Lipid nanocarriers (GeluPearl) containing amphiphilic lipid Gelucire 50/13 as a novel stabilizer: Fabrication, characterization and evaluation for oral drug delivery

Nanotechnology

Volumn 22, Issue 27, 2011, Pages

  Date, Abhijit A ^a   Vador, Nimish ^a   Jagtap, Aarti ^a   Nagarsenker, Mangal S ^a  

^a BOMBAY COLLEGE OF PHARMACY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIPHILICS; DSC STUDIES; HYDROPHOBIC DRUG; MODEL DRUGS; NANO-SIZE; NANOCARRIERS; NANOSTRUCTURED LIPID CARRIERS; ORAL ADMINISTRATION; ORAL DELIVERY; ORAL DRUG DELIVERY; POLYMORPHIC TRANSITIONS; REPAGLINIDE; SHORT TERM STABILITY; SOLID LIPID NANOPARTICLES;

CHEMICAL STABILITY; DRUG DELIVERY; LIPIDS;

RATING;

CARBAMIC ACID DERIVATIVE; DIACYLGLYCEROL; DRUG CARRIER; FAT; GELUCIRE 50 13; GELUCIRE 50-13; GLYCEROL PALMITOSTEARATE; LIPID; NANOPARTICLE; OIL; PIPERIDINE DERIVATIVE; REPAGLINIDE; SURFACTANT;

ANIMAL; ARTICLE; CHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG STABILITY; EVALUATION; EXPERIMENTAL DIABETES MELLITUS; FEASIBILITY STUDY; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; METHODOLOGY; NANOTECHNOLOGY; ORAL DRUG ADMINISTRATION; PARTICLE SIZE; RAT; ULTRASTRUCTURE;

ADMINISTRATION, ORAL; ANIMALS; BLOOD GLUCOSE; CALORIMETRY, DIFFERENTIAL SCANNING; CARBAMATES; DIABETES MELLITUS, EXPERIMENTAL; DIGLYCERIDES; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG STABILITY; FATS; FEASIBILITY STUDIES; GLUCOSE TOLERANCE TEST; LIPIDS; NANOPARTICLES; NANOTECHNOLOGY; OILS; PARTICLE SIZE; PIPERIDINES; RATS; SURFACE-ACTIVE AGENTS;

EID: 79957845732     PISSN: 09574484     EISSN: 13616528     Source Type: Journal    
DOI: 10.1088/0957-4484/22/27/275102     Document Type: Article

References (30)

1. Müller R H, Radtke M and Wissing S A 2002 Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations Adv. Drug Deliv. Rev 54 (Suppl 1) S131-55
2. Uner M and Yener G 2007 Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives Int. J. Nanomed. 2 289-300 (Pubitemid 350047774)
3. Muchow M, Maincent P and Muller R H 2008 Lipid nanoparticles with a solid matrix (SLN, NLC, LDC) for oral drug delivery Drug Dev. Ind. Pharm. 34 1394-405
4. Pardeike J, Hommoss A and Müller R H 2009 Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products Int. J. Pharm. 366 170-84
5. Martins S, Sarmento B, Ferreira D C and Souto E B 2007 Lipid-based colloidal carriers for peptide and protein delivery-liposomes versus lipid nanoparticles Int. J. Nanomed. 2 595-607
6. Wissing S A, Kayser O and Müller R H 2004 Solid lipid nanoparticles for parenteral drug delivery Adv. Drug Deliv. Rev. 56 1257-72 (Pubitemid 38510473)
7. Uner M, Wissing S A, Yener G and Müller R H 2004 Influence of surfactants on the physical stability of solid lipid nanoparticle (SLN) formulations Pharmazie 59 331-2 (Pubitemid 38480731)
8. Zhang W, Liu J, Li S, Chen M and Liu H 2008 Preparation and evaluation of stealth Tashinone IIA-loaded solid lipid nanoparticles: influence of Poloxamer 188 coating on phagocytic uptake J. Microencapsul. 25 203-9
9. Hu L, Tang X and Cui F 2004 Solid lipid nanoparticles (SLNs) to improve oral bioavailability of poorly soluble drug J. Pharm. Pharmacol. 56 1527-35 (Pubitemid 39601993)
10. Helgason T, Awad T S, Kristbergsson K, Decker E A, McClements D J and Weiss J 2009 Impact of surfactant properties on oxidative stability of beta-carotene encapsulated within solid lipid nanoparticles J. Agric. Food Chem. 57 8033-40
11. Rosenblatt K M and Bunjes H 2009 Poly(vinyl alcohol) as emulsifier stabilizes solid triglyceride drug carrier nanoparticles in the α-modification Mol. Pharm. 6 105-20
12. Yuan H, Huang L F, Du Y Z, Ying X Y, You J, Hu F Q and Zeng S 2008 Solid lipid nanoparticles prepared by solvent diffusion method in a nanoreactor system Colloids Surf. B 61 132-7
13. Heiati H, Phillips N C and Tawashi R 1996 Evidence for phospholipid bilayer formation in solid lipid nanoparticles formulated with phospholipid and triglyceride Pharm. Res. 13 1406-10 (Pubitemid 26344990)
14. Vippagunta S R, Maul K A, Tallavajhala S and Grant D J 2002 Solid-state characterization of nifedipine solid dispersions Int. J. Pharm. 236 111-23 (Pubitemid 34219378)
15. Fini A, Moyano J R, Ginés J M, Perez-Martinez J I and Rabasco A M 2005 Diclofenac salts, II. Solid dispersions in PEG6000 and Gelucire 50/13 Eur. J. Pharm. Biopharm. 60 99-111 (Pubitemid 40545866)
16. Shrivastava A R, Ursekar B and Kapadia C J 2009 Design, optimization, preparation and evaluation of dispersion granules of valsartan and formulation into tablets Curr. Drug Deliv. 6 28-37
17. Qi S, Marchaud D and Craig D Q 2010 An investigation into the mechanism of dissolution rate enhancement of poorly water-soluble drugs from spray chilled gelucire 50/13 microspheres J. Pharm. Sci. 99 262-74
18. Dhumal R S, Biradar S V, Aher S and Paradkar A R 2009 Cefuroxime axetil solid dispersion with polyglycolized glycerides for improved stability and bioavailability J. Pharm. Pharmacol. 61 743-51
19. Shimpi S L, Chauhan B, Mahadik K R and Paradkar A 2005 Stabilization and improved in vivo performance of amorphous etoricoxib using Gelucire 50/13 Pharm. Res. 22 1727-34 (Pubitemid 41355913)
20. Sathianarayanan L, Paradkar A R and Mahadik K R 2010 In vivo and in vitro antioxidant activity of lipid based extract of Bacopa monniera Linn. compared to conventional extract and traditional preparation Eur. J. Integrat. Med. 2 93-101
21. Gilda S, Kanitkar M, Bhonde R and Paradkar A R 2010 Activity of water-soluble turmeric extract using hydrophilic excipients LWT-Food Sci. Technol. 43 59-66
22. Hamdani J, Mos A J and Amighi K 2003 Physical and thermal characterisation of Precirol and Compritol as lipophilic glycerides used for the preparation of controlled-release matrix pellets Int. J. Pharm. 260 47-57 (Pubitemid 36724860)
23. Reitz C and Kleinebudde P 2007 Solid lipid extrusion of sustained release dosage forms Eur. J. Pharm. Biopharm. 67 440-8 (Pubitemid 47211916)
24. Shah K A, Date A A, Joshi M D and Patravale V B 2007 Solid lipid nanoparticles (SLN) of tretinoin: potential in topical delivery Int. J. Pharm. 345 163-71 (Pubitemid 350087549)
25. Hur B K, Kim C B and Lee C G 2000 Functional relationship between volume concentration of dispersed phase and relative viscosity in a liquid-liquid dispersion and emulsions J. Ind. Eng. Chem. 6 318-24
26. Gaikwad S G and Pandit A B 2008 Ultrasound emulsification: effect of ultrasonic and physicochemical properties on dispersed phase volume and droplet size Ultrason. Sonochem. 15 554-63 (Pubitemid 351735976)
27. Wang S, Sun M and Ping Q 2008 Enhancing effect of Labrafac Lipophile WL 1349 on oral bioavailability of hydroxysafflor yellow A in rats Int. J. Pharm. 358 198-204
28. Teeranachaideekul V, Boonme P, Souto E B, Müller R H and Junyaprasert V B 2008 Influence of oil content on physicochemical properties and skin distribution of Nile red-loaded NLC J. Control Release 128 134-41
29. Jain S K, Agrawal G P and Jain N K 2006 A novel calcium silicate based microspheres of repaglinide: in vivo investigations J. Control Release 113 111-6 (Pubitemid 43928144)
30. Fukushima K, Terasaka S, Haraya K, Kodera S, Seki Y, Wada A, Ito Y, Shibata N, Sugioka N and Takada K 2007 Pharmaceutical approach to HIV protease inhibitor atazanavir for bioavailability enhancement based on solid dispersion system Biol. Pharm. Bull. 30 733-8 (Pubitemid 46571002)