-
1
-
-
0008492714
-
-
In;, Eds.; Italian Society of Chemistry: Roma,; Vol., pp.
-
Simoni, D.; Rondanin, R.; Roberti, M. In Targets in Heterocyclic Systems; Attanasi, O. A., Spinelli, D., Eds.; Italian Society of Chemistry: Roma, 1999; Vol. 3, pp 147-183.
-
(1999)
Targets in Heterocyclic Systems
, vol.3
, pp. 147-183
-
-
Simoni, D.1
Rondanin, R.2
Roberti, M.3
Attanasi, O.A.4
Spinelli, D.5
-
2
-
-
0023265754
-
-
Ritz, M. C.; Lamb, R. J.; Goldberg, S. R.; Kuhar, M. J. Science 1987, 237, 1219-1223
-
(1987)
Science
, vol.237
, pp. 1219-1223
-
-
Ritz, M.C.1
Lamb, R.J.2
Goldberg, S.R.3
Kuhar, M.J.4
-
3
-
-
0025855256
-
-
Kuhar, M. J.; Ritz, M. C.; Boja, J. W. Trends Neurosci. 1991, 14, 299-302
-
(1991)
Trends Neurosci.
, vol.14
, pp. 299-302
-
-
Kuhar, M.J.1
Ritz, M.C.2
Boja, J.W.3
-
5
-
-
77957904093
-
-
Substance Abuse and Mental Health Services Administration. (. (Office of Applied Studies, NSDUH Series H-38A, HHS Publication No. SMA 10-4586Findings), Rockville, MD.
-
Substance Abuse and Mental Health Services Administration. ((2010). Results from the 2009 National Survey on Drug Use and Health: Vol. I. Page 1. Summary of National Findings (Office of Applied Studies, NSDUH Series H-38A, HHS Publication No. SMA 10-4586Findings), Rockville, MD. http://oas.samhsa.gov/ NSDUH/2k9NSDUH/2k9ResultsP.pdf.
-
(2010)
Results from the 2009 National Survey on Drug Use and Health: Vol. I. Page 1. Summary of National Findings
-
-
-
6
-
-
21644457409
-
-
Herman, B. H.; Elkashef, A.; Vocci, F. Drug Discovery Today: Therapeutic Strategies 2005, 2, 87-92
-
(2005)
Drug Discovery Today: Therapeutic Strategies
, vol.2
, pp. 87-92
-
-
Herman, B.H.1
Elkashef, A.2
Vocci, F.3
-
7
-
-
0027139321
-
-
For some reports of synthesis of cocaine analogues, see: racemic 6β- and 7β-methoxylated cocaine
-
For some reports of synthesis of cocaine analogues, see: racemic 6β- and 7β-methoxylated cocaine: Simoni, D.; Stoelwinder, J.; Kozikowski, A. P.; Johnson, K. M.; Bergmann, J. S.; Ball, R. G. J. Med. Chem. 1993, 36, 3975-3977
-
(1993)
J. Med. Chem.
, vol.36
, pp. 3975-3977
-
-
Simoni, D.1
Stoelwinder, J.2
Kozikowski, A.P.3
Johnson, K.M.4
Bergmann, J.S.5
Ball, R.G.6
-
8
-
-
0030598004
-
-
racemic 6 β - and 7 β -hydroxylated cocaine
-
racemic 6 β-and 7 β -hydroxylated cocaine: Kozikowski, A. P.; Simoni, D.; Manfredini, S.; Roberti, M.; Stoelwinder, J. Tetrahedron Lett. 1996, 37, 5333-5336
-
(1996)
Tetrahedron Lett.
, vol.37
, pp. 5333-5336
-
-
Kozikowski, A.P.1
Simoni, D.2
Manfredini, S.3
Roberti, M.4
Stoelwinder, J.5
-
9
-
-
77956574170
-
-
enantiopure C1-alkyl cocaine analogues
-
enantiopure C1-alkyl cocaine analogues: Davis, F. A.; Theddu, N.; Edupuganti, R. Org. Lett. 2010, 12, 4118-4121
-
(2010)
Org. Lett.
, vol.12
, pp. 4118-4121
-
-
Davis, F.A.1
Theddu, N.2
Edupuganti, R.3
-
10
-
-
78649873024
-
-
For some reports of synthesis of C2 and C3 tropane analogues, see
-
For some reports of synthesis of C2 and C3 tropane analogues, see: Carroll, F. I.; Blough, B. E.; Mascarella, S. W.; Navarro, H. A.; Eaton, J. B.; Lukas, R. J.; Damaj, M. I. J. Med. Chem. 2010, 53, 8345-8353
-
(2010)
J. Med. Chem.
, vol.53
, pp. 8345-8353
-
-
Carroll, F.I.1
Blough, B.E.2
Mascarella, S.W.3
Navarro, H.A.4
Eaton, J.B.5
Lukas, R.J.6
Damaj, M.I.7
-
11
-
-
58149098059
-
-
Stehouwer, J. S.; Jarkas, N.; Zeng, F.; Voll, R. J.; Williams, L.; Camp, V. M.; Malveaux, E. J.; Votaw, J. R.; Howell, L.; Owens, M. J.; Goodman, M. M. J. Med. Chem. 2008, 51, 7788-7799
-
(2008)
J. Med. Chem.
, vol.51
, pp. 7788-7799
-
-
Stehouwer, J.S.1
Jarkas, N.2
Zeng, F.3
Voll, R.J.4
Williams, L.5
Camp, V.M.6
Malveaux, E.J.7
Votaw, J.R.8
Howell, L.9
Owens, M.J.10
Goodman, M.M.11
-
12
-
-
33750052304
-
-
Zhang, S.; Izenwasser, S.; Wade, D.; Xu, L.; Trudell, M. L. Bioorg. Med. Chem. 2006, 14, 7943-7952
-
(2006)
Bioorg. Med. Chem.
, vol.14
, pp. 7943-7952
-
-
Zhang, S.1
Izenwasser, S.2
Wade, D.3
Xu, L.4
Trudell, M.L.5
-
13
-
-
1842640037
-
-
Bois, F.; Baldwin, R. M.; Kula, N. S.; Baldessarini, R. J.; Innis, R. B.; Tamagnan, G. Bioorg. Med. Chem. Lett. 2004, 14, 2117-2120
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, pp. 2117-2120
-
-
Bois, F.1
Baldwin, R.M.2
Kula, N.S.3
Baldessarini, R.J.4
Innis, R.B.5
Tamagnan, G.6
-
14
-
-
0034710706
-
-
Zhao, L.; Johnson, K. M.; Zhang, M.; Flippen-Anderson, J.; Kozikowski, A. P. J. Med. Chem. 2000, 43, 3283-3294
-
(2000)
J. Med. Chem.
, vol.43
, pp. 3283-3294
-
-
Zhao, L.1
Johnson, K.M.2
Zhang, M.3
Flippen-Anderson, J.4
Kozikowski, A.P.5
-
15
-
-
62349127208
-
-
Shing, T. K. M.; Wong, W. F.; Ikeno, T.; Yamada, T. Chem.-Eur. J. 2009, 15, 2693-2707
-
(2009)
Chem.-Eur. J.
, vol.15
, pp. 2693-2707
-
-
Shing, T.K.M.1
Wong, W.F.2
Ikeno, T.3
Yamada, T.4
-
16
-
-
33645797302
-
-
Shing, T. K. M.; Wong, A. W. F.; Ikeno, T.; Yamada, T. J. Org. Chem. 2006, 71, 3253-3263
-
(2006)
J. Org. Chem.
, vol.71
, pp. 3253-3263
-
-
Shing, T.K.M.1
Wong, A.W.F.2
Ikeno, T.3
Yamada, T.4
-
17
-
-
0032511118
-
-
For previous asymmetric syntheses of cocaine, see
-
For previous asymmetric syntheses of cocaine, see: Lin, R.; Castells, J.; Rapoport, H. J. Org. Chem. 1998, 63, 4069-4078
-
(1998)
J. Org. Chem.
, vol.63
, pp. 4069-4078
-
-
Lin, R.1
Castells, J.2
Rapoport, H.3
-
18
-
-
0343962577
-
-
Lee, J. C.; Lee, K.; Cha, J. K. J. Org. Chem. 2000, 65, 4773-4775
-
(2000)
J. Org. Chem.
, vol.65
, pp. 4773-4775
-
-
Lee, J.C.1
Lee, K.2
Cha, J.K.3
-
20
-
-
77956574170
-
-
Davis, F. A.; Theddu, N.; Edupuganti, R. Org. Lett. 2010, 12, 4118-4121
-
(2010)
Org. Lett.
, vol.12
, pp. 4118-4121
-
-
Davis, F.A.1
Theddu, N.2
Edupuganti, R.3
-
21
-
-
79953869862
-
-
Cheng, G.; Wang, X.; Zhu, R.; Shao, C.; Xu, J.; Hu, Y. J. Org. Chem. 2011, 76, 2694-2700
-
(2011)
J. Org. Chem.
, vol.76
, pp. 2694-2700
-
-
Cheng, G.1
Wang, X.2
Zhu, R.3
Shao, C.4
Xu, J.5
Hu, Y.6
-
23
-
-
33846649589
-
-
Shing, T. K. M.; Wong, W. F.; Ikeno, T.; Yamada, T. Org. Lett. 2007, 9, 207-209
-
(2007)
Org. Lett.
, vol.9
, pp. 207-209
-
-
Shing, T.K.M.1
Wong, W.F.2
Ikeno, T.3
Yamada, T.4
-
24
-
-
0034685462
-
-
Chatterjee, A. K.; Morgan, J. P.; Scholl, M.; Grubbs, R. H. J. Am. Chem. Soc. 2000, 122, 3783-3784
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 3783-3784
-
-
Chatterjee, A.K.1
Morgan, J.P.2
Scholl, M.3
Grubbs, R.H.4
-
26
-
-
79957813650
-
-
Our studies showed that the INAC of nitrone 22, bearing an α,β-unsaturated ester and a cis -acetonide, gave exo -cycloadduct 23 exclusively. The regio- and stereochemistry was confirmed by X-ray crystallographic analysis of its benzoate 24 (CCDC 681970).
-
Our studies showed that the INAC of nitrone 22, bearing an α,β-unsaturated ester and a cis -acetonide, gave exo -cycloadduct 23 exclusively. The regio- and stereochemistry was confirmed by X-ray crystallographic analysis of its benzoate 24 (CCDC 681970).
-
-
-
-
27
-
-
79957825557
-
-
Please refer to Supporting Information for X-ray structures of 9 (CCDC 737152) and 10 (CCDC 752110).
-
Please refer to Supporting Information for X-ray structures of 9 (CCDC 737152) and 10 (CCDC 752110).
-
-
-
-
28
-
-
79957814104
-
-
The structure of azetidine-diol 12 was confirmed by X-ray crystallographic analysis of its tribenzoate derivative (CCDC 798275). Its preparation is described in the Supporting Information.
-
The structure of azetidine-diol 12 was confirmed by X-ray crystallographic analysis of its tribenzoate derivative (CCDC 798275). Its preparation is described in the Supporting Information.
-
-
-
-
30
-
-
33947472339
-
-
The existence of such ammonium ion 18 was supported by the racemization of acetate product upon acetylation of l -2 α -tropanol as reported by Archer et al.; see
-
The existence of such ammonium ion 18 was supported by the racemization of acetate product upon acetylation of l -2 α -tropanol as reported by Archer et al.; see: Archer, S.; Lewis, T. R.; Bell, M. R.; Schulenberg, J. W. J. Am. Chem. Soc. 1961, 83, 2386-2387
-
(1961)
J. Am. Chem. Soc.
, vol.83
, pp. 2386-2387
-
-
Archer, S.1
Lewis, T.R.2
Bell, M.R.3
Schulenberg, J.W.4
-
31
-
-
34347384998
-
-
The (7 R)-hydroxy cocaine had been used to synthesize haptens for immunopharmacotherapy in cocaine abuse; see
-
The (7 R)-hydroxy cocaine had been used to synthesize haptens for immunopharmacotherapy in cocaine abuse; see: Ino, A.; Dickerson, T. J.; Janda, K. D. Bioorg. Med. Chem. Lett. 2007, 17, 4280-4283
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 4280-4283
-
-
Ino, A.1
Dickerson, T.J.2
Janda, K.D.3
-
33
-
-
0035826379
-
-
Davis, F. A.; Zhang, H.; Lee, S. H. Org. Lett. 2001, 3, 759-762
-
(2001)
Org. Lett.
, vol.3
, pp. 759-762
-
-
Davis, F.A.1
Zhang, H.2
Lee, S.H.3
|