The recurrent translocation t(14;20)(q32;q12) in multiple myeloma results in aberrant expression of MAFB: A molecular and genetic analysis of the chromosomal breakpoint

British Journal of Haematology

Volumn 126, Issue 3, 2004, Pages 355-363

  Boersma Vreugdenhil, Gienke R ^a   Kuipers, Jeroen ^a,c   Van Stralen, Esther ^a,c   Peeters, Ton ^a   Michaux, Lucienne ^b   Hagemeijer, Anne ^b   Pearson, Peter L ^a   Clevers, Hans C ^a,c   Bast, Bert J E G ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

Immunoglobulin H translocation; MAFB; Multiple myeloma

Indexed keywords

MESSENGER RNA;

ADULT; AGED; ARTICLE; CELL LINE; CHROMOSOME; CHROMOSOME BREAKAGE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; HYBRID GENE; IMMUNOFLUORESCENCE; MALE; MULTIPLE MYELOMA; MYELOMA CELL; ONCOGENE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; RECIPROCAL CHROMOSOME TRANSLOCATION; SAMPLE;

AGED; AVIAN PROTEINS; BLOTTING, NORTHERN; CELL LINE, TUMOR; CHROMOSOMES, HUMAN, PAIR 14; CHROMOSOMES, HUMAN, PAIR 20; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MAFB TRANSCRIPTION FACTOR; MULTIPLE MYELOMA; ONCOGENE PROTEINS; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC;

EID: 3442891280     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2004.05050.x     Document Type: Article

References (24)

1. Avet-Loiseau, H., Facon, T., Grosbois, B., Magrangeas, F., Rapp, M.J., Harousseau, J.L., Minvielle, S. & Bataille, R. (2002) Oncogenesis of multiple myeloma: 14q32 and 13q chromosomal abnormalities are not randomly distributed, but correlate with natural history, immunological features, and clinical presentation. Blood, 99, 2185-2191.
2. Banerji, J., Olson, L. & Schaffner, W. (1983) A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes. Cell, 33, 729-740.
3. Barillé-Nion, S., Barlogie, B., Bataille, R., Bergsagel, P.L., Epstein, J., Fenton, R.G., Jacobson, J., Kuehl, W.M., Shaughnessy, J. & Tricot, G. (2003) Advances in Biology and Therapy of Multiple Myeloma. In: Hematology (American Society of Hematology Education Program), pp. 248-278. American Society of Hematology, Washington DC.
4. Bergsagel, P.L. & Kuehl, W.M. (2001) Chromosome translocations in multiple myeloma. Oncogene, 20, 5611-5622.
5. Boersma-Vreugdenhil, G.R., Peeters, T., Lokhorts, H.M. & Bast, B.J.E.G. (2003) Translocation of the IgH locus is nearly ubiquitous in multiple myeloma as detected by immuno-FISH. Blood, 101, 1653.
6. Chesi, M., Nardini, E., Lim, R.S.C., Smith, K.D., Kuehl, W.M. & Bergsagel, P.L. (1998) The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/ MMSET hybrid transcripts. Blood, 92, 3025-3034.
7. Dalla-Favera, R., Martinotti, S., Gallo, R.C., Erikson, J. & Croce, C.M. (1983) Translocation and rearrangements of the c-myc oncogene locus in human undifferentiated B-cell lymphomas. Science, 219, 963-967.
8. Deloukas, P., Matthews, L.H., Ashurst, J., Burton J., Gilbert J.G., Jones, M., Stavrides, G., Almeida, J.P., Babbage, A.K., Bagguley, C.L., Bailey, J., Barlow, K.F., Bates, K.N., Beard, L.M., Beare, D.M., Beasley, O.P., Bird, C.P., Blakey, S.E., Bridgeman, A.M., Brown, A.J., Buck, D., Burrill, W., Butler, A.P., Carder, C., Carter, N.P., Chapman, J.C., Clamp, M., Clark, G., Clark, L.N., Clark, S.Y., Glee, C.M., Clegg, S., Cobley, V.E., Collier, R.E., Connor, R., Corby, N.R., Coulson, A., Coville, G.J., Deadman, R., Dhami, P., Dunn, M., Ellington, A.G., Frankland, J.A., Fraser, A., French, L., Garner, P., Grafham, D.V., Griffiths, C., Griffiths, M.N., Gwilliam, R., Hall, R.E., Hammond, S., Harley, J.L., Heath, P.D., Ho, S., Holden, J.L., Howden, P.J., Huckle, E., Hunt, A.R., Hunt, S.E., Jekosch, K., Johnson, C.M., Johnson, D., Kay, M.P., Kimberley, A.M., King, A., Knights, A., Laird, G.K., Lawlor, S., Lehvaslaiho, M.H., Leversha, M., Lloyd, C., Lloyd, D.M., Lovell, J.D., Marsh, V.L., Martin, S.L., McConnachie, L.J., McLay, K., McMurray, A.A., Milne, S., Mistry, D., Moore, M.J., Mullikin, J.C., Nickerson, T., Oliver, K., Parker, A., Patel, R., Pearce, T.A., Peck, A.I., Phillimore, B.J., Prathalingam, S.R., Plumb, R.W., Ramsay, H., Rice, C.M., Ross, M.T., Scott, C.E., Sehra, H.K., Shownkeen, R., Sims, S., Skuce, C.D., Smith, M.L., Soderlund, C., Steward, C.A., Sulston, I.E., Swann, M., Sycamore, N., Taylor, R., Tee, L., Thomas, D.W., Thorpe, A., Tracey, A., Tromans, A.C., Vaudin, M., Wall, M., Wallis, J.M., Whitehead, S.L., Whittaker, P., Willey, D.L., Williams, L., Williams, S.A., Wilming, L., Wray, P.W., Hubbard, T., Durbin, R.M., Bentley, D.R., Beck, S. & Rogers, J. (2001) The DNA sequence and comparative analysis of human chromosome 20. Nature, 414, 865-871.
9. Drexler, H.G. (2001) The Leukemia-Lymphoma Cell Line Facts Book. Academic Press, London.
10. Eton, O., Scheinberg, D.A. & Houghton, A.N. (1989) Establishment and characterization of two human myeloma cell lines secreting kappa light chains. Leukemia, 3, 729-735.
11. Fenton, J.A., Pratt, G., Rawstron, A.C. & Morgan, G.J. (2002) Isotype class switching and the pathogenesis of multiple myeloma. Hematological Oncology, 20, 75-85.
12. Fonseca, R., Blood, E.A., Oken, M.M. Kyle, R.A., Dewald, G.W., van Ness, B., van Wier, S.A., Henderson, K.J., Bailey, R.J. & Greipp, P.R. (2002) Myeloma and the t(11;14)(q13;q32); evidence for a biologically defined unique subset of patients. Blood, 99, 3735-3741.
13. Hamilton, M.S., Ball, J., Bromidge, E. & Franklin, J.M. (1990) Characterization of new IgG lambda myeloma plasma cell line (EJM): a further tool in the investigation of the biology of multiple myeloma. British Journal of Haematology, 75, 378-384.
14. Hanamura, I., Iida, S., Akano, Y., Hayami, Y., Kato, M., Miura, K., Harada, S., Banno, S., Wakita, A., Kiyoi, H., Naoe, T., Shimizu, S., Sonta, S.I., Nitta, M., Taniwaki, M. & Ueda, R. (2001) Ectopic expression of MAFB gene in human myeloma cells carrying(14;20(q32;q11) chromosomal translocations. Japanese Journal of Cancer Research, 92, 638-644.
15. Kataoka, K., Fujiwara, K.T., Noda, M. & Nishizawa, M. (1994) MafB, a new Maf family transcription activator that can associate with Maf and Fos but not with Jun. Molecular Cellular Biology 14, 7581-7591.
16. Kelly, L.M., Englmeier, U., Lafon, I., Sieweke, M.H. & Graf, T. (2000) MafB is an inducer of monocytic differentiation. EMBO Journal, 19, 1987-1997.
17. Kuipers, J., Vaandrager, J.W., Oldeweghuis, D., Peorson, P.L., Scheres, J., Lokhorst, H.M., Clevers, H.C. & Bast, B.J. (1999) FISH analysis shows the frequent occurrence of 14q32.3 rearrangements with involvement of the immunoglobulin switch regions in myeloma cell lines. Cancer Genetics & Cytogenetics, 109, 99-107.
18. Kuppers, R. & Dalla-Favera, R. (2001) Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene 20, 5580-5594.
19. Lieberson, R., Ong, J., Shi, X. & Eckhardt, L.A. (1995) Immunoglobulin gene transcription ceases upon deletion of a distant enhancer. EMBO Journal, 14, 6229-6238.
20. Moreau, P., Facon, T., Leleu, X., Morineau, N. Huyghe, P., Harousseau, J.L., Bataille, R. & Avet-Loiseau, H. (2002) Recurrent 14q32 translocations determine the prognosis of multiple myeloma, especially in patients receiving intensive chemotherapy. Blood, 100, 1579-1583.
21. Ohbayashi, K., Taniwaki, M., Ninomiya, M., Kiyoi, H., Iida, S., Ueda, R. & Naoe, T. (2003) A xeno-transplantable plasma cell leukaemia line with a split translocation of the IgH gene. Cancer Genetics & Cytogenetics, 144, 31-35.
22. enu mutation reveals multiple roles of Kreisler in hindbrain segmentation. Developmental Dynamics, 227, 134-142.
23. Sieweke, M.H., Tekotte, H., Frampton, J. & Graf, T. (1996) MafB is an interaction partner and represser of Ets-1 that inhibits erythroid differentiation. Cell, 85, 49-60.
24. Wang, P.W., Eisenbart, J.D., Cordes, S.P., Barsh, G.S., Stoffel, M. & Le Beau, M.M. (1999) Human KRML (MAFB): cDNA cloning, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias. Genomics, 59, 275-281. Indicates breakpoints in the UM3 cell line.