The New Zealand obese mouse model of obesity insulin resistance and poor breeding performance: Evaluation of ovarian structure and function

Journal of Endocrinology

Volumn 209, Issue 3, 2011, Pages 307-315

  Radavelli Bagatini, Simone ^b   Blair, Amy R ^a   Proietto, Joseph ^a   Spritzer, Poli Mara ^b,c   Andrikopoulos, Sofianos ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^c HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; GLUCOSE; INSULIN; LEPTIN; SEX HORMONE;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; BODY WEIGHT; BREEDING; CELL COUNT; CONTROLLED STUDY; CORPUS LUTEUM; ESTRADIOL BLOOD LEVEL; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GRANULOSA CELL; HISTOLOGY; HYPERINSULINEMIA; INSULIN RESISTANCE; INSULIN TOLERANCE TEST; MORPHOLOGY; MOUSE; NEW ZEALAND; NONHUMAN; OBESITY; OVARY FOLLICLE; OVARY FUNCTION; OVULATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; TISSUE SECTION;

ANIMALS; FEMALE; INFERTILITY, FEMALE; INSULIN RESISTANCE; MICE; MICE, OBESE; OBESITY; OVARY; POLYCYSTIC OVARY SYNDROME;

EID: 79958235331     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-11-0022     Document Type: Article

References (69)

1. Abbott DH, Dumesic DA, Eisner JR, Colman RJ & Kemnitz JW 1998 Insights into the development of polycystic ovary syndrome (PCOS) from studies of prenatally androgenized female rhesus monkeys. Trends in Endocrinology and Metabolism 9 62-67.
2. Abbott DH, Barnett DK, Bruns CM & Dumesic DA 2005 Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome? Human Reproduction Update 11 357-374
3. Abbott DH, Zhou R, Bird IM, Dumesic DA & Conley AJ 2008 Fetal programming of adrenal androgen excess: lessons from a nonhuman primate model of polycystic ovary syndrome. Endocrine Development 13 145-158.
4. Anderson E & Lee GY 1997 The polycystic ovarian (PCO) condition: apoptosis and epithelialization of the ovarian antral follicles are aspects of cystogenesis in the dehydroepiandrosterone (DHEA)-treated rat model. Tissue & Cell 29 171-189.
5. Andrikopoulos S, Thorburn AW& Proietto J 2000a The New Zealand obese mouse: a polygenic model of type 2 diabetes. In Animal Models of Diabetes. A Primer, pp 171-183. Eds AAF Sima & E Shafrir. Amsterdam: Harwood Academic Publishers.
6. Andrikopoulos S, Verchere CB, Terauchi Y, Kadowaki T & Kahn SE 2000b Beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes. Diabetes 49 2056-2062.
7. Andrikopoulos S, Blair AR, Deluca N, Fam BC & Proietto J 2008 Evaluating the glucose tolerance test in mice. American Journal of Physiology. Endocrinology and Metabolism 295 E1323-E1332.
8. Arroyo A, Laughlin GA, Morales AJ & Yen SS 1997 Inappropriate gonadotropin secretion in polycystic ovary syndrome: influence of adiposity. Journal of Clinical Endocrinology and Metabolism 82 3728-3733.
9. Asuncion M, Calvo RM, San Millan JL, Sancho J, Avila S & Escobar-Morreale HF 2000 A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain. Journal of Clinical Endocrinology and Metabolism 85 2434-2438.
10. Azziz R,Woods KS, Reyna R, Key TJ, Knochenhauer ES & Yildiz BO 2004 The prevalence and features of the polycystic ovary syndrome in an unselected population. Journal of Clinical Endocrinology and Metabolism 89 2745-2749.
11. Baravalle C, Salvetti NR, Mira GA, Pezzone N & Ortega HH 2006 Microscopic characterization of follicular structures in letrozole-induced polycystic ovarian syndrome in the rat. Archives of Medical Research 37 830-839.
12. Barber TM, McCarthy MI, Wass JA & Franks S 2006 Obesity and polycystic ovary syndrome. Clinical Endocrinology 65 137-145.
13. Barnes RB, Rosenfield RL, Ehrmann DA, Cara JF, Cuttler L, Levitsky LL & Rosenthal IM 1994 Ovarian hyperandrogynism as a result of congenital adrenal virilizing disorders: evidence for perinatal masculinization of neuroendocrine function in women. Journal of Clinical Endocrinology and Metabolism 79 1328-1333.
14. Beloosesky R, Gold R, Almog B, Sasson R, Dantes A, Land-Bracha A, Hirsh L, Itskovitz-Eldor J, Lessing JB, Homburg R et al. 2004 Induction of polycystic ovary by testosterone in immature female rats: modulation of apoptosis and attenuation of glucose/insulin ratio. International Journal of Molecular Medicine 14 207-215.
15. Bielschowsky F 1953 The role of ovarian secretions in the pathogenesis of chemically induced cancers. Acta Physiologica Latino Americana 3 57-59.
16. Bielschowsky F & Bielschowsky M 1956 The New Zealand strain of obese mice; their response to stilboestrol and to insulin. Australian Journal of Experimental Biology and Medical Science 34 181-198.
17. Bowman BM & Miller SC 1996 Elevated progesterone during pseudopregnancy may prevent bone loss associated with low estrogen. Journal of Bone and Mineral Research 11 15-21.
18. Brawer JR, Munoz M & Farookhi R 1986 Development of the polycystic ovarian condition (PCO) in the estradiol valerate-treated rat. Biology of Reproduction 35 647-655.
19. Brouillette J, Rivard K, Lizotte E & Fiset C 2005 Sex and strain differences in adult mouse cardiac repolarization: importance of androgens. Cardiovascular Research 65 148-157.
20. Caligioni CS 2009 Assessing reproductive status/stages in mice. Current Protocols in Neuroscience Appendox 4 Appendix 4I.
21. Carmina E, Orio F, Palomba S, Longo RA, Lombardi G & Lobo RA 2005 Ovarian size and blood flow in women with polycystic ovary syndrome and their correlations with endocrine parameters. Fertility and Sterility 84 413-419.
22. Convery M, McCarthy GF & Brawer JR 1990 Remission of the polycystic ovarian condition (PCO) in the rat following hemiovariectomy. Anatomical Record 226 328-336.
23. Crosignani PG & Nicolosi AE 2001 Polycystic ovarian disease: heritability and heterogeneity. Human Reproduction Update 7 3-7.
24. Desjardins GC & Brawer JR 1989 Development and maintenance of a polycystic condition in ovaries autotransplanted under the kidney capsule. Anatomical Record 225 118-123.
25. Dunaif A 1997 Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocrine Reviews 18 774-800.
26. Eagleson CA, Gingrich MB, Pastor CL, Arora TK, Burt CM, Evans WS & Marshall JC 2000 Polycystic ovarian syndrome: evidence that flutamide restores sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone. Journal of Clinical Endocrinology and Metabolism 85 4047-4052.
27. Ehrmann DA 2005 Polycystic ovary syndrome. New England Journal of Medicine 352 1223-1236.
28. Ewart-Toland A, Mounzih K, Qiu J & Chehab FF 1999 Effect of the genetic background on the reproduction of leptin-deficient obese mice. Endocrinology 140 732-738.
29. Fam BC, Morris MJ, Hansen MJ, Kebede M, Andrikopoulos S, Proietto J & Thorburn AW 2007 Modulation of central leptin sensitivity and energy balance in a rat model of diet-induced obesity. Diabete, Obesity and Metabolism 9 840-852.
30. Franks S, Mason H & Willis D 2000 Follicular dynamics in the polycystic ovary syndrome. Molecular and Cellular Endocrinology 163 49-52.
31. Franks S, McCarthy MI & Hardy K 2006 Development of polycystic ovary syndrome: involvement of genetic and environmental factors. International Journal of Andrology 29 278-285 discussion 286-290.
32. Frick KM 2009 Estrogens and age-related memory decline in rodents: what have we learned and where do we go from here? Hormones and Behavior 55 2-23
33. Garland HO, Atherton JC, Baylis C, Morgan MR & Milne CM 1987 Hormone profiles for progesterone, oestradiol, prolactin, plasma renin activity, aldosterone and corticosterone during pregnancy and pseudopregnancy in two strains of rat: correlation with renal studies. Journal of Endocrinology 113 435-444.
34. Hahn S, Bering van Halteren W, Roesler S, Schmidt M, Kimmig R, Tan S, Mann K & Janssen OE 2006 The combination of increased ovarian volume and follicle number is associated with more severe hyperandrogenism in German women with polycystic ovary syndrome. Experimental and Clinical Endocrinology and Diabetes 114 175-181.
35. Herter LD, Magalhaes JA & Spritzer PM 1996 Relevance of the determination of ovarian volume in adolescent girls with menstrual disorders. Journal of Clinical Ultrasound 24 243-248.
36. Holte J, Bergh T, Gennarelli G & Wide L 1994 The independent effects of polycystic ovary syndrome and obesity on serum concentrations of gonadotrophins and sex steroids in premenopausal women. Clinical Endocrinology 41 473-481.
37. Kafali H, Iriadam M, Ozardali I & Demir N 2004 Letrozole-induced polycystic ovaries in the rat: a new model for cystic ovarian disease. Archives of Medical Research 35 103-108.
38. Kauffman AS, Gottsch ML, Roa J, Byquist AC, Crown A, Clifton DK, Hoffman GE, Steiner RA & Tena-Sempere M 2007 Sexual differentiation of Kiss1 gene expression in the brain of the rat. Endocrinology 148 1774-1783.
39. Koza RA, Flurkey K, Graunke DM, Braun C, Pan HJ, Reifsnyder PC, Kozak LP & Leiter EH 2004 Contributions of dysregulated energy metabolism to type 2 diabetes development in NZO/H1Lt mice with polygenic obesity. Metabolism 53 799-808.
40. Krishnamurthy H, Babu PS, Morales CR & Sairam MR 2001 Delay in sexual maturity of the follicle-stimulating hormone receptor knockout male mouse. Biology of Reproduction 65 522-531.
41. Lara HE, Dissen GA, Leyton V, Paredes A, Fuenzalida H, Fiedler JL & Ojeda SR 2000 An increased intraovarian synthesis of nerve growth factor and its low affinity receptor is a principal component of steroid-induced polycystic ovary in the rat. Endocrinology 141 1059-1072.
42. Leeman L & Acharya U 2009 The use of metformin in the management of polycystic ovary syndrome and associated anovulatory infertility: the current evidence. Journal of Obstetrics and Gynaecology 29 467-472.
43. LeFevre J & McClintock MK 1988 Reproductive senescence in female rats: a longitudinal study of individual differences in estrous cycles and behavior. Biology of Reproduction 38 780-789.
44. Lobo RA & Carmina E 2000 The importance of diagnosing the polycystic ovary syndrome. Annals of Internal Medicine 132 989-993.
45. Lu KH, Hopper BR, Vargo TM & Yen SS 1979 Chronological changes in sex steroid, gonadotropin and prolactin secretions in aging female rats displaying different reproductive states. Biology of Reproduction 21 193-203.
46. MacNiven E, deCatanzaro D & Younglai EV 1992 Chronic stress increases estrogen and other steroids in inseminated rats. Physiology and Behavior 52 159-162.
47. Manneras L, Cajander S, Holmang A, Seleskovic Z, Lystig T, Lonn M & Stener-Victorin E 2007 A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome. Endocrinology 148 3781-3791.
48. Morales AJ, Laughlin GA, Butzow T, Maheshwari H, Baumann G & Yen SS 1996 Insulin, somatotropic, and luteinizing hormone axes in lean and obese women with polycystic ovary syndrome: common and distinct features. Journal of Clinical Endocrinology and Metabolism 81 2854-2864.
49. Nelson JF, Karelus K, Bergman MD & Felicio LS 1995 Neuroendocrine involvement in aging: evidence from studies of reproductive aging and caloric restriction. Neurobiology of Aging 16 837-843 discussion 855-836.
50. Norman RJ 2002 Hyperandrogenaemia and the ovary. Molecular and Cellular Endocrinology 191 113-119.
51. Norman RJ, Wu R & Stankiewicz MT 2004 4: polycystic ovary syndrome. Medical Journal of Australia 180 132-137.
52. Ortlepp JR, Kluge R, Giesen K, Plum L, Radke P, Hanrath P & Joost HG 2000 A metabolic syndrome of hypertension, hyperinsulinaemia and hypercholesterolaemia in the New Zealand obese mouse. European Journal of Clinical Investigation 30 195-202.
53. Pagan YL, Srouji SS, Jimenez Y, Emerson A, Gill S & Hall JE 2006 Inverse relationship between luteinizing hormone and body mass index in polycystic ovarian syndrome: investigation of hypothalamic and pituitary contributions. Journal of Clinical Endocrinology and Metabolism 91 1309-1316.
54. Pedersen T & Peters H 1968 Proposal for a classification of oocytes and follicles in the mouse ovary. Journal of Reproduction and Fertility 17 555-557.
55. Piouka A, Farmakiotis D, Katsikis I, Macut D, Gerou S & Panidis D 2009 Anti-Mullerian hormone levels reflect severity of PCOS but are negatively influenced by obesity: relationship with increased luteinizing hormone levels. American Journal of Physiology. Endocrinology and Metabolism 296 E238-E243.
56. Ravichandran KS 2003 "Recruitment" signals from apoptotic cells: invitation to a quiet meal. Cell 113 817-820.
57. Rotterdam 2004 Revised 2003 consensus on diagnostic criteria and longterm health risks related to polycystic ovary syndrome (PCOS). Human Reproduction 19 41-47.
58. Runner MN & Gates A 1954 Conception in prepuberal mice following artificially induced ovulation and mating. Nature 174 222-223.
59. Shapiro BH, Niedermeyer TM & Babalola GO 1989 Serum androgen levels in senescent Cr1:CD-1 (ICR)BR mice: effects of castration and testosterone treatment. Journal of Gerontology 44 B15-B19.
60. Shors TJ, Pickett J, Wood G & Paczynski M 1999 Acute stress persistently enhances estrogen levels in the female rat. Stress 3 163-171.
61. Sikka P, Gainder S, Dhaliwal LK, Bagga R, Sialy R & Sahdev S 2007 Ultrasonography of the ovaries and its correlation with clinical and endocrine parameters in infertile women with PCOS. International Journal of Fertility and Women's Medicine 52 41-47.
62. Spritzer PM, Poy M, Wiltgen D, Mylius LS & Capp E 2001 Leptin concentrations in hirsute women with polycystic ovary syndrome or idiopathic hirsutism: influence on LH and relationship with hormonal, metabolic, and anthropometric measurements. Human Reproduction 16 1340-1346.
63. Taylor AE, McCourt B, Martin KA, Anderson EJ, Adams JM, Schoenfeld D & Hall JE 1997 Determinants of abnormal gonadotropin secretion in clinically defined women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism 82 2248-2256.
64. Toscani M, Migliavacca R, Sisson de Castro JA & Spritzer PM 2007 Estimation of truncal adiposity using waist circumference or the sum of trunk skinfolds: a pilot study for insulin resistance screening in hirsute patients with or without polycystic ovary syndrome. Metabolism 56 992-997.
65. Veroni MC, Proietto J & Larkins RG 1991 Evolution of insulin resistance in New Zealand obese mice. Diabetes 40 1480-1487.
66. Webber LJ, Stubbs S, Stark J, Trew GH, Margara R, Hardy K & Franks S 2003 Formation and early development of follicles in the polycystic ovary. Lancet 362 1017-1021.
67. Wong N, Blair AR, Morahan G & Andrikopoulos S 2010 The deletion variant of nicotinamide nucleotide transhydrogenase (Nnt) does not affect insulin secretion or glucose tolerance. Endocrinology 151 96-102.
68. Woodruff TK & Shea LD 2011 A new hypothesis regarding ovarian follicle development: ovarian rigidity as a regulator of selection and health. Journal of Assisted Reproduction and Genetics 28 3-6.
69. Zain MM & Norman RJ 2008 Impact of obesity on female fertility and fertility treatment. Women's Health 4 183-194.