Protective effect of aminoguanidine against cyclophosphamide-induced oxidative stress and renal damage in rats

Redox Report

Volumn 16, Issue 1, 2011, Pages 8-14

  Abraham, Premila ^a   Rabi, Suganthy ^a  

^a CHRISTIAN MEDICAL COLLEGE   (India)

Author keywords

Aminoguanidine; Cyclophospharmide; Oxideative stress; Rats; Renal damage

Indexed keywords

AMINOGUANIDINE; CATALASE; CYCLOPHOSPHAMIDE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; MALONALDEHYDE; MYELOPEROXIDASE;

ARTICLE; CONTROLLED STUDY; KIDNEY INJURY; LIPID PEROXIDATION; MALE; MICROSCOPY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEPLETION; RAT; RENAL PROTECTION;

ANIMALS; CATALASE; CYCLOPHOSPHAMIDE; GUANIDINES; KIDNEY; KIDNEY DISEASES; MALE; MALONDIALDEHYDE; MODELS, ANIMAL; OXIDATIVE STRESS; PEROXIDASE; PILOT PROJECTS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES;

RATTUS;

EID: 79957876649     PISSN: 13510002     EISSN: 17432928     Source Type: Journal    
DOI: 10.1179/174329211X12968219310837     Document Type: Article

References (47)

1. Fleming RA. An overview of cyclophosphamide and ifosfamide pharmacology. Pharmacotherapy 1997;17:146-54S.
2. Boddy AV, Yule SM. Metabolism and pharmacokinetics of oxazaphosphorines. Clin pharmacokinetics 2000;38:291-304.
3. Trefler J, Matyska-Piekarska E, Lacki JK. Cyclophosphamide in the therapy of rheumatoid arthritis and its complications (in Polish). Pol Merkur Lekarski 2007;22:566-70.
4. Sugumar E, Kanakasabapathy I, Abraham P. Normal plasma creatinine level despite histological evidence of damage and increased oxidative stress in the kidneys of cyclophosphamide treated rats. Clin Chim Acta 2007;376:244-5.
5. Ghosh S, Ghosh D, Chattopadhyay S, Debnath J. Effect of ascorbic acid supplementation on liver and kidney toxicity in cyclophosphamide-treated female albino rats. J Toxicol Sci 1999;24:141-4.
6. Senthilkumar S, Devaki T, Manohar BM, Babu MS. Effect of squalene on cyclophosphamide-induced toxicity. Clin Chim Acta 2006;364:335-42.
7. Stankiewicz A, Skrzydlewska E. Protection against cyclophosphamide- induced renal oxidative stress by amifostine: the role of antioxidative mechanisms. Toxicol Mech Methods 2003;13: 301-8.
8. Haque R, Bin-Hafeez B, Parvez S, Pandey S, Sayeed I, Ali M, et al. Aqueous extract of walnut (Juglans regia L.) protects mice against cyclophosphamide-induced biochemical toxicity. Hum Exp Toxicol 2003;22:473-80.
9. Manda K, Bhatia AL. Prophylactic action of melatonin against cyclophosphamide-induced oxidative stress in mice. Cell 2003; 19:367-72.
10. Sayed-Ahmed MM. Progression of cyclophosphamide-induced acute renal metabolic damage in carnitine-depleted rat model. Clin Exp Nephrol 2010;14:418-26.
11. Kedziora-Kornatowska KZ, Luciak M, Blaszczyk J, Pawlak W. Effect of aminoguanidine on erythrocyte lipid peroxidation and activities of antioxidant enzymes in experimental diabetes. Clin Chem Lab Med 1998;36:771-5.
12. Di Paola R, Marzocco S, Mazzon E. Effect of aminoguanidine in ligature-induced periodontitis in rats. J Dent Res 2004;83: 343-8.
13. Baynes JW, Thorpe SR. Glycoxidation and lipoxidation in atherogenesis. Free Radic Biol Med 2000;28:1708-16.
14. Abd El-Gawad HM, El-Sawalhi MM. Nitric oxide and oxidative stress in brain and heart of normal rats treated with doxorubicin: role of aminoguanidine. J Biochem Mol Toxicol 2004;18:69-77.
15. Hung CR. Role of gastric oxidative stress and nitric oxide in formation of hemorrhagic erosion in rats with ischemic brain. World J Gastroenterol 2006;12:574-81.
16. Ara C, Karabulut AB, Kirimlioglu H. Protective effect of aminoguanidine against oxidative stress in an experimental peritoneal adhesion model in rats. Cell Biochem Funct 2006;24:443-8.
17. Atasayar S, Gürer-Orhan H, Orhan H, Gürel B, Girgin G, Ozgüneş H. Preventive effect of amino guanidine compared to vitamin E and C on cisplatin-induced nephrotoxicity in rats. Exp Toxicol Pathol 2009;61:23-32.
18. Eroglu C, Yildiz OG, Saraymen R, Soyuer S, Kilic E, Ozcan S. Aminoguanidine ameliorates radiation-induced oxidative lung damage in rats. Clin Invest Med 2008;31:E182-8.
19. Abdel-Zaher AO, Abdel-Rahman MM, Hafez MM, Omran FM. Role of nitric oxide and reduced glutathione in the protective effects of aminoguanidine, gadolinium chloride and oleanolic acid against acetaminophen-induced hepatic and renal damage. Toxicology 2007;234:124-34.
20. Ahluwalia A, Maggi CA, Santicioli P, Lecci A, Giuliani S. Characterizationof the capsaicin-sensitive component of cyclophosphamide induced inflammation in the rat urinary bladder. Br J Pharmacol 1994;111:1017-22.
21. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351-8.
22. Sohal RS, Agarwal S, Dubey A, Orr WC. Protein oxidative damage is associated with life expectancy of houseflies. Proc Natl Acad Sci USA 1993;90:7255-59.
23. Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem 1968;25:192-205.
24. Diaz-Granados N, Howe K, Lu J, McKay DM. Dextran sulfate sodium-induced colonic histopathology, but not altered epithelial ion transport, is reduced by inhibition of phosphodiesterase activity. Am J Pathol 2000;156:2169-77.
25. Aebi IH. Catalase in vitro. Methods Enzymol 1984;105:121-6.
26. Awasthi YC, Dao DD, Saneto RP. Interrelationship between anionic and cationic forms of glutathione S-transferases of human liver. Biochem J 1980;191:1-10.
27. E. Glutathione reductase from bakers' yeast and beef liver. J Biol Chem 1955;217:855-65.
28. Nakamura W, Hosada S. Purification and properties of rat liver glutathione peroxidase. Biochim Biophys Acta 1974;358: 251-61.
29. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951; 93:265-75.
30. Radi R, Beckman JS, Bush KM. Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide. Arch Biochem Biophys 1991;288:481-5.
31. Radi R. Nitric oxide, oxidants, and protein tyrosine nitration. Proc Natl Acad Sci USA 2004;101:4003-8.
32. Radi R, Cassina A, Hodara R, Quijano C, Castro L. Peroxynitrite reactions and formation in mitochondria. Free Radic Biol Med 2002;33:1451-64.
33. Olas B, Nowak P, Wachowicz B. Resveratrol protects against peroxynitrite-induced thiol oxidation in blood platelets. Cell Mol Biol Lett 2004;9:577-87.
34. Varma SD, Hegde KR. Lens thiol depletion by peroxynitrite. Protective effect of pyruvate. Mol Cell Biochem 2007;298: 199-204.
35. Reinartz M, Ding Z, Flögel U, Gödecke A, Schrader J. Nitrosative stress leads to protein glutathiolation, increased s-nitrosation, and up-regulation of peroxiredoxins in the heart. J Biol Chem 2008;283:17440-9.
36. Courderot-Masuyer C, Dalloz F, Maupoil V, Rochette L. Antioxidant properties of aminoguanidine. Fundam Clin Pharmacol 1999;13:535-40.
37. Burcham PC, Kaminskas LM, Fontaine FR, Petersen DR, Pyke SM. Aldehyde-sequestering drugs: tools for studying protein damage by lipid peroxidation products. Toxicology 2002; 181-182:229-36.
38. Polat A, Parlakpinar H, Tasdemir S. Protective role of aminoguanidine on gentamicin-induced acute renal failure in rats. Acta Histochem 2006;108:365-71.
39. Mansour MA, Mostafa AM, Nagi MN, Khattab MM, Al- Shabanah OA. Protective effect of aminoguanidine against nephrotoxicity induced by cisplatin in normal rats. Comp Biochem Physiol Toxicol Pharmacol 2002;132:123-8.
40. Kedziora-Kornatowska KZ, Luciak M, Blaszczyk J, Pawlak W. Effect of aminoguanidine on the generation of superoxide anion and nitric oxide by peripheral blood granulocytes of rats with streptozotocin induced diabetes. Clin Chim Acta 1998;278: 45-53.
41. Stoppa GR, Cesquini M, Roman EA, Ogo SH, Torsoni MA. Aminoguanidine prevented impairment of blood antioxidant system in insulin dependent diabetic rats. Life Sci 2006;78: 1352-61.
42. Apinar D, Yargicoglu P, Derin N, Aslan M, Agar A. Effect of aminoguanidine on visual evoked potentials (VEPs), antioxidant status and lipid peroxidation in rats exposed to chronic restraint stress. Brain Res 2007;1186:87-94.
43. Brodiak IV, Sybirna NO. Effect of aminoguanidine on oxidative modification of proteins in experimental diabetes mellitus in rats [Article in Ukrainian]. Ukr Biokhim Zh 2006;78:114-9.
44. Abraham P, Rabi S, Kulothungan P. Aminoguanidine, selective nitric oxide synthase inhibitor, ameliorates cyclophosphamideinduced hemorrhagic cystitis by inhibiting protein nitration and PARS activation. Urology 2009;73:1402-6.
45. Abraham P, Rabi S, Selvakumar D. Protective effect of aminoguanidine against oxidative stress and bladder injury in cyclophosphamide- induced hemorrhagic cystitis in rat. Cell Biochem Funct 2009;27:56-62.
46. Korkmaz A, Oter S, Sadir S, Coskun O, Topal T, Ozler M, et al. Peroxynitrite may be involved in bladder damage caused by cyclophosphamide in rats. J Urol 2005;173:1793-6.
47. Bolton WK, Cattran DC, Williams ME, Adler SG, Appel GB, Cartwright K, et al. Randomized trial of an inhibitor of formation of advanced glycation end products in diabetic nephropathy. Am J Nephrol 2004;24:32-40.