Evolution of the internal fixation of long bone fractures

Journal of Bone and Joint Surgery - Series B

Volumn 84, Issue 8, 2002, Pages 1093-1110

  Perren, Stephan M ^a  

^a AO RESEARCH INSTITUTE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTATION; BIOMECHANICS; BONE NAIL; BONE NECROSIS; BONE PLATE; BONE REMODELING; BONE SCREW; BONE STRESS; CALLUS; COMPRESSION; CONTROLLED STUDY; DISEASE SEVERITY; EXTERNAL FIXATOR; FRACTURE; FRACTURE HEALING; FRACTURE REDUCTION; HUMAN; IMPLANT; INTERLOCKING NAIL; INTERMETHOD COMPARISON; LONG BONE; LONG TERM CARE; MINIMALLY INVASIVE SURGERY; OSTEOLYSIS; OSTEOSYNTHESIS; POROSITY; PRIORITY JOURNAL; PROTECTION; REVIEW; SPLINTING; SURGICAL INJURY; SURGICAL TECHNIQUE; TREATMENT INDICATION; VASCULARIZATION;

EID: 0036854433     PISSN: 0301620X     EISSN: None     Source Type: Journal    
DOI: 10.1302/0301-620X.84B8.13752     Document Type: Review

References (130)

1. Mueller M, Allgower M, Willenegger H. Technik der operativen Frakturenbehandlung. Berlin, etc: Springer-Verlag, 1963.
2. Schatzker J, Tile M. The rationale of operative fracture care. Berlin: Springer Verlag, 1987.
3. Klaue K. Principles of plate and screw osteosynthesis. In: Bulstrode C, Buckwalter J, Carr A et al, eds. Oxford textbook of orthopaedics and trauma. Oxford: Oxford University Press 2002:1697-1710.
4. Rozbruch SR, Müller U, Gautier E, Ganz R. The evolution of femoral shaft plating technique. Clin Orthop 1998;354:195-208.
5. Kleinig R, Hax PM. Die interne Überbrückungsosteosynthese ohne Reposition des Stückbruchbereiches als Alternative zur internen Fragmentfixation von Stückbrüchen nach anatomischer Reposition. Hefte Unfallheilkd 1980;153:213-8.
6. Gerber C, Mast J, Ganz R. Biological internal fixation of fractures. Arch Orthop Trauma Surg 1990;109:295-303.
7. Claudi B, Oedekoven G. Biological osteosynthesis. Chirurg 1991;62:367-77.
8. Baumgaertel F, Gotzen L. The "biological" plate osteosynthesis in multi-fragment fractures of the para-articular femur: a prospective study. Unfallchirurg 1994;97:78-84.
9. Gautier E, Ganz R. The biological plate osteosynthesis. Zentralbl Chir 1994;119:564-72.
10. Thielemann FW, Blersch E, Holz U. Plate osteosynthesis of femoral shaft fracture with reference to biological aspects. Unfallchirurg 1988;91:389-94.
11. Ganz R, Mast J, Weber B, Perren S. Clinical aspects of "bio-logical" plating. Injury 1991;22:4-5.
12. Mast JW, Jakob R, Ganz R. Planning and reduction technique in fracture surgery. Berlin, etc: Springer-Verlag, 1989.
13. Leunig M, Hertel R, Siebenrock KA, et al. The evolution of indirect reduction techniques for the treatment of fractures. Clin Orthop 2000;375:7-14.
14. Kuentscher G. Die Marknagelung des Truemmerbruches. Langenbecks Arch Chir 1968;322:1063-9.
15. Klemm K, Schellmann W. Dynamische und statische Verriegelung des Marknagels. Monastsschr Unfallheilkd 1972;75:568-75.
16. Kempf I, Leung K. Practice of intramedullary locked nails: scientific basis and standard technique recommended by AIOD. Berlin, etc: Springer Verlag, 2002.
17. Lane WA. The operative treatment of fractures. London: Medical Publishing, 1913.
18. Heitemeyer U, Hierholzer G, Terhorst J. Der Stellenwert der ueberbrueckenden Plattenosteosynthese bei Mehrfragmentbruchschaedigungen des Femur in klinischen Vergleich. Der Unfallchirurg 1986;12:533-8.
19. Blatter G, Weber BG. Wave plate osteosynthesis as a salvage procedure. Arch Orthop Trauma Surg 1990;109:330-3.
20. Hoffmann R. Osteotaxis - Percutane Knochenfixierung - technische un klinische Beurteilung. Stuttgart: Ferdinand Enke Verlag, 1959.
21. Burny F, Donkerwolcke M, Saric O. Elastic external fixation of tibial fractures: influence of associated internal fixation. Heidelberg, etc: Springer-Verlag 1982;59-167.
22. Vuillemin T, Raveh J, Sutter F. Mandibular reconstruction with the titanium hollow screw reconstruction plate (THORP) system: evaluation of 62 cases. Plast Reconstr Surg 1988;82:804-14.
23. Ramotowski W, Granowski R, Bielawski J. ZESPOL - osteosynthesis theory and clinical practice. Warsaw: Panstwowy Zaklad Wydawnictw Lekarskich, 1988.
24. Wolter D. Der Plattenfixateur interne für lange Röhrenknochen. In: Wolter D, Zimmer W, eds. Die Plattenosteosynthese un ihre Konkurrenzverfahren Von Hansmann bis Ilisarow. Berlin, etc: Springer Verlag, 1991.
25. Auer JA, Lischer C, Kaegi B, et al. Application of the Point Contact Fixator in large animals. Injury 1995;26:SB37-SB46.
26. Seibold R, Schlegel U, Kessler SB, et al. Healing of spiral fractures in the sheep tibia comparing different methods - osteosynthesis with internal fixation, interlocking nailing and dynamic compression plate. Unfallchirurg 1995;620-6.
27. Kolodziej P, Lee FS, Patel A, et al. Biomechanical evaluation of the Schuhli nut. Clin Orthop 1998;347:79-85.
28. Schawalder P, Stich H, Oetliker M, et al. Clinical use of hollow cylinder screw implants for various indications (functional mandible reconstruction after tumor resection osteotomy, stable maintenance of spinal column, prosthetics): 20 years' experience. Schweiz Arch Tierheilkd 2000;142:279-88.
29. Tayton K, Johnson-Nurse C, McKibbin B, Bradley J, Hastings G. The use of semi-rigid carbon-fibre reinforced plastic plates for fixation of human fractures. J Bone Joint Surg [Br] 1982;64-B:105-11.
30. Schmidtmann U, Knopp W, Wolff C, Sturmer KM. Results of elastic plate osteosynthesis of simple femoral shaft fractures in polytraumatized patients: an alternative procedure. Unfallchirurg 1997;100:949-56.
31. Goodship AE, Kenwright J. The influence of induced micromovement upon the healing of experimental tibial fractures. J Bone Joint Surg [Br] 1985;67-B:650-5.
32. Kenwright J, Goodship AE, Kelly DJ, et al. Effect of controlled axial micromovement on healing of tibial fractures. Lancet 1986;ii:1185-7.
33. Kinast C, Bolhofner B, Mast JW, Ganz R. Subtrochanteric fractures of the femur: results of treatment with the 95° condylar blade-plate. Clin Orthop 1989;238:122-30.
34. Sarmiento A, Latta LL. Closed functional treatment of fractures. Berlin, etc: Springer Verlag, 1981.
35. Sumner Smith G, Fackelman GE, ed. Bone in clinical orthopaedics. Stuttgart: Thieme Verlag, 2002:1-492.
36. Stuermer K, Schuchardt W. Neue Aspekte der gedeckten Marknagelung und des Aufbohrens der Markhoehle im Tierexperiment. II. Der intramedullaere Druck beim Aufbohren der Markhoehle. Unfallheilkunde 1980;83:346-52.
37. Rhinelander FW. The vascular response of bone to internal fixation. In: Browner B, Edwards C, eds. The science and practice of intramedullary nailing. Philadelphia: Lea and Febiger, 1987;25-59.
38. Klein MP, Rahn B, Frigg R, Kessler S, Perren SM. Reaming versus non-reaming in medullary nailing: interference with cortical circulation of the canine tibia. Arch Orthop Trauma Surg 1990;109:314-6.
39. Ikeda K, Tomita K, Hashimoto F, Morikawa S. Long term follow-up of vascularized bone graft for the reconstruction of tibial nonunion: evaluation with computed tomographic scanning. J Trauma 1992;32:693-7.
40. Brookes M, Revell WJ. Blood supply of bone: scientific aspects. London: Springer Verlag, 1998:1-359.
41. Rahn BA. Intra vitam staining techniques. In: von Recum AF, ed. Handbook of biomaterials evaluation: scientific, technical, and clinical testing of implant materials. Philadelphia, etc: Taylor & Francis, 1999:727-38.
42. Knothe Tate ML, Knothe U. An ex vivo model to study transport processes and fluid flow in loaded bone. J Biomech 2000;33:247-54.
43. Bourne G, ed. The biochemistry and physiology of bone. Vol. 1. Structure. New York, etc: Academic Press, 1972.
44. Frost HM. A determinant of bone architecture: the minimum effective strain. Clin Orthop 1983;286-92.
45. Rahn BA. Fracture biology, mechanics and healing. In: Auer JA, Stick JA, eds. Equine surgery. 2nd edition. Philadelphia: W. B. Saunders Company, 1999:629-34.
46. Ruedi TP, Murphy WM. AO principles of fracture management: AO teaching videos on CD-ROM included. Stuttgart: AO Publishing - Thieme Verlag, 2000:1-864.
47. Pauwels F. Biomechanics of the locomotor apparatus: contributions on the functional anatomy of the locomotor apparatus. Berlin, etc: Springer-Verlag, 1980.
48. Chao EY, Kasman R, An KN. Rigidity and stress analyses of external fracture fixation devices: a theoretical approach. J Biomech 1982;15:971-83.
49. Bergmann G, Graichen F, Rohlmann A. Hip joint loading during walking and running, measured in two patients. J Biomech 1993;26:969-90.
50. Duda GN, Mandruzzato F, Heller M, et al. Mechanical boundary conditions of fracture healing: borderline indications in the treatment of unreamed tibial nailing. J Biomech 2001;34:639-50.
51. Danis R. Theorie et practique de l'osteosynthèse. Paris: Masson & Cie Éditeurs, 1949.
52. Ilizarov GA. Clinical application of the tension-stress effect for limb lengthening. Clin Orthop 1990;250:8-26.
53. Perren SM. Physical and biological aspects of fracture healing with special reference to internal fixation. Clin Orthop 1979;138:175-96.
54. Tepic S, Perren SM. The biomechanics of the PC-Fix internal fixator. Injury 1995;26:2SB5-SB10.
55. McKibbin B. The biology of fracture healing in long bones. J Bone Joint Surg [Br] 1978;60-B:150-62.
56. Schenk R, Willenegger H. Zum histologischen Bild der sogenannten Primaerheilung der Knochenkompakta nach experimentellen Osteotomien am Hund. Experientia 1963;19:593-5.
57. Rahn B, Gallinaro P, Schenk R, Baltensperger A. Compression interfragmentaire et surcharge locale de l'os. In: Boitzy A, ed. Ostéogénèse et compression. Bern, etc: Hans Huber 1972:146-53.
58. Ganz R, Perren SM, Rueter A. Mechanische Induktion der Knochenresorption. Fortschr Kiefer Gesichtschir 1975;19:45-8.
59. Wiss D, Johnson D, Miao M. Compression plating for non-union after failed external fixation of open tibial fractures. J Bone Joint Surg [Am] 1992;74-A:1279-85.
60. Weber B, Cech O. Pseudarthrosen. Pathophysiologie - Biomechanik - Therapie - Ergebnisse. Bern, etc: Verlag Hans Huber, 1973.
61. Böhler L. Die Technik der Knochenbruchbehandlung. Vol. 1. Wien: Verlag Maudrich, 1953.
62. Hente R, Lechner J, Fuechtmeier B, Schlegel U, Perren SM. Der Einfluss einer zeitlich limitierten kontrollierten Bewegung auf die Frakturheilung. Hefte Unfallchirurg 2001;283:23-4.
63. Perren SM, Boitzy A. Cellular differentiation and bone biomechanics during the consolidation of a fracture. Anat Clin 1978;1:13-28.
64. Yamada H. Strength of biological materials. Baltimore: Williams & Wilkins Co, 1970:99-104.
65. Roasenda F, Lorenzi G, Gherlinzoni G. Moderni orientamenti nelle osteosintesi delle fratture diafisarie. Bologna: Aulo Gaggi Editore, 1969.
66. Olerud S, Danckwardt Lilliestroem G. Fracture healing in compression osteosynthesis in the dog. J Bone Joint Surg [Br] 1968;50-B:844-51.
67. Gallinaro P, Perren SM, Crova M, Rahn B. La osteosintesi con placca a compressione. Estratto da: Moderni orientamenti nelle osteosintesi delle fratture diafisarie. LIV Congresso SIOT, Roma, 1969. Bologna: Aulo Gaggi Editore, 1969;21-61.
68. Cheal EJ, Mansmann KA, DiGioia AM III, Hayes WC, Perren SM. Role of interfragmentary strain in fracture healing: ovine model of a healing osteotomy. J Orthop Res 1991;9:131-42,
69. Claes L. The mechanical and morphological properties of bone beneath internal fixation plates of differing rigidity. J Orthop Res 1989;72:170-7.
70. McKibbin B. Carbon plates. In: Uhthoff HK, ed. Current concepts of internal fixation of fractures. Berlin, etc: Springer-Verlag 1980:146-8.
71. Williams DF. Titanium as a metal for implantation. Part 2: biological properties and clinical applications. J Med Eng Technol 1977;1:266-70.
72. Brunette DM, Tengvall P, Textor M, Thomsen P, ed. Titan in medicine. Berlin: Springer Verlag, 2001.
73. Steinemann S. The essential properties of bone plates for fracture fixation. Biomat Biomech 1984;173-81.
74. Ungersboeck A, Hunt J, Kraehenbuehl U, Perren SM. Vergleich der Gewebsreaktion auf LC-DCP Platten aus rostfreiem Stahl und Reintitan. Eine prospektive klinische Studie. Swiss Surg Suppl. 1996;2:46.
75. Cordey J, Rahn B, Perren SM. Human torque control in the use of bone screws. In: Uhthoff HK, ed. Current concepts of internal fixation of fractures. Berlin, etc: Springer-Verlag 1980:235-43.
76. Haas N, Hauke C, Schuetz M, Kaeaeb M, Perren SM. Treatment of diaphyseal fractures of the forearm using the Point Contact Fixator (PC-Fix): results of 387 fractures of a prospective multicentric study (PC-Fix II). Injury 2001;322:SB51-SB62.
77. Enzler M, Perren SM. Coefficient of plate-bone friction in vitro: the effect of duration and amount of load. In: Asmussen E, Jorgensen K. Biomechanics VI-B. Baltimore: University Press 1978;239-43.
78. Frigg R. Locking Compression Plate (LCP): an osteosynthesis plate based on the dynamic compression plate and the Point Contact Fixator (PC-Fix). Injury 2001;322:SB63-SB6.
79. Wolff J. Das Gesetz der Transformation der Knochen. Berlin: Verlag von August Hirschwald, 1892.
80. Huiskes R. If bone is the answer, then what is the question? J Anat 2000;197:145-56.
81. Uhthoff HK, Dubuc FL. Bone structure changes in the dog under rigid internal fixation. Clin Orthop 1971;81:165-70.
82. Akeson WH, Woo SL, Rutherford L, et al. The effects of rigidity of internal fixation plates on long bone remodelling: a biomechanical and quantitative histological study. Acta Orthop Scand 1976;47:241-9.
83. Woo SL, Akeson WH, Coutts RD, et al. A comparison of cortical bone atrophy secondary to fixation with plates with large differences in bending stiffness. J Bone Joint Surg [Am] 1976;58-A:190-5.
84. Claes L, Kinzl L, Neugebauer R. Experimental studies on the influence of plate material on stress-relief and atrophy of the bone osteosynthesis plates. Biomed Tech (Berl) 1981;26:66-71.
85. Uhthoff HK, Finnegan M. The effects of metal plates on post-traumatic bone remodelling and bone mass. J Bone Joint Surg [Br] 1983;65-B:66-71.
86. Zhu ZA, Dai KR, Qiu SJ. Repair of regional osteoporosis after removal of rigid fixing plate: an experimental investigation. Chin Med J (Engl) 1994;107:364-7.
87. Pfister U, Rahn B, Perren SM, Weller S. Vaskularitaet und Knochenumbau nach Marknagelung langer Roehrenknochen. Aktuel Traumatol 1979;9:191-5.
88. Gautier E, Perren SM. Die Limited Contact Dynamic Compression Plate (LC-DCP): Biomechanische Forschung als Grundlage des neuen Plattendesigns. Orthopaede 1992;21:11-23.
89. Vattollo M. Der Einfluss von Rillen in Osteosyntheseplatten auf den Umbau der Kortikalis. 1986. Universität Bern.
90. Gautier E, Perren SM. Die Reaktion der Kortikalis nach Verplattung - eine folge der Belastungsveraenderung des Knochens oder Vaskularitaetsprobleme? In: Die Plattenosteosynthese und ihre Konkurrenzverfahren Berlin, etc: Springer Verlag 1991;21-37.
91. Kessler SB. "Spongiosation" of cortical bone. Hefte Unfallheikd 1983;161:76-9.
92. Wenda K, Runkel M, Degreif J, et al. Minimally invasive plate fixation in femoral shaft fractures. Injury 1997;281:A13-A19.
93. Pfister U. Vascularitaet und Knochenumbau nach Marknagelung der Schafstibias. Hefte Unfallheikunde 1982;158:51-2.
94. Perren SM, Russenberger M, Steinemann S, Müller ME, öwer M. A Dynamic compression plate. Acta Orthop Scand 1969;Suppl. 125:31-41.
95. Perren SM, et al. The concept of biological plating using the limited contact-dynamic compression plate (LC-DCP): scientific background, design and application. Injury 1991;22(Suppl 1):1-41.
96. Field J, Hearn TC, Caldwell CB. Bone plate fixation: an evaluation of interface contact area and force of the dynamic compression plate (DCP) and the limited contact-dynamic compression plate (LC-DCP) applied to cadaveric bone. J Orthop Trauma 1997;11:368-73.
97. Klaue K, Fengels I, Perren SM. Long-term effects of plate osteosynthesis: comparison of four different plates. Injury 2000;132:51-62.
98. Rittmann W, Perren SM. Cortical bone healing after internal fixation and infection. Berlin, etc: Springer-Verlag, 1974:1-76.
99. Gagnon RF, Richards GK. A mouse model of implant-associated infection. Int J Artif Organs 1993;1611:789-98.
100. Melcher GA, Claudi B, Schlegel U, et al. Influence of type of medullary nail on the development of local infection: an experimental study of solid and slotted nails in rabbits. J Bone Joint Surg [Br] 1994;76-B:955-9.
101. Arens S, Schlegel U, Printzen G, et al. Influence of materials for fixation of implants on local infection: an experimental study of steel versus titanium DCP in rabbits. J Bone Joint Surg [Br] 1996;78-B:647-51.
102. Hauke C, Schlegel U, Melcher GA, Printzen G, Perren SM. Local infection in relation to different implant materials: an experimental study using stainless steel and titanium solid, unlocked, intramedullary nails in rabbits. Orthop Trans 1997;21:835-6.
103. Mainil-Varlet P, Hauke C, Maquet V, et al. Polylactide implants and bacterial contamination: an animal study. J Biomed Mater Res 2001;54:335-43.
104. Metzdorf A. Einfluss der Markraumbohrung auf die Entstehung eines lokalen Infektes. 1996. Universität Würzburg.
105. Arens S, Kraft C, Schlegel U, et al. Susceptibility to local infection in biological internal fixation: experimental study of open versus minimally invasive plate osteosynthesis in rabbits. Arch Orthop Trauma Surg 1999;119:82-5.
106. Perren SM, Schlegel U. Surgical aspects of implants and infection: the effect of material, design and application on resistance to local infection. Nova Acta Leopoldina 2001;NF 84:65-73.
107. Kessler SB. Analyse der Refrakturen nach Plattenosteosynthese. In: Wolter D, Zimmer W, eds. Die Plattenosteosynthese und ihre Konkurrenzverfahren Von Hansmann bis Ilisarow. Berlin, etc: Springer Verlag, 1991:38-40.
108. Hoenig JF, Merten HA, Ficker E. Die Multi-Point-Contact-(MPC) Osteosyntheseplatte. Teil 1: Tierexperimentelle histomorphologische Untersuchungen am Goettinger Miniaturschwein. Unfallchirurgie 1997;23:227-37.
109. Hoenig JF, Burchardt H, Wuestner M, et al. Die Multi-Point-Contact-(MPC) Osteosyntheseplatte. Teil 2: Erste klinische Ergebnisse zur Therapie der Unterarmfraktur mittels MPC-Platten. Unfallchirurgie 1997;23:238-45.
110. von Arx C. Schubuebertragung dutch Reibung bei Plattenosteosynthesen. 1975;1-34.
111. Klaue K, Perren SM, Kowalski M. Internal fixation with a self-compressing plate and lag screw: improvements of the plate and hole design. 1. Mechanical investigation. J Orthop Trauma 1991;5:280-8.
112. Miclau T, Remiger A, Tepic S, Lindsey R, McIff T. A mechanical comparison of the dynamic compression plate, limited contact-dynamic compression plate, and point contact fixator. J Orthop Trauma 1995;9:17-22.
113. Lindsey R, Leggon R, Panjabi M. Biomechanics of healed experimental fractures. Clin Biomech 1991;6:83-7.
114. Seebeck J, Lill C, Morlock MM, Schneider E. Implantatverankerung in osteoporotschem Knochen mittels monokortikaler Schrauben. Trauma Berufskrankh 1999;1:411-4.
115. van Frank Haasnoot E, Muench T, Matter P, Perren SM. Radiological sequences of healing in internal plates and splints of different contact surface to bone (DCP, LC-DCP and PC-Fix). Injury 1995;26:SB28-SB36.
116. Tepic S, Remiger AR, Morikawa K, Predieri M, Perren SM. Strength recovery in fractured sheep tibia treated with a plate or an internal fixator: an experimental study with a two-year follow-up. J Orthop Trauma 1997;11:14-23.
117. Savoldelli D, Montavon PM. Clinical handling: small animals. Injury 1995;262:47-50.
118. Fernandez Dell'Oca AA, Tepic S, Frigg R, et al. Treating forearm fractures using an internal fixator: a prospective study. Clin Orthop 2001;389:196-205.
119. Hofer HP, Wildburger R, Szyszkowitz R. Observations concerning different patterns of bone healing using the Point Contact Fixator (PC-Fix) as a new technique for fracture fixation. Injury 2001;322:SB15-SB25.
120. Krettek C, Schandelmaier P, Miclau T, et al. Minimally invasive percutaneous plate osteosynthesis (MIPPO) using the DCS in proximal and distal femoral fractures. Injury 1997;28:A20-A30.
121. Schuetz M, Schmeling A, Ito K, Wieling R, Haas NP. Der Einfluss des chirurgischen Zuganges auf die Frakturheilung: Vergleich von minimal Invasiver Technik (MIC) mit konventioneller offener Reposition und Stabilisierung (ORIF) mit Fixateur intern in einer tierexperimentellen Untersuchung an der Schafstibia. Hefte Unfallchirurg 1999;275:473-4.
122. Chow SP. Introduction to the point contact fixator (Part II). Injury 2001;322:SB1-SB2.
123. Kregor PJ, Stannard JP, Cole PA, Zlowodski M, Alonso JA. Prospective clinical trial of the less invasive stabilization system (LISS) for sypracondylar femur fractures. Proceedings of Orthopedic Trauma Association Annual Meeting. J Orthop Trauma 2000;14:133-4.
124. Marti A, Fankhauser C, Frenk A, Cordey J, Gasser B. Biomechanical evaluation of the less invasive stabilization system for the internal fixation of distal femur fractures. J Orthop Trauma 2001;15:482-7.
125. Schwyn R, Hehli M, Alonso J, Fernandez Dell'Oca A, Messmer P, Regazzoni P. Neue Konzepte fuer Repositionsinstrumente - Poster Presentation. Hefte Unfallchirurg 2000;282:461-2.
126. Schneider E, Michel MC, Genge M, et al. Loads acting in an intramedullary nail during fracture healing in the human femur. J Biomech 2001;34:848-57.
127. An YH. Internal fixation in osteoporotic bone. New York: Thieme Verlag, 2002.
128. Meinig R, Goglewski S, Rahn B, Perren SM. Directed bone formation in diaphyseal defects with resorbable polylactide membranes. Int J Artif Organs 1990;139:577.
129. Gugala Z, Gogolewski S. Regeneration of segmental diaphyseal defects in sheep tibiae using resorbable polymeric membranes: a preliminary study. J Orthop Trauma 1999;187-95.
130. Ito K, Hungerbuhler R, Wahl D, Grass R. Improved intramedullary nail interlocking in osteoporotic bone. J Orthop Trauma 2001;15:192-6.