Characterization of deoxynivalenol-induced anorexia using mouse bioassay

Food and Chemical Toxicology

Volumn 49, Issue 8, 2011, Pages 1863-1869

  Flannery, Brenna M ^a,b   Wu, Wenda ^d   Pestka, James J ^a,b,c  

^a Michigan State University   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c NONE   (United States)

^d NANJING AGRICULTURAL UNIVERSITY   (China)

Author keywords

Anorexia; Deoxynivalenol; Mycotoxin; Trichothecene

Indexed keywords

VOMITOXIN;

ANIMAL EXPERIMENT; ANOREXIA; ARTICLE; BIOASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EXPOSURE; FEMALE; FOOD INTAKE; MOUSE; NONHUMAN; NUTRITIONAL TOLERANCE;

ADMINISTRATION, ORAL; ANIMALS; ANOREXIA; BIOLOGICAL ASSAY; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; FEMALE; LINEAR MODELS; MICE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; TRICHOTHECENES;

MUS;

EID: 79958697775     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.05.004     Document Type: Article

References (50)

1. Amuzie C.J., Pestka J.J. Suppression of insulin-like growth factor acid-labile subunit expression - a novel mechanism for deoxynivalenol-induced growth retardation. Toxicol. Sci. 2010, 113:412-421.
2. Amuzie C.J., Harkema J.R., Pestka J.J. Tissue distribution and proinflammatory cytokine induction by the trichothecene deoxynivalenol in the mouse: comparison of nasal vs. oral exposure. Toxicology 2008, 248:39-44.
3. Amuzie C.J., Shinozuka J., Pestka J.J. Induction of suppressors of cytokine signaling by the trichothecene deoxynivalenol in the mouse. Toxicol. Sci. 2009, 111:277-287.
4. Amuzie C.J., Flannery B.M., Ulrich A.M., Pestka J.J. Effects of deoxynivalenol consumption on body weight and adiposity in the diet-induced obese mouse. J. Toxicol. Environ. Health 2011, 74:658-667.
5. Andrews P.L., Horn C.C. Signals for nausea and emesis: implications for models of upper gastrointestinal diseases. Auton. Neurosci. 2006, 125:100-115.
6. Arnold D.L., McGuire P.F., Nera E.A., Karpinski K.F., Bickis M.G., Zawidzka Z.Z., Fernie S., Vesonder R.F. The toxicity of orally administered deoxynivalenol (vomitoxin) in rats and mice. Food Chem. Toxicol. 1986, 24:935-941.
7. Azcona-Olivera J.I., Ouyang Y., Murtha J., Chu F.S., Pestka J.J. Induction of cytokine mRNAs in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): relationship to toxin distribution and protein synthesis inhibition. Toxicol. Appl. Pharmacol. 1995, 133:109-120.
8. Banks W.A., Kastin A.J., Gutierrez E.G. Penetration of interleukin-6 across the murine blood-brain barrier. Neurosci. Lett. 1994, 179:53-56.
9. Boisclair Y.R., Wang J., Shi J., Hurst K.R., Ooi G.T. Role of the suppressor of cytokine signaling-3 in mediating the inhibitory effects of interleukin-1beta on the growth hormone-dependent transcription of the acid-labile subunit gene in liver cells. J. Biol. Chem. 2000, 275:3841-3847.
10. Cameron K.M., Speakman J.R. The extent and function of 'food grinding' in the laboratory mouse (Mus musculus). Lab. Anim. 2010, 44:298-304.
11. Fioramonti J., Dupuy C., Dupuy J., Bueno L. The mycotoxin, deoxynivalenol, delays gastric emptying through serotonin-3 receptors in rodents. J. Pharmacol. Exp. Ther. 1993, 266:1255-1260.
12. Ford D.J. Influence of diet pellet hardness and particle size on food utilization by mice, rats and hamsters. Lab. Anim. 1977, 11:241-246.
13. Forsell J.H., Witt M.F., Tai J.H., Jensen R., Pestka J.J. Effects of 8-week exposure of the B6C3F1 mouse to dietary deoxynivalenol (vomitoxin) and zearalenone. Food Chem. Toxicol. 1986, 24:213-219.
14. Forsell J.H., Jensen R., Tai J.H., Witt M., Lin W.S., Pestka J.J. Comparison of acute toxicities of deoxynivalenol (vomitoxin) and 15-acetyldeoxynivalenol in the B6C3F1 mouse. Food Chem. Toxicol. 1987, 25:155-162.
15. Forsyth D.M., Yoshizawa T., Morooka N., Tuite J. Emetic and refusal activity of deoxynivalenol to swine. Appl. Environ. Microbiol. 1977, 34:547-552.
16. Fukuda I., Hotta M., Hizuka N., Takano K., Ishikawa Y., Asakawa-Yasumoto K., Tagami E., Demura H. Decreased serum levels of acid-labile subunit in patients with anorexia nervosa. J. Clin. Endocrinol. Metab. 1999, 84:2034-2036.
17. Girish C.K., MacDonald E.J., Scheinin M., Smith T.K. Effects of feedborne fusarium mycotoxins on brain regional neurochemistry of turkeys. Poult. Sci. 2008, 87:1295-1302.
18. Glendinning J.I. How do predators cope with chemically defended foods?. Biol. Bull. 2007, 213:252-266.
19. Kobayashi-Hattori, K., Amuzie, C.J., Flannery, B.M., Pestka, J.J., 2011. Body composition and hormonal effects following exposure to mycotoxin deoxynivalenol in the high fat diet-induced obese mouse. Mol. Nutr. Food Res., in press.
20. Lauren D.R., Smith W.A. Stability of the fusarium mycotoxins nivalenol, deoxynivalenol and zearalenone in ground maize under typical cooking environments. Food Addit. Contam. 2001, 18:1011-1016.
21. Lawrence C.B., Rothwell N.J. Anorexic but not pyrogenic actions of interleukin-1 are modulated by central melanocortin-3/4 receptors in the rat. J. Neuroendocrinol. 2001, 13:490-495.
22. Merimee T.J., Zapf J., Froesch E.R. Insulin-like growth factors in the fed and fasted states. J. Clin. Endocrinol. Metab. 1982, 55:999-1002.
23. Ossenkopp K.P., Hirst M., Rapley W.A. Deoxynivalenol (vomitoxin)-induced conditioned taste aversions in rats are mediated by the chemosensitive area postrema. Pharmacol. Biochem. Behav. 1994, 47:363-367.
24. Pestka J.J. Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevance. Arch. Toxicol. 2010, 84:663-679.
25. Pestka J.J., Zhou H.R. Interleukin-6-deficient mice refractory to IgA dysregulation but not anorexia induction by vomitoxin (deoxynivalenol) ingestion. Food Chem. Toxicol. 2000, 38:565-575.
26. Pestka J.J., Zhou H.R. Effects of tumor necrosis factor type 1 and 2 receptor deficiencies on anorexia, growth and IgA dysregulation in mice exposed to the trichothecene vomitoxin. Food Chem. Toxicol. 2002, 40:1623-1631.
27. Pestka J.J., Lin W.S., Miller E.R. Emetic activity of the trichothecene 15-acetyldeoxynivalenol in swine. Food Chem. Toxicol. 1987, 25:855-858.
28. Pestka J.J., Moorman M.A., Warner R.L. Dysregulation of IgA production and IgA nephropathy induced by the trichothecene vomitoxin. Food Chem. Toxicol. 1989, 27:361-368.
29. Pestka J.J., Islam Z., Amuzie C.J. Immunochemical assessment of deoxynivalenol tissue distribution following oral exposure in the mouse. Toxicol. Lett. 2008, 178:83-87.
30. Pieters M.N., Freijer J., Baars B.J., Fiolet D.C., van Klaveren J., Slob W. Risk assessment of deoxynivalenol in food: concentration limits, exposure and effects. Adv. Exp. Med. Biol. 2002, 504:235-248.
31. Plata-Salaman C.R., Oomura Y., Kai Y. Tumor necrosis factor and interleukin-1 beta: suppression of food intake by direct action in the central nervous system. Brain Res. 1988, 448:106-114.
32. Plata-Salaman C.R., Sonti G., Borkoski J.P., Wilson C.D., French-Mullen J.M.b. Anorexia induced by chronic central administration of cytokines at estimated pathophysiological concentrations. Physiol. Behav. 1996, 60:867-875.
33. Prelusky D.B. The effect of low-level deoxynivalenol on neurotransmitter levels measured in pig cerebral spinal fluid. J. Environ. Sci. Health B 1993, 28:731-761.
34. Prelusky D.B. The effect of deoxynivalenol on serotoninergic neurotransmitter levels in pig blood. J. Environ. Sci. Health B 1994, 29:1203-1218.
35. Prelusky D.B. Effect of intraperitoneal infusion of deoxynivalenol on feed consumption and weight gain in the pig. Nat. Toxins 1997, 5:121-125.
36. Prelusky D.B., Trenholm H.L. The efficacy of various classes of anti-emetics in preventing deoxynivalenol-induced vomiting in swine. Nat. Toxins 1993, 1:296-302.
37. Prelusky D.B., Rotter B.A., Thompson B.K., Trenholm H.L. Effect of the appetite stimulant cyproheptadine on deoxynivalenol-induced reductions in feed consumption and weight gain in the mouse. J. Environ. Sci. Health B 1997, 32:429-448.
38. Schothorst R.C., van Egmond H.P. Report from SCOOP task 3.2.10 "collection of occurrence data of Fusarium toxins in food and assessment of dietary intake by the population of EU member states" Subtask: trichothecenes. Toxicol. Lett. 2004, 153:133-143.
39. Schwartz M.W. Central nervous system regulation of food intake. Obesity (Silver Spring) 2006, 14(Suppl. 1):1S-8S.
40. Sonti G., Ilyin S.E., Plata-Salaman C.R. Anorexia induced by cytokine interactions at pathophysiological concentrations. Am. J. Physiol. 1996, 270:R1394-1402.
41. Swamy H.V., Smith T.K., MacDonald E.J. Effects of feeding blends of grains naturally contaminated with Fusarium mycotoxins on brain regional neurochemistry of starter pigs and broiler chickens. J. Anim. Sci. 2004, 82:2131-2139.
42. Trenholm H.L., Hamilton R.M., Friend D.W., Thompson B.K., Hartin K.E. Feeding trials with vomitoxin (deoxynivalenol)-contaminated wheat: effects on swine, poultry, and dairy cattle. J. Am. Vet. Med. Assoc. 1984, 185:527-531.
43. Turner P.C., Rothwell J.A., White K.L., Gong Y., Cade J.E., Wild C.P. Urinary deoxynivalenol is correlated with cereal intake in individuals from the UK. Environ. Health Perspect. 2008, 116:21-25.
44. Ueno S., Matsuki N., Saito H. Suncus murinus: a new experimental model in emesis research. Life Sci. 1987, 41:513-518.
45. Vesonder R.F., Hesseltine C.W. Vomitoxin: natural occurrence on cereal grains and significance as a refusal and emetic factor to swine. Process Biochem. 1980, 16.
46. Vesonder R.F., Ciegler A., Jensen A.H. Isolation of the emetic principle from Fusarium-infected corn. Appl. Microbiol. 1973, 26:1008-1010.
47. Vuagnat B.A., Pierroz D.D., Lalaoui M., Englaro P., Pralong F.P., Blum W.F., Aubert M.L. Evidence for a leptin-neuropeptide Y axis for the regulation of growth hormone secretion in the rat. Neuroendocrinology 1998, 67:291-300.
48. Wallenius K., Wallenius V., Sunter D., Dickson S.L., Jansson J.O. Intracerebroventricular interleukin-6 treatment decreases body fat in rats. Biochem. Biophys. Res. Commun. 2002, 293:560-565.
49. Wu S.V., Rozengurt N., Yang M., Young S.H., Sinnett-Smith J., Rozengurt E. Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells. Proc. Natl. Acad. Sci. USA 2002, 99:2392-2397.
50. Young L.G., McGirr L., Valli V.E., Lumsden J.H., Lun A. Vomitoxin in corn fed to young pigs. J. Anim. Sci. 1983, 57:655-664.