Increased nitrosoglutathione reductase activity in hypoxic pulmonary hypertension in mice

Journal of Pharmacological Sciences

Volumn 113, Issue 1, 2010, Pages 32-40

  Wu, Xiling ^a   Du, Lizhong ^a   Xu, Xuefeng ^a   Tan, Linhua ^a   Li, Ruyi ^a  

^a CHILDREN S HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Endothelial nitric oxide synthase; Glutathione and glutathione disulfide; Hypoxia; S nitrosoglutathione reductase

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; NITRATE; NITRITE; OXIDOREDUCTASE; S NITROSOGLUTATHIONE; S NITROSOTHIOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL WALL THICKNESS; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVITY; ENZYME METABOLISM; EXPOSURE; HEART RIGHT VENTRICLE HYPERTROPHY; HYPOTHESIS; HYPOXIA; LUNG BLOOD VESSEL; LUNG PARENCHYMA; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; SYSTOLIC BLOOD PRESSURE;

EID: 77953485030     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.09279FP     Document Type: Article

References (28)

1. Takemoto M, Sun J, Hiroki J, Shimokawa H, Liao JK. Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase. Circulation. 2002;106:57-62.
2. Zhao L, Mason NA, Morrell NW, Kojonazarov B, Sadykov A, Maripov A, et al. Sildenafil inhibits hypoxia-induced pulmonary hypertension. Circulation. 2001;104:424-428.
3. Chatterjee A, Catravas JD. Endothelial nitric oxide (NO) and its pathophysiologic regulation. Vascul Pharmacol. 2008;49:134-140.
4. McMahon TJ, Moon RE, Luschinger BP, Carraway MS, Stone AE, Stolp BW, et al. Nitric oxide in the human respiratory cycle. Nat Med. 2002;8:711-717.
5. Tsutsui M, Shimokawa H, Morishita T, Nakashima Y, Yanagihara N. Development of genetically engineered mice lacking all three nitric oxide synthases. J Pharmacol Sci. 2006;102:147-154.
6. Gaston B, Singel D, Doctor A, Stamler JS. S-nitrosothiol signaling in respiratory biology. Am J Respir Crit Care Med. 2006;173: 1186-1193.
7. Foster MW, McMahon TJ, Stamler JS. S-nitrosylation in health and disease. Trends Mol Med. 2003;9:160-168.
8. Moya MP, Gow AJ, Califf RM, Goldberg RN, Stamler JS. Inhaled ethyl nitrite gas for persistent pulmonary hypertension of the newborn. Lancet. 2002;360:141-143.
9. Liu L, Hausladen A, Zeng M, Que L, Heitman J, Stamler JS. A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans. Nature. 2001;410:490-494.
10. Staab CA, Hellgren M, Hoog JO. Medium-and short-chain dehydrogenase/ reductase gene and protein families: dual functions of alcohol dehydrogenase 3: implications with focus on formaldehyde dehydrogenase and S-nitrosoglutathione reductase activities. Cell Mol Life Sci. 2008;65:3950-3960.
11. Que LG, Liu L, Yan Y, Whitehead GS, Gavett SH, Schwartz DA, et al. Protection from experimental asthma by an endogenous bronchodilator. Science. 2005;308:1618-1621.
12. Fang K, Johns R, Macdonald T, Kinter M, Gaston B. S-nitrosoglutathione breakdown prevents airway smooth muscle relaxation in the guinea pig. Am J Physiol Lung Cell Mol Physiol. 2000;279: L716-L721.
13. Wu H, Romieu I, Sienra-Monge JJ, Estela-Del-Rio-Navarro B, Anderson DM, Jenchura CA, et al. Genetic variation in S-nitrosoglutathione reductase (GSNOR) and childhood asthma. J Allergy Clin Immunol. 2007;120:322-328.
14. Liu L, Yan Y, Zeng M, Zhang J, Hanes MA, Ahearn G, et al. Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. Cell. 2004;116:617-628.
15. Neuman MG, Jia AY, Steenkamp V. Senecio latifolius induces in vitro hepatocytotoxicity in a human cell line. Can J Physiol Pharmacol. 2007;85:1063-1075.
16. Tsui DY, Gambino A, Wanstall JC. S-nitrosocaptopril: in vitro characterization of pulmonary vascular effects in rats. Br J Pharmacol. 2003;138:855-864.
17. Duan S, Chen C. S-nitrosylation/denitrosylation and apoptosis of immune cells. Cell Mol Immunol. 2007;4:353-358.
18. Bhandari V, Choo-Wing R, Chapoval SP, Lee CG, Tang C, Kim YK, et al. Essential role of nitric oxide in VEGF-induced, asthmalike angiogenic, inflammatory, mucus, and physiologic responses in the lung. Proc Natl Acad Sci U S A. 2006;103:11021-11026.
19. Murata T, Kinoshita K, Hori M, Kuwahara M, Tsubone H, Karaki H, et al. Statin protects endothelial nitric oxide synthase activity in hypoxia-induced pulmonary hypertension. Arterioscler Thromb Vasc Biol. 2005;25:2335-2342.
20. McMahon TJ, Ahearn GS, Moya MP, Gow AJ, Huang YC, Luchsinger BP, et al. A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension. Proc Natl Acad Sci U S A. 2005;102: 14801-14806.
21. Moya MP, Gow AJ, McMahon TJ, Toone EJ, Cheifetz IM, Goldberg RN, et al. S-nitrosothiol repletion by an inhaled gas regulates pulmonary function. Proc Natl Acad Sci U S A. 2001; 98:5792-5797.
22. Xu A, Vita JA, Keaney JF Jr. Ascorbic acid and glutathione modulate the biological activity of S-nitrosoglutathione. Hypertension. 2000;36:291-295.
23. Heikal L, Martin GP, Dailey LA. Characterisation of the decomposition behaviour of S-nitrosoglutathione and a new class of analogues: S-Nitrosophytochelatins. Nitric Oxide. 2009;20:157-165.
24. Zhu H, Cao Z, Zhang L, Trush MA, Li Y. Glutathione and glutathione-linked enzymes in normal human aortic smooth muscle cells: chemical inducibility and protection against reactive oxygen and nitrogen species-induced injury. Mol Cell Biochem. 2007;301:47-59.
25. He J, Wang T, Wang P, Han P, Yin Q, Chen C. A novel mechanism underlying the susceptibility of neuronal cells to nitric oxide: the occurrence and regulation of protein S-nitrosylation is the checkpoint. J Neurochem. 2007;102:1863-1874.
26. Haqqani AS, Do SK, Birnboim HC. The role of a formaldehyde dehydrogenase-glutathione pathway in protein S-nitrosation in mammalian cells. Nitric Oxide. 2003;9:172-181.
27. Staab CA, Alander J, Brandt M, Lengqvist J, Morgenstern R, Grafstrom RC, et al. Reduction of S-nitrosoglutathione by alcohol dehydrogenase 3 is facilitated by substrate alcohols via direct cofactor recycling and leads to GSH-controlled formation of glutathione transferase inhibitors. Biochem J. 2008;413:493-504.
28. Gupte SA, Wolin MS. Oxidant and redox signaling in vascular oxygen sensing: implications for systemic and pulmonary hypertension. Antioxid Redox Signal. 2008;10:1137-1152.