Immortalisation of normal human urothelial cells compromises differentiation capacity

European Urology

Volumn 60, Issue 1, 2011, Pages 141-149

  Georgopoulos, Nikolaos T ^a,b   Kirkwood, Lisa A ^a   Varley, Claire L ^a   MacLaine, Nicola J ^a,c   Aziz, Naveed ^a   Southgate, Jennifer ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b UNIVERSITY OF HUDDERSFIELD   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Bladder cancer; Differentiation; Immortalisation; Telomerase; Urothelium

Indexed keywords

CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 2A; FIBROBLAST GROWTH FACTOR RECEPTOR 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN E6; PROTEIN P53; TELOMERASE REVERSE TRANSCRIPTASE; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; UROPLAKIN; UROPLAKIN 2; UROPLAKIN 3;

ARTICLE; CELL AGING; CELL CULTURE; CELL DIFFERENTIATION; CELL FUNCTION; CELL IMMORTALIZATION; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; ELECTRIC RESISTANCE; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 16; KARYOTYPE; LABORATORY; LIFESPAN; LOSS OF FUNCTION MUTATION; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; RETROVIRUS; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSEPITHELIAL ELECTRICAL RESISTANCE; TRANSGENE; TRANSITIONAL CELL CARCINOMA; TUMOR SUPPRESSOR GENE; UROTHELIUM; UROTHELIUM CELL; VIRUS RECOMBINANT; WILD TYPE;

CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 3; TELOMERASE; UROTHELIUM;

EID: 79957955584     PISSN: 03022838     EISSN: 18737560     Source Type: Journal    
DOI: 10.1016/j.eururo.2011.02.022     Document Type: Article

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