Melatonin protects human cells from clustered DNA damages, killing and acquisition of soft agar growth induced by X-rays or 970 MeV/n Fe ions

International Journal of Radiation Biology

Volumn 87, Issue 6, 2011, Pages 545-555

  Das, Birajalaxmi ^a,d   Bennett, Paula V ^a   Cutter, Noelle C ^a,b   Sutherland, John C ^a,c   Sutherland, Betsy M ^a  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c EAST CAROLINA UNIVERSITY   (United States)

^d BHABHA ATOMIC RESEARCH CENTRE   (India)

Author keywords

abasic clusters; cell survival; cell transformation; clustered DNA damage; double strand breaks; human cells; melatonin

Indexed keywords

DNA; GENOMIC DNA; IRON; MELATONIN; PLASMID DNA;

ARTICLE; CELL ASSAY; CELL KILLING; CELL PROTECTION; CELL SURVIVAL; CELL TRANSFORMATION; CONTOUR CLAMPED HOMOGENEOUS ELECTROPHORETIC FIELD; CONTROLLED STUDY; DNA DAMAGE; DNA DETERMINATION; DOSE RESPONSE; DOUBLE STRANDED DNA BREAK; DRUG EFFECT; FIBROBLAST; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; HUMAN GENOME; LINEAR ENERGY TRANSFER; MONOCYTE; NONHUMAN; NUCLEON; PLASMID; PRIORITY JOURNAL; RADIATION EXPOSURE; SINGLE STRANDED DNA BREAK; X IRRADIATION;

AGAR; CELL PROLIFERATION; CELL SURVIVAL; DNA; DNA DAMAGE; DNA, SUPERHELICAL; ENERGY TRANSFER; ESCHERICHIA COLI; HUMANS; IONS; IRON; MELATONIN; MONOCYTES; RADIATION INJURIES; X-RAYS;

EID: 79958053661     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.3109/09553002.2011.560993     Document Type: Article

References (50)

1. Antolin I, Rodriguez C, Sainz R, Mayo J, Uria H, Kotler M, Rodriguez-Colunga M, Tolivia D, Menendez-Pelaez A. 1996. Neurohormone melatonin prevents cell damage: Effect on gene expression for antioxidant enzymes. FASEB Journal 10:882-890. (Pubitemid 26184166)
2. Barlow-Walden LR, Reiter RJ, Abe M, Pablos M, Menendez-Pelaez A, Chen LD, Poeggeler B. 1995. Melatonin stimulates brain glutathione peroxidase activity. Neurochemistry International 26:497-502.
3. Burkhardt S, Reiter RJ, Tan D-X, Hardeland R, Cabrera J, Karbownik M. 2001. DNA oxidatively damaged by chromium( III) and H2O2 is protected by the antioxidants melatonin, N1-acetyl-N2-formyl-5-methoxykynuramine, resveratrol and uric acid. The International Journal of Biochemistry & Cell Biology 33:775-783. (Pubitemid 32524175)
4. Cagnoli CM, Atabay C, Kharlamova E, Mane H. 1995. Melatonin protects neurons from singlet oxygen-induced apoptosis. Journal of Pineal Research 18:222-226.
5. Cheriyan VD, Kurien CJ, Das B, Ramachandran EN, Karuppasamy CV, Thampi MV, George KP, Kesavan PC, Koya PKM, Chauhan PS. 1999. Genetic monitoring of the human population from high-level natural radiation areas of Kerala on the southwest coast of India. II. Incidence of numerical and structural chromosomal aberrations in the lymphocytes of newborns. Radiation Research 152:S154-158.
6. Crespo E, Macías M, Pozo D, Eescames G, Martín M, Vives F, Guerrero JM, Acuña-Castroviejo D. 1999. Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats. The FASEB Journal 13:1537-1546. (Pubitemid 29411787)
7. De Almeida E, Martinez GR, Klitzke CF, de Medeiros MHG, Mascio PD. 2003. Oxidation of melatonin by singlet molecular oxygen (O2 1Dg) produces N1-acetyl-N2-formyl-5-methoxykynurenine. Journal of Pineal Research 35:131-137.
8. Fang YZ, Yang S, Wu G. 2002. Free radicals, antioxidants, and nutrition. Nutrition 18:872-879. (Pubitemid 35292261)
9. Freitas I, Vairetti M, Ferrigno A, Bertone V, Guarnaschelli C, Rizzo V, Boncompagni E, Reiter RJ. 2006. Rationale for the use of melatonin as a protective agent against cosmic radiation and ischemia-reperfusion damage in long term space flight. Journal of the British Interplanetary Society 59:124-129. (Pubitemid 43387974)
10. Goodhead DT. 1995. Molecular and cell models of biological effects of heavy ion radiation. Radiation environment biophysics 34:67-72.
11. Grzelak A, Rychlik B, Bartosz G. 2000. Reactive oxygen species are formed in cell culture media. Acta Biochimica Polonica 47:1197-1198.
12. Grzelak A, Rychlik B,Bartosz B. 2001. Light-dependent generation of reactive oxygen species in cell culture media. Free Radical Biology and Medicine 30:1418-1425. (Pubitemid 32522957)
13. Gulston M, Lara C de, Jenner T, Emma D, O'Neill P. 2004. Processing of clustered DNA damage generates additional double-strand breaks in mammalian cells post-irradiation. Nucleic Acids Research 32(4):1602-1609. (Pubitemid 38854757)
14. Hall EJ. 2000. Radiation biology for the radiologist. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins.
15. Hardeland R, Tan DX, Reiter RJ. 2009. Kynuramines, meltabolites of melatonin and other indoles: The resurrection of an almost forgotten class of biogenic amines. Journal of Pineal Research 47:109-126.
16. Jaikrishan G, Andrews V, Thampi M, Koya P, Rajan V, Chauhan P. 1999. Genetic monitoring of the human population from high-level natural radiation areas of Kerala on the southwest coast of India. I. Prevalence of congenital malformations in newborns. Radiation Research 152:S149-153.
17. Karbownik M, Reiter RJ. 2000. Antioxidative effects of melatonin in protection against cellular damage caused by ionizing radiation. Proceedings of Social and Experimental Biology and Medicine 225:9-22.
18. Karbownik M, Reiter RJ, Qi W, Garcia JJ, Tan DX, Manchester LC, Vijayalaxmi. 2000. Protective effects of melatonin against oxidation of guanine bases in DNA and decreased microsomal membrane fluidity in rat liver induced by whole body ionizing radiation. Molecular and Cellular Biochemistry 211:137-144.
19. Kennedy AR, Zhou Z, Donahue JJ, Ware JH. 2006. Protection against adverse biological effects induced by space radiation by the Bowman-Birk inhibitor and antioxidants. Radiation Research 166:327-332. (Pubitemid 44157369)
20. Kim BC, Shon BS, Ryoo YW, Kim SP, Lee KS. 2001. Melatonin reduces X-ray irradiation-induced oxidative damages in cultured human skin fibroblasts. Journal of Dermatological Science 26:194-200.
21. Koc M, Taysi S, Buyukokuroglu ME, Bakan N. 2003. The effect of melatonin against oxidative damage during total-body irradiation in rats. Radiation Research 160:251-255. (Pubitemid 36897506)
22. Malyarchuk S, Castore R, Harrison L. 2008. DNA repair of clustered lesions in mammalian cells: Involvement of nonhomologous end-joining. Nucleic Acids Research 36(15): 4872-4882.
23. Manda K, Ueno M, Anzai K 2008a. Melatonin mitigates oxidative damage and apoptosis in mouse cerebellum induced by high- LET particle radiation. Journal of Pineal Research 44:189-196. (Pubitemid 351252922)
24. Manda K, Ueno M, Anzai K. 2008b. Space radiation-induced inhibition of neurogenesis in the hippocampal dentate gyrus and memory impairment in mice: Ameliorative potential of the melatonin metabolite, AFMK. Journal of Pineal Research 45:430-438.
25. Manda K, Reiter RJ. 2010. Melatonin maintains adult hippocampal neurogenesis and cognitive function after irradiation. Progress in Neurobiology 90:60-68.
26. Natarajan M, Reiter RJ, Meltz ML, Herman TS. 2001. Effect of melatonin on cell growth, metabolic activity, and cell cycle distribution. Journal of Pineal Research 31:228-233. (Pubitemid 32905232)
27. Qi W, Reiter RJ, Tan DX, Manchester LC, Kim SJ, Garcia JJ. 1999. Inhibitory effects of melatonin on ferric nitrilotriacetateinduced lipid peroxidation and oxidative DNA damage in the rat kidney. Toxicology 139:81-91. (Pubitemid 29535372)
28. Reiter RJ, Paredes SD, Manchester LC, Tan DX. 2009. Reducing oxidative/nitrosative stress: A newly-discovered genre for melatonin. Critical Reviews in Biochemistry and Molecular Biology 44:175-200.
29. Ressmeyer AR, Mayo JC, Zelosko V, Sainz RM, Tan DX, Poeggeler B, Antolin I, Zsizsik BK, Reiter RJ, Hardeland R. 2003. Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): Scavenging of free radicals and prevention of protein destruction. Redox Report 8:205-213. (Pubitemid 37236233)
30. Sewerynek E, Ortiz GG, Reiter RJ, Pablos MI, Melchiorri D, Daniels WMU. 1996. Lipopolysaccharide-induced DNA damage is greatly reduced in rats treated with the pineal hormone melatonin.Molecular and Cellular Endocrinology 117:183-188. (Pubitemid 26118933)
31. Shida CS, Castrucci AM, Lamy-Freund MT. 1994. High melatonin solubility in aqueous medium. Journal of Pineal Research 16:198-201.
32. Sutherland BM, Bennett PV. 1984. Human cell transfection with skin cancer DNA. Photodermatology 2:186-191.
33. Sutherland JC, Lin B, Monteleone DC, Mugavero J, Sutherland BM, Trunk J. 1987. Electronic imaging system for direct and rapid quantitation of fluorescence from electrophoretic gels: Application to ethidium bromide-stained DNA. Analytical Biochemistry 163:446-457.
34. Sutherland BM, Bennett PV, Conlon K, Epling GA, Sutherland JC. 1992. Quantitation of supercoiled DNA cleavage in non-radioactive DNA: Application to ionizing radiation and synthetic endonuclease cleavage. Analytical Biochemistry 201:80-86.
35. Sutherland BM, Bennett PV, Sidorkina O, Laval J. 2000. Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation. Proceedings of National Academy of Sciences of the USA 97:103-108. (Pubitemid 30055791)
36. Sutherland JC, Monteleone DC, Trunk JG, Bennett PV, Sutherland BM. 2001a. Quantifying DNA damage by gel electrophoresis, electronic Imaging and number average length analysis. Electrophoresis 22:843-854. (Pubitemid 32327910)
37. Sutherland BM, Bennett PV, Weinert E, Sidorkina O, Laval J. 2001b. Frequencies and relative levels of clustered damages in DNA exposed to gamma rays in radioquenching vs. non-radioquenching conditions. Environmental Molecular Mutagen 38:159-165.
38. Sutherland BM, Bennett PV, Sutherland JC, Laval J. 2002. Clustered DNA damages induced by x-rays in human cells. Radiation Research 157:611-616. (Pubitemid 34569127)
39. Tan DX, Chen LD, Poeggeler B, Manchester LC, Reiter RJ. 1993. Melatonin: A potent, endogenous hydroxyl radical scavenger. Endocrine Journal 1:57-60.
40. Tan DX, Manchester LC, Reiter RJ, Plummer BF, Hardies LJ, Weintraub ST, Vijayalaxmi, Shepherd AM. 1998. A novel melatonin metabolite, cyclic 3-hydroxymelatonin: A biomarker of in vivo hydroxyl radical generation. Biochemical Biophysical Research Communications 253:614-620. (Pubitemid 29039192)
41. Tan DX, Reiter RJ, Manchester LC, Yan MT, El-Sawi M, Sainz RM, Mayo JC, Kohen R, Allegra M, Hardeland R. 2002. Chemical and physical properties and potential mechanisms: Melatonin as a broad spectrum antioxidant and free radical scavenger. Current Topics on Medical Chemistry 2:181-197.
42. Taysi S, Koc M, Buyukokuroglu ME, Altinkaynak K, Sahin YN. 2003. Melatonin reduces lipid peroxidation and nitric oxide during irradiation-induced oxidative injury in the rat liver. Journal of Pineal Research 34:173-177. (Pubitemid 36356843)
43. Vijayalaxmi, Reiter RJ, Meltz ML. 1995a. Melatonin protects human blood lymphocytes from radiation-induced chromosome damage. Mutation Research 346:23-31.
44. Vijayalaxmi, Reiter RJ, Sewerynek E, Poeggeler B, Leal BZ, Meltz ML. 1995b. Marked reduction of radiation-induced micronuclei inhuman blood lymphocytes pretreated with melatonin. Radiation Research 143:102-106.
45. Vijayalaxmi, Reiter RJ, Herman TS, Meltz ML. 1996. Melatonin and radioprotection from genetic damage: In vivo/in vitro studies with human volunteers. Mutation Research/Genetic Toxicology 371:221-228. (Pubitemid 27036284)
46. Vijayalaxmi, Reiter RJ, Herman TS, Meltz ML. 1998. Melatonin reduces gamma radiation-induced primary DNA damage in human blood lymphocytes. Mutation Research 397:203-208. (Pubitemid 28156711)
47. Wang RJ. 1975. Lethal effect of 'daylight' fluorescent light on human cells in tissue-culture medium. Photochemistry and Photobiology 21:373-375.
48. Wang RJ. 1976. Effect of room fluorescent light on the deterioration of tissue culture medium. In Vitro 12:19-22.
49. Zhou G, Kawata T, Furusawa Y, Aoki M, Hirayama R, Ando K, Ito H. 2006a. Protective effects of melatonin against low- and high-LET irradiation. Journal of Radiation research (Tokyo) 47:175-181. (Pubitemid 44034036)
50. Zhou G, Bennett PV, Cutter NC, Sutherland BM. 2006b. Proton- HZE particle sequential dual beam exposures increase primary human cell anchorage- independent growth frequencies. Radiation Research 166:488-494. (Pubitemid 44353432)