Intestinal gene expression in pigs experimentally co-infected with PCV2 and PPV

Veterinary Immunology and Immunopathology

Volumn 142, Issue 1-2, 2011, Pages 72-80

  Andersson, M ^a   Ahlberg, V ^a   Jensen Waern, M ^a   Fossum, C ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

Cytokine; Microarray; PMWS; Porcine; QPCR

Indexed keywords

COMPLEMENTARY DNA; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 6; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CIRCOVIRIDAE INFECTION; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; GENE EXPRESSION; IMMUNITY; INTESTINE INFECTION; MIXED INFECTION; NONHUMAN; PARVOVIRUS INFECTION; POLYMERASE CHAIN REACTION; PORCINE PARVOVIRUS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SWINE; UPREGULATION; VIRUS GENE;

ANIMALS; CIRCOVIRUS; CYTOKINES; DNA, VIRAL; GENE EXPRESSION PROFILING; INTESTINES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PARVOVIRIDAE INFECTIONS; PARVOVIRUS, PORCINE; POLYMERASE CHAIN REACTION; PORCINE POSTWEANING MULTISYSTEMIC WASTING SYNDROME; SWINE; SWINE DISEASES;

SUIDAE; SUS;

EID: 79957940310     PISSN: 01652427     EISSN: 18732534     Source Type: Journal    
DOI: 10.1016/j.vetimm.2011.04.012     Document Type: Article

References (53)

1. Allan G., Kennedy S., McNeilly F., Foster J.C., Ellis J.A., Krakowka S.J., Meehan B.M., Adair B.M. Experimental reproduction of wasting disease and death by co-infection of pigs with porcine circovirus and porcine parvovirus. J. Comp. Pathol. 1999, 121:1-11.
2. Allan G.M., McNeilly F., Meehan B.M., Ellis J.A., Connor T.J., McNair I., Krakowka S., Kennedy S. A sequential study of experimental infection of pigs with porcine circovirus and porcine parvovirus: immunostaining of cryostat sections and virus isolation. J. Vet. Med. B Infect. Dis. Vet. Public Health 2000, 47:81-94.
3. Brass A.L., Huang I.C., Benita Y., John S.P., Krishnan M.N., Feeley E.M., Ryan B.J., Weyer J.L., van der Weyden L., Fikrig E., Adams D.J., Xavier R.J., Farzan M., Elledge S.J. The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell 2009, 139:1243-1254.
4. Chae C. Postweaning multisystemic wasting syndrome: a review of aetiology, diagnosis and pathology. Vet. J. 2004, 168:41-49.
5. Chomarat P., Rissoan M.C., Banchereau J., Miossec P. Interferon gamma inhibits interleukin 10 production by monocytes. J. Exp. Med. 1993, 177:523-527.
6. Collado-Romero M., Arce C., Ramírez-Boo M., Carvajal A., Garrido J.J. Quantitative analysis of the immune response upon Salmonella typhimurium infection along the porcine intestinal gut. Vet. Res. 2010, 41:23-34.
7. Darwich L., Segalés J., Resendes A., Balasch M., Plana-Durán J., Mateu E. Transient correlation between viremia levels and IL-10 expression in pigs subclinically infected with porcine circovirus type 2 (PCV2). Res. Vet. Sci. 2008, 84:194-198.
8. Devriendt B., Stuyven E., Verdonck F., Gooddeeris B.M., Cox E. Enterotoxigenic Escherichia coli (K88) induce proinflammatory responses in porcine intestinal epithelial cells. Dev. Comp. Immunol. 2010, 34:1175-1182.
9. Dvorak C.M., Hirsch G.N., Hyland K.A., Hendrickson J.A., Thompson B.S., Rutherford M.S., Murtaugh M.P. Genomic dissection of mucosal immunobiology in the porcine small intestine. Physiol. Genomics 2006, 28:5-14.
10. Evans S.S., Collea R.P., Leasure J.A., Lee D.B. IFN-alpha induces homotypic adhesion and Leu-13 expression in human B lymphoid cells. J. Immunol. 1993, 150:736-747.
11. Fleige S., Walf V., Huch S., Prgomet C., Sehm J., Pfaffl M.W. Comparison of relative mRNA quantification models and the impact of RNA integrity in quantitative real-time RT-PCR. Biotechnol. Lett. 2006, 28:1601-1613.
12. Fort M., Fernandes L.T., Nofrarias M., Díaz I., Sibila M., Pujols J., Mateu E., Segalés J. Development of cell-mediated immunity to porcine circovirus type 2 (PCV2) in caesarean-derived, colostrum-deprived piglets. Vet. Immunol. Immunopathol. 2009, 129:101-107.
13. Friedman R.L., Manly S.P., McMahon M., Kerr I.M., Stark G.R. Transcriptional and post-transcriptional regulation of interferon-induced gene expression in human cells. Cell 1984, 38:745-755.
14. Gillespie J., Opriessnig T., Meng X.J., Pelzer K., Buechner-Maxwell V. Porcine circovirus type 2 and porcine circovirus-associated disease. J. Vet. Intern. Med. 2009, 23:1151-1163.
15. Grau-Roma L., Fraile L., Segalés J. Recent advances in the epidemiology, diagnosis and control of diseases caused by porcine circovirus type 2. Vet. J. 2010, 10.1016/j.tvjl.2010.01.018.
16. Harding J., Clark E. Recognizing and diagnosing postweaning multisystemic wasting syndrome (PMWS). Swine Health Prod. 1997, 5:201-203.
17. Hasslung F., Wallgren P., Ladekjaer-Hansen A.-S., Bøtner A., Nielsen J., Wattrang E., Allan G.M., McNeilly F., Ellis J., Timmusk S., Belák K., Segall T., Melin L., Berg M., Fossum C. Experimental reproduction of postweaning multisystemic wasting syndrome (PMWS) in pigs in Sweden and Denmark with a Swedish isolate of porcine circovirus type 2. Vet. Microbiol. 2005, 106:49-60.
18. Hasslung Wikström F.H., Fossum C., Fuxler L., Kruse R., Lövgren T. Cytokine induction by immunostimulatory DNA in porcine PBMC is impaired by a hairpin forming sequence motif from the genome of porcine circovirus type 2 (PCV2). Vet. Immunol. Immunopathol. 2011, 139:156-166.
19. Huang da W., Sherman B.T., Lempicki R.A. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 2009, 37:1-13.
20. Huang da W., Sherman B.T., Lempicki R.A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Prod. 2009, 4:44-57.
21. Imai T., Yoshie O. C33 antigen and M38 antigen recognized by monoclonal antibodies inhibitory to syncytium formation by human T cell leukemia virus type 1 are both members of the transmembrane 4 superfamily and associate with each other and with CD4 or CD8 in T cells. J. Immunol. 1993, 151:6470-6481.
22. Inman C.F., Haverson K., Konstantinov S.R., Jones P.H., Harris C., Smidt H., Miller B., Bailey M., Stokes C. Rearing environment affects development of the immune system in neonates. Clin. Exp. Immunol. 2010, 160:431-439.
23. Irizarry R.A., Hobbs B., Collin F., Beazer-Barclay Y.D., Antonellis K.J., Scherf U., Speed T.P. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 2003, 4:249-264.
24. Jacobson, M., Andersson, M., Lindberg, R., Fossum, C., Jensen-Waern, M., submitted for publication. Microarray and cytokine analyses in pigs with diarrhoea and healthy grower-finisher pigs in herds previously shown to be infected with Lawsonia intracellularis.
25. Jensen T.K., Vigre H., Svensmark B., Bille-Hansen V. Distinction between porcine circovirus type 2 enteriris and porcine proliferative enteropathy caused by Lawsonia intracellularis. J. Comp. Pathol. 2006, 135:176-182.
26. Kekarainen T., Montoya M., Mateu E., Segalés J. Porcine circovirus type 2-induced interleukin-10 modulates recall antigen responses. J. Gen. Virol. 2008, 89:760-765.
27. Kekarainen T., McCullough K., Fort M., Fossum C., Segalés J., Allan G.M. Immune responses and vaccine-induced immunity against Porcine circovirus type 2. Vet. Immunol. Immunopathol. 2010, 136:185-193.
28. Kennedy S., Moffett D., McNeilly F., Meehan B., Ellis J., Krakowka S., Allan G.M. Reproduction of lesions of postweaning multisystemic wasting syndrome by infection of conventional pigs with porcine circovirus type 2 alone or in combination with porcine parvovirus. J. Comp. Pathol. 2000, 122:9-24.
29. Ladekjaer-Mikkelsen A.S., Nielsen J. A longitudinal study of cell-mediated immunity in pigs infected with porcine parvovirus. Viral Immunol. 2002, 15:373-384.
30. Lange U.C., Saitou M., Western P.S., Barton S.C., Surani M.A. The fragilis interferon-inducible gene family of transmembrane proteins is associated with germ cell specification in mice. BMC Dev. Biol. 2003, 3:1.
31. Lee G., Han D., Song J.Y., Lee Y.S., Kang K.S., Yoon S. Genomic expression profiling in lymph nodes with lymphoid depletion from porcine circovirus 2 (PCV2)-infected pigs. J. Gen. Virol. 2010, 91:2585-2591.
32. Lewin A.R., Reid L.E., McMahon M., Stark G.R., Kerr I.M. Molecular analysis of a human interferon inducible gene family. Eur. J. Biochem. 1991, 199:417-423.
33. Li C., Wong W.H. Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:31-36.
34. Livak K., Schmittgen T. Analysis of relative gene expression data using real-time quantitative pcr and the 2-ΔΔCT method. Methods 2001, 25:402-408.
35. Madec F., Rose N., Grasland B., Cariolet R., Jestin A. Post-weaning multisystemic wasting syndrome and other PCV2-related problems in pigs: a 12-year experience. Transbound. Emerg. Dis. 2008, 55:273-283.
36. Meerts P., Misinzo G., Nauwynck H.J. Enhancement of porcine circovirus 2 replication in porcine cell lines by IFN-gamma before and after treatment and by IFN-alpha after treatment. J. Interferon Cytokine Res. 2005, 25:684-693.
37. Oswald I.P. Role of intestinal epithelial cells in the innate immune defence of the pig intestine. Vet. Res. 2006, 37:359-368.
38. Pié S., Lallès J.P., Blazy F., Laffitte J., Sève B., Oswald I.P. Weaning is associated with an upregulation of expression of inflammatory cytokines in the intestine of piglets. J. Nutr. 2004, 134:641-647.
39. Ramamoorthy S., Meng X.J. Porcine circoviruses: a minuscule yet mammoth paradox. Anim. Health Res. Rev. 2009, 10:1-20.
40. Ramamoorthy S., Opriessnig T., Pal N., Huang F.F., Meng X.J. Effect of an interferon-stimulated response element (ISRE) mutant of porcine circovirus type 2 (PCV2) on PCV2-induced pathological lesions in a porcine reproductive and respiratory syndrome virus (PRRSV) co-infection model. Vet. Microbiol. 2010, 147:49-58.
41. Rennick D.M., Fort M.M., Davidson N.J. Studies with IL-10-/- mice: an overview. J. Leukoc. Biol. 1997, 61:389-396.
42. Segalés J., Rosell C., Domingo M. Pathological findings associated with naturally acquired porcine circovirus type 2 associated disease. Vet. Microbiol. 2004, 98:137-149.
43. Seo G.S., Lee J.K., Yu J.I., Yun K.J., Chae S.C., Choi S.C. Identification of the polymorphisms in IFITM3 gene and their association in a Korean population with ulcerative colitis. Exp. Mol. Med. 2010, 42:99-104.
44. Shirkey T.W., Siggers R.H., Goldade B.G., Marshall J.K., Drew M.D., Laarveld B., Van Kessel A.G. Effects of commensal bacteria on intestinal morphology and expression of proinflammatory cytokines in the gnotobiotic pig. Exp. Biol. Med. (Maywood) 2006, 231:1333-1345.
45. Sipos W., Duvigneau J.C., Willheim M., Schilcher F., Hartl R.T., Hofbauer G., Exel B., Pietschmann P., Schmoll F. Systemic cytokine profile in feeder pigs suffering from natural postweaning multisystemic wasting syndrome (PMWS) as determined by semiquantitative RT-PCR and flow cytometric intracellular cytokine detection. Vet. Immunol. Immunopathol. 2004, 99:63-71.
46. Sipos W., Duvigneau J.C., Pietschmann P., Schilcher F., Hofbauer G., Hartl R.T., Schmoll F. Porcine dermatitis and nephropathy syndrome (PDNS) is associated with a systemic cytokine expression profile indicative of proinflammation and a Th1 bias. Vet. Immunol. Immunopathol. 2005, 107:303-313.
47. Steiner E., Balmelli C., Gerber H., Summerfield A., McCullough K. Cellular adaptive immune response against porcine circovirus type 2 in subclinically infected pigs. BMC Vet. Res. 2009, 5:45.
48. Stevenson L.S., McCullough K., Vincent I., Gilpin D.F., Summerfield A., Nielsen J., McNeilly F., Adair B.M., Allan G.M. Cytokine and C-reactive protein profiles induced by porcine circovirus type 2 experimental infection in 3-week-old piglets. Viral Immunol. 2006, 19:189-195.
49. Timmusk S., Merlot E., Lövgren T., Järvekülg L., Berg M., Fossum C. Regulator of G protein signalling 16 is a target for a porcine circovirus type 2 protein. J. Gen. Virol. 2009, 90:2425-2436.
50. Tlaskalová-Hogenová H., Stepánková R., Hudcovic T., Tucková L., Cukrowska B., Lodinová-Zádníková R., Kozáková H., Rossmann P., Bártová J., Sokol D., Funda D.P., Borovská D., Reháková Z., Sinkora J., Hofman J., Drastich P., Kokesová A. Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases. Immunol. Lett. 2004, 93:97-108.
51. Tomás A., Fernandes L.T., Sánchez A., Segalés J. Time course differential gene expression in response to porcine circovirus type 2 subclinical infection. Vet. Res. 2010, 41:12-27.
52. Vincent I.E., Carrasco C.P., Herrmann B., Meehan B.M., Allan G.M., Summerfield A., McCullough K.C. Dendritic cells harbor infectious porcine circovirus type 2 in the absence of apparent cell modulation or replication of the virus. J. Virol. 2003, 77:13288-13300.
53. Weidner J.M., Jiang D., Pan X.B., Chang J., Block T.M., Guo J.T. Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms. J. Virol. 2010, 84:12646-12657.