Growth hormones therapy in immune response against Trypanosoma cruzi

Research in Veterinary Science

Volumn 88, Issue 2, 2010, Pages 273-278

  Frare, Eduardo Osório ^a   Santello, Fabricia Helena ^a   Caetano, Leony Cristina ^a   Caldeira, Jerri C ^b   Toldo, Míriam Paula Alonso ^a   Prado Jr , José Clóvis do ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Center for Reproductive Medicine of New Mexico   (United States)

Author keywords

IFN ; Immunity; Nitric oxide; Parasitemia; TNF ; Trypanosoma cruzi

Indexed keywords

GAMMA INTERFERON; GROWTH HORMONE; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA;

AMASTIGOTE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HISTOPATHOLOGY; HORMONAL THERAPY; IMMUNE RESPONSE; IMMUNOMODULATION; INFLAMMATORY INFILTRATE; MALE; NONHUMAN; PARASITEMIA; PERITONEUM MACROPHAGE; RAT; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS; TRYPOMASTIGOTE;

ANIMALS; CHAGAS DISEASE; GROWTH HORMONE; HEART; MALE; NITRIC OXIDE; PARASITEMIA; RATS; RATS, WISTAR; TRYPANOSOMA CRUZI; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; MAMMALIA; RATTUS; RATTUS NORVEGICUS; TRYPANOSOMA CRUZI;

EID: 76849104797     PISSN: 00345288     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rvsc.2009.10.001     Document Type: Article

References (54)

1. Abrahamsohn I.A., and Coffman R.L. Cytokine and nitric oxide regulation of the immunosuppression in Trypanosoma cruzi infection. J. Immunol. 155 (1995) 3955-3963
2. Abrahamsohn I.A., and Coffman R.L. Trypanosoma cruzi: IL-10, TNF, IFN-γ and IL-12 regulate innate and acquired immunity to infection. Exp. Parasitol. 84 (1996) 231
3. Aliberti J.C., Souto J.T., Marino A.P., Lannes-Vieira J., Teixeira M.M., Farber J., Gazzinelli R.T., and Silva J.S. Modulation of chemokine production and inflammatory responses in interferon-gamma- and tumor necrosis factor-R1-deficient mice during Trypanosoma cruzi infection. Am. J. Pathol. 158 (2001) 1433-1440
4. Badolato R., Bond H.M., Valerio G., Petrella A., Morrone G., Waters M.J., Venuta S., and Tenore A. Differential expression of surface membrane growth hormone receptor on human peripheral blood lymphocytes detected by dual fluorochrome flow cytometry. J. Clin. Endocrinol. Metab. 79 (1994) 984-990
5. Barnard R., Ng K.W., and Waters M.J. Growth hormone (GH) receptors in clonal osteoblast-like cells mediate a mitogenic response to GH. Endocrinology 128 (1991) 1459-1464
6. Besedovsky H.O., and del Rey A. Immune-neuro-endocrine interactions: facts and hypotheses. Endocr. Rev. 17 (1996) 64-102
7. Blalock J.E. The syntax of immune-neuroendocrine communication. Immunol. Today 15 (1994) 504-511
8. Brener Z. Therapeutic activity and criterion of cure in mice experimentally infected with Trypanosoma cruzi. Rev. Inst. Med. Trop. São Paulo 4 (1962) 389-396
9. Brener Z., and Krettli A.U. Immunology of Chagas' disease. In: Wyler D.J. (Ed). Modern Parasite Biology - Cellular, Immunological and Molecular Aspects. (1982), WH Freeman and Co., New York 247-261
10. Bresson J.L., Jeay S., Gagnerault M.C., Kayser C., Beressi N., Wu Z., Kinet S., Dardenne M., and Postel-Vinay M.C. Growth hormone (GH) and prolactin receptors in human peripheral blood mononuclear cells: relation with age and GH-binding protein. Endocrinology 140 (1999) 3203-3209
11. Buckner F.S., and Van Voorhis W.C. Immune Response to Trypanosoma cruzi: Control of Infection and Pathogenesis of Chagas' Disease (2000), Lippincott-Raven Press, Philadelphia, PA pp. 569-591
12. Caetano L.C., Zucoloto S., Kawasse L.M., Toldo M.P., and do Prado J.C. Influence of Trypanosoma cruzi chronic infection in the depletion of esophageal neurons in Calomys callosus. Dig. Dis. Sci. 51 (2006) 1796-1800
13. Cardillo F., Voltarelli J.C., Reed S.G., and Silva J.S. Regulation of Trypanosoma cruzi infection in mice by gamma interferon and interleukin 10: role of NK cells. Infect. Immun. 64 (1996) 128
14. Castaños-Velez E., Maerlan S., Osorio L.M., Åberg F., Biberfeld P., Orn A., and Rottenberg M.E. Trypanosoma cruzi infection in tumor necrosis factor receptor p55-deficient mice. Infect. Immun. 66 (1998) 2960
15. Castro M.A.P., and Brener Z. Estudo parasitológico e anátomo-patológico da fase aguda da doença de Chagas em cães inoculados com duas diferentes cepas do Trypanosoma cruzi. Rev. Soc. Bras. Med. Trop. 18 (1985) 233-239
16. Colao A., DiSomma C., Pivonello R., Loche S., Aimaretti G., and Cerbone G. Bone loss is correlated to the severity of growth hormone deficiency in adult patients with hypopituitarism. J. Clin. Endocrinol. Metab. 84 (1999) 1919-1924
17. Cunha-Neto E., Bilate A.M., Hyland K.V., Fonseca S.G., Kalil J., and Engman D.M. Induction of cardiac autoimmunity in Chagas heart disease: a case for molecular mimicry. Autoimmunity 39 (2006) 41-54
18. Curotto-De-Lafaille M.A., Barbosa-de-Oliveira L.C., Lima G.C., and Abrahamsohn I.A. Trypanosoma cruzi: maintenance of parasite-specific T cell responses in lymph nodes during the acute phase of infection. Exp. Parasitol. 70 (1990) 349-354
19. de Mello-Coelho V., Gagnerault M.C., Souberbielle J.C., Strasburger C.J., Savino W., Dardenne M., and Postel-Vinay M.C. Growth hormone and its receptor are expressed in human thymic cells. Endocrinology 139 (1998) 3837-3842
20. dos Santos P.V., Roffê E., Santiago H.C., Torres R.A., Marino A.P., Paiva C.N., Silva A.A., Gazzinelli R.T., and Lannes-Vieira J. Prevalence of CD8(+)alpha beta T cells in Trypanosoma cruzi-elicited myocarditis is associated with acquisition of CD62L(Low)LFA-1(High)VLA-4(High) activation phenotype and expression of IFN-gamma-inducible adhesion and chemoattractant molecules. Microbes Infect. 3 (2001) 971-984
21. Gazzinelli R.T., Oswald I.P., Hieny S., James S., and Sher A. The microbicidal activity of interferon-gamma treated macrophages against Trypanosoma cruzi involves an L-arginine-dependent, nitrogen oxide-mediated mechanism inhibitable by interleukin-10 and transforming growth factor-α. Eur. J. Immunol. 22 (1992) 2501
22. Geffner M.E., Bersch N., Lippe B.M., Rosenfeld R.G., Hintz R.L., and Golde D.W. Growth hormone mediates the growth of T-lymphoblast cell lines via locally generated insulin-like growth factor-I. J. Clin. Endocrinol. Metab. 71 (1990) 464-469
23. Golden J.M., and Tarleton R.L. Trypanosoma cruzi: cytokine effects on macrophage trypanocidal activity. Exp. Parasitol. 72 (1991) 391-402
24. Green L.C., Wagner D.A., Glogowski J., Skipper P.L., Wishnok J.S., and Tannenbaum S.R. Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Anal. Biochem. 126 (1982) 131-138
25. Hattori N., Shimatsu A., Sugita M., Kumagai S., and Imura H. Immunoreactive growth hormone (GH) secretion by human lymphocytes: augmented release by exogenous GH. Biochem. Biophys. Res. Commun. 168 (1990) 396-401
26. Holmes S.J., Economou G., Whitehouse R.W., Adams J.E., and Shalet S.M. Reduced bone mineral density in patients with adult onset growth hormone deficiency. J. Clin. Endocrinol. Metab. 78 (1994) 669-674
27. Holscher C., Kohler G., Muller U., Mossmann H., Schaub G.A., and Brombacher F. Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in alpha interferon receptor or inducible nitric oxide synthase. Infect. Immunol. 66 (1998) 1208
28. Kao T.L., Supowit S.C., Thompson E.A., and Meyer III W.J. Immunoreactive growth hormone production by human lymphocyte cell lines. Cell Mol. Neurobiol. 12 (1992) 483-498
29. Kassem M., Blum W., Ristelli J., Mosekilde L., and Eriksen E.F. Growth hormone stimulates proliferation and differentiation of normal human osteoblast-like cells in vitro. Calcif. Tissue Int. 52 (1993) 222-226
30. Kaufman J.M., Taelman P., Vermulen A., and Vandeweghe M. Bone mineral status in growth hormone deficient males with isolated and multiple pituitary deficiencies of childhood onset. J. Clin. Endocrinol. Metab. 74 (1992) 118-123
31. Kelley K.W. The role of growth hormone in modulation of the immune response. Ann. NY Acad. Sci. 594 (1990) 95-103
32. Kierszenbaum F. Where do we stand on the autoimmunity hypothesis of Chagas disease?. Trends Parasitol. 21 (2005) 513-516
33. Kiess W., and Gallaher B. Hormonal control of programmed cell death/apoptosis. Eur. J. Endocrinol. 138 (1998) 482-491
34. Kooijman R., Rijkers G.T., and Zegers B.J. IGF-I potentiates interleukin-2 production in human peripheral T cells. J. Endocrinol. 149 (1996) 351-356
35. Lytras A., Quan N., Vrontakis M.E., Shaw J.E., Cattini P.A., and Friesen H.G. Growth hormone expression in human Burkitt lymphoma serum-free Ramos cell line. Endocrinology 132 (1993) 620-628
36. Morikawa M., Nixon T., and Green H. Growth hormone and the adipose conversion of 3T3 cells. Cell 29 (1982) 783-789
37. Muñoz Fernandez M.A., Fernandez M., and Fresno M. Synergism between tumor necrosis factor a and interferon g on macrophage activation against intracellular Trypanosoma cruzi through a nitric oxide-dependent mechanism. Eur. J. Immunol. 22 (1992) 301-307
38. Nixon B.T., and Green H. Growth hormone promotes the differentiation of myoblasts and preadipocytes generated by azacytidine treatment of 10T1/2 cells. Proc. Natl. Acad. Sci. USA 81 (1984) 3429-3432
39. Postel-Vinay M.C., de Mello Coelho V., Gagnerault M.C., and Dardenne M. Growth hormone stimulates the proliferation of activated mouse T lymphocytes. Endocrinology 138 (1997) 1816-1820
40. Prado Jr. J.C., Levy A.M.A., Leal M.P., Bernard E., and Kloetzel J.K. Influence of male gonodal hormones on the parasitemia and humoral response of male Calomys callosus infected with the Y strain of Trypanosoma cruzi. Parasitol. Res. 85 (1999) 826-829
41. Ramos C., Lamoyi E., Feoli M., and Rodriguez M. Trypanosoma cruzi: immunosuppressed response to different antigens induced in the infected mouse. Exp. Parasitol. 45 (1978) 190-199
42. Redelman D., Welniak L.A., Taub D., and Murphy W.J. Neuroendocrine hormones such as growth hormone and prolactin are integral members of the immunological cytokine network. Cell Immunol. 252 (2008) 111-121
43. Reed S.G. In vivo administration of recombinant IFN-g induces macrophage activation, and prevents acute disease, immune suppression, and death in experimental Trypanosoma cruzi infections. J. Immunol. 140 (1988) 4342-4347
44. Revelli S., Davila H., Ferro M.E., Romero-Piffiguer M., Musso O., Valenti J., Bernabo J., Falcoff E., Wietzerbin J., and Bottasso O. Experimental Trypanosoma cruzi infection in the rat. Response to systemic treatment with recombinant rat interferon gamma. Microbiol. Immunol. 39 (1995) 275-282
45. Santello F.H., Frare E.O., Santos C.D., Toldo M.P.A., Kawasse L.M., Zucoloto S., and Prado Jr. J.C. Melatonin treatment reduces the severity of experimental Trypanosoma cruzi infection. J. Pineal. Res. 42 (2007) 359-363
46. Santos C.D., Caldeira J.C., Toldo M.P.A., and Prado Jr. J.C. Trypanosoma cruzi: effects of repetitive stress during the development of experimental infection. Exp. Parasitol. 110 (2005) 96-101
47. Santos C.D., Levy A.M., Toldo M.P.A., Azevedo A.P., and Prado Jr. J.C. Haematological and histopathological findings after ovariectomy in Trypanosoma cruzi infected mice. Vet. Parasitol. 143 (2007) 222-228
48. Silva L.H.P., and Nussenzweig V. Sobre uma cepa de Trypanosoma cruzi altamente virulenta para o camundongo branco. Folia Clin. Biol. 20 (1953) 191-208
49. Silva J.S., Vespa G.N., Cardoso M.A., Aliberti J.C., and Cunha F.G. Tumor necrosis factor alpha mediates resistance to Trypanosoma cruzi infection in mice by inducing nitric oxide production in infected gamma interferon-activated macrophages. Infect. Immun. 63 (1995) 4862-4867
50. Talvani A., Ribeiro C.S., Aliberti J.C., Michailowsky V., Santos P.V., Murta S.M., Romanha A.J., Almeida I.C., Farber J., Lannes-Vieira J., Silva J.S., and Gazzinelli R.T. Kinetics of cytokine gene expression in experimental chagasic cardiomyopathy: tissue parasitism and endogenous IFN-gamma as important determinants of chemokine mRNA expression during infection with Trypanosoma cruzi. Microbes Infect. 2 (2000) 851-866
51. Torrico F., Heremans H., Rivera M.T., Marck E.V., Billiau A., and Carlier Y. Endogenous IFN-gamma is required for resistance to acute Trypanosoma cruzi infection in mice. J. Immunol. 146 (1991) 3626-3632
52. Vespa G.N.R., Cunha F.Q., and Silva J.S. Nitric oxide is involved in the control of Trypanosoma cruzi induced parasitemia and directly kills parasite in vitro. Infect. Immun. 62 (1994) 5177
53. Wallis M. Growth hormone: deletions in the protein and introns in the gene. Nature 284 (1980) 512
54. WHO - World Health Organization, 2002. Control of Chagas' Disease, WHO Technical Report Series 811, Geneva.