Stress-induced premature senescence as alternative toxicological method for testing the long-term effects of molecules under development in the industry

Biogerontology

Volumn 1, Issue 2, 2000, Pages 179-183

  Toussaint, Olivier ^a   Dumont, Patrick ^a   Dierick, Jean François ^a   Pascal, Thierry ^a   Frippiat, Christophe ^a   Chainiaux, Florence ^a   Magalhaes, Joao Pedro ^a   Eliaers, François ^a   Remacle, Jose ^a  

^a UNIVERSITY OF NAMUR   (Belgium)

Author keywords

Alternative methods; Drug testing; In vitro toxicology; Irreversible effects; Premature senescence; Stress induced; Sublethal stress

Indexed keywords

BIOLOGICAL MARKER; MUTAGENIC AGENT;

CHEMICALLY INDUCED DISORDER; ENERGY METABOLISM; HUMAN; INDUSTRY; METHODOLOGY; MUTAGEN TESTING; OCCUPATIONAL EXPOSURE; PREMATURE AGING; REVIEW; STRESS; TIME;

AGING, PREMATURE; BIOLOGICAL MARKERS; ENERGY METABOLISM; HUMANS; INDUSTRY; MUTAGENICITY TESTS; MUTAGENS; OCCUPATIONAL EXPOSURE; STRESS; TIME FACTORS;

EID: 0034578468     PISSN: 13895729     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010035712199     Document Type: Review

References (22)

1. Bayreuther K, Rodemann HP, Hommel R, Dittmann K, Albiez M and Francz PI “1988” Human skin fibroblasts in vitro differentiate along a terminal cell lineage. Proc Natl Acad Sci USA 85: 5112-5116
2. Campisi J “1996” Replicative senescence: an old lives' tale? Cell 84: 497-500
3. Chen QM and Ames BN “1994” Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. Proc Natl Acad Sci USA 91: 4130-4134
4. 2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication. Biochem J 332: 43-50
5. Dierick J-F, Pascal T, Chainiaux F, Eliaers F, Remacle J, Larsen PM, Roepstorff P and Toussaint O “2000” Transcriptome analysis and proteome analysis in human senescent fibroblasts and fibroblasts undergoing premature senescence induced by repeated sublethal stresses. Ann NY Acad Sci “in press”
6. Dumont P, Burton M, Chen QM, Gonos ES, Frippiat C, Mazarati J-B, Eliaers F, Remacle J and Toussaint O “2000a” Long term effects of successive sublethal oxidative stresses on the appearance of biomarkers of human fibroblast replicative senescence. Free Radic Med Biol 28: 361-373
7. Dumont P, Balbeur L, Remacle J and Toussaint O “2000b” Appearance of biomarkers of in vitro ageing after successive stimulations of WI-38 fibroblasts with IL-1α and TNF-α: senescence associated β-galactosidase activity and morphotype transition. J Anat “in press”
8. Joint databank of the European Research Group for Alternatives in Toxicity Testing, Fund for the Replacement of Animals in Medical Experiments & European Centre for the Validation of Alternative Methods “http://embryo.ib.amwaw.edu.pl/invittox/”
9. Martin GM, Austad SN and Johnson TE “1996” Genetic analysis of ageing: role of oxidative damage and environmental stresses. Nature Genet 13: 25-34
10. Rattan SI “1998” Repeated mild heat shock delays ageing in cultured human skin fibroblasts. Biochem Mol Biol Int 45: 753-759
11. Remacle J, Raes M, Toussaint O and Rao G “1995” Low levels of reactive oxygen species as modulators of cell function. Mutation Res 316: 103-122
12. Saretzki G, Feng J, von Zglinicki T and Villeponteau B “1998” Similar gene expression pattern in senescent and hyperoxic-treated fibroblasts. J Gerontol Biol Sci 53A: B438-B442
13. Shelton DN, Chang E, Whitter PS, Choi D and Funk WD “1999” Microarray analysis of replicative senescence. Curr Biol 9: 939-945
14. Toussaint O and Remacle J “1996” Role of the cellular energetic metabolism in age-related processes. In: Rattan SI and Toussaint O “eds” Molecular Gerontology: Research Status and Strategies. Plenum Press, New York
15. Toussaint O and Schneider ED “1998” The thermodynamics and evolution of complexity in biological systems. J Comp Physiol Biochem Part A 120A: 3-9
16. Toussaint O, Raes M and Remacle J “1991” Aging as a multi-step process characterized by a lowering of entropy production leading the cell to a sequence of defined stages. Mech Ageing Dev 61: 45-64
17. Toussaint O, Houbion A and Remacle J “1992” Aging as a multi-step process characterized by a lowering of entropy production leading the cell to a sequence of defined stages. II. Experimental results with cultivated cells. Mech Ageing Dev 64: 65-83
18. Toussaint O, Michiels C, Raes M and Remacle J “1995a” Importance of the energetic factors in cellular ageing. Exp Gerontol 30: 1-22
19. Toussaint O, Eliaers F, Houbion A, Remacle J and Drieu K “1995b” Protective effect of EGb 761 and bilobalide on mortality and accelerated cellular ageing in stressful conditions. In: Christen Y, Courtois Y and Droy-Lefaix M-T “eds” Advances in Ginkgo biloba Extract Research. Effect of Ginkgo biloba Extracts “EGb 761” on Aging and Age-related Disorders. Vol 4. Elsevier, Paris
20. Toussaint O, Fuchs SY, Ronai ZA, Isoyama N, Yuko, N, Petronilli V, Bernardi P, Gonos ES, Dumont P and Remacle J “1998” Reciprocal effects between stresses and cellular aging. Molecular & Cellular View. Ann NY Acad Sci 851: 450-465
21. Toussaint O, Dumont P, Dierick J-F, Pascal T, Frippiat C, Chainiaux F, Magalhaes JP, Eliaers F and Remacle J “2000” Stress-induced premature senescence. Essence of life, evolution, stress & aging. Ann NY Acad Sci “in press”
22. Von Zglinicki T, Sarentzki G, Docke W and Lotze C “1995” Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? Exp Cell Res 220: 186-213