Intrabronchial orthotopic propagation of human lung adenocarcinoma - Characterizations of tumorigenicity, invasion and metastasis

Lung Cancer

Volumn 36, Issue 3, 2002, Pages 271-276

  Mase, Kentaro ^a,b   Iijima, Tatsuo ^a   Nakamura, Naoko ^a   Takeuchi, Tomoyo ^a   Onizuka, Masataka ^a   Mitsui, Toshio ^a   Noguchi, Masayuki ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b Hitachi Mito General Hospital   (Japan)

Author keywords

Human lung adenocarcinoma; Invasion; Matrix metalloproteinases; Metastasis; Orthotopic propagation

Indexed keywords

GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE 14; UROKINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL TRAIT; BRONCHUS; CANCER CELL CULTURE; CANCER INVASION; CANCER TRANSPLANTATION; CARCINOGENICITY; CONTROLLED STUDY; DISEASE ASSOCIATION; HISTOLOGY; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; MALE; METASTASIS; METHODOLOGY; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOCARCINOMA; ANIMALS; BLOTTING, NORTHERN; BRONCHI; CELL LINE; DISEASE MODELS, ANIMAL; HUMANS; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0036247925     PISSN: 01695002     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-5002(02)00004-1     Document Type: Article

References (30)

1. Risk of squamous cell carcinoma and adenocarcinoma of the lung. In relation to lifetime filter cigarette smoking
2. Small adenocarcinoma. Histologic characteristics and prognosis
3. Secondary growths of cancer of breast
4. Nude mouse metastatic models of human stomach cancer constructed using orthotopic implantation of histologically intact tissue
5. Orthotopic growth and metastasis of human prostate carcinoma in nude mice after transplantation of histologically intact tissue
6. A patient-like metastasizing model of human lung adenocarcinoma constructed via thoracotomy in nude mice
7. A new patient-like model of human lung cancer constructed orthotopically with intact tissue via thoracotomy in immunodeficient mice
8. A metastatic nude-mouse model of human pancreatic cancer constructed orthotopically with histologically intact patient specimens
9. Novel intrapulmonary model for orthotopic propagation of human lung cancers in athymic nude mice
10. Comparison of intrapulmonary, percutaneous intrathoracic, and subcutaneous models for the propagation of human pulmonary and non-pulmonary cancer cell lines in athymic nude mice
11. Establishment and characterization of a human lung cancer cell line NCI-H460-LNM35 with consistent lymphogenous metastasis via both subcutaneous and orthotopic propagation
12. Metastatic potential correlates with enzymatic degradation of basement membrane collagen
13. Metalloproteinases and invasion
14. Extracellular matrix 6: Role of matrix metalloproteinases in tumor invasion and metastasis
15. Tumor cell interactions with the extracellular matrix during invasion and metastasis
16. A matrix metalloproteinase expressed on the surface of invasive tumor cells
17. In vitro cultivation of human tumors: Establishment of cell lines derived from a series of solid tumors
18. Establishment and characterization of a human lung adenocarcinoma cell line (LC-2/ad) producing alpha 1-antitrypsin in vitro
19. Establishment of continuous, clonable cultures of small-cell carcinoma of lung which have amine precursor uptake and decarboxylation cell properties
20. Peripheral airway cell differentiation in human lung cancer cell lines
21. Growth of cell lines and clinical specimens of human non-small cell lung cancer in a serum-free defined medium
22. Absence of HeLa cell contamination in 169 cell lines derived from human tumors
23. Proliferative potential and p53 overexpression in precursor and early stage lesions of bronchioloalveolar lung carcinoma
24. Immunohistochemical study of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in pulmonary lymphangioleiomyomatosis (LAM)
25. Expression of matrix metalloproteinases and tissue inhibitor of matrix metalloproteinases in non-small-cell lung cancer
26. Differential expression of matrix metalloproteinases and their inhibitors in non-small-cell lung cancer
27. 72-kD (MMP-2) and 92-kD (MMP-9) type IV collagenase production and activity in different histologic types of lung cancer cells
28. Expression of matrix metalloproteinase (gelatinase) in T1 adenocarcinoma of the lung
29. Activation of the precursor of gelatinase A/72 kDa type IV collagenase/MMP-2 in lung carcinomas correlates with the expression of membrane-type matrix metalloproteinase (MT-MMP) and with lymph node metastasis
30. Solitary lung tumors and their spontaneous metastasis in athymic nude mice orthotopically implanted with human non-small cell lung cancer