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Volumn 34, Issue 2 B, 2009, Pages 327-335

Novas perspectivas no tratamento da doença degenerativa discal

Author keywords

Biologic therapy; Degenerative disc disease; Genetic therapy; Intervertebral disc; Stem cells

Indexed keywords

GENE THERAPY; HUMAN; INTERVERTEBRAL DISK DEGENERATION; REVIEW; STEM CELL TRANSPLANTATION;

EID: 79958096551     PISSN: 0303464X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (8)

References (41)
  • 1
    • 0032085075 scopus 로고    scopus 로고
    • Epidemiology of low back pain
    • Anderson GB. Epidemiology of low back pain. Acta Orthop Scand 1998;281:28-31.
    • (1998) Acta Orthop Scand , vol.281 , pp. 28-31
    • Anderson, G.B.1
  • 2
    • 0342514575 scopus 로고    scopus 로고
    • Low back pain in relation to lumbar degeneration
    • Luoma K, Riihimaki H, Luukkonen R et al. Low back pain in relation to lumbar degeneration. Spine 2000;25:487-492.
    • (2000) Spine , vol.25 , pp. 487-492
    • Luoma, K.1    Riihimaki, H.2    Luukkonen, R.3
  • 3
    • 0036400315 scopus 로고    scopus 로고
    • The economic burden of low back pain: a review of studies published between 1996 and 2001
    • Maetzel A, Li L. The economic burden of low back pain: a review of studies published between 1996 and 2001. Best Pract Res Clin Rheumatol 2002;16:23-30.
    • (2002) Best Pract Res Clin Rheumatol , vol.16 , pp. 23-30
    • Maetzel, A.1    Li, L.2
  • 4
    • 2942536282 scopus 로고    scopus 로고
    • Intervertebral disc cell therapy for regeneration: mesenchymal stem cell implantation in rat intervertebral discs
    • Crevensten G, Walsh AJ, Ananthakrishnan D et al. Intervertebral disc cell therapy for regeneration: mesenchymal stem cell implantation in rat intervertebral discs. Ann Biomed Eng 2004;32:430-434.
    • (2004) Ann Biomed Eng , vol.32 , pp. 430-434
    • Crevensten, G.1    Walsh, A.J.2    Ananthakrishnan, D.3
  • 5
    • 0346847531 scopus 로고    scopus 로고
    • Biologic strategies for the therapy of intervertebral disc degeneration
    • Gruber HE, Hanley EN Jr. Biologic strategies for the therapy of intervertebral disc degeneration. Expert Opin Biol Ther 2003;3:1209-1214.
    • (2003) Expert Opin Biol Ther , vol.3 , pp. 1209-1214
    • Gruber, H.E.1    Hanley Jr, E.N.2
  • 7
    • 33747355707 scopus 로고    scopus 로고
    • What is intervertebral disc degeneration, and what causes it
    • Adams MA, Roughley PJ. What is intervertebral disc degeneration, and what causes it? Spine 2006;31: 2151- 2161.
    • (2006) Spine , vol.31 , pp. 2151-2161
    • Adams, M.A.1    Roughley, P.J.2
  • 8
    • 0035343467 scopus 로고    scopus 로고
    • Biochemistry of intervertebral disc degeneration and the potential for gene therapy applications
    • Cassinelli EH, Hall RA, Kang JD. Biochemistry of intervertebral disc degeneration and the potential for gene therapy applications. Spine J 2001;1:205-214.
    • (2001) Spine J , vol.1 , pp. 205-214
    • Cassinelli, E.H.1    Hall, R.A.2    Kang, J.D.3
  • 9
    • 0036204872 scopus 로고    scopus 로고
    • Current understanding of cellular and molecular events in intervertebral disc degeneration: implications for therapy
    • Freemont AJ, Watkins A, Le Maitre C, Jeziorska M, Hoyland JA. Current understanding of cellular and molecular events in intervertebral disc degeneration: implications for therapy. J Pathol 2002;196:374-379.
    • (2002) J Pathol , vol.196 , pp. 374-379
    • Freemont, A.J.1    Watkins, A.2    Le Maitre, C.3    Jeziorska, M.4    Hoyland, J.A.5
  • 10
    • 33645558156 scopus 로고    scopus 로고
    • Lumbar disc degeneration: epidemiology and genetics
    • Battié MC, Videman T. Lumbar disc degeneration: epidemiology and genetics. J Bone Joint Surg Am 2006;88:3-9.
    • (2006) J Bone Joint Surg Am , vol.88 , pp. 3-9
    • Battié, M.C.1    Videman, T.2
  • 11
    • 84876428320 scopus 로고    scopus 로고
    • Genetic influence on intervertebral disc degeneration
    • Froes N, Nunes F, Negrelli W. Genetic influence on intervertebral disc degeneration. Acta Ortop Bras 2005;13:255-257.
    • (2005) Acta Ortop Bras , vol.13 , pp. 255-257
    • Froes, N.1    Nunes, F.2    Negrelli, W.3
  • 12
    • 0033575339 scopus 로고    scopus 로고
    • An allele of COL9A2 associated with intervertebral disc disease
    • Annunen S, Paassilta P, Lohiniva J et al. An allele of COL9A2 associated with intervertebral disc disease. Science 1999;285:409-412.
    • (1999) Science , vol.285 , pp. 409-412
    • Annunen, S.1    Paassilta, P.2    Lohiniva, J.3
  • 13
    • 29444444139 scopus 로고    scopus 로고
    • The TRP2 allele of COL9A2 is an age-dependent risk factor for the development and severity of intervertebral disc degeneration
    • Jim JJ, Noponen-Hietala N, Cheung KM et al. The TRP2 allele of COL9A2 is an age-dependent risk factor for the development and severity of intervertebral disc degeneration. Spine 2005;30:2735-2742.
    • (2005) Spine , vol.30 , pp. 2735-2742
    • Jim, J.J.1    Noponen-Hietala, N.2    Cheung, K.M.3
  • 14
    • 0037439062 scopus 로고    scopus 로고
    • Recent advances in disc cell biology
    • Gruber HE, Hanley EN Jr. Recent advances in disc cell biology. Spine 2003;28:186-193.
    • (2003) Spine , vol.28 , pp. 186-193
    • Gruber, H.E.1    Hanley Jr, E.N.2
  • 15
    • 6344254760 scopus 로고    scopus 로고
    • Gene therapy in clinical medicine
    • Selkirk SM. Gene therapy in clinical medicine. Postgrad Med J 2004;80:560-570.
    • (2004) Postgrad Med J , vol.80 , pp. 560-570
    • Selkirk, S.M.1
  • 16
    • 0036204872 scopus 로고    scopus 로고
    • Current understanding of cellular and molecular events in intervertebral disc degeneration: implications of therapy
    • Freemont AJ, Watkins A, Le Maitre C et al. Current understanding of cellular and molecular events in intervertebral disc degeneration: implications of therapy. J Pathol 2002;196:374-379.
    • (2002) J Pathol , vol.196 , pp. 374-379
    • Freemont, A.J.1    Watkins, A.2    Le Maitre, C.3
  • 17
    • 0031005786 scopus 로고    scopus 로고
    • Transfer of genes to chondrocytic cells of the lumbar spine Proposal for a treatment strategy of spinal disorders by local gene therapy
    • Wehling P, Schulitz KP, Robbins PD, Evans CH, Reinecke JA. Transfer of genes to chondrocytic cells of the lumbar spine. Proposal for a treatment strategy of spinal disorders by local gene therapy. Spine 1997;22:1092-1097.
    • (1997) Spine , vol.22 , pp. 1092-1097
    • Wehling, P.1    Schulitz, K.P.2    Robbins, P.D.3    Evans, C.H.4    Reinecke, J.A.5
  • 18
    • 0032533617 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer to nucleus pulposus cells Implications for the treatment of intervertebral disc degeneration
    • Nishida K, Kang JD, Suh JK, Robbins PD, Evans CH, Gilbertson LG. Adenovirus-mediated gene transfer to nucleus pulposus cells. Implications for the treatment of intervertebral disc degeneration. Spine 1998;15;23:2437-2442.
    • (1998) Spine , vol.15 , Issue.23 , pp. 2437-2442
    • Nishida, K.1    Kang, J.D.2    Suh, J.K.3    Robbins, P.D.4    Evans, C.H.5    Gilbertson, L.G.6
  • 19
    • 33645772699 scopus 로고    scopus 로고
    • Efficient and stable gene expression in rabbit intervertebral disc cells transduced with a recombinant baculovirus vector
    • Liu X, Li K, Song J, Liang C, Wang X, Chen X. Efficient and stable gene expression in rabbit intervertebral disc cells transduced with a recombinant baculovirus vector. Spine 2006;31:732-735.
    • (2006) Spine , vol.31 , pp. 732-735
    • Liu, X.1    Li, K.2    Song, J.3    Liang, C.4    Wang, X.5    Chen, X.6
  • 20
    • 0033404813 scopus 로고    scopus 로고
    • Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy: an in vivo study of adenovirus-mediated transfer of the human transforming growth factor beta 1 encoding gene
    • Nishida K, Kang JD, Gilbertson LG et al. Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy: an in vivo study of adenovirus-mediated transfer of the human transforming growth factor beta 1 encoding gene. Spine 1999;24:2419-2425.
    • (1999) Spine , vol.24 , pp. 2419-2425
    • Nishida, K.1    Kang, J.D.2    Gilbertson, L.G.3
  • 21
    • 0034667326 scopus 로고    scopus 로고
    • Human intervertebral disc cells are genetically modifiable by adenovirus-mediated gene transfer: implications for the clinical management of intervertebral disc disorders
    • Moon SH, Gilbertson LG, Nishida K et al. Human intervertebral disc cells are genetically modifiable by adenovirus-mediated gene transfer: implications for the clinical management of intervertebral disc disorders. Spine 2000;15;25:2573-2579.
    • (2000) Spine , vol.15 , Issue.25 , pp. 2573-2579
    • Moon, S.H.1    Gilbertson, L.G.2    Nishida, K.3
  • 22
    • 33644619565 scopus 로고    scopus 로고
    • Safety assessment of intradiscal gene transfer: a pilot study
    • Wallach CJ, Kim JS, Sobajima S et al. Safety assessment of intradiscal gene transfer: a pilot study. Spine J 2006;6:107-112.
    • (2006) Spine J , vol.6 , pp. 107-112
    • Wallach, C.J.1    Kim, J.S.2    Sobajima, S.3
  • 23
    • 33644951210 scopus 로고    scopus 로고
    • A preliminary in vitro study into the use of IL-1Ra gene therapy for the inhibition of intervertebral disc degeneration
    • Le Maitre CL, Freemont AJ, Hoyland JA. A preliminary in vitro study into the use of IL-1Ra gene therapy for the inhibition of intervertebral disc degeneration. IntJ Exp Pathol 2006;87:17-28.
    • (2006) IntJ Exp Pathol , vol.87 , pp. 17-28
    • Le Maitre, C.L.1    Freemont, A.J.2    Hoyland, J.A.3
  • 24
    • 34848893110 scopus 로고    scopus 로고
    • Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study
    • Le Maitre CL, Hoyland JA, Freemont AJ. Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study. Arthritis Res Ther 2007;9:R83.
    • (2007) Arthritis Res Ther , vol.9
    • Le Maitre, C.L.1    Hoyland, J.A.2    Freemont, A.J.3
  • 25
    • 12444273295 scopus 로고    scopus 로고
    • Potential use of Sox9 gene therapy for intervertebral degenerative disc disease
    • Paul R, Haydon RC, Cheng H et al. Potential use of Sox9 gene therapy for intervertebral degenerative disc disease. Spine 2003;28:755-763.
    • (2003) Spine , vol.28 , pp. 755-763
    • Paul, R.1    Haydon, R.C.2    Cheng, H.3
  • 26
    • 43749083304 scopus 로고    scopus 로고
    • Mouse growth and differentiation factor-5 protein and ADN therapy potentiates intervertebral disc cell aggregation and chondrogenic gene expression
    • Cui M, Wan Y, Anderson DG et al. Mouse growth and differentiation factor-5 protein and ADN therapy potentiates intervertebral disc cell aggregation and chondrogenic gene expression. Spine J 2008;8:287--295.
    • (2008) Spine J , vol.8 , pp. 287-295
    • Cui, M.1    Wan, Y.2    Anderson, D.G.3
  • 27
    • 33644619565 scopus 로고    scopus 로고
    • Safety assessment of intradiscal gene transfer: a pilot study
    • Wallach CJ, Kim JS, Sobajima S et al. Safety assessment of intradiscal gene transfer: a pilot study. Spine J 2006;6:107-112.
    • (2006) Spine J , vol.6 , pp. 107-112
    • Wallach, C.J.1    Kim, J.S.2    Sobajima, S.3
  • 28
    • 34249908639 scopus 로고    scopus 로고
    • Regulation of transgene expression using an inducible system for improved safety of intervertebral disc gene therapy
    • Vadalà G, Sowa GA, Smith L et al. Regulation of transgene expression using an inducible system for improved safety of intervertebral disc gene therapy. Spine 2007;32:1381-1387.
    • (2007) Spine , vol.32 , pp. 1381-1387
    • Vadalà, G.1    Sowa, G.A.2    Smith, L.3
  • 29
    • 33745111263 scopus 로고    scopus 로고
    • Sustained transgene expression in intervertebral disc cells in vivo mediated by microbubble-enhanced ultrasound gene therapy
    • Nishida K, Doita M, Takada T et al. Sustained transgene expression in intervertebral disc cells in vivo mediated by microbubble-enhanced ultrasound gene therapy. Spine 2006;31:1415-1419.
    • (2006) Spine , vol.31 , pp. 1415-1419
    • Nishida, K.1    Doita, M.2    Takada, T.3
  • 30
    • 34248326042 scopus 로고    scopus 로고
    • Nucleus pulposus cellular longevity by telomerase gene therapy
    • Chung SA, Wei AQ, Connor DE et al. Nucleus pulposus cellular longevity by telomerase gene therapy. Spine 2007;32:1188-1196.
    • (2007) Spine , vol.32 , pp. 1188-1196
    • Chung, S.A.1    Wei, A.Q.2    Connor, D.E.3
  • 31
    • 0036668306 scopus 로고    scopus 로고
    • Autologous intervertebral disc cell implantation: a model using Psammomys obesus, the sand rat
    • Gruber HE, Johnson TL, Leslie K et al. Autologous intervertebral disc cell implantation: a model using Psammomys obesus, the sand rat. Spine 2002;27: 1626-1633
    • (2002) Spine , vol.27 , pp. 1626-1633
    • Gruber, H.E.1    Johnson, T.L.2    Leslie, K.3
  • 32
    • 3242681459 scopus 로고    scopus 로고
    • Upregulation of the viability of nucleus pulposus cells by boné marrow-derived stromal cells: significance of direct cellto-cell contact in coculture system
    • Yamamoto Y, Mochida J, Sakai D et al. Upregulation of the viability of nucleus pulposus cells by boné marrow-derived stromal cells: significance of direct cellto-cell contact in coculture system. Spine 2004:1508--1514.
    • (2004) Spine , pp. 1508-1514
    • Yamamoto, Y.1    Mochida, J.2    Sakai, D.3
  • 33
    • 0346486744 scopus 로고    scopus 로고
    • Biochemical injection treatment for discogenic low back pain: a pilot study
    • Klein RG, Eek BC, O'Neill CW et al. Biochemical injection treatment for discogenic low back pain: a pilot study. Spine J 2003;3:220-226.
    • (2003) Spine J , vol.3 , pp. 220-226
    • Klein, R.G.1    Eek, B.C.2    O'Neill, C.W.3
  • 34
    • 0036894339 scopus 로고    scopus 로고
    • New in vivo animal model to create intervertebral disc degeneration and to investigate the effects of therapeutic strategies to stimulate disc regeneration
    • Kroeber MW, Unglaub F, Wang H et al. New in vivo animal model to create intervertebral disc degeneration and to investigate the effects of therapeutic strategies to stimulate disc regeneration. Spine 2002;27:2684-2690.
    • (2002) Spine , vol.27 , pp. 2684-2690
    • Kroeber, M.W.1    Unglaub, F.2    Wang, H.3
  • 35
    • 14044269226 scopus 로고    scopus 로고
    • Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: implications for cell-based transplantation therapy
    • Risbud MV, Albert TJ, Guttapalli A et al. Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: implications for cell-based transplantation therapy. Spine 2004;29: 2627-2632.
    • (2004) Spine , vol.29 , pp. 2627-2632
    • Risbud, M.V.1    Albert, T.J.2    Guttapalli, A.3
  • 36
    • 4644349216 scopus 로고    scopus 로고
    • Stem cell regeneration of the nucleus pulposus
    • Risbud MV, Shapiro IM, Vaccaro AR et al. Stem cell regeneration of the nucleus pulposus. Spine J 2004;4:348-353
    • (2004) Spine J , vol.4 , pp. 348-353
    • Risbud, M.V.1    Shapiro, I.M.2    Vaccaro, A.R.3
  • 37
    • 15544381999 scopus 로고    scopus 로고
    • Induction of intervertebral disc-like cells from adult mesenchymal tem cells
    • Steck E, Bertram H, Abel R et al. Induction of intervertebral disc-like cells from adult mesenchymal tem cells. Stem Cells 2005;23:403-411.
    • (2005) Stem Cells , vol.23 , pp. 403-411
    • Steck, E.1    Bertram, H.2    Abel, R.3
  • 38
    • 11844266479 scopus 로고    scopus 로고
    • Bone mesenchymal stem cells transplanted into rabbit intervertebral discs can increase proteoglycans
    • Zhang YG, Guo X, Xu P et al. Bone mesenchymal stem cells transplanted into rabbit intervertebral discs can increase proteoglycans. Clin Orthop Relat Res 2005;430:219-226.
    • (2005) Clin Orthop Relat Res , vol.430 , pp. 219-226
    • Zhang, Y.G.1    Guo, X.2    Xu, P.3
  • 39
    • 0037708391 scopus 로고    scopus 로고
    • Transplantation of mesenchymal stem cells embedded in Atelocollagen gel to the intervertebral disc: a potencial therapeutic model for disc degeneration
    • Sakai D, Mochida J, Yamamoto Y et al. Transplantation of mesenchymal stem cells embedded in Atelocollagen gel to the intervertebral disc: a potencial therapeutic model for disc degeneration. Biomaterials 2003,24:3531-3541.
    • (2003) Biomaterials , vol.24 , pp. 3531-3541
    • Sakai, D.1    Mochida, J.2    Yamamoto, Y.3
  • 40
    • 0036184589 scopus 로고    scopus 로고
    • Human autologous culture expanded boné marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees
    • Wakitani S, Imoto K, Yamamoto T et al. Human autologous culture expanded boné marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees. Osteoarthritic Cartilage 2002;10:199-206.
    • (2002) Osteoarthritic Cartilage , vol.10 , pp. 199-206
    • Wakitani, S.1    Imoto, K.2    Yamamoto, T.3
  • 41
    • 1642579717 scopus 로고    scopus 로고
    • In vivo growth factor treatment of degenerated intervertebral discs
    • Walsh AJ, Bradford DS, Lotz JC. In vivo growth factor treatment of degenerated intervertebral discs. Spine 2004;29:156-163.
    • (2004) Spine , vol.29 , pp. 156-163
    • Walsh, A.J.1    Bradford, D.S.2    Lotz, J.C.3


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