Exposure of adult male rats to cadmium: Assessment of sexual behaviour, fertility, aggression as well as anxiety like behaviour with special reference to biochemical and pathological alterations

Life Science Journal

Volumn 8, Issue 2, 2011, Pages 106-119

  Kamel, Mervat M ^a   El Razek, Abeer H Abd ^a   Ahmed, Kawkab A ^b   Kamel, Gehan M ^a  

^a Cairo University   (Egypt)

^b Department of Pathology ^*  (Egypt)

Author keywords

Aggression; Anxiety like behaviour; Cadmium chloride (CdCl2); Fertility; Histopathological changes; Serotonin; Sexual behaviour; SOD; TBARs; Testosterone

Indexed keywords

RATTUS; RATTUS NORVEGICUS;

EID: 79957802437     PISSN: 10978135     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (72)

1. Adaikpoh M. A. and Obi F. O. (2009): Prevention of cadmium-induced alteration in rat testes and prostate lipid patterns by tocopherol. African Journal of Biochemistry. Research Vol. 3 (10), pp. 321-325.
2. Aitken R.J. (1995): Free radicals, Lipid peroxidation and sperm function. Reprod. Fertil. Dev., 7, 659-668.
3. Amara S, Abdelmelek H, Garrel C, Guiraud P, Douki T, Ravanat J, Favier A, Sakly M, Rhounia KB (2008). Preventive effect of Zinc against cadmium-induced oxidative stress in rat testes. J. Reprod. Dev. 54(2): 129-134.
4. Antonio, M.T.; Benito, M.J.; Lerret, M.L.; Corpase, I. (1988): Gestational administration of cadmium alters the neurotransmitter levels in newborn rat brains. Journal of Applied Toxicology 18, 83-88.
5. Bancroft, J.D., Stevens, A., and Turner, D.R. (1996): Theory and Practice of Histological Techniques. 4th Ed. New York, Churchill, Livingstone.
6. Barbara zieliska-Psuja; Lukaszyk, A.; Senczuk, w. (2008): The anti-reproductive effects of long term oral administration of Cadmium on the adult male rat. International Journal of Andrology, (2) 150-161.
7. Batainch, H., Al-Hmood, M.H., Elbetieha, A.M. (1998); Assessment of aggression, sexual behaviour and fertility in adult male rat following long-term ingestion of four industrial metal salts. Hum Exp Toxicol; 17: 570-6.
8. Bearden J.H.; Fluquary J.W. (1980): Applied animals reproduction. Reston, VA: reston Publishers, p. 157-169.
9. Bench, G., Corzett, M.H., Martinelli, R., Balhorn, R. (1999): Cadmium concentrations in the testes, sperm and spermatids of mice subjected to long-term Cadmium chloride exposure. Cytometry 35: 30-36.
10. Benoff, S., Auborn, K., Marmar, L. J., Hurley, R. I. (2008): Link between low-dose environmentally relevant cadmium exposures and asthenozoospermia in a rat model. Fertil. Steril., Feb., 89, 2: 73-79.
11. Bermond B., Mos J., Meelis W. et al., (1982): Aggression induced by stimulation of the hypothalamus: effects of androgens. Pharmacology, Biochemistry and Behaviour 1982, 16: 145-155.
12. Beyersmann D., Hechtenberg S. (1997): Cadmium gene regulation and cellular signaling in mammalian cells. Toxicol Appl Pharmacol. (1997): 144: 247-261.
13. Bull, S. (2010): Cadmium; Toxicological Overview CHAPD HQ HPA-version: page, 1-15.
14. Cagiano, R., Ancona, D., Cassano, T., Tattoli, M., Trabace, L., Cuomo, V. (1998): Effects of prenatal exposure to low concentrations of carbon monoxide on sexual behaviour and mesolimbic dopaminergic function in rat offspring. British Journal of Pharmacology, 125, 909-915.
15. 1A receptor in aggressive and non-aggressive mice: An across-strain comparison. Physiology & Behaviour, volume 90, 4, 590-601.
16. Casalino E., Calzaretti G., Sblano C., Landriscina C. (2002): Molecular inhibitory mechanisms of antioxidant enzymes in rat liver and kidney by cadmium. Toxicology, (2002): 179: 37-50.
17. Clark, A. S. and Henderson, L.P. (2003): Behavioural and physiological responses to anabolic-androgenic steroids. Neurosci Biobehav Rev; 27: 413-36.
18. Dobashi M., Fujisawa M.; Yamazaki T., Okuda Y., Kanzaki M., Tatsumi N., Tsuji T., Okada H., Kamidono S. (2001): Inhibition of steroidogenesis in leydig cells by exogenous nitric oxide occurs independently of steroidogenic acute regulatory protein (Star) MRNA. Arch. Androl., 47, 203-209.
19. Edwards, S.P. (2005): The Amygdala: the body's alarm circuit. Brain work-The DANA foundation.
20. Ellis G.B., Desjardins C. (1982): Male rats secrete leutinizing hormone and testosterone episodically. Endocrinology 1982, 110: 1637-1648.
21. El-Missiry M.A. and Shalaby F., 2000): Role of the β-carotene in ameliorating the cadmium induced oxidative stress in rat brain and testis. Journal of Biochemical and Molecular Toxicology, volume 14, 5, 238-243.
22. Esterbauer H.; Cheeseman K.H. (1990): Determination of aldehydic lipid peroxidation products: malonal-dehyde and 4-hydroxynonenal. Methods Enzymol., 186, 407-421.
23. Fatma Gokce Uzun, Suna Kalender, Dilek Durak, Filiz Demir and Yusuf Kalender (2009): Malathion-induced testicular toxicity in male rats and the protective effect of vitamins C and E. Food and Chemical Toxicology, 47 (8): 1903-1908.
24. Fernandez-Guasti A, Escalante A L, Ahlenius S, Hillegaart V, Larsson K. (1992): Stimulation of 5-HT1B receptors in brain regions and its effects on male rat sexual behaviour. Eur J Pharmacol, 210: 121-9.
25. File, S.E., Kenny, P. J., Cheeta, S. (2000): The role of the dorsal hippocampal serotonergic and cholinergic system in the modulation of anxiety. Pharmacol Biochem Behav., 66: 65.
26. Giannopolitis C.N. and Ries S.K. (1977): Superoxide dismutase. I. Occurrence in higher plants. Plant Physiol., 59: 309-314.
27. Gunn, S.A., Gould, T. C., Anderson, W.A.D. (1970): Maintenance of the structure and function of the cauda epididymidis and contained spermatozoa by testosterone following cadmium-induced testicular necrosis in the rat. J. Reprod. Fert. 21, 443.
28. Ibrahim M. E.; Sameh A. Y. (2002): The Antagonistic Effect of Chlorpromazine on Cadmium Toxicity. Toxicology and Applied Pharmacology Volume 161, Issue 1, 15 November 2002, Pages 34-3,
29. Ismail A.A. (1986): The role of testosterone measurement in the investigation of androgen disorders. Ann. Clin. Biochem. (1986), 23: 113-134.
30. Jeremy L. A., John G.n., David M. A., Peter J.J. (2002): Testosterone rapidly reduces anxiety in male house mice (Mus musculus). Hormones and Behaviour, 42 4, 448-460.
31. John T. C; Braulio J; Stanely L. E; Roxanne, B.; Mary, W; James, J.M. (1994): Cadmium induced sexual dysfunction does not involve increased hepatic metabolism of testosterone nor increased circulating levels of corticosterone. Physiology & Behaviour, 56, 5, 975-981.
32. Kanbura M., Eraslan G., Silici S. (2009): Antioxidant effect of propolis against exposure to propetamphos in rats. Ecotoxical. Environ. Safety, 72, 900-915.
33. Kassandra L.E., Cheryl A.F. (2006): Intrahippocampal administration of an androgen receptor antagonist, flutamide, can increase anxiety-like behaviour in intact and DHT-replaced male rats. hormones and Behaviour, 50, 2, 216-222.
34. Kassandra L.E., Cheryl A.F. (2007): Sexual experience of male rats influences anxiety-like behaviour and androgen levels. Physiology and Behaviour, 92, 3, 443-453.
35. Katherine, S. (2001): The role of testosterone in aggression. MJM 6: 32-40.
36. Kierstin, P.G. (2003): Lactational transfer of cadmium in rodents-CNS effects in the offspring. Doctoral thesis-Swedish University of Agricultural Sciences-Uppsala.
37. Kim J.G. and parthasarathy S. (1998): Oxidation and the spermatozoa Semon. Reprod. Endocrinol., 16, 235-239.
38. King LM, Banks AW, George WJ (1999). Differences in Cadmium Transport to the Testis, Epididymis and Brain in Cd-sensitive and Resistant Murine Strains Pharmacol. Exp. Ther., 2: 825-830.
39. Kostic M.M., Ognjanovic B., Dimitrijevic S., Zikic R.V., Stajn A., Rosic G.L. (1993): Cadmium-induced changes of antioxidant and metyabolic status in red blood cells of rat: In vivo effects. Eur. J. Haematol., 51: 86-92.
40. Leret, M. L., Millan, J. A., Antonio, M.T. (2003): Perinatal exposure to lead and cadmium affects anxiety-like behaviour. Toxicology, 186: 125-30.
41. Lowry, C.A., Hale, M.W. (2010): Serotonin and the neurobiology of anxious states. In: The Behavioural Neurobiology of Serotonin, Muller CP, Jacobs BL (eds.). ISBN: 978-0-12-374634-4.
42. Maines, M.D. (1984): Characterization of hame oxygenase activity in leydig and sertoli cells of the rat testes: differential distribution of activity and response to cadmium. Biochemical pharmacology, 33, 1493-1502.
43. Marco, G.; Garden T.; Santo G.; Danlla, D.M. and Maurizio G. (2005): Testosterone and aggressiveness. Medical science monitor, 11, 4, 136-145.
44. Martelli A., Rousselet E., Dycke C., Bouron A., Moulis J.M. (2006): Cadmium toxicity in animal cells by interference with essential metals. Biochimie 2006; 88: 1807-1814.
45. Mas, M., Fumero, B., Gonzalez-Mora, J.L. (1995): Voltammetric and microdialysis monitoring of brain monoamine neurotransmitter release during sociosexual interactions. Behav Brain Res., 71: 69-79.
46. Melvyn, R. W. (1995): Nutritional influences on aggressive behaviour. Journal of orthomolecular Medicine. Vol. 7, No. 1.
47. Miller F.P.; Cox jr R. H.; Snodgrass W.R. and Maickel R. P. (1970): Comparative effects of P. chloroamph rtamine and P-Chloro-Nmethylamphetamin e on rat brain Norepinephrine, serotonin and S-hydroxyindole-3-acetic acid. Biochm Pharmacol 19 (2), pp 435-442.
48. Miller P.G.; Pass N.P. (1952): «Manual of infertility and artificial insemination in cattle». Biolliere Tindall and Cox, London, U.K., p. 29-35.
49. Moeller, F.G., Dougherty, A.C., Swann, A.C., Collins, D., Davis, C. M., Cherek, D.R. (1996): Tryptophan depletion and aggressive responding in healthy males Psychopharmacology (126): 97-103.
50. Murphy, V.A. (1997): Cadmium: Acute and chronic neurological disorders, In: Yasui M, Strong M, Ota K, Verity MA (Eds). Mineral and Metal Neurotoxicology, Boca Raton, FI: CRC press, pp. 229-24o.
51. Murugesan P., Muthusamy T., Balasubramanian K. and Arunakaran J. (2007): Effects of vitamins C and E on steroidogenic enzymes mRNA expression in polychlorinated biphenyl (Aroclor 1254) eposed adult rat leydig cells. Toxicology, 232, 170-182.
52. Nabil, A. K, Zeyad, E. A. (2005): Antiandrogenic activity of Ruta graveolens L in male Albino rats with emphasis on sexual and aggressive behaviour. Neuroendocrinology Letters; 26 (6): 823-829.
53. Neveen, T., Elbetieha, A., Darmani, H., Khamas, W. (2007): Effects of long term exposure to Cadmium chloride on fertility in adult male mice. Veterinary Research, 1(2): 40-48.
54. Ognjanovic B.I., Markovic S.D., Pavlovic S.Z., Zikic R.V., Stajn A.S., Saicic Z.S. (2008): Effect of chronic cadmium exposure on antioxidant defense system in some tissues of rats: Protective effect of selenium. Physiol. Res., 57: 403-411.
55. Okamura, A., Kamijima, M., Shibata, E., Ohtani, K., Takagi, K., Ueyama, J., Watanabe, y., Omura, M., Wang, H., Ichihara, G., Kondo, T., Nakajima, T. (2005): A comprehensive evaluation of the testicul ar toxicity of dichlorvos in Wistar rats. Toxicology, 213; 129-137.
56. Oluyemi Akinloye, Ayodele O. Arowojolu, Olayiwola B. Shittu and John I Anetor (2006): Cadmium toxicity: a possible cause of male infertility in Nigeria. Reproductive Biology, 6 (1): 17-30.
57. Pavlovic S.Z., Ognjanovic B.I., Stajn A.S., Zikic R.V., Saicic Z.S., Petrovic V.M. (2001): Antioxidant defense system in skeletal muscle of rats treated with cadmium. A possible protective role of coenzyme Q10. Jugoslav. Med. Biochem., 20: 229-235.
58. Piasek M., Laskey J.W. (1994): Acute cadmium exposure and ovarian steroidogenesis in cyclic and pregnant rats. Reprod. Toxicol., 8, 495-507.
59. Pier, F. F., Paola, P., Stefano, P. Rosa M.M. de Almedia, Klaus, A.M. (2005): Serotonin and aggressive behaviour in rodents and nonhuman primates: Predispositions and plasticity. European Journal of Pharmacology. 526, 259-273.
60. Rastogi, R.B.; Merali, z.; Singhal, R.L. (1977): Cadmium alters behaviour and the biosynthetic capacity for catecholamines and serotonin in neonatal brains. Journal of Neurochemistry, 28, 789-794.
61. Rosen, R. C., Lane, R.M., Menza, M. (1999): Effects of SSRIs on sexual function: a Critical review, J Clin Psychopharmacol, 19: 67-85.
62. Simpkins J., Kalra S., Kalra P. (1983): Variable effects of testosterone on dopamine activity in several microdissected regions in the preoptic area and medial basal hypothalamus. Endocrinology 1983, 112: 665-669.
63. SPSS (2006): SPSS for Windows 14.0.
64. Stajn A., Zikic R.V., Ognjanovic B., Saicic Z.S. Pavlovic V.M. (1997): Effect of cadmium and selenium on the antioxidant defense system in rat kidneys. Comp. Biochem. Physiol., 117 C: 167-172.
65. Thomas, J.A.; Brogan, C.P. (1983): Some actions of lead on the sperm and on the male reproductive system. Am. J. Ind. Med. 4: 127-134.
66. Trullas, R., Skolnick, P. (1993): Differences in fear motivated behaviours among inbred mouse strains. Psychopharmacology 111: 323-331.
67. Turner T.T., Lysiak J.L. (2008): Oxidative stress:a a common factor in testi cular dysfunction. J. Androl., 29, 488-498.
68. Waalkes, M.P.; Anver, M. R.; Diwan, B.A. (1999): Chronic toxic and carcinogenic effects of oral cadmium in the Noble (NBL./Cr): induction of neoplastic and proliferative lesions of the adrenal, kidney. Prostate and testes. J. Toxicol. Environ. Health A. 58, 199-214
69. Waisberg M., Josph P., Hale B., Beyersmann D. (2003): Molecular and cellular mechanisms of cadmium carcinogenesis: a review. Toxicology, 192: 95-117.
70. Zangen, A., Overstreet, D.H., Yaldid, G. (1999): Increased catecholamine levels in specific brain regions of a rat model of depression, normalization by chronic antidepressant treatment. Brain Res. 10, 824 (2) 243-50.
71. Zhang X. M.; Gu R-J.; Zhang Z-X.; Yin J-G; Chai J-K (1994): A rapid Flourophotometry for serum 5-hydroxytryptamine. Shanghai J Med Lab. Sci, pp 21-22.
72. Zikic R.V., Stajn A.S., Ognjanovic B.I. Saicic Z.S., Kostic M.M., Pavlovic S.Z., Petrovic V.M. (1998): The effect of cadmium and selenium on the antioxidant enzyme activities in rat heart. J. Environ Pathol. Toxicol. Oncol., 17: 259-264.