Resident B cells regulate thymic expression of myelin oligodendrocyte glycoprotein

Journal of Neuroimmunology

Volumn 235, Issue 1-2, 2011, Pages 33-39

  Akirav, Eitan M ^a   Xu, Yan ^a   Ruddle, Nancy H ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

B cells; Insulin; Myelin oligodendrocyte glycoprotein; Self antigens; Thymus

Indexed keywords

AUTOANTIGEN; GLYCOPROTEIN; INSULIN; LYMPHOTOXIN; MESSENGER RNA; MYELIN; TISSUE ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; CELL COUNT; CELL POPULATION; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; GENE EXPRESSION; IMMUNOREGULATION; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; THYMOCYTE;

ANIMALS; B-LYMPHOCYTE SUBSETS; FEMALE; LYMPHOCYTE COUNT; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, NUDE; MYELIN-ASSOCIATED GLYCOPROTEIN; RNA, MESSENGER; THYMUS GLAND; TRANSPLANTATION CHIMERA;

EID: 79957992373     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2011.03.013     Document Type: Article

References (41)

1. Akiyama T., Shimo Y., Yanai H., Qin J., Ohshima D., Maruyama Y., Asaumi Y., Kitazawa J., Takayanagi H., Penninger J.M., Matsumoto M., Nitta T., Takahama Y., Inoue J. The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity 2008, 29:423-437.
2. Anderson M.S., Venanzi E.S., Klein L., Chen Z., Berzins S.P., Turley S.J., von Boehmer H., Bronson R., Dierich A., Benoist C., Mathis D. Projection of an immunological self shadow within the thymus by the aire protein. Science 2002, 298:1395-1401.
3. Andreu-Sanchez J.L., Faro J., Alonso J.M., Paige C.J., Martinez C., Marcos M.A. Ontogenic characterization of thymic B lymphocytes. Analysis in different mouse strains. Eur. J. Immunol. 1990, 20:1767-1773.
4. Beutner U., Kraus E., Kitamura D., Rajewsky K., Huber B.T. B cells are essential for murine mammary tumor virus transmission, but not for presentation of endogenous superantigens. J. Exp. Med. 1994, 179:1457-1466.
5. Boehm T., Scheu S., Pfeffer K., Bleul C.C. Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR. J. Exp. Med. 2003, 198:757-769.
6. Chin R.K., Lo J.C., Kim O., Blink S.E., Christiansen P.A., Peterson P., Wang Y., Ware C., Fu Y.X. Lymphotoxin pathway directs thymic Aire expression. Nat. Immunol. 2003, 4:1121-1127.
7. Chin R.K., Zhu M., Christiansen P.A., Liu W., Ware C., Peltonen L., Zhang X., Guo L., Han S., Zheng B., Fu Y.X. Lymphotoxin pathway-directed, autoimmune regulator-independent central tolerance to arthritogenic collagen. J. Immunol. 2006, 177:290-297.
8. Collins T.J. ImageJ for microscopy. Biotechniques 2007, 43:25-30.
9. De Togni P., Goellner J., Ruddle N.H., Streeter P.R., Fick A., Mariathasan S., Smith S.C., Carlson R., Shornick L.P., Strauss-Schoenberger J., et al. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science 1994, 264:703-707.
10. Drayton D.L., Ying X., Lee J., Lesslauer W., Ruddle N.H. Ectopic LT alpha beta directs lymphoid organ neogenesis with concomitant expression of peripheral node addressin and a HEV-restricted sulfotransferase. J. Exp. Med. 2003, 197:1153-1163.
11. Ferrero I., Anjuere F., Martin P., Martinez del Hoyo G., Fraga M.L., Wright N., Varona R., Marquez G., Ardavin C. Functional and phenotypic analysis of thymic B cells: role in the induction of T cell negative selection. Eur. J. Immunol. 1999, 29:1598-1609.
12. Feyerabend T.B., Terszowski G., Tietz A., Blum C., Luche H., Gossler A., Gale N.W., Radtke F., Fehling H.J., Rodewald H.R. Deletion of Notch1 converts pro-T cells to dendritic cells and promotes thymic B cells by cell-extrinsic and cell-intrinsic mechanisms. Immunity 2009, 30:67-79.
13. Foy T.M., Page D.M., Waldschmidt T.J., Schoneveld A., Laman J.D., Masters S.R., Tygrett L., Ledbetter J.A., Aruffo A., Claassen E., Xu J.C., Flavell R.A., Oehen S., Hedrick S.M., Noelle R.J. An essential role for gp39, the ligand for CD40, in thymic selection. J. Exp. Med. 1995, 182:1377-1388.
14. Gray D.H., Chidgey A.P., Boyd R.L. Analysis of thymic stromal cell populations using flow cytometry. J. Immunol. Methods 2002, 260:15-28.
15. Gray D., Abramson J., Benoist C., Mathis D. Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J. Exp. Med. 2007, 204:2521-2528.
16. Hikosaka Y., Nitta T., Ohigashi I., Yano K., Ishimaru N., Hayashi Y., Matsumoto M., Matsuo K., Penninger J.M., Takayanagi H., Yokota Y., Yamada H., Yoshikai Y., Inoue J., Akiyama T., Takahama Y. The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity 2008, 29:438-450.
17. Hjelmstrom P., Fjell J., Nakagawa T., Sacca R., Cuff C.A., Ruddle N.H. Lymphoid tissue homing chemokines are expressed in chronic inflammation. Am. J. Pathol. 2000, 156:1133-1138.
18. Juedes A.E., Ruddle N.H. Resident and infiltrating central nervous system APCs regulate the emergence and resolution of experimental autoimmune encephalomyelitis. J. Immunol. 2001, 166:5168-5175.
19. Juedes A.E., Hjelmstrom P., Bergman C.M., Neild A.L., Ruddle N.H. Kinetics and cellular origin of cytokines in the central nervous system: insight into mechanisms of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. J. Immunol. 2000, 164:419-426.
20. Kleindienst P., Chretien I., Winkler T., Brocker T. Functional comparison of thymic B cells and dendritic cells in vivo. Blood 2000, 95:2610-2616.
21. Koni P.A., Sacca R., Lawton P., Browning J.L., Ruddle N.H., Flavell R.A. Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta in lymphotoxi-beta deficient mice. Immunity 1997, 6:491-500.
22. Kurobe H., Liu C., Ueno T., Saito F., Ohigashi I., Seach N., Arakaki R., Hayashi Y., Kitagawa T., Lipp M., Boyd R.L., Takahama Y. CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance. Immunity 2006, 24:165-177.
23. Kuroda N., Mitani T., Takeda N., Ishimaru N., Arakaki R., Hayashi Y., Bando Y., Izumi K., Takahashi T., Nomura T., Sakaguchi S., Ueno T., Takahama Y., Uchida D., Sun S., Kajiura F., Mouri Y., Han H., Matsushima A., Yamada G., Matsumoto M. Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice. J. Immunol. 2005, 174:1862-1870.
24. Kyewski B., Derbinski J. Self-representation in the thymus: an extended view. Nat. Rev. Immunol. 2004, 4:688-698.
25. Martins V.C., Boehm T., Bleul C.C. Ltbetar signaling does not regulate Aire-dependent transcripts in medullary thymic epithelial cells. J. Immunol. 2008, 181:400-407.
26. Mathis D., Benoist C. A decade of AIRE. Nat. Rev. Immunol. 2007, 7:645-650.
27. Mori S., Inaba M., Sugihara A., Taketani S., Doi H., Fukuba Y., Yamamoto Y., Adachi Y., Inaba K., Fukuhara S., Ikehara S. Presence of B cell progenitors in the thymus. J. Immunol. 1997, 158:4193-4199.
28. Ngo V.N., Korner H., Gunn M.D., Schmidt K.N., Riminton D.S., Cooper M.D., Browning J.L., Sedgwick J.D., Cyster J.G. Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. J. Exp. Med. 1999, 189:403-412.
29. Oliver A.R., Lyon G.M., Ruddle N.H. Rat and human myelin oligodendrocyte glycoproteins induce experimental autoimmune encephalomyelitis by different mechanisms in C57BL/6 mice. J. Immunol. 2003, 171:462-468.
30. Reif K., Ekland E.H., Ohl L., Nakano H., Lipp M., Forster R., Cyster J.G. Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position. Nature 2002, 416:94-99.
31. Rossi S.W., Kim M.Y., Leibbrandt A., Parnell S.M., Jenkinson W.E., Glanville S.H., McConnell F.M., Scott H.S., Penninger J.M., Jenkinson E.J., Lane P.J., Anderson G. RANK signals from CD4+3-inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. J. Exp. Med. 2007, 204:1267-1272.
32. Seach N., Ueno T., Fletcher A.L., Lowen T., Mattesich M., Engwerda C.R., Scott H.S., Ware C.F., Chidgey A.P., Gray D.H., Boyd R.L. The lymphotoxin pathway regulates Aire-independent expression of ectopic genes and chemokines in thymic stromal cells. J. Immunol. 2008, 180:5384-5392.
33. Silva-Santos B., Pennington D.J., Hayday A.C. Lymphotoxin-mediated regulation of gammadelta cell differentiation by alphabeta T cell progenitors. Science 2005, 307:925-928.
34. Takahama Y. Journey through the thymus: stromal guides for T-cell development and selection. Nat. Rev. Immunol. 2006, 6:127-135.
35. Tullin S., Farris P., Petersen J.S., Hornum L., Jackerott M., Markholst H. A pronounced thymic B cell deficiency in the spontaneously diabetic BB rat. J. Immunol. 1997, 158:5554-5559.
36. Tumanov A., Kuprash D., Lagarkova M., Grivennikov S., Abe K., Shakhov A., Drutskaya L., Stewart C., Chervonsky A., Nedospasov S. Distinct role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues. Immunity 2002, 17:239-250.
37. Ueno T., Saito F., Gray D.H., Kuse S., Hieshima K., Nakano H., Kakiuchi T., Lipp M., Boyd R.L., Takahama Y. CCR7 signals are essential for cortex-medulla migration of developing thymocytes. J. Exp. Med. 2004, 200:493-505.
38. Venanzi E.S., Gray D.H., Benoist C., Mathis D. Lymphotoxin pathway and Aire influences on thymic medullary epithelial cells are unconnected. J. Immunol. 2007, 179:5693-5700.
39. Ware C.F. Network communications: lymphotoxins, LIGHT, and TNF. Annu. Rev. Immunol. 2005, 23:787-819.
40. Williams J.A., Sharrow S.O., Adams A.J., Hodes R.J. CD40 ligand functions non-cell autonomously to promote deletion of self-reactive thymocytes. J. Immunol. 2002, 168:2759-2765.
41. Zhu M., Chin R.K., Tumanov A.V., Liu X., Fu Y.X. Lymphotoxin beta receptor is required for the migration and selection of autoreactive T cells in thymic medulla. J. Immunol. 2007, 179:8069-8075.