Quantitative determination of methylphenidate in plasma by gas chromatography negative ion chemical ionisation mass spectrometry using o-(pentafluorobenzyloxycarbonyl)-benzoyl derivatives

Analytical and Bioanalytical Chemistry

Volumn 400, Issue 8, 2011, Pages 2663-2670

  Leis, Hans J ^a   Schütz, Helmut ^b   Windischhofer, Werner ^a  

^a ST ANNA CHILDREN S HOSPITAL   (Austria)

^b BEBAC   (Austria)

Author keywords

Derivatisation; GC MS; Methylphenidate; Negative ion chemical ionisation; PBBCl

Indexed keywords

ACCURACY AND PRECISION; AS EXTRACTION; AUTOSAMPLERS; BATCH SIZES; BENZOYL CHLORIDES; DERIVATISATION; EXTRACTION SOLVENTS; FREEZE-THAW STABILITY; GC-MS; INTERNAL STANDARDS; LONG TERM STABILITY; MATRIX EFFECTS; METHYLPHENIDATE; N-HEXANE; PBBCL; PLASMA SAMPLES; QUANTITATIVE DETERMINATIONS; SHORT TERM STABILITY; SINGLE-STEP; STOCK SOLUTIONS; VALIDATION DATA;

ALKALINITY; CHLORINE COMPOUNDS; GAS CHROMATOGRAPHY; HEXANE; ION CHROMATOGRAPHY; IONIZATION; ISOTOPES; NEGATIVE IONS; ORGANIC SOLVENTS; PLASMAS; SOLVENT EXTRACTION; STABILITY;

MASS SPECTROMETRY;

2 (PENTAFLUOROBENZYLOXYCARBONYL)BENZOYL CHLORIDE; 2-(PENTAFLUOROBENZYLOXYCARBONYL)BENZOYL CHLORIDE; BENZOIC ACID DERIVATIVE; METHYLPHENIDATE;

ARTICLE; BLOOD; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; MASS FRAGMENTOGRAPHY; STEREOISOMERISM; SYNTHESIS;

BENZOATES; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; METHYLPHENIDATE; MOLECULAR STRUCTURE; STEREOISOMERISM;

EID: 79958084979     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-011-5048-6     Document Type: Article

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