;15:457-464.
3. Neben K, Jauch A, Bertsch U, Heiss C, Hielscher T, Seckinger A, et al. Combining chromosomal aberrations t(4;14) and del(17p13) with International Staging System Classification allows a stratification of myeloma patients undergoing autologous stem cell transplantation. Haematologica 2010;95:1150-1157.
4. Mansoor A, Medeiros LJ, Weber DM, Alexanian R, Hayes K, Jones D, et al. Cytogenetic findings in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia. Chromosomal abnormalities are associated with the polymorphous subtype and an aggressive clinical course. Am J Clin Pathol 2001;116:543-549.
5. Schop RF, Kuehl WM, van Wier SA, Ahmann GJ, Price-Troska T, Bailey RJ, et al. Waldenström macroglobulinemia neoplastic cells lack immunoglobulin heavy chain locus translocations but have frequent 6q deletions. Blood 2002;100:2996-3001.
6. Ocio EM, Schop RF, Gonzalez B, van Wier SA, Hernandez-Rivas JM, Gutierrez NC, et al. 6q deletion in Waldenström macroglobulinemia is associated with features of adverse prognosis. Br J Haematol 2007;136:80-86.
7. Terré C, Nguyen-Khac F, Barin C, Mozziconacci MJ, Eclache V, Léonard C, et al. Trisomy 4, a new chromosomal abnormality in Waldenström's macroglobulinemia: a study of 39 cases. Leukemia 2006;20:1634-1636
8. Nilsson T, Nilsson L, Lenhoff S, Rylander L, Astrand-Grundström I, Strömbeck B, et al. MDS/AML-associated cytogenetic abnormalities in multiple myeloma and monoclonal gammopathy of undetermined significance: evidence for frequent de novo occurrence and multipotent stem cell involvement of del(20q). Genes Chromosome Cancer 2004;41:223-231.
9. Březinová J, Zemanová Z, Cárka Ransdorfová Š, Sindelárová L, Sisková M, Neuwirtová R, et al. Prognostic significance of del(20q) in patients with hematological malignancies. Cancer Genet Cytogenet 2005;160:188-192.
10. Liu YC, Miyazawa K, Sashida G, Kodama A, Ohyashiki K. Deletion (20q) as the sole abnormality in Waldenström macroglobulinemia suggests distinct pathogenesis of 20q11 anomaly. Cancer Genet Cytogenet 2006;169:69-72.
11. Blanna MM, Velagaletib GV, Morgana DL, Martinez RE, Conlin PA, Tonk VS, et al. Interstitial deletion of 20q in a patient with Waldenström macroglobulinemia following chemotherapy. Cancer Genet Cytogenet 2002;132:145-148.
12. Douet-Guilbert N, Basinko A, Morel F, Le Bris MJ, Ugo V, Morice P, et al. Chromosome 20 deletions in myelodysplastic syndromes and Philadelphia-chromosome-negative myeloproli-ferative disorders: characterization by molecular cytogenetics of commonly deleted and retained regions. Ann Hematol 2008;87:537-544.
13. Hanamura I, Iida S, Akano Y, Hayami Y, Kato M, Miura K, et al. Ectopic expression of MAFB gene in human myeloma cells carrying t(14;20)(q32;q11) chromosomal translocations. Jpn J Cancer Res 2001;92:638-644.
14. Boersma-Vreugdenhil GR, Kuipers J, van Stralen E, Peeters T, Michaux L, Hagemeijer A, et al. The recurrent translocation t(14;20)(q32;q12) in multiple myeloma results in aberrant expression of MAFB: a molecular and genetic analysis of the chromosomal breakpoint. Br J Haematol 2004;126:355-363.
15. Oshimura M, Barrett JC. Double nondisjunction during karyotypic progression of chemically induced Syrian hamster cell lines. Cancer Genet Cytogenet 1985;18:131-139.