TWIK-1 two-pore domain potassium channels change ion selectivity and conduct inward leak sodium currents in hypokalemia

Science Signaling

Volumn 4, Issue 176, 2011, Pages

  Ma, Liqun ^a   Zhang, Xuexin ^a   Chen, Haijun ^a  

^a STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHANNEL; POTASSIUM CHANNEL TWIK 1; SODIUM ION; THREONINE; UNCLASSIFIED DRUG; KCNK1 PROTEIN, HUMAN; KCNK1 PROTEIN, MOUSE; POTASSIUM; SODIUM; TANDEM PORE DOMAIN POTASSIUM CHANNEL;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HEART DEPOLARIZATION; HEART MUSCLE CELL; HEART MUSCLE EXCITABILITY; HEART MUSCLE FIBER MEMBRANE STEADY POTENTIAL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYPOKALEMIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SODIUM CURRENT; ACTION POTENTIAL; ANIMAL; CELL MEMBRANE PERMEABILITY; CELL MEMBRANE POTENTIAL; METABOLISM; PHYSIOLOGY; RAT;

RATTUS;

ACTION POTENTIALS; ANIMALS; CELL MEMBRANE PERMEABILITY; HUMANS; HYPOKALEMIA; MEMBRANE POTENTIALS; MICE; MYOCYTES, CARDIAC; POTASSIUM; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; RATS; SODIUM;

EID: 79958212816     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2001726     Document Type: Article

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58. Acknowledgments: We thank L. K. Kaczmarek, S. A. Goldstein, F. Lesage, and D. Thomas for providing K2P plasmids; W. C. Claycomb for providing cultured HL-1 cells; and S. H. Heinemann, J. Schmidt, and G. Lnenicka for comments on the manuscript. Funding: This work is supported by an American Heart Association Scientist Development Grant, start-up funds, and a Faculty Research Award Program A award from State University of New York-Albany (to H.C.). Author contributions: H.C. designed the experiments, analyzed and interpreted the data in electrophysiology, and wrote the manuscript. L.M. performed experiments on molecular biology, Western blot analysis, and electrophysiology in CHO cells, mouse HL-1 cells, and human primary cardiac myocytes. X.Z. performed electrophysiological experiments in CHO cells and mouse HL-1 cells. Competing interests: The authors declare that they have no competing interests.