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Volumn 50, Issue 21, 2011, Pages 4550-4560

Stress-induced phosphorylation of PACT reduces its interaction with TRBP and leads to PKR activation

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE SUBSTITUTION; CONSTITUTIVELY ACTIVES; INITIATION FACTORS; OVER-EXPRESSION; PROTEIN KINASE; PROTEIN SYNTHESIS; SIGNALING PATHWAYS; STRESS-INDUCED;

EID: 79958158639     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200104h     Document Type: Article
Times cited : (51)

References (58)
  • 1
    • 0025298202 scopus 로고
    • Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon
    • Meurs, E., Chong, K., Galabru, J., Thomas, N. S., Kerr, I. M., Williams, B. R., and Hovanessian, A. G. (1990) Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon. Cell 62, 379-390.
    • (1990) Cell , vol.62 , pp. 379-390
    • Meurs, E.1    Chong, K.2    Galabru, J.3    Thomas, N.S.4    Kerr, I.M.5    Williams, B.R.6    Hovanessian, A.G.7
  • 2
    • 0033230617 scopus 로고    scopus 로고
    • PKR; a sentinel kinase for cellular stress
    • Williams, B. R. (1999) PKR; a sentinel kinase for cellular stress. Oncogene 18, 6112-6120.
    • (1999) Oncogene , vol.18 , pp. 6112-6120
    • Williams, B.R.1
  • 4
    • 0023180020 scopus 로고
    • The double-stranded RNA-dependent protein kinase is also activated by heparin
    • Hovanessian, A. G., and Galabru, J. (1987) The double-stranded RNA-dependent protein kinase is also activated by heparin. Eur. J. Biochem. 167, 467-473. (Pubitemid 17129999)
    • (1987) European Journal of Biochemistry , vol.167 , Issue.3 , pp. 467-473
    • Hovanessian, A.G.1    Galabru, J.2
  • 5
  • 6
    • 34347225099 scopus 로고    scopus 로고
    • The dsRNA protein kinase PKR: Virus and cell control
    • DOI 10.1016/j.biochi.2007.03.001, PII S030090840700051X
    • Garcia, M. A., Meurs, E. F., and Esteban, M. (2007) The dsRNA protein kinase PKR: Virus and cell control. Biochimie 89, 799-811. (Pubitemid 47001637)
    • (2007) Biochimie , vol.89 , Issue.6-7 , pp. 799-811
    • Garcia, M.A.1    Meurs, E.F.2    Esteban, M.3
  • 7
    • 0027418321 scopus 로고
    • The eIF-2α protein kinases, regulators of translation in eukaryotes from yeasts to humans
    • Samuel, C. E. (1993) The eIF-2 alpha protein kinases, regulators of translation in eukaryotes from yeasts to humans. J. Biol. Chem. 268, 7603-7606. (Pubitemid 23120319)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.11 , pp. 7603-7606
    • Samuel, C.E.1
  • 8
    • 0028815704 scopus 로고
    • Regulation of the interferon-induced PKR: Can viruses cope?
    • Katze, M. G. (1995) Regulation of the interferon-induced PKR: Can viruses cope?. Trends Microbiol. 3, 75-78.
    • (1995) Trends Microbiol. , vol.3 , pp. 75-78
    • Katze, M.G.1
  • 9
    • 0028797781 scopus 로고
    • The role of the dsRNA-activated kinase, PKR, in signal transduction
    • Williams, B. R. G. (1995) The role of the dsRNA-activated kinase, PKR, in signal transduction. Semin. Virol. 6, 191-202.
    • (1995) Semin. Virol. , vol.6 , pp. 191-202
    • Williams, B.R.G.1
  • 10
    • 0035800333 scopus 로고    scopus 로고
    • Signal integration via PKR
    • Williams, B. R. (2001) Signal integration via PKR. Sci. STKE 2001, RE2.
    • (2001) Sci. STKE , vol.2001
    • Williams, B.R.1
  • 12
    • 0026686791 scopus 로고
    • Identification of the doublestranded RNA-binding domain of the human interferon-inducible protein kinase
    • Patel, R. C., and Sen, G. C. (1992) Identification of the doublestranded RNA-binding domain of the human interferon-inducible protein kinase. J. Biol. Chem. 267, 7671-7676.
    • (1992) J. Biol. Chem. , vol.267 , pp. 7671-7676
    • Patel, R.C.1    Sen, G.C.2
  • 13
    • 0026653870 scopus 로고
    • Identification of double-stranded RNA-binding domains in the interferon- induced double-stranded RNA-activated p68 kinase
    • Feng, G. S., Chong, K., Kumar, A., and Williams, B. R. (1992) Identification of double-stranded RNA-binding domains in the interferon- induced double-stranded RNA-activated p68 kinase. Proc. Natl. Acad. Sci. U. S. A. 89, 5447-5451.
    • (1992) Proc. Natl. Acad. Sci. U. S. A. , vol.89 , pp. 5447-5451
    • Feng, G.S.1    Chong, K.2    Kumar, A.3    Williams, B.R.4
  • 15
    • 0027105279 scopus 로고
    • Two RNA-binding motifs in the double stranded RNA-activated protein kinase, DAI
    • Green, S. R., and Mathews, M. B. (1992) Two RNA-binding motifs in the double-stranded RNA-activated protein kinase, DAI. Genes Dev. 6, 2478-2490. (Pubitemid 23052877)
    • (1992) Genes and Development , vol.6 , Issue.12 B , pp. 2478-2490
    • Green, S.R.1    Mathews, M.B.2
  • 16
    • 0026716255 scopus 로고
    • Mechanism of interferon action: Identification of a RNA binding domain within the N-terminal region of the human RNA-dependent P1/eIF-2 alpha protein kinase
    • McCormack, S. J., Thomis, D. C., and Samuel, C. E. (1992) Mechanism of interferon action: Identification of a RNA binding domain within the N-terminal region of the human RNA-dependent P1/eIF-2 alpha protein kinase. Virology 188, 47-56.
    • (1992) Virology , vol.188 , pp. 47-56
    • McCormack, S.J.1    Thomis, D.C.2    Samuel, C.E.3
  • 17
    • 0032530310 scopus 로고    scopus 로고
    • Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation
    • DOI 10.1093/emboj/17.18.5458
    • Nanduri, S., Carpick, B. W., Yang, Y., Williams, B. R., and Qin, J. (1998) Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation. EMBO J. 17, 5458-5465. (Pubitemid 28427059)
    • (1998) EMBO Journal , vol.17 , Issue.18 , pp. 5458-5465
    • Nanduri, S.1    Carpick, B.W.2    Yang, Y.3    Williams, B.R.G.4    Qin, J.5
  • 18
    • 0034675856 scopus 로고    scopus 로고
    • A dynamically tuned double-stranded RNA binding mechanism for the activation of antiviral kinase PKR
    • Nanduri, S., Rahman, F., Williams, B. R., and Qin, J. (2000) A dynamically tuned double-stranded RNA binding mechanism for the activation of antiviral kinase PKR. EMBO J. 19, 5567-5574.
    • (2000) EMBO J. , vol.19 , pp. 5567-5574
    • Nanduri, S.1    Rahman, F.2    Williams, B.R.3    Qin, J.4
  • 19
    • 33846700754 scopus 로고    scopus 로고
    • Activation of PKR: an open and shut case?
    • DOI 10.1016/j.tibs.2006.12.003, PII S0968000406003288
    • Cole, J. L. (2007) Activation of PKR: An open and shut case?. Trends Biochem. Sci. 32, 57-62. (Pubitemid 46199193)
    • (2007) Trends in Biochemical Sciences , vol.32 , Issue.2 , pp. 57-62
    • Cole, J.L.1
  • 20
    • 0029115903 scopus 로고
    • The interferon-inducible double-stranded RNAactivated protein kinase self-associates in vitro and in vivo
    • Patel, R. C., Stanton, P., McMillan, N. M., Williams, B. R., and Sen, G. C. (1995) The interferon-inducible double-stranded RNAactivated protein kinase self-associates in vitro and in vivo. Proc. Natl. Acad. Sci. U. S. A. 92, 8283-8287.
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 8283-8287
    • Patel, R.C.1    Stanton, P.2    McMillan, N.M.3    Williams, B.R.4    Sen, G.C.5
  • 21
    • 0032480017 scopus 로고    scopus 로고
    • PACT, a protein activator of the interferon-induced protein kinase, PKR
    • DOI 10.1093/emboj/17.15.4379
    • Patel, R. C., and Sen, G. C. (1998) PACT, a protein activator of the interferon-induced protein kinase, PKR. EMBO J. 17, 4379-4390. (Pubitemid 28362628)
    • (1998) EMBO Journal , vol.17 , Issue.15 , pp. 4379-4390
    • Patel, R.C.1    Sen, G.C.2
  • 22
    • 0033575228 scopus 로고    scopus 로고
    • DRBP76, a doublestranded RNA-binding nuclear protein, is phosphorylated by the interferon- induced protein kinase, PKR
    • Patel, R. C., Vestal, D. J., Xu, Z., Bandyopadhyay, S., Guo, W., Erme, S. M., Williams, B. R., and Sen, G. C. (1999) DRBP76, a doublestranded RNA-binding nuclear protein, is phosphorylated by the interferon- induced protein kinase, PKR. J. Biol. Chem. 274, 20432-20437.
    • (1999) J. Biol. Chem. , vol.274 , pp. 20432-20437
    • Patel, R.C.1    Vestal, D.J.2    Xu, Z.3    Bandyopadhyay, S.4    Guo, W.5    Erme, S.M.6    Williams, B.R.7    Sen, G.C.8
  • 24
    • 0031014063 scopus 로고    scopus 로고
    • Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR
    • DOI 10.1093/emboj/16.3.611
    • Benkirane, M., Neuveut, C., Chun, R. F., Smith, S. M., Samuel, C. E., Gatignol, A., and Jeang, K. T. (1997) Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNAdependent protein kinase PKR. EMBO J. 16, 611-624. (Pubitemid 27067790)
    • (1997) EMBO Journal , vol.16 , Issue.3 , pp. 611-624
    • Benkirane, M.1    Neuveut, C.2    Chun, R.F.3    Smith, S.M.4    Samuel, C.E.5    Gatignol, A.6    Jeang, K.-T.7
  • 25
    • 39449113635 scopus 로고    scopus 로고
    • Interaction of human tRNA-dihydrouridine synthase-2 with interferon-induced protein kinase PKR
    • DOI 10.1093/nar/gkm1129
    • Mittelstadt, M., Frump, A., Khuu, T., Fowlkes, V., Handy, I., Patel, C. V., and Patel, R. C. (2008) Interaction of human tRNAdihydrouridine synthase-2 with interferon-induced protein kinase PKR. Nucleic Acids Res. 36, 998-1008. (Pubitemid 351267253)
    • (2008) Nucleic Acids Research , vol.36 , Issue.3 , pp. 998-1008
    • Mittelstadt, M.1    Frump, A.2    Khuu, T.3    Fowlkes, V.4    Handy, I.5    Patel, C.V.6    Patel, R.C.7
  • 26
    • 0034531395 scopus 로고    scopus 로고
    • PACT, a stress-modulated cellular activator of interferon-induced double-stranded RNA-activated protein kinase, PKR
    • DOI 10.1074/jbc.M004762200
    • Patel, C. V., Handy, I., Goldsmith, T., and Patel, R. C. (2000) PACT, a stress-modulated cellular activator of interferon-induced double-stranded RNA-activated protein kinase, PKR. J. Biol. Chem. 275, 37993-37998. (Pubitemid 32004921)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.48 , pp. 37993-37998
    • Patel, C.V.1    Handy, I.2    Goldsmith, T.3    Patel, R.C.4
  • 27
    • 0035012516 scopus 로고    scopus 로고
    • Modular structure of PACT: Distinct domains for binding and activating PKR
    • DOI 10.1128/MCB.21.6.1908-1920.2001
    • Peters, G. A., Hartmann, R., Qin, J., and Sen, G. C. (2001) Modular structure of PACT: Distinct domains for binding and activating PKR. Mol. Cell. Biol. 21, 1908-1920. (Pubitemid 32479615)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.6 , pp. 1908-1920
    • Peters, G.A.1    Hartmann, R.2    Qin, J.3    Sen, G.C.4
  • 28
    • 0037103840 scopus 로고    scopus 로고
    • The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR)
    • DOI 10.1042/BJ20020204
    • Huang, X., Hutchins, B., and Patel, R. C. (2002) The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR). Biochem. J. 366, 175-186. (Pubitemid 34971816)
    • (2002) Biochemical Journal , vol.366 , Issue.1 , pp. 175-186
    • Huang, X.1    Hutchins, B.2    Patel, R.C.3
  • 29
    • 0033056848 scopus 로고    scopus 로고
    • RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling
    • Ito, T., Yang, M., and May, W. S. (1999) RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling. J. Biol. Chem. 274, 15427-15432.
    • (1999) J. Biol. Chem. , vol.274 , pp. 15427-15432
    • Ito, T.1    Yang, M.2    May, W.S.3
  • 30
    • 33746596969 scopus 로고    scopus 로고
    • RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infection
    • DOI 10.1182/blood-2005-11-006817
    • Bennett, R. L., Blalock, W. L., Abtahi, D. M., Pan, Y., Moyer, S. A., and May, W. S. (2006) RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infection. Blood 108, 821-829. (Pubitemid 44154613)
    • (2006) Blood , vol.108 , Issue.3 , pp. 821-829
    • Bennett, R.L.1    Blalock, W.L.2    Abtahi, D.M.3    Pan, Y.4    Moyer, S.A.5    May, W.S.6
  • 31
    • 58149104379 scopus 로고    scopus 로고
    • Essential role of PACT-mediated PKR activation in tunicamycin-induced apoptosis
    • Singh, M., Fowlkes, V., Handy, I., Patel, C. V., and Patel, R. C. (2009) Essential Role of PACT-Mediated PKR Activation in Tunicamycin- Induced Apoptosis. J. Mol. Biol. 385, 457-468.
    • (2009) J. Mol. Biol. , vol.385 , pp. 457-468
    • Singh, M.1    Fowlkes, V.2    Handy, I.3    Patel, C.V.4    Patel, R.C.5
  • 32
    • 5644234968 scopus 로고    scopus 로고
    • Serine 18 phosphorylation of RAX, the PKR activator, is required for PKR activation and consequent translation inhibition
    • DOI 10.1074/jbc.M403321200
    • Bennett, R. L., Blalock, W. L., and May, W. S. (2004) Serine 18 phosphorylation of RAX, the PKR activator, is required for PKR activation and consequent translation inhibition. J. Biol. Chem. 279, 42687-42693. (Pubitemid 39372154)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.41 , pp. 42687-42693
    • Bennett, R.L.1    Blalock, W.L.2    May, W.S.3
  • 33
    • 33845746006 scopus 로고    scopus 로고
    • Phosphorylation of specific serine residues in the PKR activation domain of PACT is essential for its ability to mediate apoptosis
    • DOI 10.1074/jbc.M607714200
    • Peters, G. A., Li, S., and Sen, G. C. (2006) Phosphorylation of specific serine residues in the PKR activation domain of PACT is essential for its ability to mediate apoptosis. J. Biol. Chem. 281, 35129-35136. (Pubitemid 46036552)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.46 , pp. 35129-35136
    • Peters, G.A.1    Li, S.2    Sen, G.C.3
  • 34
    • 0034052232 scopus 로고    scopus 로고
    • Analysis of a binding difference between the two dsRNA-binding domains in TRBP reveals the modular function of a KR-helix motif
    • DOI 10.1046/j.1432-1327.2000.01256.x
    • Daviet, L., Erard, M., Dorin, D., Duarte, M., Vaquero, C., and Gatignol, A. (2000) Analysis of a binding difference between the two dsRNA-binding domains in TRBP reveals the modular function of a KRhelix motif. Eur. J. Biochem. 267, 2419-2431. (Pubitemid 30220090)
    • (2000) European Journal of Biochemistry , vol.267 , Issue.8 , pp. 2419-2431
    • Daviet, L.1    Erard, M.2    Dorin, D.3    Duarte, M.4    Vaquero, C.5    Gatignol, A.6
  • 35
    • 0033773221 scopus 로고    scopus 로고
    • Characterization of TRBP1 and TRBP2. Stable stem-loop structure at the 50 end of TRBP2 mRNA resembles HIV-1 TAR and is not found in its processed pseudogene
    • Duarte, M., Graham, K., Daher, A., Battisti, P. L., Bannwarth, S., Segeral, E., Jeang, K. T., and Gatignol, A. (2000) Characterization of TRBP1 and TRBP2. Stable stem-loop structure at the 50 end of TRBP2 mRNA resembles HIV-1 TAR and is not found in its processed pseudogene. J. Biomed. Sci. 7, 494-506.
    • (2000) J. Biomed. Sci. , vol.7 , pp. 494-506
    • Duarte, M.1    Graham, K.2    Daher, A.3    Battisti, P.L.4    Bannwarth, S.5    Segeral, E.6    Jeang, K.T.7    Gatignol, A.8
  • 36
    • 0025876881 scopus 로고
    • Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR
    • Gatignol, A., Buckler-White, A., Berkhout, B., and Jeang, K. T. (1991) Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR. Science 251, 1597-1600. (Pubitemid 21916930)
    • (1991) Science , vol.251 , Issue.5001 , pp. 1597-1600
    • Gatignol, A.1    Buckler-White, A.2    Berkhout, B.3    Jeang, K.-T.4
  • 37
    • 23644433363 scopus 로고    scopus 로고
    • TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
    • DOI 10.1038/nature03868
    • Chendrimada, T. P., Gregory, R. I., Kumaraswamy, E., Norman, J., Cooch, N., Nishikura, K., and Shiekhattar, R. (2005) TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 436, 740-744. (Pubitemid 41117280)
    • (2005) Nature , vol.436 , Issue.7051 , pp. 740-744
    • Chendrimada, T.P.1    Gregory, R.I.2    Kumaraswamy, E.3    Norman, J.4    Cooch, N.5    Nishikura, K.6    Shiekhattar, R.7
  • 39
    • 27144550559 scopus 로고    scopus 로고
    • TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing
    • DOI 10.1038/sj.embor.7400509, PII 7400509
    • Haase, A. D., Jaskiewicz, L., Zhang, H., Laine, S., Sack, R., Gatignol, A., and Filipowicz, W. (2005) TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing. EMBO Rep 6, 961-967. (Pubitemid 41521952)
    • (2005) EMBO Reports , vol.6 , Issue.10 , pp. 961-967
    • Haase, A.D.1    Jaskiewicz, L.2    Zhang, H.3    Laine, S.4    Sack, R.5    Gatignol, A.6    Filipowicz, W.7
  • 40
    • 34547115237 scopus 로고    scopus 로고
    • Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA
    • Kok, K. H., Ng, M. H., Ching, Y. P., and Jin, D. Y. (2007) Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA. J. Biol. Chem. 282, 17649-17657.
    • (2007) J. Biol. Chem. , vol.282 , pp. 17649-17657
    • Kok, K.H.1    Ng, M.H.2    Ching, Y.P.3    Jin, D.Y.4
  • 43
    • 45849141942 scopus 로고    scopus 로고
    • Interactions between the double-stranded RNA-binding proteins TRBP and PACT define the Medipal domain that mediates protein-protein interactions
    • Laraki, G., Clerzius, G., Daher, A., Melendez-Pena, C., Daniels, S., and Gatignol, A. (2008) Interactions between the double-stranded RNA-binding proteins TRBP and PACT define the Medipal domain that mediates protein-protein interactions. RNA Biol. 5, 92-103. (Pubitemid 351881377)
    • (2008) RNA Biology , vol.5 , Issue.2 , pp. 92-103
    • Laraki, G.1    Clerzius, G.2    Daher, A.3    Melendez-Pena, C.4    Daniels, S.5    Gatignol, A.6
  • 45
    • 0035823590 scopus 로고    scopus 로고
    • Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression
    • Daher, A., Longuet, M., Dorin, D., Bois, F., Segeral, E., Bannwarth, S., Battisti, P. L., Purcell, D. F., Benarous, R., Vaquero, C., Meurs, E. F., and Gatignol, A. (2001) Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression. J. Biol. Chem. 276, 33899-33905.
    • (2001) J. Biol. Chem. , vol.276 , pp. 33899-33905
    • Daher, A.1    Longuet, M.2    Dorin, D.3    Bois, F.4    Segeral, E.5    Bannwarth, S.6    Battisti, P.L.7    Purcell, D.F.8    Benarous, R.9    Vaquero, C.10    Meurs, E.F.11    Gatignol, A.12
  • 46
    • 0038813691 scopus 로고    scopus 로고
    • The TAR RNA-binding protein, TRBP, stimulates the expression of TAR-containing RNAs in vitro and in vivo independently of its ability to inhibit the dsRNA-dependent kinase PKR
    • DOI 10.1074/jbc.M208954200
    • Dorin, D., Bonnet, M. C., Bannwarth, S., Gatignol, A., Meurs, E. F., and Vaquero, C. (2003) The TAR RNA-binding protein, TRBP, stimulates the expression of TAR-containing RNAs in vitro and in vivo independently of its ability to inhibit the dsRNA-dependent kinase PKR. J. Biol. Chem. 278, 4440-4448. (Pubitemid 36800938)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.7 , pp. 4440-4448
    • Dorin, D.1    Bonnet, M.C.2    Bannwarth, S.3    Gatignol, A.4    Meurs, E.F.5    Vaquero, C.6
  • 49
    • 68249097024 scopus 로고    scopus 로고
    • Biochemical analysis of PKR activation by PACT
    • Peters, G. A., Dickerman, B., and Sen, G. C. (2009) Biochemical analysis of PKR activation by PACT. Biochemistry 48, 7441-7447.
    • (2009) Biochemistry , vol.48 , pp. 7441-7447
    • Peters, G.A.1    Dickerman, B.2    Sen, G.C.3
  • 50
    • 0037711199 scopus 로고    scopus 로고
    • The dsRNA binding protein family: Critical roles, diverse cellular functions
    • DOI 10.1096/fj.02-0958rev
    • Saunders, L. R., and Barber, G. N. (2003) The dsRNA binding protein family: Critical roles, diverse cellular functions. FASEB J. 17, 961-983. (Pubitemid 36676385)
    • (2003) FASEB Journal , vol.17 , Issue.9 , pp. 961-983
    • Saunders, L.R.1    Barber, G.N.2
  • 52
    • 0034192148 scopus 로고    scopus 로고
    • Proteins binding to duplexed RNA: One motif, multiple functions
    • DOI 10.1016/S0968-0004(00)01580-2, PII S0968000400015802
    • Fierro-Monti, I., and Mathews, M. B. (2000) Proteins binding to duplexed RNA: One motif, multiple functions. Trends Biochem. Sci. 25, 241-246. (Pubitemid 30236222)
    • (2000) Trends in Biochemical Sciences , vol.25 , Issue.5 , pp. 241-246
    • Fierro-Monti, I.1    Mathews, M.B.2
  • 53
    • 18444380595 scopus 로고    scopus 로고
    • The double-stranded RNA-binding motif, a versatile macromolecular docking platform
    • DOI 10.1111/j.1742-4658.2005.04652.x
    • Chang, K. Y., and Ramos, A. (2005) The double-stranded RNA-binding motif, a versatile macromolecular docking platform. FEBS J. 272, 2109-2117. (Pubitemid 40646782)
    • (2005) FEBS Journal , vol.272 , Issue.9 , pp. 2109-2117
    • Chang, K.-Y.1    Ramos, A.2
  • 54
    • 32544460452 scopus 로고    scopus 로고
    • The role of PACT in the RNA silencing pathway
    • DOI 10.1038/sj.emboj.7600942, PII 7600942
    • Lee, Y., Hur, I., Park, S. Y., Kim, Y. K., Suh, M. R., and Kim, V. N. (2006) The role of PACT in the RNA silencing pathway. EMBO J. 25, 522-532. (Pubitemid 43237659)
    • (2006) EMBO Journal , vol.25 , Issue.3 , pp. 522-532
    • Lee, Y.1    Hur, I.2    Park, S.-Y.3    Kim, Y.-K.4    Mi, R.S.5    Kim, V.N.6
  • 55
    • 70349767012 scopus 로고    scopus 로고
    • Structure of the human Dicer-TRBP complex by electron microscopy
    • Lau, P. W., Potter, C. S., Carragher, B., and MacRae, I. J. (2009) Structure of the human Dicer-TRBP complex by electron microscopy. Structure 17, 1326-1332.
    • (2009) Structure , vol.17 , pp. 1326-1332
    • Lau, P.W.1    Potter, C.S.2    Carragher, B.3    MacRae, I.J.4
  • 56
    • 0142247418 scopus 로고    scopus 로고
    • The carboxy-terminal, M3 motifs of PACT and TRBP have opposite effects on PKR activity
    • DOI 10.1016/S0042-6822(03)00589-0
    • Gupta, V., Huang, X., and Patel, R. C. (2003) The carboxyterminal, M3 motifs of PACT and TRBP have opposite effects on PKR activity. Virology 315, 283-291. (Pubitemid 37324618)
    • (2003) Virology , vol.315 , Issue.2 , pp. 283-291
    • Gupta, V.1    Huang, X.2    Patel, R.C.3
  • 57
    • 70349577785 scopus 로고    scopus 로고
    • Phosphorylation of the human microRNA-generating complex mediates MAPK/Erk signaling
    • Paroo, Z., Ye, X., Chen, S., and Liu, Q. (2009) Phosphorylation of the human microRNA-generating complex mediates MAPK/Erk signaling. Cell 139, 112-122.
    • (2009) Cell , vol.139 , pp. 112-122
    • Paroo, Z.1    Ye, X.2    Chen, S.3    Liu, Q.4


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