Nitric oxide and oxidative stress in brain and heart of normal rats treated with doxorubicin: Role of aminoguanidine

Journal of Biochemical and Molecular Toxicology

Volumn 18, Issue 2, 2004, Pages 69-77

  Abd El Gawad, Hanan M ^a   El Sawalhi, Maha M ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

Aminoguanidine; Brain; Doxorubicin; Heart; Nitric oxide; Oxidative stress; Rat

Indexed keywords

ALKADIENE; AMINOGUANIDINE; CALCIUM; CREATINE KINASE; DOXORUBICIN; FREE RADICAL; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LACTATE DEHYDROGENASE; MALONALDEHYDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CARDIOTOXICITY; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DISEASE SEVERITY; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME RELEASE; LACTATE DEHYDROGENASE BLOOD LEVEL; MALE; MOLECULAR MECHANICS; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; RAT; RAT STRAIN;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BRAIN; DOXORUBICIN; ENZYME INHIBITORS; GLUTATHIONE; GUANIDINES; HEART; MALE; MALONDIALDEHYDE; MYOCARDIUM; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; RATS; RATS, WISTAR;

ANIMALIA;

EID: 2342663205     PISSN: 10956670     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbt.20013     Document Type: Article

References (58)

1. Ciaccio M, Valenza M, Tesoriere L, Bongiorno A, Albiero R, Livrea MA. Vitamin A inhibits doxorubicin-induced membrane lipid peroxidation in rat tissues in vivo. Arch Biochem Biophys 1993;302:103-108.
2. Julka D, Sandhir R, Gill KD. Adriamycin-induced oxidative stress in rat central nervous system. Biochem Mol Biol Int 1993;29:807-820.
3. McIntosh LJ, Sapolsky RM. Glucocorticoids increase the accumulation of reactive oxygen species and enhance adriamycin-induced toxicity in neuronal culture. Exp Neurol 1996;141:201-206.
4. Howard S, Bottino C, Brooke S, Cheng E, Giffard RG, Sapolsky R. Neuroprotective effects of bcl-2 overexpression in hippocampal cultures: Interactions with pathways of oxidative damage. J Neurochem 2002;83:914-923.
5. Joshi P, Vig PJ, Veerisetty V, Cameron JA, Sekhon BS, Desaiah D. Increase in brain nitric oxide synthase activity in daunorubicin-treated rats. Pharmacol Toxicol 1996;78:99-103.
6. Gelperina SE, Khalansky AS, Skidan IN, Smirnova ZS, Bobruskin AI, Severin SE, Turowski B, Zanella FE, Kreuter J. Toxicological studies of doxorubicin bound to polysorbate 80 coated poly(butyl cyanoacrylate) nanoparticles in healthy rats with intracranial glioblastoma. Toxicol Lett 2002;126:131-141.
7. Olson RD, Mushlin PS. Doxorubicin cardiotoxicity: Analysis of prevailing hypotheses. FASEB J 1990;4:3076-3086.
8. Piccinini F, Cova D, Sassano M, Monti E. DNA damage by anthracyclines and their copper (II) complexes. Eur J Pharmacol 1990;183:1528-1529.
9. Anders RJ, Shanes JG, Zeller FP. Lower incidence of doxorubicin-induced cardiomyopathy by once-a-week low dose administration. Am Heart J 1991;111:755-759.
10. Garner AP, Paine MJ, Rodriguez-Crespo I, Chinje EC, Ortiz De Montellano P, Stratford IJ, Tew DG, Wolf CR. Nitric oxide synthases catalyze the activation of redox cycling and bioreductive anticancer agents. Cancer Res 1999;59:1929-1934.
11. Sayed-Ahmed MM, Khattab MM, Gad MZ, Osman AM. Increased plasma endothelin-1 and cardiac nitric oxide during doxorubicin-induced cardiomyopathy. Phamacol Toxicol 2001;89:140-144.
12. Lind DS, Kontaridis MI, Edwards PD, Josephs MD, Moldawer LL, Copeland EM III. Nitric oxide contributes to adriamycin's antitumor effect. J Surg Res 1997;69:283-287.
13. Konovalova NP, Goncharova SA, Volkova LM, Raevskaia TA, Erem LT, Korolev AM. Nitric oxide donor increases the effectiveness of cytostatic therapy and inhibits the development of drug resistance. Vopr Onkol 2003;49:71-75.
14. Pacher P, Liaudet L, Bai P, Mabley JG, Kaminski PM, Virag L, Deb A, Szabo E, Ungvari Z, Wolin MS, Groves JT, Szabo C. Potent metalloporphyrin peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction. Circulation 2003;107:896-904.
15. Giardino I, Fard AK, Hatchell DL, Brownlee M. Aminoguanidine inhibits reactive oxygen species formation, lipid peroxidation, and oxidant-induced apoptosis. Diabetes 1998;47:1114-1120.
16. Xu MF, Tang PL, Qian ZM, Ashraf M. Effects by doxorubicin on the myocardium are mediated by oxygen free radicals. Life Sci 2001;68:889-901.
17. Buhl SN, Jackson KY. Optimal conditions and comparison of lactate dehydrogenase catalysis of the lactate-to-pyruvate and pyruvate-to-lactate reactions in human serum at 25, 30, and 37°C. Clin Chem 1978;24:828-831.
18. Rosalki SB. An improved procedure for serum creatine phosphokinase determination. J Lab Clin Med 1967;69:696-705.
19. Beutler E, Duron O, Kelly BM. Improved method for the determination of blood glutathione. J Lab Clin Med 1963;61:882-888.
20. Uchiyama M, Mihara M. Determination of malondialdehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 1978;86:271-288.
21. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1559;37:911-917.
22. Recknagel RO, Glende EA. Jr. Spectrophotometric detection of lipid conjugated dienes. Methods Enzymol 1984;105:331-337.
23. Tracey WR, Tse J, Carter G. Lipopolysaccharide-induced changes in plasma nitrite and nitrate concentrations in rats and mice: Pharmacological evaluation of nitric oxide synthase inhibitors. J Pharmacol Exp Ther 1995;272:1011-1015.
24. Grandati M, Verrecchia C, Revaud ML, Allix M, Boulu RG, Plotkine M. Calcium-independent NO-synthase activity and nitrites/nitrates production in transient focal cerebral ischemia in mice. Br J Pharmacol 1997;122:625-630.
25. Bachur NR, Morre AL, Bernstein JC, Lin A. Tissue distribution and disposition of daunomycin (NSC-82151) in mice: Fluorometric and isotopic method. Cancer Chemother Rep 1970;54:89-95.
26. Marklund S, Marklund G. Involvement of superoxide anion radical in the autooxidation of pyrogallol and convenient assay for superoxide dismutase. Eur J Biochem 1974;47:469-474.
27. Paglia DE, Vatentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967;70:158-161.
28. Subramania RS. Storage and preservation of blood and urine for trace element analysis: A review. Biol Trace Elem Res 1995;49:187-210.
29. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-275.
30. Mostafa AM, Nagi MN, Al-Rikabi AC, Al-Shabanah OA, El-Kashef HA. Protective effect of aminoguanidine against cardiovascular toxicity of chronic doxorubicin treatment in rats. Res Commun Mol Pathol Pharmacol 1999;106:193-202.
31. Venkatesan N. Curcumin attenuation of acute adriamycin myocardial toxicity in rats. Br J Pharmacol 1998;124:425-427.
32. Zhou S, Palmeira CM, Wallace KB. Doxorubicin-induced persistent oxidative stress to cardiac myocytes. Toxicol Lett 2001;121:151-157.
33. Pritsos CA, Ma J. Basal and drug-induced antioxidant enzyme activities correlate with age-dependent doxorubicin oxidative toxicity. Chem Biol Interact 2000;127:1-11.
34. Agapito MT, Antolin Y, del Brio MT, Lópes-Burillo S, Pablos MI, Recio JM. Protective effect of melatonin against adriamycin toxicity in the rat. J Pineal Res 2001;31:23-30.
35. Minotti G, Mancuso C, Frustaci A, Mordente A, Santini SA, Calafiore AM, Liberi G, Gentiloni N. Paradoxical inhibition of cardiac lipid peroxidation in cancer patients treated with doxorubicin. J Clin Invest 1996;98:650-661.
36. Vora J, Khaw BA, Narula J, Boroujerdi M. Protective effect of butylated hydroxyanisole on adriamycin induced cardiotoxicity. J Pharm Pharmacol 1996;48:940-944.
37. Alegria AE, Samuni A, Mitchell JB, Riesz P, Russo A. Free radicals induced by adriamycin-sensitive and adriamycin-resistant cells: A spin-trapping study Biochemistry 1989;28:8653-8658.
38. Luo X, Reichetzer B, Trines J, Benson LN, Lehotay DC. L-carnitine attenuates doxorubicin-induced lipid peroxidation in rats. Free Radical Biol Med 1999;26:1158-1165.
39. Thomas JA. Oxidative stress: Oxidant defense and dietary constituents. In: Maurice E, Shilss ME, Olson JA, Shike M, editors. Modern Nutrition in Health and Disease. Challotesville, University of Virginia: Awaverly Company; 1994, pp. 501-512.
40. Walker MW, Kinter MT, Roberts RJ, Spitz DR. Nitric oxide-induced cytotoxicity: Involvement of cellular resistance to oxidative stress and the role of glutathione in protection. Pediatr Res 1995;37:41-49.
41. Ozen S, Usta Y, Sahin-Erdermli I, Orhan D, Gumusel B, Yang B, Gursoy Y, Tulunay O, Dalkara T, Bakkaloglu A, El-Nahas M. Association of nitric oxide production and apoptosis in a model of experimental nephropathy. Nephrol Dial Transplant 2001;16:32-38.
42. Luo D, Vincent SR. Inhibition of nitric oxide synthase by antineoplastic anthracyclines. Biochem Pharmacol 1994;47:2111-2112.
43. Skaper SD, Facci L, Leon A. Inflammatory mediator stimulation of astrocytes and meningeal fibroblasts induces neuronal degeneration via the nitridergic pathway. J Neurochem 1995;64:266-276.
44. Radi R, Beckman JS, Bush KM, Freeman BA. Peroxynitrite oxidation of sulf-hydryls: The cytotoxic potential of superoxide and nitric oxide. J Biol Chem 1991;266:4244-4250.
45. Kreuser ED, Wadler S, Thiel E. Biochemical modulation of cytotoxic drugs by cytokines: Molecular mechanisms in experimental oncology. Recent Results Cancer Res 1995;139:371-382.
46. Ursell PC, Mayes M. Anatomic distribution of nitric oxide synthase of the heart. Int J Cardiol 1995;50:217-223.
47. Cendan JC, Copeland EM III, Souba WW, Lind DS. Cytokines regulate endotoxin stimulation of arginine transport. Surgery 1995;117:213-219.
48. Solem LE, Heller LJ, Wallace KB. Dose-dependent increase in sensitivity to calcium-induced mitochondrial dysfunction and cardiomyocyte cell injury by doxorubicin. J Mol Cell Cardiol 1996;28:1023-1032.
49. 2+-handling mechanisms in the sarcoplasmic reticulum in the rat. Can J Physiol Pharmacol 2000; 78:329-338.
50. 3 adenosine receptor protects against doxorubicin-induced cardiotoxicity. J Mol Cell Cardiol 2001;33:1249-1261.
51. Olson HM, Young DM, Prieur AF, Roy LE, Reagen RL. Electrolyte and morphologic alterations of myocardium in adriamycin-treated rabbits. Am J Pathol 1974;77:439-454.
52. Harman AW, Maxwell MJ. An evaluation of the role of calcium in cell injury. Annu Rev Pharmacol Toxicol 1995;35:129-144
53. Doroshow JH, Locker GY, Myers CE. Enzymatic defenses of the mouse heart reactive oxygen metabolites: Alterations produced by doxorubicin. J Clin Invest 1980;65:128-135.
54. Bachur NF, Gordon SL, Gee MV. A general mechanism for microsomal activation of quinone anticancer agents to free radicals. Cancer Res 1978;38:1745-1750.
55. Picard S, Parthasarathy S, Fruebis J, Witztum JL. Aminoguanidine inhibits the oxidative modification of low density lipoprotein and the subsequent increase in uptake by macrophage scavenger receptors. Proc Natl Acad Sci USA 1992;89:6876-6880.
56. Tilton RG, Chang K, Hasan KS, Smith SR, Petrash JM, Misko TP, Moore WM, Currie MG, Corbett JA, McDaniel ML. Prevention of diabetic vascular dysfunction by guanidines: Inhibition of nitric oxide synthase versus advanced glycation end-product formation. Diabetes 1993;42:221-232.
57. Tilton RG, Chang K, Corbett JA, Misko TP, Currie MG, Bora NS, Kaplan HJ, Williamson JR. Endotoxin-induced uveitis in the rat is attenuated by inhibition of nitric oxide production. Invest Ophthalmol Visual Sci 1994;35:3278-3288.
58. Ishiyama S, Hiroe M, Nishikawa T, Abe S, Shimojo T, Ito H, Ozasa S, Yamakawa K, Matsuzaki, M, Mohammed MU, Nakazawa H, Kasajima T, Marumo F. Nitric oxide contributes to the progression of myocardial damage in experimental autoimmune myocarditis in rats. Circulation 1997;95:489-496.