Stress responses of human dermal fibroblasts exposed to zinc pyrithione

Toxicology Letters

Volumn 204, Issue 2-3, 2011, Pages 164-173

  Rudolf, Emil ^a   Cervinka, Miroslav ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Dermal fibroblasts; DNA damage; In vitro; P53; Premature senescence; Zinc pyrithione

Indexed keywords

CASPASE; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN P16; PROTEIN P53; PYRITHIONE ZINC; SYNAPTOPHYSIN;

APOPTOSIS; ARTICLE; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; ENZYME ACTIVATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; IN VITRO STUDY; NORMAL HUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE; SIGNAL TRANSDUCTION; SKIN FIBROBLAST; UPREGULATION;

APOPTOSIS; CELL AGING; CELL PROLIFERATION; CELLS, CULTURED; DNA; FIBROBLASTS; HUMANS; KERATOLYTIC AGENTS; MITOGEN-ACTIVATED PROTEIN KINASES; ORGANOMETALLIC COMPOUNDS; OXIDATIVE STRESS; PYRIDINES; SKIN; STRESS, PHYSIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

MAMMALIA;

EID: 79957999420     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.04.028     Document Type: Article

References (41)

1. Bae Y.S., Hill N.D., Bibi Y., Dreiher J., Cohen A.D. Innovative uses for zinc in dermatology. Dermatol. Clin. 2010, 28:587-597.
2. Bailey P., Arrowsmith C., Darling K., Dexter J., Eklund J., Lane A., Little C., Murray B., Scott A., Williams A., Wilson D. A double-blind randomized vehicle-controlled clinical trial investigating the effect of ZnPTO dose on the scalp vs. antidandruff efficacy and antimycotic activity. Int. J. Cosmet. Sci. 2003, 25:183-188.
3. Bayreuther K., Rodemann H.P., Hommel R., Dittmann K., Albiez M., Francz P.I. Human skin fibroblasts in vitro differentiate along a terminal cell lineage. Proc. Natl. Acad. Sci. U.S.A. 1988, 85:5112-5116.
4. Bray T.M., Bettger W.J. The physiological role of zinc as an antioxidant. Free Radic. Biol. Med. 1990, 8:281-291.
5. Bronaugh R.L., Stewart R.F., Storm J.E. Extent of cutaneous metabolism during percutaneous absorption of xenobiotics. Toxicol. Appl. Pharmacol. 1989, 99:534-543.
6. Brown H.S., Bishop D.R., Rowan C.A. The role of skin absorption as a route of exposure for volatile organic compounds (VOCs) in drinking water. Am. J. Public Health 1984, 74:479-484.
7. Bulavin D.V., Saito S., Hollander M.C., Sakaguchi K., Anderson C.W., Appella E., Fornace A.J. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J. 1999, 18:6845-6854.
8. Cammarano M.S., Nekrasova T., Noel B., Minden A. Pak4 induces premature senescence via a pathway requiring p16INK4/p19ARF and mitogen-activated protein kinase signaling. Mol. Cell. Biol. 2005, 25:9532-9542.
9. Castilho R.M., Squarize C.H., Chodosh L.A., Williams B.O., Gutkind J.S. mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. Cell Stem Cell 2009, 5:279-289.
10. Chuong C.M., Nickoloff B.J., Elias P.M., Goldsmith L.A., Macher E., Maderson P.A., Sundberg J.P., Tagami H., Plonka P.M., Thestrup-Pederson K., Bernard B.A., Schroder J.M., Dotto P., Chang C.M., Williams M.L., Feingold K.R., King L.E., Kligman A.M., Rees J.L., Christophers E. What is the 'true' function of skin?. Exp. Dermatol. 2002, 11:159-187.
11. Clark R.A. Regulation of fibroplasia in cutaneous wound repair. Am. J. Med. Sci. 1993, 306:42-48.
12. Cortese M.M., Suschek C.V., Wetzel W., Kroncke K.D., Kolb-Bachofen V. Zinc protects endothelial cells from hydrogen peroxide via Nrf2-dependent stimulation of glutathione biosynthesis. Free Radic. Biol. Med. 2008, 44:2002-2012.
13. Dimri G.P., Lee X., Basile G., Acosta M., Scott G., Roskelley C., Medrano E.E., Linskens M., Rubelj I., Pereira-Smith O., et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. U.S.A. 1995, 92:9363-9367.
14. Feil R. Environmental and nutritional effects on the epigenetic regulation of genes. Mutat. Res. 2006, 600:46-57.
15. Fraker P.J., Telford W.G. A reappraisal of the role of zinc in life and death decisions of cells. Proc. Soc. Exp. Biol. Med. 1997, 215:229-236.
16. Gaither L.A., Eide D.J. Eukaryotic zinc transporters and their regulation. Biometals 2001, 14:251-270.
17. Grynkiewicz G., Poenie M., Tsien R.Y. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 1985, 260:3440-3450.
18. Gulson B., McCall M., Korsch M., Gomez L., Casey P., Oytam Y., Taylor A., McCulloch M., Trotter J., Kinsley L., Greenoak G. Small amounts of zinc from zinc oxide particles in sunscreens applied outdoors are absorbed through human skin. Toxicol. Sci. 2010, 118:140-149.
19. Guthery E., Seal L.A., Anderson E.L. Zinc pyrithione in alcohol-based products for skin antisepsis: persistence of antimicrobial effects. Am. J. Infect. Control 2005, 33:15-22.
20. Kim C.H., Kim J.H., Moon S.J., Chung K.C., Hsu C.Y., Seo J.T., Ahn Y.S. Pyrithione, a zinc ionophore, inhibits NF-kappaB activation. Biochem. Biophys. Res. Commun. 1999, 259:505-509.
21. Klein C., Creach K., Irintcheva V., Hughes K.J., Blackwell P.L., Corbett J.A., Baldassare J.J. Zinc induces ERK-dependent cell death through a specific Ras isoform. Apoptosis 2006, 11:1933-1944.
22. Korotchkina L.G., Leontieva O.V., Bukreeva E.I., Demidenko Z.N., Gudkov A.V., Blagosklonny M.V. The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway. Aging (Albany NY) 2010, 2:344-352.
23. Lamore S.D., Cabello C.M., Wondrak G.T. The topical antimicrobial zinc pyrithione is a heat shock response inducer that causes DNA damage and PARP-dependent energy crisis in human skin cells. Cell Stress Chaperon. 2010, 15:309-322.
24. Leyden J.J., Stewart R., Kligman A.M. Updated in vivo methods for evaluating topical antimicrobial agents on human skin. J. Invest. Dermatol. 1979, 72:165-170.
25. MacDonald R.S. The role of zinc in growth and cell proliferation. J. Nutr. 2000, 130:1500S-1508S.
26. Mann J.J., Fraker P.J. Zinc pyrithione induces apoptosis and increases expression of Bim. Apoptosis 2005, 10:369-379.
27. Maret W., Vallee B.L. Thiolate ligands in metallothionein confer redox activity on zinc clusters. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:3478-3482.
28. Paris R., Henry R.E., Stephens S.J., McBryde M., Espinosa J.M. Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation. Cell Cycle 2008, 7:2427-2433.
29. Powell S.R. The antioxidant properties of zinc. J. Nutr. 2000, 130:1447S-1454S.
30. Provinciali M., Donnini A., Argentati K., Di Stasio G., Bartozzi B., Bernardini G. Reactive oxygen species modulate Zn(2+)-induced apoptosis in cancer cells. Free Radic. Biol. Med. 2002, 32:431-445.
31. Rostan E.F., DeBuys H.V., Madey D.L., Pinnell S.R. Evidence supporting zinc as an important antioxidant for skin. Int. J. Dermatol. 2002, 41:606-611.
32. Rudolf E., Cervinka M. Zinc pyrithione induces cellular stress signaling and apoptosis in Hep-2 cervical tumor cells: the role of mitochondria and lysosomes. Biometals 2010, 23:339-354.
33. Sciaudone M.P., Chattopadhyay S., Freake H.C. Chelation of zinc amplifies induction of growth hormone mRNA levels in cultured rat pituitary tumor cells. J. Nutr. 2000, 130:158-163.
34. Sugrue M.M., Shin D.Y., Lee S.W., Aaronson S.A. Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:9648-9653.
35. Toussaint O., Dumont P., Dierick J.F., Pascal T., Frippiat C., Chainiaux F., Magalhaes J.P., Eliaers F., Remacle J. Stress-induced premature senescence as alternative toxicological method for testing the long-term effects of molecules under development in the industry. Biogerontology 2000, 1:179-183.
36. Toussaint O., Remacle J., Dierick J.F., Pascal T., Frippiat C., Zdanov S., Magalhaes J.P., Royer V., Chainiaux F. From the Hayflick mosaic to the mosaics of ageing. Role of stress-induced premature senescence in human ageing. Int. J. Biochem. Cell Biol. 2002, 34:1415-1429.
37. Truong-Tran A.Q., Carter J., Ruffin R., Zalewski P.D. New insights into the role of zinc in the respiratory epithelium. Immunol. Cell Biol. 2001, 79:170-177.
38. Vallee B.L., Falchuk K.H. The biochemical basis of zinc physiology. Physiol. Rev. 1993, 73:79-118.
39. Van Cutsem J., Van Gerven F., Fransen J., Schrooten P., Janssen P.A. The in vitro antifungal activity of ketoconazole, zinc pyrithione, and selenium sulfide against Pityrosporum and their efficacy as a shampoo in the treatment of experimental pityrosporosis in guinea pigs. J. Am. Acad. Dermatol. 1990, 22:993-998.
40. Wang Y., Blandino G., Givol D. Induced p21waf expression in H1299 cell line promotes cell senescence and protects against cytotoxic effect of radiation and doxorubicin. Oncogene 1999, 18:2643-2649.
41. Ziller S.A. Absorption, excretion and tissue distribution of 2-pyridinethiol-1-oxide. Food Cosmet. Toxicol. 1977, 15:49-54.