Synthesis of dopamine transporter selective 3-diarylmethoxymethyl-8-arylalkyl-8-azabicyclo[3.2.1]octane derivatives

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 23, 2006, Pages 7943-7952

  Zhang, Suhong ^a   Izenwasser, Sari ^b   Wade, Dean ^b   Xu, Liang ^a   Trudell, Mark L ^a  

^a UNIVERSITY OF NEW ORLEANS   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Cocaine; Dopamine transporter; Serotonin transporter; Tropane

Indexed keywords

3 (DIPHENYLMETHOXYMETHYL) 8 (3 PHENYLPROPYL) 8 BICYCLO[3.2.1]OCT 2 ENE; 3 BIS(4 FLUOROPHENYL)METHOXYMETHYL 8 (3 PHENYLPROPYL) 8 AZABICYCLO[3.2.1]OCT 2 ENE; 3 BIS(4 FLUOROPHENYL)METHOXYMETHYL 8 METHYL 8 AZABICYCLO[3.2.1]OCT 2 ENE; 3ALPHA BIS(4 FLUOROPHENYL)METHOXYMETHYL 8 (3 PHENYLPROPYL) 8 AZABICYCLO[3.2.1]OCTANE; 3ALPHA DIPHENYLMETHOXYMETHYL 8 (3 PHENYLPROPYL) 8 AZABICYCLO[3.2.1]OCTANE; 3BETA BIS(4 FLUOROPHENYL)METHOXYMETHYL 8 (3 PHENYLPROPYL) 8 AZABICYCLO[3.2.1]OCTANE; 3BETA BIS(4 FLUOROPHENYL)METHOXYMETHYL 8 (3 PHENYLPROPYL) 8 BICYCLO[3.2.1]OCTANE; 3BETA BIS(4 FLUOROPHENYL)METHOXYMETHYL 8 METHYL 8 AZABICYLO[3.2.1]OCTANE; 3BETA DIPHENYLMETHOXYMETHYL 8 (3 PHENYLPROPYL) 8 BICYCLO[3.2.1]OCTANE; 8 BENZYL 3 BIS(4 FLUOROPHENYL)METHOXYMETHYL 8 AZABICYCLO[3.2.1]OCT 2 ENE; 8 BENZYL 3 DIPHENYLMETHOXYMETHYL 8 AZABICYCLO[3.2.1]OCT 2 ENE; 8 BENZYL 3ALPHA (DIPHENYLMETHOXY)METHYL 8 AZABICYCLO[3.2.1]OCTANE; 8 BENZYL 3ALPHA BIS(4 FLUOROPHENYL)METHOXYMETHYL 8 BICYCLO[3.2.1]OCTANE; 8 BENZYL 3BETA BIS(4 FLUOROPHENYL)METHOXYMETHYL 8 BICYCLO[3.2.1]OCTANE; 8 BENZYL 3BETA DIPHENYLMETHOXYMETHYL 8 AZABICYCLO[3.2.1]OCTANE; 8 METHYL 3 DIPHENYLMETHOXYMETHYL 8 AZABICYCLO[3.2.1]OCT 2 ENE; 8 METHYL 3ALPHA DIPHENYLMETHOXYMETHYL 8 AZABICYCLO[3.2.1]OCTANE; 8 METHYL 3BETA BIS(4 FLUOROPHENYL)METHOXYMETHYL 8 AZABICYCLO[3.2.1]OCTANE; 8 METHYL 3BETA DIPHENYLMETHOXYMETHY 8 AZABICYCLO[3.2.1]OCTANE; CITALOPRAM; DOPAMINE TRANSPORTER; ETHER DERIVATIVE; NITROGEN; OCTANE; TROPANE ALKALOID; UNCLASSIFIED DRUG; VANOXERINE;

ANIMAL TISSUE; ARTICLE; ATOM; CHEMICAL PROCEDURES; CONFORMATION; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; MALE; NONHUMAN; RAT; RECEPTOR AFFINITY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

BICYCLO COMPOUNDS, HETEROCYCLIC; DOPAMINE ANTAGONISTS; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; OCTANES; PROTEIN BINDING; RECEPTORS, SEROTONIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33750052304     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.07.051     Document Type: Article

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