Aerosolized bc-819 inhibits primary but not secondary lung cancer growth

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Hasenpusch, Günther ^a   Pfeifer, Corinna ^a   Aneja, Manish Kumar ^a   Wagner, Kai ^a   Reinhardt, Dietrich ^a   Gilon, Michal ^b   Ohana, Patricia ^b   Hochberg, Avraham ^b   Rudolph, Carsten ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BC 819; DIPHTHERIA TOXIN; PLASMID DNA; POLYETHYLENEIMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHUS CANCER; CANCER INHIBITION; CANCER MODEL; CONTROLLED STUDY; DRUG EFFICACY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LUNG ADENOCARCINOMA; LUNG METASTASIS; LUNG PARENCHYMA; MOUSE; NONHUMAN; TREATMENT DURATION; TUMOR XENOGRAFT; AEROSOL; ANIMAL; CELL PROLIFERATION; CELL TRANSFORMATION; CHEMISTRY; DRUG EFFECT; GENETICS; INHALATIONAL DRUG ADMINISTRATION; LUNG TUMOR; METASTASIS; ONCOGENE; PATHOLOGY; PLASMID; TUMOR CELL LINE;

MUS;

ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MICE; ONCOGENES; PLASMIDS; POLYETHYLENEIMINE;

EID: 79958121853     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020760     Document Type: Article

References (27)

1. Parkin DM, Bray F, Ferlay J, Pisani P, (2005) Global cancer statistics, 2002. CA Cancer J Clin 55: 74-108.
2. Toloza EM, Morse MA, Lyerly HK, (2006) Gene therapy for lung cancer. J Cell Biochem 99: 1-22.
3. Vachani A, Moon E, Wakeam E, Albelda SM, (2010) Gene therapy for mesothelioma and lung cancer. Am J Respir Cell Mol Biol 42: 385-393.
4. Davies JC, Alton EW, (2005) Airway gene therapy. Adv Genet 54: 291-314.
5. Hershey AE, Kurzman ID, Forrest LJ, Bohling CA, Stonerook M, et al. (1999) Inhalation chemotherapy for macroscopic primary or metastatic lung tumors: proof of principle using dogs with spontaneously occurring tumors as a model. Clin Cancer Res 5: 2653-2659.
6. Koshkina NV, Waldrep JC, Roberts LE, Golunski E, Melton S, et al. (2001) Paclitaxel liposome aerosol treatment induces inhibition of pulmonary metastases in murine renal carcinoma model. Clin Cancer Res 7: 3258-3262.
7. Rudolph C, Schillinger U, Ortiz A, Plank C, Golas MM, et al. (2005) Aerosolized nanogram quantities of plasmid DNA mediate highly efficient gene delivery to mouse airway epithelium. Mol Ther 12: 493-501.
8. Davies LA, McLachlan G, Sumner-Jones SG, Ferguson D, Baker A, et al. (2008) Enhanced lung gene expression after aerosol delivery of concentrated pDNA/PEI complexes. Mol Ther 16: 1283-1290.
9. Densmore CL, (2003) The re-emergence of aerosol gene delivery: a viable approach to lung cancer therapy. Curr Cancer Drug Targets 3: 275-286.
10. Ohana P, Bibi O, Matouk I, Levy C, Birman T, et al. (2002) Use of H19 regulatory sequences for targeted gene therapy in cancer. Int J Cancer 98: 645-650.
11. Erdmann VA, Barciszewska MZ, Szymanski M, Hochberg A, de Groot N, et al. (2001) The non-coding RNAs as riboregulators. Nucleic Acids Res 29: 189-193.
12. Ariel I, Lustig O, Schneider T, Pizov G, Sappir M, et al. (1995) The imprinted H19 gene as a tumor marker in bladder carcinoma. Urology 45: 335-338.
13. Matouk IJ, DeGroot N, Mezan S, Ayesh S, Abu-lail R, et al. (2007) The H19 non-coding RNA is essential for human tumor growth. PLoS One 2: e845.
14. Giard DJ, Aaronson SA, Todaro GJ, Arnstein P, Kersey JH, et al. (1973) In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors. J Natl Cancer Inst 51: 1417-1423.
15. Mase K, Iijima T, Nakamura N, Takeuchi T, Onizuka M, et al. (2002) Intrabronchial orthotopic propagation of human lung adenocarcinoma-characterizations of tumorigenicity, invasion and metastasis. Lung Cancer 36: 271-276.
16. Jenkins DE, Oei Y, Hornig YS, Yu SF, Dusich J, et al. (2003) Bioluminescent imaging (BLI) to improve and refine traditional murine models of tumor growth and metastasis. Clin Exp Metastasis 20: 733-744.
17. Buckley SM, Howe SJ, Wong SP, Buning H, McIntosh J, et al. (2008) Luciferin detection after intra-nasal vector delivery is improved by intra-nasal rather than intra-peritoneal luciferin administration. Hum Gene Ther.
18. Rudolph C, Ortiz A, Schillinger U, Jauernig J, Plank C, et al. (2005) Methodological optimization of polyethylenimine (PEI)-based gene delivery to the lungs of mice via aerosol application. J Gene Med 7: 59-66.
19. Aneja MK, Geiger JP, Himmel A, Rudolph C, (2009) Targeted gene delivery to the lung. Expert Opin Drug Deliv 6: 567-583.
20. Leblond AL, Naud P, Forest V, Gourden C, Sagan C, et al. (2009) Developing cell therapy techniques for respiratory disease: intratracheal delivery of genetically engineered stem cells in a murine model of airway injury. Hum Gene Ther 20: 1329-1343.
21. Sidi AA, Ohana P, Benjamin S, Shalev M, Ransom JH, et al. (2008) Phase I/II marker lesion study of intravesical BC-819 DNA plasmid in H19 over expressing superficial bladder cancer refractory to bacillus Calmette-Guerin. J Urol 180: 2379-2383.
22. Barsyte-Lovejoy D, Lau SK, Boutros PC, Khosravi F, Jurisica I, et al. (2006) The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis. Cancer Res 66: 5330-5337.
23. Densmore CL, Kleinerman ES, Gautam A, Jia SF, Xu B, et al. (2001) Growth suppression of established human osteosarcoma lung metastases in mice by aerosol gene therapy with PEI-p53 complexes. Cancer Gene Ther 8: 619-627.
24. Gautam A, Densmore CL, Waldrep JC, (2001) Pulmonary cytokine responses associated with PEI-DNA aerosol gene therapy. Gene Ther 8: 254-257.
25. Lesina E, Dames P, Flemmer A, Hajek K, Kirchner T, et al. (2010) CpG-free plasmid DNA prevents deterioration of pulmonary function in mice. Eur J Pharm Biopharm 74: 427-434.
26. Lesina E, Dames P, Rudolph C, (2010) The effect of CpG motifs on gene expression and clearance kinetics of aerosol administered polyethylenimine (PEI)-plasmid DNA complexes in the lung. J Control Release 143: 243-250.
27. Otterson GA, Villalona-Calero MA, Sharma S, Kris MG, Imondi A, et al. (2007) Phase I study of inhaled Doxorubicin for patients with metastatic tumors to the lungs. Clin Cancer Res 13: 1246-1252.