Influence of physical inactivity on associations between single nucleotide polymorphisms and genetic predisposition to childhood obesity

American Journal of Epidemiology

Volumn 173, Issue 11, 2011, Pages 1256-1262

  Xi, Bo ^a,b   Wang, Chunyu ^c   Wu, Lijun ^a   Zhang, Meixian ^a   Shen, Yue ^a,d   Zhao, Xiaoyuan ^a   Wang, Xingyu ^d   Mi, Jie ^a  

^a CAPITAL INSTITUTE OF PEDIATRICS   (China)

^b SHANDONG UNIVERSITY   (China)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d Beijing Hypertension League Institute   (China)

Author keywords

motor activity; obesity; polymorphism, single nucleotide

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; DEAMINASE; FAS ANTIGEN; FAS APOPTOTIC INHIBITORY MOLECULE 2; FAT MASS AND OBESITY ASSOCIATED PROTEIN; GLUCOSAMINE 6 PHOSPHATE DEAMINASE 2; MELANOCORTIN 4 RECEPTOR; NIEMANN PICK DISEASE C1 PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

CHILD DEVELOPMENT; CHILD HEALTH; DISEASE CONTROL; DISEASE PREVALENCE; ENVIRONMENTAL FACTOR; HEALTH RISK; OBESITY; POLYMORPHISM; RISK FACTOR;

ADOLESCENT; ADULT; ALLELE; ARTICLE; CHILD; CHILDHOOD OBESITY; CHINESE; COHORT ANALYSIS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC RISK; GENOTYPE; HUMAN; IMMOBILIZATION; MAJOR CLINICAL STUDY; MALE; OBESITY; PHYSICAL ACTIVITY; POPULATION RESEARCH; PRESCHOOL CHILD; QUESTIONNAIRE; SCHOOL CHILD; SEDENTARY LIFESTYLE; SINGLE NUCLEOTIDE POLYMORPHISM;

BEIJING [CHINA]; CHINA;

EID: 79957834015     PISSN: 00029262     EISSN: 14766256     Source Type: Journal    
DOI: 10.1093/aje/kwr008     Document Type: Article

References (41)

1. Reilly JJ, Methven E, McDowell ZC, et al. Health consequences of obesity. Arch Dis Child. 2003;88(9):748-752. (Pubitemid 37094225)
2. Qi L, Cho YA. Gene-environment interaction and obesity. Nutr Rev. 2008;66(12):684-694.
3. Frayling TM, Timpson NJ, Weedon MN, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science. 2007;316(5826):889-894. (Pubitemid 46764279)
4. Loos RJ, Lindgren CM, Li S, et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet. 2008;40(6):768-775. (Pubitemid 351748863)
5. Benzinou M, Creemers JW, Choquet H, et al. Common nonsynonymous variants in PCSK1 confer risk of obesity. Nat Genet. 2008;40(8):943-945.
6. Willer CJ, Speliotes EK, Loos RJ, et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet. 2009;41(1):25-34.
7. Xi B, Mi J. FTO polymorphisms are associated with obesity but not with diabetes in East Asian populations: a metaanalysis. Biomed Environ Sci. 2009;22(6):449-457.
8. Liu Y, Liu Z, Song Y, et al. Meta-analysis added power to identify variants in FTO associated with type 2 diabetes and obesity in the Asian population. Obesity (Silver Spring). 2010; 18(8):1619-1624.
9. Xi B, Wang C, Wang R, et al. FTO gene polymorphisms are associated with obesity and type 2 diabetes in east Asian populations: an update. Obesity (Silver Spring). 2011;19(2): 236-237.
10. Wang D, Ma J, Zhang S, et al. Association of the MC4RV103I polymorphism with obesity: a Chinese case-control study and meta-analysis in 55,195 individuals. Obesity (Silver Spring). 2010;18(3):573-579.
11. Thorleifsson G, Walters GB, Gudbjartsson DF, et al. Genomewide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet. 2009; 41(1):18-24.
12. Meyre D, Delplanque J, Chèvre JC, et al. Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet. 2009;41(2):157-159.
13. Shan XY, Xi B, Cheng H, et al. Prevalence and behavioral risk factors of overweight and obesity among children aged 2-18 in Beijing, China. Int J Pediatr Obes. 2010;5(5): 383-889.
14. Lioret S, Touvier M, Lafay L, et al. Dietary and physical activity patterns in French children are related to overweight and socioeconomic status. J Nutr. 2008;138(1):101-107.
15. Lioret S, Maire B, Volatier JL, et al. Child overweight in France and its relationship with physical activity, sedentary behaviour and socioeconomic status. Eur J Clin Nutr. 2007;61(4):509-516. (Pubitemid 46605222)
16. Mitchell JA, Mattocks C, Ness AR, et al. Sedentary behavior and obesity in a large cohort of children. Obesity (Silver Spring). 2009;17(8):1596-1602.
17. Danielzik S, Czerwinski-Mast M, Langnäse K, et al. Parental overweight, socioeconomic status and high birth weight are the major determinants of overweight and obesity in 5-7 y-old children: baseline data of the Kiel Obesity Prevention Study (KOPS). Int J Obes Relat Metab Disord. 2004;28(11):1494-1502. (Pubitemid 39481855)
18. Dietz WH. The obesity epidemic in young children. Reduce television viewing and promote playing. BMJ. 2001;322(7282): 313-314. (Pubitemid 32150727)
19. Andreasen CH, Stender-Petersen KL, Mogensen MS, et al. Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes. 2008;57(1):95-101.
20. Rampersaud E, Mitchell BD, Pollin TI, et al. Physical activity and the association of common FTO gene variants with body mass index and obesity. Arch Intern Med. 2008;168(16): 1791-1797.
21. Berentzen T, Kring SI, Holst C, et al. Lack of association of fatness-related FTO gene variants with energy expenditure or physical activity. J Clin Endocrinol Metab. 2008;93(7): 2904-2908. (Pubitemid 352008569)
22. Lappalainen TJ, Tolppanen AM, Kolehmainen M, et al. The common variant in the FTO gene did not modify the effect of lifestyle changes on body weight: the Finnish Diabetes Prevention Study. Obesity (Silver Spring). 2009;17(4):832-836.
23. Mi J, Cheng H, Hou DQ, et al. Prevalence of overweight and obesity among children and adolescents in Beijing in 2004 [in Chinese]. Zhonghua Liu Xing Bing Xue Za Zhi. 2006;27(6): 469-474.
24. Ji CY. Report on childhood obesity in China (1)-body mass index reference for screening overweight and obesity in Chinese school-age children.Working Group on Obesity in China. Biomed Environ Sci. 2005;18(6):390-400.
25. Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. World Health Organ Tech Rep Ser. 1995;854:1-452.
26. American Academy of Pediatrics, Committee on Public Education. American Academy of Pediatrics: children, adolescents, and television. Pediatrics. 2001;107(2):423-426.
27. Abbaszadegan MR, Struewing JP, Brown KM, et al. Automated detection of prevalent mutations in BRCA1 and BRCA2 genes, using a fluorogenic PCR allelic discrimination assay. Genet Test. 1997-1998;1(3):171-180.
28. Heid CA, Stevens J, Livak KJ, et al. Real time quantitative PCR. Genome Res. 1996;6(10):986-994. (Pubitemid 26388091)
29. Lewis CM. Genetic association studies: design, analysis and interpretation. Brief Bioinform. 2002;3(2):146-153.
30. Li H, Wu Y, Loos RJ, et al. Variants in the fat massand obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population. Diabetes. 2008; 57(1):264-268.
31. Chang YC, Liu PH, Lee WJ, et al. Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population. Diabetes. 2008;57(8):2245-2252.
32. Hotta K, Nakata Y, Matsuo T, et al. Variations in the FTO gene are associated with severe obesity in the Japanese. J Hum Genet. 2008;53(6):546-553. (Pubitemid 351749344)
33. Xi B, Shen Y, Zhang M, et al. The common rs9939609 variant of the fat mass and obesity-associated gene is associated with obesity risk in children and adolescents of Beijing, China. BMC Med Genet. 2010;11:107 (doi:10.1186/ 1471-2350-11-107).
34. Wu L, Xi B, Zhang M, et al. Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children. Diabetes. 2010;59(12): 3085-3089.
35. Rosmond R. Association studies of genetic polymorphisms in central obesity: a critical review. Int J Obes Relat Metab Disord. 2003;27(10):1141- 1151. (Pubitemid 37281662)
36. Hetherington MM, Cecil JE. Gene-environment interactions in obesity. Forum Nutr. 2010;63:195-203.
37. Andreasen CH, Andersen G. Gene-environment interactions and obesity-further aspects of genomewide association studies. Nutrition. 2009;25(10):998-1003.
38. Rankinen T, Bouchard C. Gene-physical activity interactions: overview of human studies. Obesity (Silver Spring). 2008;16(suppl 3):S47-S50.
39. Fiebig R, Gore MT, Ji LL. Exercise attenuates nuclear protein binding to gene regulatory sequences of hepatic fatty acid synthase. J Appl Physiol. 1999;87(3):1009-1015. (Pubitemid 29436978)
40. Goodridge AG. Dietary regulation of gene expression: enzymes involved in carbohydrate and lipid metabolism. Annu Rev Nutr. 1987;7:157-185.
41. Chanock SJ, Manolio T, Boehnke M, et al. Replicating genotype- phenotype associations. NCI-NHGRI Working Group on Replication in Association Studies. Nature. 2007;447(7145): 655-660.