Synthesis and characterization of fluorinated homocysteine derivatives as potential molecular probes for 19F magnetic resonance spectroscopy and imaging

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 13, 2011, Pages 4050-4053

  Chubarov, Alexey S ^a,b   Shakirov, Makhmut M ^c   Koptyug, Igor V ^b,d   Sagdeev, Renad Z ^d   Knorre, Dmitry G ^a   Godovikova, Tatyana S ^a,b  

^a INSTITUTE OF CHEMICAL BIOLOGY AND FUNDAMENTAL MEDICINE   (Russian Federation)

^b NOVOSIBIRSK STATE UNIVERSITY   (Russian Federation)

^c N N VOROZHTSOV NOVOSIBIRSK INSTITUTE OF ORGANIC CHEMISTRY   (Russian Federation)

^d INTERNATIONAL TOMOGRAPHY CENTER   (Russian Federation)

Author keywords

19F NMR spectroscopy; Fluorinated N homocysteinylated protein; Homocysteine thiolactone; Human serum albumin; Hyperhomocysteinemia; N Homocysteinylation; N Trifluoroacetylhomocysteine thiolactone

Indexed keywords

2,2,2 TRIFLUORO N (2 OXO TETRAHYDROTHIOPHEN 3 YL)ACETAMIDE; ACETAMIDE; AMINO ACID DERIVATIVE; HOMOCYSTEINE; HOMOCYSTEINE THIOLACTONE; HUMAN SERUM ALBUMIN; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; AMINO ACID SYNTHESIS; ARTICLE; FLUORINATION; FLUORINE NUCLEAR MAGNETIC RESONANCE; HUMAN; IN VIVO STUDY; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR PROBE; ORGAN DISTRIBUTION; PLASMA CLEARANCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN MODIFICATION; PROTON NUCLEAR MAGNETIC RESONANCE; ULTRAVIOLET SPECTROSCOPY;

ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLUORESCENT DYES; HOMOCYSTEINE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

TRIFLUORO;

EID: 79958696285     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.04.119     Document Type: Article

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