Th2-like immune response in radiation-induced lung fibrosis

Oncology Reports

Volumn 26, Issue 2, 2011, Pages 383-388

  Han, Guang ^a,b   Zhang, Hui ^a   Xie, Cong Hua ^a   Zhou, Yun Feng ^a  

^a WUHAN UNIVERSITY   (China)

^b HUBEI CANCER HOSPITAL   (China)

Author keywords

Arginase 1; GATA binding protein; Interleukin 13; Radiation induced lung fibrosis; Th2 like immune response

Indexed keywords

ARGINASE 1; HYDROXYPROLINE; INTERLEUKIN 13; TRANSCRIPTION FACTOR GATA 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; IMMUNE RESPONSE; LUNG; LUNG FIBROSIS; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RADIATION INDUCED LUNG FIBROSIS; RADIATION INJURY;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; IMMUNOHISTOCHEMISTRY; LUNG; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; PULMONARY FIBROSIS; RADIATION PNEUMONITIS; TH2 CELLS;

EID: 79958240238     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2011.1300     Document Type: Article

References (34)

1. Marks LB, Bentzen SM, Deasy JO, Kong FM, Bradley JD, Vogelius IS, El Naqa I, Hubbs JL, Lebesque JV, Timmerman RD, Martel MK and Jackson A: Radiation dose-volume effects in the lung. Int J Radiat Oncol Biol Phys 76: 70-76, 2010.
2. Rübe CE, Uthe D, Wilfert F, Ludwig D, Yang K, König J, Palm J, Schuck A, Willich N, Remberger K and Rübe C: The bronchiolar epithelium as a prominent source of pro-inflammatory cytokines after lung irradiation. Int J Radiat Oncol Biol Phys 61: 1482-1492, 2005.
3. Brush J, Lipnick SL, Phillips T, Sitko J, McDonald JT and McBride WH: Molecular mechanisms of late normal tissue injury. Semin Radiat Oncol 17: 121-130, 2007. (Pubitemid 46467382)
4. Murphy KM and Reiner SL: The lineage decisions of helper T cells. Nat Rev Immunol 2: 933-944, 2002.
5. Abbas AK, Murphy KM and Sher A: Functional diversity of helper T lymphocytes. Nature 383: 787-793, 1996.
6. Wynn TA: Fibrotic disease and the THL/TH2 paradigm. Nat Rev Immunol 4: 583-549, 2004.
7. Lee CG, Homer RJ, Zhu Z, Lanone S, Wang X, Koteliansky V, Shipley JM, Gotwals P, Noble P, Chen Q, Senior RM and Elias JA: Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor. J Exp Med 194: 809-821, 2001. (Pubitemid 32983016)
8. Xu J, Mora AL, LaVoy J, Brigham KL and Rojas M: Increased bleomycin-induced lung injury in mice deficient in the transcription factor T-bet. Am J Physiol Lung Cell Mol Physiol 291: 658-667, 2006.
9. Buttner C, Skupin A and Peimann T: Local production of interleukin-4 during radiation-induced pneumonitis and pulmonary fibrosis in rats: macrophages as a prominent source of interleukin-4. Am J Respir Cell Mol Biol 17: 315-325, 1997. (Pubitemid 127500836)
10. Huaux F, Liu T, McGarry B, Ullenbruch M and Phan SH: Dual roles of IL-4 in lung injury and fibrosis. J Immunol 170: 2083-2092, 2003. (Pubitemid 36197430)
11. Tabata C, Kadokawa Y, Tabata R, Takahashi M, Okoshi K, Sakai Y, Mishima M and Kubo H: All-trans-retinoic acid prevents radiation-or bleomycin-induced pulmonary fibrosis. Am J Pespir Crit Care Med 174: 1352-1360, 2006. (Pubitemid 44913037)
12. Haase MG, Klawitter A, Geyer P and Baretton GB: Expression of the immunomodulator IL-10 in type I pneumocytes of the rat: alterations of IL-10 expression in radiation-induced lung damage. J Histochem Cytochem 55: 1167-1172, 2007. (Pubitemid 350006299)
13. Yang XB: Molecular and Cellular Mediators in Radiation-induced Lung Injury. The University of North Carolina at Chapel Hill, UMI Dissertation Publication 3354527, pp17, 2009.
14. Kehrer JP, Lee YC and Solem SM: Comparison of in vitro and in vivo rates of collagen synthesis in normal and damaged lung tissue. Exp Lung Res 10: 197-201, 1986.
15. Ko LJ and Engel JD: DNA-binding specificities of the GATA transcription factor family. Mol Cell Biol 13: 4011-4022, 1991.
16. Chakir H, Wang H, Lefebvre DE, Webb J and Scott FW: T-bet/ GATA-3 ratio as a measure of the Th1/Th2 cytokine profile in mixed cell populations: predominant role of GATA-3. J Immunol Methods 278: 157-169, 2003. (Pubitemid 37281199)
17. Park SW, Ahn MH, Jang HK, Jang AS, Kim DJ, Koh ES, Park JS, Uh ST, Kim YH, Park JS, Paik SH, Shin HK, Youm W and Park CS: Interleukin-13 and its receptors in idiopathic interstitial pneumonia: clinical implications for lung function. J Korean Med Sci 24: 614-620, 2009.
18. Reiman RM, Thompson RW, Feng CG, Hari D, Knight R, Cheever AW, Rosenberg HF and Wynn TA: Interleukin-5 (IL-5) augments the progression of liver fibrosis by regulating FL-13 activity. Infect Immun 74: 1471-1479, 2006. (Pubitemid 43346779)
19. Kishikawa H, Sun J, Choi A, Miaw SC and Ho IC: The cell type-specific expression of the murine IL-13 gene is regulated by GATA-3. J Immunol 167: 4414-4420, 2001. (Pubitemid 32954318)
20. Lavenu-Bombled C, Trainor CD, Makeh I, Romeo PH and Max-Audit I: Interleukin-13 gene expression is regulated by GATA-3 in T cells: role of a critical association of a GATA and two GATG motifs. J Biol Chem 277: 18313-18321, 2002. (Pubitemid 34952375)
21. Hesse M, Modolell M, La Flamme AC, Schito M, Fuentes JM, Cheever AW, Pearce EJ and Wynn TA: Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism. J Immunol 167: 6533-6544, 2001. (Pubitemid 33081589)
22. Kitowska K, Zakrzewicz D, Königshoff M, Chrobak I, Grimminger F, Seeger W, Bulau P and Eickelberg O: Functional role and species-specific contribution of arginases in pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 294: 34-45, 2008.
23. Wei LH, Jacobs AT, Morris SM Jr and Ignarro LJ: IL-4 and IL-13 upregulate arginase I expression by cAMP and JAK/ STAT6 pathways in vascular smooth muscle cells. Am J Physiol Cell Physiol 279: 248-256, 2000.
24. Kropf P, Fuentes JM, Fähnrich E, Arpa L, Herath S, Weber V, Soler G, Celada A, Modolell M and Müller I: Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo. FASEB J 19: 1000-1002, 2005. (Pubitemid 40827731)
25. Lange M and Malyusz M: Improved determination of small amounts of free hydroxyproline in biological fluids. Clin Chem 40: 1735-1738, 1994. (Pubitemid 24273097)
26. Liu W and David AS: Validation of a quantitative method for real time kinetics. Biochem Biophys Res Commun 294: 347-353, 2002. (Pubitemid 34694101)
27. Fuentes JM, Lompré AM, Møller JV, Falson P and le Maire M: Clean Western blots of membrane proteins after yeast heterologous expression following a shortened version of the method of Perini et al: Anal Biochem 285: 276-278, 2000.
28. Sime PJ and O'Reilly KM: Fibrosis of the lung and other tissues: new concepts in pathogenesis and treatment Clin Immunol 99: 308-319, 2001.
29. David MM: The many faces of macrophage activation. J Leukoc Biol 73: 209-212, 2003.
30. Mosser DM and Edwards JP: Exploring the full spectrum of macrophage activation. Nat Rev Immunol 8: 958-969, 2008.
31. Mora AL, Torres-González E, Rojas M, Corredor C, Ritzenthaler J, Xu J, Roman J, Brigham K and Stecenko A: Activation of alveolar macrophages via the alternative pathway in herpesvirus-induced lung fibrosis. Am J Pespir Cell Mol Biol 35: 466-473, 2006. (Pubitemid 44477646)
32. Munder M, Eichmann K, Moran JM, Centeno F, Soler G and Modolell M: Th1/Th2-regulated expression of arginase isoforms in murine macrophages and dendritic cells. J Immunol 163: 3771-3777, 1999. (Pubitemid 29450901)
33. Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A and Locati M: The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 125: 677-686, 2004. (Pubitemid 39457982)
34. Boscá L, Zeini M, Través PG and Hortelano S: Nitric oxide and cell viability in inflammatory cells: a role for NO in macrophage function and fate. Toxicology 208: 249-258, 2005. (Pubitemid 40187335)