Neuroanatomy of body weight control: Lessons learned from leptin

Journal of Clinical Investigation

Volumn 121, Issue 6, 2011, Pages 2152-2155

  Williams, Diana L ^a   Schwartz, Michael W ^b  

^a FLORIDA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; LEPTIN RECEPTOR;

BODY WEIGHT; CALORIC INTAKE; ENERGY EXPENDITURE; FEEDING; FOOD INTAKE; HUMAN; HYPOTHALAMUS; NERVE CELL; NEUROANATOMY; NONHUMAN; NOTE; OBESITY; PRIORITY JOURNAL; PROTEIN FUNCTION; RHOMBENCEPHALON; WEIGHT CONTROL;

ANIMALS; BODY WEIGHT; BRAIN; DECEREBRATE STATE; ENERGY INTAKE; ENERGY METABOLISM; FEEDING BEHAVIOR; HOMEOSTASIS; HUMANS; HYPERPHAGIA; LEPTIN; MICE; MICE, KNOCKOUT; NEURONS; OBESITY; ORGAN SPECIFICITY; PEPTIDE HORMONES; RATS; RECEPTORS, LEPTIN;

EID: 79957896096     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI58027     Document Type: Note

References (21)

1. Porte D Jr, Baskin DG, Schwartz MW. Leptin and insulin action in the central nervous system. Nutr Rev. 2002;60(10 pt 2):S20-S29.
2. Scott MM, Williams KW, Rossi J, Lee CE, Elmquist JK. Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice. J Clin Invest. 2011;121(6):2413-2421.
3. van de Wall E, et al. Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology. 2008;149(4):1773-1785.
4. Dhillon H, et al. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron. 2006;49(2):191-203. (Pubitemid 43089637)
5. Balthasar N, et al. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron. 2004;42(6):983-991. (Pubitemid 38798236)
6. Zheng H, Berthoud HR. Neural systems controlling the drive to eat: mind versus metabolism. Physiology (Bethesda). 2008;23:75-83.
7. Woods SC. Gastrointestinal satiety signals I. An overview of gastrointestinal signals that influence food intake. Am J Physiol Gastrointest Liver Physiol. 2004;286(1):G7-G13. (Pubitemid 38055830)
8. Grill HJ, Kaplan JM. The neuroanatomical axis for control of energy balance. Front Neuroendocrinol. 2002;23(1):2-40. (Pubitemid 34121907)
9. Skibicka KP, Grill HJ. Hindbrain leptin stimulation induces anorexia and hyperthermia mediated by hindbrain melanocortin receptors. Endocrinology. 2009;150(4):1705-1711.
10. Hayes MR, et al. Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation. Cell Metab. 2010;11(1):77-83.
11. Williams DL, Baskin DG, Schwartz MW. Hindbrain leptin receptor stimulation enhances the anorexic response to cholecystokinin. Am J Physiol Regul Integr Comp Physiol. 2009;297(5):R1238-R1246.
12. Huo L, Maeng L, Bjorbaek C, Grill HJ. Leptin and the control of food intake: neurons in the nucleus of the solitary tract are activated by both gastric distension and leptin. Endocrinology. 2007;148(5):2189-2197. (Pubitemid 46997029)
13. Morton GJ, et al. Leptin action in the forebrain regulates the hindbrain response to satiety signals. J Clin Invest. 2005;115(3):703-710. (Pubitemid 40322245)
14. Ellacott KL, Halatchev IG, Cone RD. Characterization of leptin-responsive neurons in the caudal brainstem. Endocrinology. 2006;147(7):3190-3195. (Pubitemid 43901109)
15. Huo L, Grill HJ, Bjorbaek C. Divergent regulation of proopiomelanocortin neurons by leptin in the nucleus of the solitary tract and in the arcuate hypothalamic nucleus. Diabetes. 2006;55(3):567-573. (Pubitemid 43343211)
16. Mercer JG, Moar KM, Findlay PA, Hoggard N, Adam CL. Association of leptin receptor (OB-Rb), NPY and GLP-1 gene expression in the ovine and murine brainstem. Regul Pept. 1998;75-76:271-278. (Pubitemid 28477537)
17. Goldstone AP, et al. Leptin interacts with glucagon-like peptide-1 neurons to reduce food intake and body weight in rodents. FEBS Lett. 1997;415(2):134-138. (Pubitemid 27430055)
18. Huo L, Gamber KM, Grill HJ, Bjorbaek C. Divergent leptin signaling in proglucagon neurons of the nucleus of the solitary tract in mice and rats. Endocrinology. 2008;149(2):492-497. (Pubitemid 351159324)
19. Myers MG Jr, Leibel RL, Seeley RJ, Schwartz MW. Obesity and leptin resistance: distinguishing cause from effect. Trends Endocrinol Metab. 2010;21(11):643-651.
20. Munzberg H, Flier JS, Bjorbaek C. Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology. 2004;145(11):4880-4889. (Pubitemid 39551104)
21. Ring LE, Zeltser LM. Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels. J Clin Invest. 2010;120(8):2931-2941.