MDS/AML-associated cytogenetic abnormalities in multiple myeloma and monoclonal gammopathy of undetermined significance: Evidence for frequent de novo occurrence and multipotent stem cell involvement of del(20q)

Genes Chromosomes and Cancer

Volumn 41, Issue 3, 2004, Pages 223-231

  Nilsson, Therese ^a   Nilsson, Lars ^a   Lenhoff, Stig ^a   Rylander, Lars ^a   Åstrand Grundström, Ingbritt ^a   Strömbeck, Bodil ^a   Höglund, Mattias ^a   Turesson, Ingemar ^a   Westin, Jan ^a   Mitelman, Felix ^a   Jacobsen, Sten E W ^a   Johansson, Bertil ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CD38 ANTIGEN;

ACUTE GRANULOCYTIC LEUKEMIA; AGED; ARTICLE; B LYMPHOCYTE; BONE MARROW CELL; CHROMOSOME 14Q; CHROMOSOME 20Q; CHROMOSOME ABERRATION; CHROMOSOME DELETION; CHROMOSOME REARRANGEMENT; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; KARYOTYPE; MAJOR CLINICAL STUDY; MALE; MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE; MONOCLONAL IMMUNOGLOBULINEMIA; MULTIPLE MYELOMA; MULTIPOTENT STEM CELL; MYELODYSPLASTIC SYNDROME; PLOIDY; PRIORITY JOURNAL; TRISOMY;

AGED; AGED, 80 AND OVER; CELL SEPARATION; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 20; CYTOGENETICS; FEMALE; FLOW CYTOMETRY; GENE DELETION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; LEUKEMIA, MYELOCYTIC, ACUTE; MALE; MULTIPLE MYELOMA; MYELODYSPLASTIC SYNDROMES; PARAPROTEINEMIAS; PLOIDIES; STEM CELLS;

EID: 4644288964     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.20078     Document Type: Article

References (41)

1. Amiel A, Fridman K, Elis A, Gaber E, Manor Y, Fejgin M, Lishner M. 1999. Deletion 5q31 in patients with stable, melphalan-treated multiple myeloma. Cancer Genet Cytogenet 113:45-48.
2. Avet-Loiseau H, Andree-Ashley LE, Moore D 2nd, Mellerin MP, Feusner J, Bataille R, Pallavicini MG. 1997. Molecular cytogenetic abnormalities in multiple myeloma and plasma cell leukemia measured using comparative genomic hybridization. Genes Chromosomes Cancer 19:124-133.
3. Avet-Loiseau H, Facon T, Daviet A, Godon C, Rapp M-J, Harousseau J-L, Grosbois B, Bataille R. 1999. 14q32 translocations and monosomy 13 observed in monoclonal gammopathy of undetermined significance delineate a mukistep process for the oncogenesis of multiple myeloma. Cancer Res 59:4546-4550.
4. Bergsagel DE. 1982. Plasma cell neoplasms and acute leukaemia. Clin Haematol 11:221-234.
5. Blann MM, Gopalrao VN, Velagaleti GVN, Morgan DL, Martinez RE, Conlin PA, Tonk VS. 2002. Interstitial deletion of 20q in a patient with Waldenström macroglobulinemia following chemotherapy. Cancer Genet Cytogenet 132:145-148.
6. Clark RE, Geddes AD, Whittaker JA, Jacobs A. 1989. Differences in bone marrow cytogenetic characteristics between treated and untreated myeloma. Eur J Cancer Oncol 25:1789-1793.
7. Dewald GW, Kyle RA, Hicks GA, Greipp PR. 1985. The clinical significance of cytogenetic studies in 100 patients with multiple myeloma, plasma cell leukemia, or amyloidosis. Blood 66:380-390.
8. Drach J, Angerler J, Schuster J, Rothermundt C, Thalhammer R, Haas OA, Juger U, Fiegl M, Geissler K, Ludwig H, Huber H. 1995. Interphase fluorescence in situ hybridization identifies chromosomal abnormalities in plasma cells from patients with monoclonal gammopathy of undetermined significance. Blood 86:3915-3921.
9. Drach J, Kaufmann H, Urbauer E, Screiber S, Ackermann J, Huber H. 2000. The biology of multiple myeloma. J Cancer Res Clin Oncol 126:441-447.
10. Ferro MT, Hernaez R, Villalon C, Sordo MT, Garcia-Sagredo JM, Vallcorba I, Roman CS, Lopez J. 2002. Chromosome 9 interstitial deletion in multiple myeloma. Cancer Genet Cytogenet 139:88-89.
11. Fonseca R, Rajkumar SV, Ahmann GJ, Jalal SM, Hover JD, Gertz M, Kyle RA, Greipp PR, Dewald GW. 2000. FISH demonstrates treatment-related chromosome damage in myeloid but not plasma cells in primary systemic amyloidosis. Leuk Lymphoma 39:391-395.
12. Fonseca R, Oken MM, Greipp PR. 2001. The t(4;14)(p16.3;q32) is strongly associated with chromosome 13 abnormalities in both multiple myeloma and monoclonal gammopathy of undetermined significance. Blood 98:1271-1272.
13. Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz M, Vallespi T, Hamblin T, Oscier D, Ohyashiki K, Toyama K, Aul C, Mufti G, Bennett J. 1997. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 89:2079-2088.
14. Herens C, Brasseur E, Jamar M, Vierset L, Sehoenen I, Kouliseher L. 1999. Loss of the Y chromosome in bone marrow cells: results on 1907 consecutive cases of leukemia and preleukemia. Clin Lab Haematol 21:17-20.
15. ISCN. 1995. An International System for Human Cytogenetic Nomenclature. Mitelman F, editor. Basel, Switzerland: S. Karger.
16. Johansson B, Mertens F, Mitelman F. 1993. Geographic heterogeneity of neoplasia-associated chromosome aberrations. Genes Chromosomes Cancer 3:1-7.
17. Johansson B, Waldenström J, Hasselblom S, Mitelman F. 1995. Waldenström's macroglobulinemia with the AML/MDS-associated t(1;3)(p36;q21). Leukemia 9:1136-1138.
18. Kuehl WM, Bergsagel PL. 2002. Multiple myeloma: evolving genetic events and host interactions. Nat Rev Cancer 2:175-187.
19. Larochelle A, Vormoor J, Hanenberg H, Wang JC, Bhatia M, Lapidot T, Moritz T, Murdoch B, Xiao XL, Kato I, Williams DA, Dick JE. 1996. Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy. Nat Med 2:1329-1337.
20. Lee W, Man K, Drut RM, Harris CP, Meisner LF. 1993. Use of fluorescence in situ hybridization for retrospective detection of aneuploidy in multiple myeloma. Genes Chromosomes Cancer 7:137-143.
21. Mauritzson N, Albin M, Rylander L, Billström R, Ahlgren T, Mikoczy Z, Björk J, Strömberg U, Nilsson PG, Mitelman F, Hagmar L, Johansson B. 2002. Pooled analysis of clinical and cytogenetic features in treatment-related and de novo adult acute myeloid leukemia and myelodysplastic syndromes based on a consecutive series of 761 patients analyzed 1976-1993 and on 5098 unselected cases reported in the literature 1974-2001. Leukemia 16:2366-2378.
22. Merlat A, Laï JL. Sterkers Y, Demory JL, Bauters F, Preudhomme C, Fenaux P. 1999. Therapy-related myelodysplastic syndrome and acute myeloid leukemia with 17p deletion. A report on 25 cases. Leukemia 13:250-257.
23. Mitelman F, Johansson B, Mertens F. 2004. Mitelman Database of Chromosome Aberrations in Cancer. Available from: http://cgap. nci.nih.gov/Chromosomes/ Mitelman
24. Nilsson L, Åstrand-Grundström I, Arvidsson I, Jacobsson B, Hellström-Lindberg E, Hast R, Jacobsen SEW. 2000. Isolation and characterization of hematopoietic progenitor/stem cells in 5q-deleted myelodysplastic syndromes: evidence for involvement at the hematopoietic stem cell level. Blood 96:2012-2021.
25. + hematopoietic stem cell pool in myelodysplastic syndromes with trisomy 8. Blood 100: 259-267.
26. Nilsson T, Lenhoff S, Turesson I, Rylander L, Mitelman F, Westin J, Höglund M, Johansson B. 2002b. Cytogenetic features of multiple myeloma: impact of gender, age, disease phase, culture time, and cytokine stimulation. Eur J Haematol 68:345-353.
27. Nilsson T, Höglund M, Lenhoff S, Rylander L, Turesson I, Westin F, Mitelman F, Johansson B. 2003. A pooled analysis of karyotypic patterns, breakpoints and imbalances in 783 cytogenetically abnormal multiple myelomas reveals frequently involved chromosome segments as well as significant age- and sex-related differences. Br J Haematol 120:960-969.
28. Nishida K, Tamura A, Nakazawa N, Ueda Y, Abe T, Matsuda F, Kashima K, Taniwaki M. 1997. The Ig heavy chain gene is frequently involved in chromosomal translocations in multiple myeloma and plasma cell leukemia as detected by in situ hybridization. Blood 90:526-534.
29. Ögmundsdottir HM, Haraldsdottir V, Johannesson GM, Olafdottir G, Bjarndottir K, Sigvaldson H, Tulinius H. 2002. Monoclonal gammopathy in Iceland: a population-based registry and follow-up. Br J Haematol 118:166-173.
30. Pedersen-Bjergaard J, Andersen MK, Christiansen DH, Nerlov C. 2002. Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia. Blood 99:1909-1912.
31. Rasillo A, Tabernero MD, Sanchez ML, Pérez de Andres M, Martín Ayuso M, Hernández J, Moro MJ, Fernández-Calvo J, Sayagues JM, Bortoluci A, San Miguel JF, Orfao A. 2003. Fluorescence in situ hybridization analysis of aneuploidization patterns in monoclonal gammopathy of undetermined significance versus multiple myeloma and plasma cell leukemia. Cancer 97:601-609.
32. Redei I, Mangan KF, Ming PL, Mullaney MT, Rao PN, Goldberg SL, Klumpp TR. 1997. Detection of a dormant 20q-leukemia clone in bone marrow cultures with hematopoietic growth factors: implications for secondary leukemia post-transplant. Bone Marrow Transplant 19:521-523.
33. Rödjer S, Swolin B, Weinfeld A, Westin J. 1990. Cytogenetic abnormalities in acute leukemia complicating melphalan-treated multiple myeloma. Cancer Genet Cytogenet 48:67-73.
34. Sawyer JR, Lukacs JL, Munshi N, Desikan KR, Singhal S, Mehta J, Siegel D, Shaughnessy J, Barlogie B. 1998. Identification of new nonrandom translocations in multiple myeloma with multicolor spectral karyotyping. Blood 92:4269-4278.
35. Shaughnessy JD Jr, Barlogie B. 2003. Interpreting the molecular biology and clinical behavior of multiple myeloma in the context of global gene expression profiling. Immunol Rev 194:140-163.
36. Smith SM, Le Beau MM, Huo D, Karrison T, Sobecks RM, Anastasi J, Vardiman JW, Rowley JD, Larson RA. 2003. Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series. Blood 102:43-52.
37. Steensma DP, Dewald GW, Hodnefield JM, Terreri A, Hanson CA. 2003. Clonal cytogenetic abnormalities in bone marrow specimens without clear morphologic evidence of dysplasia: a form fruste of myelodysplasia? Leuk Res 27:235-242.
38. Turesson I, Zettervall O, Cuzik J, Waldenström JG, Velez R. 1984. Comparison of ttends in the incidence of multiple myeloma in Malmö, Sweden, and other countries, 1950-1979. N Engl J Med 310:421-424.
39. Weh HJ, Seeger D, Junge I, Hossfeld DK. 1996. Trisomy 8 preceding diagnosis of acute nonlymphocytic leukemia by 2 years in a patient with multiple myeloma without cytological evidence of myelodysplasia. Ann Hematol 72:81-82.
40. White NJ, Nacheva E, Asimakopoulos FA, Bloxham D, Paul B, Green AR. 1994. Deletion of chromosome 20q in myelodysplasia can occur in a multipotent precursor of both myeloid cells and B cells. Blood 83:2809-2816.
41. Zandecki M, Obein V, Bernardi E, Soenen V, Flactif M, Laï JL, Francois M, Facon T. 1995. Monoclonal gammopathy of undetermined significance: chromosome changes are a common finding within bone marrow plasma cells. Br J Haematol 90: 693-696.