메뉴 건너뛰기




Volumn 15, Issue 6, 2009, Pages 457-464

Risk stratification in the era of novel therapies

Author keywords

Bortezomib; Deletion 17p; Early relapse; High S phase; High Risk myeloma; Lenalidomide; T(14; 16); T(4; 14); Thalidomide

Indexed keywords

BORTEZOMIB; CARMUSTINE; CYCLIN D; CYCLOPHOSPHAMIDE; DEXAMETHASONE; DOXORUBICIN; LENALIDOMIDE; MELPHALAN; MICRORNA; PREDNISONE; THALIDOMIDE; VINCRISTINE;

EID: 75149115877     PISSN: 15289117     EISSN: 1540336X     Source Type: Journal    
DOI: 10.1097/PPO.0b013e3181c51efa     Document Type: Review
Times cited : (8)

References (66)
  • 1
    • 3242777803 scopus 로고    scopus 로고
    • Advances in biology of multiple myeloma: Clinical applications
    • Hideshima T, Bergsagel PL, Kuehl WM, et al. Advances in biology of multiple myeloma: clinical applications. Blood. 2004;104:607-618.
    • (2004) Blood , vol.104 , pp. 607-618
    • Hideshima, T.1    Bergsagel, P.L.2    Kuehl, W.M.3
  • 2
    • 33847197966 scopus 로고    scopus 로고
    • A practical guide to defining high-risk myeloma for clinical trials, patient counseling and choice of therapy
    • Stewart AK, Bergsagel PL, Greipp PR, et al. A practical guide to defining high-risk myeloma for clinical trials, patient counseling and choice of therapy. Leukemia. 2007;21:529-534.
    • (2007) Leukemia , vol.21 , pp. 529-534
    • Stewart, A.K.1    Bergsagel, P.L.2    Greipp, P.R.3
  • 3
    • 45749091430 scopus 로고    scopus 로고
    • Individualizing treatment of patients with myeloma in the era of novel agents
    • San-Miguel J, Harousseau JL, Joshua D, et al. Individualizing treatment of patients with myeloma in the era of novel agents. J Clin Oncol. 2008;26: 2761-2766.
    • (2008) J Clin Oncol , vol.26 , pp. 2761-2766
    • San-Miguel, J.1    Harousseau, J.L.2    Joshua, D.3
  • 5
    • 20444433230 scopus 로고    scopus 로고
    • Assessment of Proteasome Inhibition for Extending Remissions (APEX) Investigators. Bortezomib or high-dose dexamethasone for relapsed multiple myeloma
    • Richardson PG, Sonneveld P, Schuster MW, et al; Assessment of Proteasome Inhibition for Extending Remissions (APEX) Investigators. Bortezomib or high-dose dexamethasone for relapsed multiple myeloma. N Engl J Med. 2005;352:2487-2498.
    • (2005) N Engl J Med , vol.352 , pp. 2487-2498
    • Richardson, P.G.1    Sonneveld, P.2    Schuster, M.W.3
  • 6
    • 36349023319 scopus 로고    scopus 로고
    • Multiple Myeloma (010) Study Investigators. Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma
    • Dimopoulos M, Spencer A, Attal M, et al; Multiple Myeloma (010) Study Investigators. Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma. N Engl J Med. 2007;357:2123-2132.
    • (2007) N Engl J Med , vol.357 , pp. 2123-2132
    • Dimopoulos, M.1    Spencer, A.2    Attal, M.3
  • 7
    • 44649108963 scopus 로고    scopus 로고
    • Prolonged overall survival with lenalidomide plus dexamethasone compared with dexamethasone alone in patients with relapsed or refractory multiple myeloma (ASH Annual Meeting Abstracts)
    • Weber D, Knight R, Chen C, et al. Prolonged overall survival with lenalidomide plus dexamethasone compared with dexamethasone alone in patients with relapsed or refractory multiple myeloma (ASH Annual Meeting Abstracts). Blood. 2007;110:128a.
    • (2007) Blood , vol.110
    • Weber, D.1    Knight, R.2    Chen, C.3
  • 8
    • 50449086728 scopus 로고    scopus 로고
    • Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma
    • San Miguel JF, Schlag R, Khuageva NK, et al. Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma. N Engl J Med. 2008;359:906-917.
    • (2008) N Engl J Med , vol.359 , pp. 906-917
    • San Miguel, J.F.1    Schlag, R.2    Khuageva, N.K.3
  • 10
    • 35948990849 scopus 로고    scopus 로고
    • Prognostic factors and staging in multiple myeloma
    • Fonseca R, San MJ. Prognostic factors and staging in multiple myeloma. Hematol Oncol Clin North Am. 2007;21:1115-1140.
    • (2007) Hematol Oncol Clin North Am , vol.21 , pp. 1115-1140
    • Fonseca, R.1    San, M.J.2
  • 11
    • 20644460600 scopus 로고    scopus 로고
    • International staging system for multiple myeloma
    • Greipp PR, San MJ, Durie BG, et al. International staging system for multiple myeloma. J Clin Oncol. 2005;23:3412-3420.
    • (2005) J Clin Oncol , vol.23 , pp. 3412-3420
    • Greipp, P.R.1    San, M.J.2    Durie, B.G.3
  • 12
    • 0038142356 scopus 로고    scopus 로고
    • Clinical and biologic implications of recurrent genomic aberrations in myeloma
    • Fonseca R, Blood E, Rue M, et al. Clinical and biologic implications of recurrent genomic aberrations in myeloma. Blood. 2003;101:4569-4575.
    • (2003) Blood , vol.101 , pp. 4569-4575
    • Fonseca, R.1    Blood, E.2    Rue, M.3
  • 13
    • 33847378314 scopus 로고    scopus 로고
    • Genetic abnormalities and survival in multiple myeloma: The experience of the Intergroupe Francophone du Myelome
    • Avet-Loiseau H, Attal M, Moreau P, et al. Genetic abnormalities and survival in multiple myeloma: the experience of the Intergroupe Francophone du Myelome. Blood. 2007;109:3489-3495.
    • (2007) Blood , vol.109 , pp. 3489-3495
    • Avet-Loiseau, H.1    Attal, M.2    Moreau, P.3
  • 14
    • 33845546906 scopus 로고    scopus 로고
    • Prognostic and biological implications of genetic abnormalities in multiple myeloma undergoing autologous stem cell transplantation: T(4;14) is the most relevant adverse prognostic factor, whereas RB deletion as a unique abnormality is not associated with adverse prognosis
    • Gutierrez NC, Castellanos MV, Martin ML, et al. Prognostic and biological implications of genetic abnormalities in multiple myeloma undergoing autologous stem cell transplantation: t(4;14) is the most relevant adverse prognostic factor, whereas RB deletion as a unique abnormality is not associated with adverse prognosis. Leukemia. 2007;21:143-150.
    • (2007) Leukemia , vol.21 , pp. 143-150
    • Gutierrez, N.C.1    Castellanos, M.V.2    Martin, M.L.3
  • 15
    • 10744223381 scopus 로고    scopus 로고
    • Genetics and cytogenetics of multiple myeloma: A workshop report
    • Fonseca R, Barlogie B, Bataille R, et al. Genetics and cytogenetics of multiple myeloma: a workshop report. Cancer Res. 2004;64:1546-1558.
    • (2004) Cancer Res , vol.64 , pp. 1546-1558
    • Fonseca, R.1    Barlogie, B.2    Bataille, R.3
  • 16
    • 33748196399 scopus 로고    scopus 로고
    • Frequent gain of chromosome band 1q21 in plasma-cell dyscrasias detected by fluorescence in situ hybridization: Incidence increases from MGUS to relapsed myeloma and is related to prognosis and disease progression following tandem stem-cell transplantation
    • Hanamura I, Stewart JP, Huang Y, et al. Frequent gain of chromosome band 1q21 in plasma-cell dyscrasias detected by fluorescence in situ hybridization: incidence increases from MGUS to relapsed myeloma and is related to prognosis and disease progression following tandem stem-cell transplantation. Blood. 2006;108:1724-1732.
    • (2006) Blood , vol.108 , pp. 1724-1732
    • Hanamura, I.1    Stewart, J.P.2    Huang, Y.3
  • 17
    • 74549190701 scopus 로고    scopus 로고
    • Prognostic significance of copynumber alterations in multiple myeloma
    • Avet-Loiseau H, Li C, Magrangeas F, et al. Prognostic significance of copynumber alterations in multiple myeloma. J Clin Oncol. 2009;27:4585-4590.
    • (2009) J Clin Oncol , vol.27 , pp. 4585-4590
    • Avet-Loiseau, H.1    Li, C.2    Magrangeas, F.3
  • 18
    • 33846852215 scopus 로고    scopus 로고
    • Tumor suppressor p16 methylation in multiple myeloma: Biological and clinical implications
    • Gonzalez-Paz N, Chng WJ, McClure RF, et al. Tumor suppressor p16 methylation in multiple myeloma: biological and clinical implications. Blood. 2007;109:1228-1232.
    • (2007) Blood , vol.109 , pp. 1228-1232
    • Gonzalez-Paz, N.1    Chng, W.J.2    McClure, R.F.3
  • 19
    • 33745779502 scopus 로고    scopus 로고
    • The molecular classification of multiple myeloma
    • Zhan F, Huang Y, Colla S, et al. The molecular classification of multiple myeloma. Blood. 2006;108:2020-2028.
    • (2006) Blood , vol.108 , pp. 2020-2028
    • Zhan, F.1    Huang, Y.2    Colla, S.3
  • 20
    • 33947217497 scopus 로고    scopus 로고
    • A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1
    • Shaughnessy JD Jr, Zhan F, Burington BE, et al. A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1. Blood. 2007;109:2276-2284.
    • (2007) Blood , vol.109 , pp. 2276-2284
    • Shaughnessy Jr., J.D.1    Zhan, F.2    Burington, B.E.3
  • 21
    • 54249092519 scopus 로고    scopus 로고
    • Prediction of survival in multiple myeloma based on gene expression profiles reveals cell cycle and chromosomal instability signatures in high-risk patients and hyperdiploid signatures in low-risk patients: A study of the Intergroupe Francophone du Myelome
    • Decaux O, Lode L, Magrangeas F, et al. Prediction of survival in multiple myeloma based on gene expression profiles reveals cell cycle and chromosomal instability signatures in high-risk patients and hyperdiploid signatures in low-risk patients: a study of the Intergroupe Francophone du Myelome. J Clin Oncol. 2008;26:4798-4805.
    • (2008) J Clin Oncol , vol.26 , pp. 4798-4805
    • Decaux, O.1    Lode, L.2    Magrangeas, F.3
  • 22
    • 40949160248 scopus 로고    scopus 로고
    • Low expression of ZHX2, but not RCBTB2 or RAN, is associated with poor outcome in multiple myeloma
    • Armellini A, Sarasquete ME, Garcia-Sanz R, et al. Low expression of ZHX2, but not RCBTB2 or RAN, is associated with poor outcome in multiple myeloma. Br J Haematol. 2008;141:212-215.
    • (2008) Br J Haematol , vol.141 , pp. 212-215
    • Armellini, A.1    Sarasquete, M.E.2    Garcia-Sanz, R.3
  • 23
    • 51349093465 scopus 로고    scopus 로고
    • MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis
    • Pichiorri F, Suh SS, Ladetto M, et al. MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis. Proc Natl Acad Sci USA. 2008;105:12885-12890.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 12885-12890
    • Pichiorri, F.1    Suh, S.S.2    Ladetto, M.3
  • 24
    • 69249225706 scopus 로고    scopus 로고
    • MicroRNAs 15a and 16 regulate tumor proliferation in multiple myeloma
    • Roccaro AM, Sacco A, Thompson B, et al. MicroRNAs 15a and 16 regulate tumor proliferation in multiple myeloma. Blood. 2009;113:6669-6680.
    • (2009) Blood , vol.113 , pp. 6669-6680
    • Roccaro, A.M.1    Sacco, A.2    Thompson, B.3
  • 25
    • 75149137558 scopus 로고    scopus 로고
    • MicroRNA expression profiling in multiple myeloma: Correlation with genetic abnormalities
    • Gutierrez NC, Sarasquete ME, Delgado M. MicroRNA expression profiling in multiple myeloma: correlation with genetic abnormalities. Blood. 2008;112: 629a.
    • (2008) Blood , vol.112
    • Gutierrez, N.C.1    Sarasquete, M.E.2    Delgado, M.3
  • 26
    • 22044440425 scopus 로고    scopus 로고
    • Cyclin D dysregulation: An early and unifying pathogenic event in multiple myeloma
    • Bergsagel PL, Kuehl WM, Zhan F, et al. Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma. Blood. 2005;106:296-303.
    • (2005) Blood , vol.106 , pp. 296-303
    • Bergsagel, P.L.1    Kuehl, W.M.2    Zhan, F.3
  • 27
    • 20244363331 scopus 로고    scopus 로고
    • Chromosome abnormalities clustering and its implications for pathogenesis and prognosis in myeloma
    • Debes-Marun CS, Dewald GW, Bryant S. Chromosome abnormalities clustering and its implications for pathogenesis and prognosis in myeloma. Leukemia. 2003;17:427-436.
    • (2003) Leukemia , vol.17 , pp. 427-436
    • Debes-Marun, C.S.1    Dewald, G.W.2    Bryant, S.3
  • 28
    • 0344142354 scopus 로고    scopus 로고
    • Primary plasma cell leukemia: Clinical, immunophenotypic, DNA ploidy, and cytogenetic characteristics
    • Garcia-Sanz R, Orfao A, Gonzalez M, et al. Primary plasma cell leukemia: clinical, immunophenotypic, DNA ploidy, and cytogenetic characteristics. Blood. 1999;93:1032-1037.
    • (1999) Blood , vol.93 , pp. 1032-1037
    • Garcia-Sanz, R.1    Orfao, A.2    Gonzalez, M.3
  • 29
    • 0024551187 scopus 로고
    • Detection of hypodiploidy using multi-parameter flow cytometric analysis: A prognostic indicator in multiple myeloma
    • Morgan RJ Jr, Gonchoroff NJ, Katzmann JA, et al. Detection of hypodiploidy using multi-parameter flow cytometric analysis: a prognostic indicator in multiple myeloma. Am J Hematol. 1989;30:195-200.
    • (1989) Am J Hematol , vol.30 , pp. 195-200
    • Morgan Jr., R.J.1    Gonchoroff, N.J.2    Katzmann, J.A.3
  • 30
    • 0026522839 scopus 로고
    • Immunophenotype and DNA content of myeloma cells in primary plasma cell leukemia
    • Shimazaki C, Gotoh H, Ashihara E, et al. Immunophenotype and DNA content of myeloma cells in primary plasma cell leukemia. Am J Hematol. 1992;39:159-162.
    • (1992) Am J Hematol , vol.39 , pp. 159-162
    • Shimazaki, C.1    Gotoh, H.2    Ashihara, E.3
  • 31
    • 0029070777 scopus 로고
    • Prognostic implications of DNA aneuploidy in 156 untreated multiple myeloma patients
    • Castelano-Leones (Spain) Cooperative Group for the Study of Monoclonal Gammopathies
    • Garcia-Sanz R, Orfao A, Gonzalez M, et al. Prognostic implications of DNA aneuploidy in 156 untreated multiple myeloma patients. Castelano-Leones (Spain) Cooperative Group for the Study of Monoclonal Gammopathies. Br J Haematol. 1995;90:106-112.
    • (1995) Br J Haematol , vol.90 , pp. 106-112
    • Garcia-Sanz, R.1    Orfao, A.2    Gonzalez, M.3
  • 32
    • 0028899614 scopus 로고
    • A new staging system for multiple myeloma based on the number of S-phase plasma cells
    • San Miguel JF, Garcia-Sanz R, Gonzalez M, et al. A new staging system for multiple myeloma based on the number of S-phase plasma cells. Blood. 1995;85:448-455.
    • (1995) Blood , vol.85 , pp. 448-455
    • San Miguel, J.F.1    Garcia-Sanz, R.2    Gonzalez, M.3
  • 33
    • 0032866976 scopus 로고    scopus 로고
    • Is flow cytometric DNA content hypodiploidy prognostic in multiple myeloma?
    • Greipp PR, Trendle MC, Leong T, et al. Is flow cytometric DNA content hypodiploidy prognostic in multiple myeloma? Leuk Lymphoma. 1999;35: 83-89.
    • (1999) Leuk Lymphoma , vol.35 , pp. 83-89
    • Greipp, P.R.1    Trendle, M.C.2    Leong, T.3
  • 34
    • 7244234267 scopus 로고    scopus 로고
    • Prognostic and biologic significance of chromosomal imbalances assessed by comparative genomic hybridization in multiple myeloma
    • Gutierrez NC, Garcia JL, Hernandez JM, et al. Prognostic and biologic significance of chromosomal imbalances assessed by comparative genomic hybridization in multiple myeloma. Blood. 2004;104:2661-2666.
    • (2004) Blood , vol.104 , pp. 2661-2666
    • Gutierrez, N.C.1    Garcia, J.L.2    Hernandez, J.M.3
  • 35
    • 0027164309 scopus 로고
    • Plasma cell labeling index and beta 2-microglobulin predict survival independent of thymidine kinase and C-reactive protein in multiple myeloma
    • Greipp PR, Lust JA, O'Fallon WM, et al. Plasma cell labeling index and beta 2-microglobulin predict survival independent of thymidine kinase and C-reactive protein in multiple myeloma. Blood. 1993;81:3382-3387.
    • (1993) Blood , vol.81 , pp. 3382-3387
    • Greipp, P.R.1    Lust, J.A.2    O'Fallon, W.M.3
  • 37
    • 7244232591 scopus 로고    scopus 로고
    • Proliferative activity of plasma cells is the most relevant prognostic factor in elderly multiple myeloma patients
    • Garcia-Sanz R, Gonzalez-Fraile MI, Mateo G, et al. Proliferative activity of plasma cells is the most relevant prognostic factor in elderly multiple myeloma patients. Int J Cancer. 2004;112:884-889.
    • (2004) Int J Cancer , vol.112 , pp. 884-889
    • Garcia-Sanz, R.1    Gonzalez-Fraile, M.I.2    Mateo, G.3
  • 38
    • 0026093537 scopus 로고
    • Immunophenotypic heterogeneity of multiple myeloma: Influence on the biology and clinical course of the disease
    • Castellano-Leones (Spain) Cooperative Group for the Study of Monoclonal Gammopathies
    • San Miguel JF, Gonzalez M, Gascon A, et al. Immunophenotypic heterogeneity of multiple myeloma: influence on the biology and clinical course of the disease. Castellano-Leones (Spain) Cooperative Group for the Study of Monoclonal Gammopathies. Br J Haematol. 1991;77:185-190.
    • (1991) Br J Haematol , vol.77 , pp. 185-190
    • San Miguel, J.F.1    Gonzalez, M.2    Gascon, A.3
  • 39
    • 0029118548 scopus 로고
    • Adhesion molecules on human myeloma cells: Significant changes in expression related to malignancy, tumor spreading, and immortalization
    • Pellat-Deceunynck C, Barille S, Puthier D, et al. Adhesion molecules on human myeloma cells: significant changes in expression related to malignancy, tumor spreading, and immortalization. Cancer Res. 1995;55:3647-3653.
    • (1995) Cancer Res , vol.55 , pp. 3647-3653
    • Pellat-Deceunynck, C.1    Barille, S.2    Puthier, D.3
  • 40
    • 17344378375 scopus 로고    scopus 로고
    • CD28, a marker associated with tumoral expansion in multiple myeloma
    • Robillard N, Jego G, Pellat-Deceunynck C, et al. CD28, a marker associated with tumoral expansion in multiple myeloma. Clin Cancer Res. 1998;4:1521-1526.
    • (1998) Clin Cancer Res , vol.4 , pp. 1521-1526
    • Robillard, N.1    Jego, G.2    Pellat-Deceunynck, C.3
  • 41
    • 45749097488 scopus 로고    scopus 로고
    • Prognostic value of immunophenotyping in multiple myeloma: A study by the PETHEMA/GEM cooperative study groups on patients uniformly treated with high-dose therapy
    • Mateo G, Montalban MA, Vidriales MB, et al. Prognostic value of immunophenotyping in multiple myeloma: a study by the PETHEMA/GEM cooperative study groups on patients uniformly treated with high-dose therapy. J Clin Oncol. 2008;26:2737-2744.
    • (2008) J Clin Oncol , vol.26 , pp. 2737-2744
    • Mateo, G.1    Montalban, M.A.2    Vidriales, M.B.3
  • 42
    • 36349031205 scopus 로고    scopus 로고
    • Complete response correlates with long-term survival and progression-free survival in high-dose therapy in multiple myeloma
    • Van de Velde H, Liu X, Chen G, et al. Complete response correlates with long-term survival and progression-free survival in high-dose therapy in multiple myeloma. Haematologica. 2007;92:1399-1406.
    • (2007) Haematologica , vol.92 , pp. 1399-1406
    • Van De Velde, H.1    Liu, X.2    Chen, G.3
  • 43
    • 57449109100 scopus 로고    scopus 로고
    • Influence of pre-and post-transplantation responses on outcome of patients with multiple myeloma: Sequential improvement of response and achievement of complete response are associated with longer survival
    • Lahuerta JJ, Mateos MV, Martinez-Lopez J, et al. Influence of pre- and post-transplantation responses on outcome of patients with multiple myeloma: sequential improvement of response and achievement of complete response are associated with longer survival. J Clin Oncol. 2008;26:5775-5782.
    • (2008) J Clin Oncol , vol.26 , pp. 5775-5782
    • Lahuerta, J.J.1    Mateos, M.V.2    Martinez-Lopez, J.3
  • 44
    • 51349092940 scopus 로고    scopus 로고
    • Relapsed/refractory multiple myeloma patients treated with lenalidomide/dexamethasone who achieve a complete or near complete response have longer overall survival and time to progression compared with patients achieving a partial response (ASH Annual Meeting Abstracts)
    • Harousseau JL, Weber D, Dimopoulos M, et al. Relapsed/refractory multiple myeloma patients treated with lenalidomide/dexamethasone who achieve a complete or near complete response have longer overall survival and time to progression compared with patients achieving a partial response (ASH Annual Meeting Abstracts). Blood. 2007;110:1052a.
    • (2007) Blood , vol.110
    • Harousseau, J.L.1    Weber, D.2    Dimopoulos, M.3
  • 45
    • 70249142129 scopus 로고    scopus 로고
    • Superior outcomes associated with complete response: Analysis of the phase III VISTA study of bortezomib plus melphalan-prednisone versus melphalan-prednisone
    • Harousseau JL, Palumbo A, Richardson P. Superior outcomes associated with complete response: analysis of the phase III VISTA study of bortezomib plus melphalan-prednisone versus melphalan-prednisone. Blood. 2008;112:2778a.
    • (2008) Blood , vol.112
    • Harousseau, J.L.1    Palumbo, A.2    Richardson, P.3
  • 46
    • 84988241358 scopus 로고    scopus 로고
    • International uniform response criteria for multiple myeloma
    • Durie BG, Harousseau JL, Miguel JS, et al. International uniform response criteria for multiple myeloma. Leukemia. 2006;20:1467-1473.
    • (2006) Leukemia , vol.20 , pp. 1467-1473
    • Durie, B.G.1    Harousseau, J.L.2    Miguel, J.S.3
  • 47
    • 59449099316 scopus 로고    scopus 로고
    • Multiparameter flow cytometric remission is the most relevant prognostic factor for multiple myeloma patients who undergo autologous stem cell transplantation
    • Paiva B, Vidriales MB, Cervero J, et al. Multiparameter flow cytometric remission is the most relevant prognostic factor for multiple myeloma patients who undergo autologous stem cell transplantation. Blood. 2008;112:4017-4023.
    • (2008) Blood , vol.112 , pp. 4017-4023
    • Paiva, B.1    Vidriales, M.B.2    Cervero, J.3
  • 48
    • 27144546033 scopus 로고    scopus 로고
    • Minimal residual disease monitoring in multiple myeloma: A comparison between allelic-specific oligonucleotide real-time quantitative polymerase chain reaction and flow cytometry
    • Sarasquete ME, Garcia-Sanz R, Gonzalez D, et al. Minimal residual disease monitoring in multiple myeloma: a comparison between allelic-specific oligonucleotide real-time quantitative polymerase chain reaction and flow cytometry. Haematologica. 2005;90:1365-1372.
    • (2005) Haematologica , vol.90 , pp. 1365-1372
    • Sarasquete, M.E.1    Garcia-Sanz, R.2    Gonzalez, D.3
  • 49
    • 33847369790 scopus 로고    scopus 로고
    • Treatment of newly diagnosed multiple myeloma based on mayo stratification of myeloma and risk-adapted therapy (mSMART): Consensus statement
    • Dispenzieri A, Rajkumar SV, Gertz MA, et al. Treatment of newly diagnosed multiple myeloma based on mayo stratification of myeloma and risk-adapted therapy (mSMART): consensus statement. Mayo Clin Proc. 2007;82:323-341.
    • (2007) Mayo Clin Proc , vol.82 , pp. 323-341
    • Dispenzieri, A.1    Rajkumar, S.V.2    Gertz, M.A.3
  • 50
    • 0032748385 scopus 로고    scopus 로고
    • Antitumor activity of thalidomide in refractory multiple myeloma
    • Singhal S, Mehta J, Desikan R, et al. Antitumor activity of thalidomide in refractory multiple myeloma. N Engl J Med. 1999;341:1565-1571.
    • (1999) N Engl J Med , vol.341 , pp. 1565-1571
    • Singhal, S.1    Mehta, J.2    Desikan, R.3
  • 51
    • 37249024095 scopus 로고    scopus 로고
    • Up-front thalidomide-dexamethasone (THAL) and double autologous transplantation (Double TX) for multiple myeloma: Comparison with double TX without added thalidomide and prognostic implications of chromosome 13 deletion and translocation t(4;14)
    • Cavo M, Testoni N, Terragna C, et al. Up-front thalidomide-dexamethasone (THAL) and double autologous transplantation (Double TX) for multiple myeloma: comparison with double TX without added thalidomide and prognostic implications of chromosome 13 deletion and translocation t(4;14). Blood. 2006;108:3081a.
    • (2006) Blood , vol.108
    • Cavo, M.1    Testoni, N.2    Terragna, C.3
  • 52
    • 60849136109 scopus 로고    scopus 로고
    • Final analysis of HOVON-50 randomized phase III study on the effect of thalidomide combined with adriamycine dexamethasone (AD) and high dose melphalan (HDM) in patients with multiple myeloma (MM)
    • Lokhorst H, van der Holt B, Zweegman S. Final analysis of HOVON-50 randomized phase III study on the effect of thalidomide combined with adriamycine, dexamethasone (AD) and high dose melphalan (HDM) in patients with multiple myeloma (MM). Blood. 2008;112:157a.
    • (2008) Blood , vol.112
    • Lokhorst, H.1    Van Der Holt, B.2    Zweegman, S.3
  • 53
    • 33751164196 scopus 로고    scopus 로고
    • Maintenance therapy with thalidomide improves survival in patients with multiple myeloma
    • Attal M, Harousseau JL, Leyvraz S, et al. Maintenance therapy with thalidomide improves survival in patients with multiple myeloma. Blood. 2006; 108:3289-3294.
    • (2006) Blood , vol.108 , pp. 3289-3294
    • Attal, M.1    Harousseau, J.L.2    Leyvraz, S.3
  • 54
    • 60849114852 scopus 로고    scopus 로고
    • Maintenance thalidomide may improve progression free but not overall survival; Results from the myeloma IX maintenance randomisation
    • Morgan G, Jackson GH, Davies FE. Maintenance thalidomide may improve progression free but not overall survival; results from the myeloma IX maintenance randomisation. Blood. 2008;112:656a.
    • (2008) Blood , vol.112
    • Morgan, G.1    Jackson, G.H.2    Davies, F.E.3
  • 55
    • 54049148621 scopus 로고    scopus 로고
    • Thalidomide arm of total therapy 2 improves complete remission duration and survival in myeloma patients with metaphase cytogenetic abnormalities
    • Barlogie B, Pineda-Roman M, van RF, et al. Thalidomide arm of total therapy 2 improves complete remission duration and survival in myeloma patients with metaphase cytogenetic abnormalities. Blood. 2008;112:3115-3121.
    • (2008) Blood , vol.112 , pp. 3115-3121
    • Barlogie, B.1    Pineda-Roman, M.2    Van, R.F.3
  • 56
    • 70149113290 scopus 로고    scopus 로고
    • Influence of cytogenetics in patients with relapsed or refractory multiple myeloma treated with lenalidomide plus dexamethasone: Adverse effect of deletion 17p13
    • Reece D, Song KW, Fu T, et al. Influence of cytogenetics in patients with relapsed or refractory multiple myeloma treated with lenalidomide plus dexamethasone: adverse effect of deletion 17p13. Blood. 2009;114:522-525.
    • (2009) Blood , vol.114 , pp. 522-525
    • Reece, D.1    Song, K.W.2    Fu, T.3
  • 57
    • 70449485576 scopus 로고    scopus 로고
    • Impact of chromosomal abnormalities del(13), T(4;14), and del(17p) and prior treatment on outcomes in patients with relapsed or refractory multiple myeloma treated with lenalidomide
    • Avet-Loiseau H, Soulier J, Fermand J. Impact of chromosomal abnormalities del(13), T(4;14), and del(17p) and prior treatment on outcomes in patients with relapsed or refractory multiple myeloma treated with lenalidomide. Blood. 2008;112:3685a.
    • (2008) Blood , vol.112
    • Avet-Loiseau, H.1    Soulier, J.2    Fermand, J.3
  • 58
    • 70149107680 scopus 로고    scopus 로고
    • Impact of risk stratification on outcome among patients with multiple myeloma receiving initial therapy with lenalidomide and dexamethasone
    • Kapoor P, Kumar S, Fonseca R, et al. Impact of risk stratification on outcome among patients with multiple myeloma receiving initial therapy with lenalidomide and dexamethasone. Blood. 2009;114:518-521.
    • (2009) Blood , vol.114 , pp. 518-521
    • Kapoor, P.1    Kumar, S.2    Fonseca, R.3
  • 59
    • 33845518467 scopus 로고    scopus 로고
    • Bortezomib appears to overcome the poor prognosis conferred by chromosome 13 deletion in phase 2 and 3 trials
    • Jagannath S, Richardson PG, Sonneveld P, et al. Bortezomib appears to overcome the poor prognosis conferred by chromosome 13 deletion in phase 2 and 3 trials. Leukemia. 2007;21:151-157.
    • (2007) Leukemia , vol.21 , pp. 151-157
    • Jagannath, S.1    Richardson, P.G.2    Sonneveld, P.3
  • 60
    • 33845524012 scopus 로고    scopus 로고
    • Bortezomib in relapsed multiple myeloma: Response rates and duration of response are independent of a chromosome 13q-deletion
    • Sagaster V, Ludwig H, Kaufmann H, et al. Bortezomib in relapsed multiple myeloma: response rates and duration of response are independent of a chromosome 13q-deletion. Leukemia. 2007;21:164-168.
    • (2007) Leukemia , vol.21 , pp. 164-168
    • Sagaster, V.1    Ludwig, H.2    Kaufmann, H.3
  • 61
    • 62649159169 scopus 로고    scopus 로고
    • Bortezomib/dexamethasone versus VAD as induction prior to autologous stem cell transplantation (ASCT) in previously untreated multiple myeloma (MM): Updated data from IFM 2005/01 trial
    • Harousseau J, Mathiot C, Attal M. Bortezomib/dexamethasone versus VAD as induction prior to autologous stem cell transplantation (ASCT) in previously untreated multiple myeloma (MM): updated data from IFM 2005/01 trial. J Clin Oncol. 2008;26:8505a.
    • (2008) J Clin Oncol , vol.26
    • Harousseau, J.1    Mathiot, C.2    Attal, M.3
  • 62
    • 77950530986 scopus 로고    scopus 로고
    • Superior rate of complete response with up-front velcade-thalidomide- dexamethasone versus thalidomide-dexamethasone in newly diagnosed multiple myeloma is not affected by adverse prognostic factors, including high-risk cytogenetic abnormalities
    • Cavo M, Testoni N, Terragna C. Superior rate of complete response with up-front velcade-thalidomide-dexamethasone versus thalidomide-dexamethasone in newly diagnosed multiple myeloma is not affected by adverse prognostic factors, including high-risk cytogenetic abnormalities. Blood. 2008;112:1662a.
    • (2008) Blood , vol.112
    • Cavo, M.1    Testoni, N.2    Terragna, C.3
  • 63
    • 66849135527 scopus 로고    scopus 로고
    • Thalidomide/dexamethasone (TD) vs. bortezomib (velcade®)/thalidomide/ dexamethasone (VTD)) vs. VBMCP/ VBAD/velcade® as induction regimens prior autologous stem cell transplantation (ASCT) in younger patients with multiple myeloma (MM): First results of a prospective phase III PETHEMA/Gem trial
    • Rosinol L, Cibeira MT, Martinez J. Thalidomide/dexamethasone (TD) vs. bortezomib (velcade®)/thalidomide/dexamethasone (VTD)) vs. VBMCP/ VBAD/velcade® as induction regimens prior autologous stem cell transplantation (ASCT) in younger patients with multiple myeloma (MM): first results of a prospective phase III PETHEMA/Gem trial. Blood. 2008;112:654a.
    • (2008) Blood , vol.112
    • Rosinol, L.1    Cibeira, M.T.2    Martinez, J.3
  • 64
    • 70349296572 scopus 로고    scopus 로고
    • Lenalidomide, bortezomib, and dexamethasone in patients with relapsed or relapsed/refractory multiple myeloma (MM): Encouraging response rates and tolerability with correlation of outcome and adverse cytogenetics in a phase II study
    • Richardson P, Jagannath S, Jakubowiak A. Lenalidomide, bortezomib, and dexamethasone in patients with relapsed or relapsed/refractory multiple myeloma (MM): encouraging response rates and tolerability with correlation of outcome and adverse cytogenetics in a phase II study. Blood. 2008;112:1742a.
    • (2008) Blood , vol.112
    • Richardson, P.1    Jagannath, S.2    Jakubowiak, A.3
  • 65
    • 64749088516 scopus 로고    scopus 로고
    • Lenalidomide, bortezomib, and dexamethasone in patients with newly diagnosed multiple myeloma: Encouraging efficacy in high risk groups with updated results of a phase I/II Study
    • Richardson P, Lonial S, Jakubowiak A. Lenalidomide, bortezomib, and dexamethasone in patients with newly diagnosed multiple myeloma: encouraging efficacy in high risk groups with updated results of a phase I/II Study. Blood. 2008;112:92a.
    • (2008) Blood , vol.112
    • Richardson, P.1    Lonial, S.2    Jakubowiak, A.3
  • 66
    • 70249112584 scopus 로고    scopus 로고
    • Ninety percent sustained complete response (CR) rate projected 4 years after onset of CR in gene expression profiling (GEP)-defined low-risk multiple myeloma (MM) treated with total therapy 3 (TT3): Basis for GEP-risk-adapted TT4 and TT5
    • Barlogie B, Anaissie E, Shaughnessy J. Ninety percent sustained complete response (CR) rate projected 4 years after onset of CR in gene expression profiling (GEP)-defined low-risk multiple myeloma (MM) treated with total therapy 3 (TT3): basis for GEP-risk-adapted TT4 and TT5. Blood. 2008;112:162a.
    • (2008) Blood , vol.112
    • Barlogie, B.1    Anaissie, E.2    Shaughnessy, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.