Synthesis, structure-affinity relationships, and molecular modeling studies of novel pyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 12, 2011, Pages 3757-3768

  Lenzi, Ombretta ^a   Colotta, Vittoria ^a   Catarzi, Daniela ^a   Varano, Flavia ^a   Squarcialupi, Lucia ^a   Filacchioni, Guido ^a   Varani, Katia ^b   Vincenzi, Fabrizio ^b   Borea, Pier Andrea ^b   Ben, Diego Dal ^c   Lambertucci, Catia ^c   Cristalli, Gloria ^c  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

^c UNIVERSITY OF CAMERINO   (Italy)

Author keywords

Adenosine receptor antagonists; G protein coupled receptors; Ligand receptor modeling studies; Pyrazoloquinolines; Tricyclic heteroaromatic systems

Indexed keywords

2 METHYLPYRAZOLO[3,4 C]QUINOLIN 4 AMINE; 2 METHYLPYRAZOLO[3,4 C]QUINOLIN 4 ONE; 2 PHENYL 2H PYRAZOLO[3,4 C]QUINOLIN 4,6 DIAMINE; 2 PHENYLPYRAZOLO[3,4 C]QUINOLIN 4 AMINE; 2 PHENYLPYRAZOLO[3,4 C]QUINOLIN 4 ONE; 2,5 DIHYDRO 2 PHENYL 4H PYRAZOLO[3,4 C]QUINOLIN 4 ONE; 6 AMINO 2,5 DIHYDRO 2 PHENYL 4H PYRAZOLO[3,4 C]QUINOLIN 4 ONE; 6 BENZHYDRYLOXY 2,5 DIHYDRO 2 PHENYL 4H PYRAZOLO[3,4 C]QUINOLIN 4 ONE; 6 BENZYLOXY 2 PHENYL 2H PYRAZOLO[3,4 C]QUINOLIN 4 AMINE; 6 BENZYLOXY 2,5 DIHYDRO 2 PHENYL 4H PYRAZOLO[3,4 C]QUINOLIN 4 ONE; 6 BENZYLOXY 4 CHLORO 2 PHENYL 2H PYRAZOLO[3,4 C]QUINOLINE; 6 BENZYLOXYCARBONYLAMINO 2 PHENYL 2H PYRAZOLO[3,4 C]QUINOLINE; 6 BENZYLOXYCARBONYLAMINO 2,5 DIHYDRO 2 PHENYL 4H PYRAZOLO[3,4 C]QUINOLIN 4 ONE; 6 BENZYLOXYCARBONYLAMINO 4 CHLORO 2 PHENYL 2H PYRAZOLO[3,4 C]QUINOLINE; 6 BROMO 2 PHENYL 2H PYRAZOLO[3,4 C]QUINOLIN 4 AMINE; 6 BROMO 2,5 DIHYDRO 2 PHENYL 4H PYRAZOLO[3,4 C]QUINOLIN 4 ONE; 6 BROMO 4 CHLORO 2 PHENYL 2H PYRAZOLO[3,4 C]QUINOLINE; 6 HYDROXY 2 PHENYL 2H PYRAZOLO[3,4 C]QUINOLIN 4 AMINE; 6 HYDROXY 2,5 DIHYDRO 2 PHENYL 4H PYRAZOLO[3,4 C]QUINOLIN 4 ONE; 6 PHENETOXY 2 PHENYL 2H PYRAZOLO[3,4 C]QUINOLIN 4 AMINE; 6 SUBSTITUTED 2 PHENYL 2H PYRAZOLO[3,4 C]QUINOLIN 4 AMINE; 6 SUBSTITUTED 4 CHLORO 2 PHENYL 2H PYRAZOLO[3,4 C]QUINOLINE; ADENOSINE RECEPTOR BLOCKING AGENT; ETHYL (7 BENZHYDRYLOXY 1H INDOL 3 YL)GLYOXYLIC ACID; ETHYL (7 BENZYLOXY 1H INDOL 3 YL)GLYOXYLIC ACID; ETHYL (7 BENZYLOXYCARBONYLAMINO 1H INDOL 3 YL)GLYOXYLIC ACID; ETHYL (7 BROMO 1H INDOL 3 YL)GLYOXYLIC ACID; ETHYL 7 SUBSTITUTED 3 INDOLYLGLYOXYLIC ACID; PYRAZOLO[3,4 C]QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; MOLECULAR DOCKING; MOLECULAR MODEL; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHO CELLS; COMPUTER SIMULATION; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; PURINERGIC P1 RECEPTOR ANTAGONISTS; PYRAZOLES; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79958264926     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.05.001     Document Type: Article

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