Quinine-induced thrombocytopenia: Drug-dependent GPIb/IX antibodies inhibit megakaryocyte and proplatelet production in vitro

Blood

Volumn 117, Issue 22, 2011, Pages 5975-5986

  Perdomo, José ^a,b   Yan, Feng ^a,b   Ahmadi, Zohra ^a,b   Jiang, Xing Mai ^a,b   Stocker, Roland ^c   Chong, Beng H ^a,b  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; GLYCOPROTEIN ANTIBODY; GLYCOPROTEIN IB; GLYCOPROTEIN IIB; GLYCOPROTEIN IX; IMMUNOGLOBULIN G; PROTEIN ANTIBODY; QUININE; THROMBOPOIETIN; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL SIZE; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; DNA CONTENT; DRUG MECHANISM; FEMALE; HUMAN; HUMAN CELL; MALE; MEGAKARYOCYTE; MEGAKARYOPOIESIS; NONHUMAN; PLOIDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL; THROMBOCYTOPENIA; THROMBOCYTOPOIESIS;

EID: 79958010989     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-10-314310     Document Type: Article

References (35)

1. Chong BH, Berndt MC, Koutts J, Castaldi PA. Quinidine-induced thrombocytopenia and leukopenia: Demonstration and characterization of distinct antiplatelet and antileukocyte antibodies. Blood. 1983;62(6):1218-1223. (Pubitemid 14209669)
2. Aster RH. Drug-induced immune cytopenias. Toxicology. 2005;209(2):149-153. (Pubitemid 40568642)
3. Aster RH, Bougie DW. Drug-induced immune thrombocytopenia. New Engl J Med. 2007; 357(6):580-587. (Pubitemid 47236283)
4. Breton-Gorius J, Vainchenker W. Expression of platelet proteins during the in vitro and in vivo differentiation of megakaryocytes and morphological aspects of their maturation. Semin Hematol. 1986;23(1):43-67.
5. McKenna JL, Pisciotta AV, Hinz J. Fluorescence of megakaryocytes in idiopathic thrombocytopenic purpura (ITP) stained with fluorescent antiglobulin serum. Blood. 1962;19(6):664-675.
6. Chang M, Nakagawa PA, Williams SA, et al. Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro. Blood. 2003;102(3):887-895. (Pubitemid 36917780)
7. McMillan R, Wang L, Tomer A, Nichol J, Pistillo J. Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP. Blood. 2004;103(4):1364-1369. (Pubitemid 38168649)
8. Greinacher A, Fuerll B, Zinke H, et al. Megakaryocyte impairment by eptifibatide-induced antibodies causes prolonged thrombocytopenia. Blood. 2009;114(6):1250-1253.
9. Asvadi P, Ahmadi Z, Chong BH. Drug-induced thrombocytopenia: Localization of the binding site of GPIX-specific quinine-dependent antibodies. Blood. 2003;102(5):1670-1677. (Pubitemid 37022559)
10. Burgess JK, Lopez JA, Berndt MC, et al. Quinine-dependent antibodies bind a restricted set of epitopes on the glycoprotein Ib-IX complex: Characterization of the epitopes. Blood. 1998;92(7):2366-2373. (Pubitemid 28452979)
11. Chong BH, Du X, Berndt MC, Horn S, Chesterman CN. Characterization of the binding domains on platelet glycoproteins Ib-IX and IIb/IIIa complexes for the quinine/quinidine-dependent antibodies. Blood. 1991;77(10):2190-2199.
12. Fock E, Yan F, Pan S, Chong BH. NF-E2-mediated enhancement of megakaryocytic differentiation and platelet production in vitro and in vivo. Exp Hematol. 2008;36(1):78-92. (Pubitemid 350266967)
13. Perdomo J, Fock EL, Kaur G, et al. A monopartite sequence is essential for P45 NF-E2 nuclear translocation, transcriptional activity and platelet production. J Thromb Haemost. 2010;8(11):2542-2553.
14. Takahashi R, Sekine N, Nakatake T. Influence of monoclonal antiplatelet glycoprotein antibodies on in vitro human megakaryocyte colony formation and proplatelet formation. Blood. 1999;93(6):1951-1958. (Pubitemid 29128497)
15. Schipper LF, Brand A, Reniers N, et al. Differential maturation of megakaryocyte progenitor cells from cord blood and mobilized peripheral blood. Exp Hematol. 2003;31(4):324-330. (Pubitemid 36407609)
16. Lambert MP, Wang Y, Bdeir KH, et al. Platelet factor 4 regulates megakaryopoiesis through lowdensity lipoprotein receptor-related protein 1 (LRP1) on megakaryocytes. Blood. 2009;114(11):2290-2298.
17. Hillmen P, Muus P, Duhrsen U, et al. Effect of the complement inhibitor eculizumab on thromboembolism in patients with paroxysmal nocturnal hemoglobinuria. Blood. 2007;110(12):4123-4128. (Pubitemid 350248472)
18. Lu KH, Lue KH, Chou MC, Chung JG. Paclitaxel induces apoptosis via caspase-3 activation in human osteogenic sarcoma cells (U-2 OS). J Orth Res. 2005;23(5):988-994.
19. Odell TT, Jackson CW, Reiter RS. Generation cycle of rat megakaryocytes. Exp Cell Res. 1968;53(2-3):321-328.
20. Vitrat N, Cohen-Solal K, Pique C, et al. Endomitosis of human megakaryocytes are due to abortive mitosis. Blood. 1998;91(10):3711-3723. (Pubitemid 28225739)
21. Jackson CW, Brown LK, Somerville BC. Twocolor flow cytometric measurement of DNA distributions of rat megakaryocytes in unfixed, unfractionated marrow cell suspensions. Blood. 1984;63(4):768-778. (Pubitemid 14141293)
22. Debili N, Issaad C, Masse JM, et al. Expression of CD34 and platelet glycoproteins during human megakaryocytic differentiation. Blood. 1992;80(12):3022-3035. (Pubitemid 23004505)
23. Mathur A, Hong Y, Wang G, Erusalimsky JD. Assays of megakaryocyte development: surface antigen expression, ploidy, and size. Methods Mol Biol. 2004;272:309-322.
24. Italiano Jr JE, Lecine P, Shivdasani RA, Hartwig JH. Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes. J Cell Biol. 1999;147(6):1299-1312. (Pubitemid 30012814)
25. Junt T, Schulze H, Chen Z, et al. Dynamic visualization of thrombopoiesis within bone marrow. Science. 2007;317(5845):1767-1770. (Pubitemid 47461844)
26. Powell SE, O'Brien SJ, Barnes R, Warren RF, Wickiewicz TL. Quinine-induced thrombocytopenia. A case report. J Bone Joint Surg Series A. 1988;70(7):1097-1099.
27. Christie DJ, Walker RH, Kolins MD. Quinine-induced thrombocytopenia following intravenous use of heroin. Arch Intern Med. 1983;143(6): 1174-1175. (Pubitemid 13100652)
28. Pathan NI, Chu P, Hariharan K, et al. Mediation of apoptosis by and antitumor activity of lumiliximab in chronic lymphocytic leukemia cells and CD23+ lymphoma cell lines. Blood. 2008;111(3):1594-1602. (Pubitemid 351213450)
29. Piguet PF, Vesin C. Modulation of platelet caspases and life-span by anti-platelet antibodies in mice. Eur J Haematol. 2002;68(5):253-261.
30. Li S, Wang Z, Liao Y, et al. The glycoprotein Ibalpha-von Willebrand factor interaction induces platelet apoptosis. J Thromb Haemost. 2010;8(2):341-350.
31. Bluteau D, Lordier L, Di Stefano A, et al. Regulation of megakaryocyte maturation and platelet formation. J Thromb Haemost. 2009;7(Suppl 1):227-234.
32. Yamane A, Nakamura T, Suzuki H, et al. Interferon-{alpha}2b-induced thrombocytopenia is caused by inhibition of platelet production but not proliferation and endomitosis in human megakaryocytes. Blood. 2008;112(3):542-550.
33. Balduini A, Pallotta I, Malara A, et al. Adhesive receptors, extracellular proteins and myosin IIA orchestrate proplatelet formation by human megakaryocytes. J Thromb Haemost. 2008;6(11):1900-1907.
34. Poujol C, Ware J, Nieswandt B, Nurden AT, Nurden P. Absence of GPIbalpha is responsible for aberrant membrane development during megakaryocyte maturation: Ultrastructural study using a transgenic model. Exp Hematol. 2002;30(4):352-360. (Pubitemid 34286441)
35. Hackett T, Kelton JG, Powers P. Drug-induced platelet destruction. Semin Thromb Hemost. 1982;8(2):116-137.