Cellular adaptive immune response against porcine circovirus type 2 in subclinically infected pigs

BMC Veterinary Research

Volumn 5, Issue , 2009, Pages

  Steiner, Esther ^a,b   Balmelli, Carole ^a,c   Gerber, Heidi ^a   Summerfield, Artur ^a   McCullough, Kenneth ^a  

^a INSTITUTE OF VIROLOGY AND IMMUNOLOGY   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c AGROSCOPE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; CIRCOVIRUS; PORCINE CIRCOVIRUS 2; PORCINE PARVOVIRUS; SUIDAE;

GAMMA INTERFERON; VIRUS ANTIBODY;

ANIMAL; ANIMAL DISEASE; ARTICLE; BIOSYNTHESIS; CELLULAR IMMUNITY; CIRCOVIRIDAE INFECTION; CIRCOVIRUS; IMMUNOLOGY; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; SWINE; SWINE DISEASE; T LYMPHOCYTE; VIREMIA; VIROLOGY;

ANIMALS; ANTIBODIES, VIRAL; CIRCOVIRIDAE INFECTIONS; CIRCOVIRUS; IMMUNITY, CELLULAR; INTERFERON-GAMMA; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; SWINE; SWINE DISEASES; T-LYMPHOCYTES; VIREMIA;

EID: 77449104981     PISSN: None     EISSN: 17466148     Source Type: Journal    
DOI: 10.1186/1746-6148-5-45     Document Type: Article

References (42)

1. Todd D, Bendinelli M, Biagini P, Hino S, Mankertz A, Mishiro S, Niel C, Okamoto H, Raidal S, Ritchie BW, Teo GC. Circoviridae. Virus taxonomy: Eight report of the international committee on taxonomy of viruses 2005, 327-334. San Diego: Elsevier academic press, Fauquet CM, Mayo MA, Maniloff J, Desselberger U, Ball LA, 2.
2. Allan GM, McNeilly F, Meehan BM, Kennedy S, Mackie DP, Ellis JA, Clark EG, Espuna E, Saubi N, Riera P. Isolation and characterisation of circoviruses from pigs with wasting syndromes in Spain, Denmark and Northern Ireland. Vet Microbiol 1999, 66(2):115-123. 10.1016/S0378-1135(99)00004-8, 10227473.
3. Mankertz A, Persson F, Mankertz J, Blaess G, Buhk HJ. Mapping and characterization of the origin of DNA replication of porcine circovirus. J Virol 1997, 71(3):2562-2566. 191374, 9032401.
4. Ellis J, Hassard L, Clark E, Harding J, Allan G, Willson P, Strokappe J, Martin K, McNeilly F, Meehan B. Isolation of circovirus from lesions of pigs with postweaning multisystemic wasting syndrome. Can Vet J 1998, 39(1):44-51. 1539838, 9442952.
5. Allan GM, McNeilly F, Kennedy S, Daft B, Clarke EG, Ellis JA, Haines DM, Meehan BM, Adair BM. Isolation of porcine circovirus-like viruses from pigs with a wasting disease in the USA and Europe. J Vet Diagn Invest 1998, 10(1):3-10.
6. Allan GM, Kennedy S, McNeilly F, Foster JC, Ellis JA, Krakowka SJ, Meehan BM, Adair BM. Experimental reproduction of severe wasting disease by co-infection of pigs with porcine circovirus and porcine parvovirus. J Comp Pathol 1999, 121(1):1-11. 10.1053/jcpa.1998.0295, 10373289.
7. Ellis J, Krakowka S, Lairmore M, Haines D, Bratanich A, Clark E, Allan G, Konoby C, Hassard L, Meehan B. Reproduction of lesions of postweaning multisystemic wasting syndrome in gnotobiotic piglets. J Vet Diagn Invest 1999, 11(1):3-14.
8. Grasland B, Loizel C, Blanchard P, Oger A, Nignol AC, Bigarre L, Morvan H, Cariolet R, Jestin A. Reproduction of PMWS in immunostimulated SPF piglets transfected with infectious cloned genomic DNA of type 2 porcine circovirus. Vet Res 2005, 36(5-6):685-697. 10.1051/vetres:2005024, 16120245.
9. Krakowka S, Ellis JA, McNeilly F, Ringler S, Rings DM, Allan G. Activation of the immune system is the pivotal event in the production of wasting disease in pigs infected with porcine circovirus-2 (PCV-2). Vet Pathol 2001, 38(1):31-42. 10.1354/vp.38-1-31, 11199162.
10. Ladekjaer-Mikkelsen AS, Nielsen J, Stadejek T, Storgaard T, Krakowka S, Ellis J, McNeilly F, Allan G, Botner A. Reproduction of postweaning multisystemic wasting syndrome (PMWS) in immunostimulated and non-immunostimulated 3-week-old piglets experimentally infected with porcine circovirus type 2 (PCV2). Vet Microbiol 2002, 89(2-3):97-114. 10.1016/S0378-1135(02)00174-8, 12243888.
11. Tischer I, Peters D, Rasch R, Pociuli S. Replication of porcine circovirus: induction by glucosamine and cell cycle dependence. Arch Virol 1987, 96(1-2):39-57. 10.1007/BF01310989, 3619654.
12. Allan GM, Ellis JA. Porcine circoviruses: a review. J Vet Diagn Invest 2000, 12(1):3-14.
13. Segales J, Rosell C, Domingo M. Pathological findings associated with naturally acquired porcine circovirus type 2 associated disease. Vet Microbiol 2004, 98(2):137-149. 10.1016/j.vetmic.2003.10.006, 14741126.
14. Opriessnig T, Janke BH, Halbur PG. Cardiovascular lesions in pigs naturally or experimentally infected with porcine circovirus type 2. JComp Pathol 2006, 134(1):105-110.
15. Rosell C, Segales J, Plana-Duran J, Balasch M, Rodriguez-Arrioja GM, Kennedy S, Allan GM, McNeilly F, Latimer KS, Domingo M. Pathological, immunohistochemical, and in-situ hybridization studies of natural cases of postweaning multisystemic wasting syndrome (PMWS) in pigs. J Comp Pathol 1999, 120(1):59-78. 10.1053/jcpa.1998.0258, 10098016.
16. Meerts P, Misinzo G, Lefebvre D, Nielsen J, Botner A, Kristensen CS, Nauwynck HJ. Correlation between the presence of neutralizing antibodies against porcine circovirus 2 (PCV2) and protection against replication of the virus and development of PCV2-associated disease. BMC Vet Res 2006, 2:6. 10.1186/1746-6148-2-6, 1386657, 16445856.
17. Jensen TK, Vigre H, Svensmark B, Bille-Hansen V. Distinction between porcine circovirus type 2 enteritis and porcine proliferative enteropathy caused by Lawsonia intracellularis. J Comp Pathol 2006, 135(4):176-182. 10.1016/j.jcpa.2006.08.006, 17070535.
18. Yu S, Opriessnig T, Kitikoon P, Nilubol D, Halbur PG, Thacker E. Porcine circovirus type 2 (PCV2) distribution and replication in tissues and immune cells in early infected pigs. Vet Immunol Immunopathol 2007, 115(3-4):261-272. 10.1016/j.vetimm.2006.11.006, 17175030.
19. Vincent IE, Carrasco CP, Herrmann B, Meehan BM, Allan GM, Summerfield A, McCullough KC. Dendritic cells harbor infectious porcine circovirus type 2 in the absence of apparent cell modulation or replication of the virus. J Virol 2003, 77(24):13288-13300. 10.1128/JVI.77.24.13288-13300.2003, 296043, 14645585.
20. Gilpin DF, McCullough K, Meehan BM, McNeilly F, McNair I, Stevenson LS, Foster JC, Ellis JA, Krakowka S, Adair BM, et al. In vitro studies on the infection and replication of porcine circovirus type 2 in cells of the porcine immune system. Vet Immunol Immunopathol 2003, 94(3-4):149-161. 10.1016/S0165-2427(03)00087-4, 12909411.
21. Steiner E, Balmelli C, Herrmann B, Summerfield A, McCullough K. Porcine circovirus type 2 displays pluripotency in cell targeting. Virology 2008, 378(2):311-322. 10.1016/j.virol.2008.06.009, 18617215.
22. Meerts P, Misinzo G, McNeilly F, Nauwynck HJ. Replication kinetics of different porcine circovirus 2 strains in PK-15 cells, fetal cardiomyocytes and macrophages. Arch Virol 2005, 150(3):427-441. 10.1007/s00705-004-0444-2, 15578238.
23. Nielsen J, Vincent IE, Botner A, Ladekaer-Mikkelsen AS, Allan G, Summerfield A, McCullough KC. Association of lymphopenia with porcine circovirus type 2 induced postweaning multisystemic wasting syndrome (PMWS). Vet Immunol Immunopathol 2003, 92(3-4):97-111. 10.1016/S0165-2427(03)00031-X, 12730011.
24. Darwich L, Balasch M, Plana-Duran J, Segales J, Domingo M, Mateu E. Cytokine profiles of peripheral blood mononuclear cells from pigs with postweaning multisystemic wasting syndrome in response to mitogen, superantigen or recall viral antigens. J Gen Virol 2003, 84(Pt 12):3453-3457. 10.1099/vir.0.19364-0, 14645926.
25. Balmelli C, Ruggli N, McCullough K, Summerfield A. Fibrocytes are potent stimulators of anti-virus cytotoxic T cells. J Leukoc Biol 2005, 77(6):923-933. 10.1189/jlb.1204701, 15767291.
26. Charerntantanakul W, Roth JA. Biology of porcine T lymphocytes. Anim Health Res Rev 2006, 7(1-2):81-96. 10.1017/S1466252307001235, 17389056.
27. Okuda Y, Ono M, Yazawa S, Shibata I. Experimental reproduction of postweaning multisystemic wasting syndrome in cesarean-derived, colostrum-deprived piglets inoculated with porcine circovirus type 2 (PCV2): investigation of quantitative PCV2 distribution and antibody responses. J Vet Diagn Invest 2003, 15(2):107-114.
28. Ostanello F, Caprioli A, Di Francesco A, Battilani M, Sala G, Sarli G, Mandrioli L, McNeilly F, Allan GM, Prosperi S. Experimental infection of 3-week-old conventional colostrum-fed pigs with porcine circovirus type 2 and porcine parvovirus. Vet Microbiol 2005, 108(3-4):179-186. 10.1016/j.vetmic.2005.04.010, 15916871.
29. Kekarainen T, Montoya M, Mateu E, Segales J. Porcine circovirus type 2-induced interleukin-10 modulates recall antigen responses. J Gen Virol 2008, 89(Pt 3):760-765. 10.1099/vir.0.83354-0, 18272768.
30. Bandrick M, Pieters M, Pijoan C, Molitor TW. Passive transfer of maternal Mycoplasma hyopneumoniae-specific cellular immunity to piglets. Clin Vaccine Immunol 2008, 15(3):540-543. 10.1128/CVI.00466-07, 2268269, 18184823.
31. Le Jan C. A study by flow cytometry of lymphocytes in sow colostrum. Res Vet Sci 1994, 57(3):300-304.
32. Tuboly S, Bernath S, Glavits R, Medveczky I. Intestinal absorption of colostral lymphoid cells in newborn piglets. Vet Immunol Immunopathol 1988, 20(1):75-85. 10.1016/0165-2427(88)90027-X, 3238920.
33. Opriessnig T, Ramamoorthy S, Madson DM, Patterson AR, Pal N, Carman S, Meng XJ, Halbur PG. Differences in virulence among porcine circovirus type 2 isolates are unrelated to cluster type 2a or 2b and prior infection provides heterologous protection. J Gen Virol 2008, 89(Pt 10):2482-2491. 10.1099/vir.0.2008/001081-0, 18796717.
34. Opriessnig T, McKeown NE, Zhou EM, Meng XJ, Halbur PG. Genetic and experimental comparison of porcine circovirus type 2 (PCV2) isolates from cases with and without PCV2-associated lesions provides evidence for differences in virulence. J Gen Virol 2006, 87(Pt 10):2923-2932. 10.1099/vir.0.82099-0, 16963751.
35. Hasslung F, Wallgren P, Ladekjaer-Hansen AS, Botner A, Nielsen J, Wattrang E, Allan GM, McNeilly F, Ellis J, Timmusk S. Experimental reproduction of postweaning multisystemic wasting syndrome (PMWS) in pigs in Sweden and Denmark with a Swedish isolate of porcine circovirus type 2. Vet Microbiol 2005, 106(1-2):49-60. 10.1016/j.vetmic.2004.12.011, 15737473.
36. Joo HS, Johnson RH. Serological responses in pigs vaccinated with inactivated porcine parvovirus. Aust Vet J 1977, 53(11):550-552. 10.1111/j.1751-0813.1977.tb07945.x, 565631.
37. Sedlik C, Dridi A, Deriaud E, Saron MF, Rueda P, Sarraseca J, Casal JI, Leclerc C. Intranasal delivery of recombinant parvovirus-like particles elicits cytotoxic T-cell and neutralizing antibody responses. J Virol 1999, 73(4):2739-2744. 104030, 10074120.
38. Segales J, Domingo M, Chianini F, Majo N, Dominguez J, Darwich L, Mateu E. Immunosuppression in postweaning multisystemic wasting syndrome affected pigs. Vet Microbiol 2004, 98(2):151-158. 10.1016/j.vetmic.2003.10.007, 14741127.
39. Souza M, Cheetham SM, Azevedo MS, Costantini V, Saif LJ. Cytokine and antibody responses in gnotobiotic pigs after infection with human norovirus genogroup II.4 (HS66 strain). J Virol 2007, 81(17):9183-9192. 10.1128/JVI.00558-07, 1951422, 17581999.
40. Diaz I, Darwich L, Pappaterra G, Pujols J, Mateu E. Immune responses of pigs after experimental infection with a European strain of Porcine reproductive and respiratory syndrome virus. J Gen Virol 2005, 86(Pt 7):1943-1951. 10.1099/vir.0.80959-0, 15958672.
41. McCullough KC, Schaffner R, Fraefel W, Kihm U. The relative density of CD44-positive porcine monocytic cell populations varies between isolations and upon culture and influences susceptibility to infection by African swine fever virus. Immunol Lett 1993, 37(1):83-90. 10.1016/0165-2478(93)90136-P, 8225410.
42. Laval F, Paillot R, Bollard S, Fischer L, Audonnet JC, Andreoni C, Juillard V. Quantitative analysis of the antigen-specific IFNgamma+ T cell-mediated immune response in conventional outbred pigs: kinetics and duration of the DNA-induced IFNgamma+ CD8+ T cell response. Vet Immunol Immunopathol 2002, 90(3-4):191-201. 10.1016/S0165-2427(02)00261-1, 12459166.