Could LogP be a principal determinant of biological activity in 18-crown-6 ethers? Synthesis of biologically active adamantane-substituted diaza-crowns

European Journal of Medicinal Chemistry

Volumn 46, Issue 8, 2011, Pages 3444-3454

  Supek, Fran ^a   Ramljak, Tatjana Šumanovac ^a   Marjanović, Marko ^a   Buljubašić, Maja ^a   Kragol, Goran ^a   Ilić, Nataša ^a   Šmuc, Tomislav ^a   Zahradka, Davor ^a   Mlinarić Majerski, Kata ^a   Kralj, Marijeta ^a  

^a RUDER BO KOVI INSTITUTE   (Croatia)

Author keywords

Adamantane substituted diaza crowns; Biological activity; Crown ethers; Ionophores; Support vector machine

Indexed keywords

ADAMANTANE DERIVATIVE; N,N' BIS(1 ADAMANTANOYL) 4,13 DIAZA 18 CROWN 6; N,N' BIS(1 ADAMANTYLMETHYL) 4,13 DIAZA 18 CROWN 6; N,N' BIS[1 OXO 2 (1 ADAMANTYL)ETHYL] 4,13 DIAZA 18 CROWN 6; N,N' BIS[1 OXO 2 (1 ADAMANTYL)PROPYL] 4,13 DIAZA 18 CROWN 6; N,N'BIS[2 (1 ADAMANTYL)ETHYL] 4,13 DIAZA 18 CROWN 6; N,N'BIS[2 (1 ADAMANTYL)PROPYL] 4,13 DIAZA 18 CROWN 6; UNCLASSIFIED DRUG;

ARTICLE; BACILLUS SUBTILIS; BIOLOGICAL ACTIVITY; CANCER CELL; DRUG POTENCY; ESCHERICHIA COLI; HUMAN; HUMAN CELL; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ADAMANTANE; ALGORITHMS; ANTINEOPLASTIC AGENTS; BACILLUS SUBTILIS; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; CROWN ETHERS; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ESCHERICHIA COLI; ETHERS; FEMALE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; NEOPLASMS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SOFTWARE; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79958278161     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.05.009     Document Type: Article

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