New site(s) of methylglyoxal-modified human serum albumin, identified by multiple reaction monitoring, alter warfarin binding and prostaglandin metabolism

Chemico-Biological Interactions

Volumn 192, Issue 1-2, 2011, Pages 122-128

  Kimzey, Michael J ^a   Yassine, Hussein N ^b   Riepel, Brent M ^a   Tsaprailis, George ^a   Monks, Terrence J ^a   Lau, Serrine S ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

15 keto PGE2; Arginine damage; Carbonyl stress; Diabetic complications; Dicarbonyl adduction; Human serum albumin; Methylgloxal; MG H1; Multiple reaction monitoring; Prostaglandin; Warfarin

Indexed keywords

ARGININE; HUMAN SERUM ALBUMIN; METHYLGLYOXAL; PROSTAGLANDIN; WARFARIN;

CATALYSIS; CHEMICAL MODIFICATION; CONFERENCE PAPER; DRUG BINDING; INHIBITION KINETICS; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MONITORING; PROSTAGLANDIN METABOLISM; SIMULATION;

CATALYTIC DOMAIN; HUMANS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PROSTAGLANDINS; PROTEIN BINDING; PYRUVALDEHYDE; SERUM ALBUMIN; WARFARIN;

EID: 79958064063     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.09.032     Document Type: Conference Paper

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