Antiandrogenic activity of Ruta graveolens L in male Albino rats with emphasis on sexual and aggressive behavior

Neuroendocrinology Letters

Volumn 26, Issue 6, 2005, Pages 823-829

  Khouri, Nabil Azar ^a   EL Akawi, Zeyad ^a  

^a JORDAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Jordan)

Author keywords

Behavior; Fertility; Male and female albino rats; Ruta graveolens L; Spermatogenesis

Indexed keywords

FOLLITROPIN; RUTA GRAVEOLENS EXTRACT; TESTOSTERONE;

AGGRESSION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL POPULATION; CONTROLLED STUDY; DRUG DOSE REGIMEN; DRUG MECHANISM; EJACULATION; EPIDIDYMIS TAIL; FETAL WELL BEING; GENITAL SYSTEM; HORMONE DETERMINATION; MALE; MALE FERTILITY; NIDATION; NONHUMAN; ORGAN WEIGHT; RAT; SEMINIFEROUS TUBULE; SEXUAL BEHAVIOR; SPERMATID; SPERMATOCYTE; SPERMATOGENESIS; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; TESTIS CELL; WEIGHT REDUCTION;

EID: 33644997884     PISSN: 0172780X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Aberrcrombie M. Estimation of nuclear population from mictome section. Anat Rec 1946; 94:238-248.
2. Agrawal S. Chauhan S. and Mathur R. Andrologia 1986; 18:125.
3. Bennetts HW, Underwood EJ, Shier FL. A specific breeding problem of sheep on subterranean clover pastures in westen Australia. Aust Vet J 1964; 22: 2-12.
4. Bharagava SK. Antifertility agent from plants. Fitoterapia 1988a; LIX 163-177.
5. Bataineh H, Al-Hamood MH, Elbetieha A. and Bani Hani I. Effect of long-term ingestion of chromium compounds on aggression, sex behavior and fertility in adult male rat. Drug and Chemical Toxicology 1997; 20:133-149.
6. Bataineh H, Al-Hamood MH and Elbetieha A. Assessment of aggression, sexual behavior and fertility in adult male rat following long-term ingestion of four industrial metals salts. Human & Experimental Toxicology 1998; 17:570-576.
7. Klint T and Larsson K. Clozapine acts as a 5-HT2 antagonist by attenuating DOI-induced inhibition of male rat sexual behavior. Psychopharmacology 1995; 119:291-294.
8. Bharagava SK. Antifertility effects of Sapindus trifoliatus I. Fruit extract in rats. Internal J Crude Drug Res 1988b; 26:229-233.
9. Choudhary A and Steinberger E. Effect of 5a-reduced androgen on sex accessory organs, initiation and maintenance of spermatogenesis in the rat. Biol Reprod 1975; 12:609-617.
10. Desta B. Ethiopian traditional herbal drugs: Part III. Antifertility activity of 70 medicinal plants. J Ethnopharmacol 1994; 44:199-209.
11. Dixon W and Massey FJ. Introduction of statistical analysis. McGRaw Hill Book Co. ubs. NewYork: 1957. pp. 228.
12. Dym MR, Raj HGM, Lin YC, Chemes HE, Kotitie NJ, Nayfeh SN. and French FS. Is FSH required for maintenance of spermatogenesis in adult rats? J Reprod Fertil 1979; 26(Supp I):175-181.
13. Elisabetsky E, Posey DA. Use of contraceptive and related plants by the Kayapo indians (Brazil ). J. Ethnopharmacol 1989; 26:299-316.
14. Fransworth NR, Bingle AS, Cordell GA, Grane FA. and Frong HHS. Potential value of plants as a source of new fertility agents. J Pharm sci 1975; 64: 535-598.
15. Ipstein J and Poly F. In: Banchroft's introduction to biostatics II Ed. (Harper international) 1970. pp. 44-64.
16. Ke YB and Tso WW. Variations of Gossypol susceptibility in rat spermatozoa during spermatogenesis. Int J Fert 1982; 27(l):42-46
17. Lohiya NK, Goyal RB, Jayaprakash D, Ansari AS, Sharma S. Antifertility effects of aqueous extract of Carica papaya seeds in male rats. Planta Medica 1994; 60:400-404.
18. Li P. Preliminary study on anti-implantation and anti-early fertility effect of Chinese herbal medicine. Herbal Leonuri up on mice. J of XI AN. 1988. pp. 317- 320.
19. Lynch JM, Raphel SS, Mellor LD, Spare PD. and Inwood MJH. Medical laboratory technology and clinical pathology. WB Saunders Company. Ig. Ku Shoin Ltd. Toky: 1969. pp. 626, 647,662.
20. Man T, Davies DV and Humphrey GF. Fructose and citric acid assay in the secretion of the accessory of glands of reproduction as indicator testes of male sex hormone activity. J Endocr 1949; 6:75-85.
21. Mann T, Ed. The biochemistry of semen and of the male reproductive tract. Metauen, London: 1964. pp. 239.
22. Noda Y, Natsuyama S, Moria T. Effect of traditional herbal medicines on cultured hamster epididymal cells. Jap J Fertil Steril 1993; 38:262-268.
23. Pakrashi A and Pakrashi PL. Antispermatogenic effect of the extract of Aristolocuia indica Linn. on male mice. Ind J Expt Bio 1977; 15:256-259.
24. Pakarashi A, Pakarashi P. Antifertility efficacy of the plant Aristolochi indica Linn on mouse. Contraception 1979; 20:49-54.
25. Petry R, Mauss J, Rausch-Stromann JG and Vermenten A. Reversible inhibition of spermatogenesis in men. Horm Metabol Res 1972; 4:386-388.
26. Prasad MRN, Singh SP and Rajalakshmi M. Fertility control in male rats by continuous release of microquantities of cyproterone acetate from subcutaneous silastic capsules. Contraception. 1970; 2:165-178.
27. Prasad MRN, Chinoy NJ, Chinoy NJ and Kadam KM. Changes in succinate dehydrogenase levels in the rat epididymis under normal and altered physiological condition. Fert Ster 1972; 23:186-190.
28. Prasad MRN, Rajalakshmi M, Gupta G. and Karkun T. Hormonal control of epididymal function. J Reprod Fertil (Suppl) 1973; 18:215-222.
29. Purohit A and Daradka HMM. Antiandrogenic efficacy of Curcuma longa (50%EtOH exttract) with special emphasis on testicular cell population dynamics. Indian Drugs 1999; 36:142 - 143.
30. Ramanadham S, Paulette D and Thomos E. Effect of insulin replacement on SZ. Induced effect in the rat heart. Life Sciences 1983; 33:289-296.
31. Rajalakshmi M and Prasad MRN. Changes in sialic acid in testes and epididymis of rats during onset of puberty. J Endocr 1969; 44: 379-385.
32. Rajalakshmi M, Reddy PRK and Prasad MRN. Distribution of fructose, citric acid, sialic acid and lipids in male accessory glands of the hamstar Mesocricebus auratus. J Endocr 1973; 58: 349-350.
33. Rugh R. The mouse,its reproduction and development.Burgess, Minneapolis: 1968.
34. Sethi N, Nath D, Snigh RK, Srivastava RK. Antifertility and teratogenic activity of some indigenous medicinal plants in rats. Fitoterapia 1990; LXI:64-66.
35. Sinha R. Post-testicular antifertility effects of Abrus precatorius seed of extractin albino rats. J Ethnopharmacol 1990; 28:173-181
36. Usuki S. Blended effects of herbal components of Tokishakuyakusan on rat corpus luteum function in vivo. Am J Hin Med 1988; 16(3-4):107-16.
37. Ushiroyama T, Tsubokura S, Saeki M, Okuda K, Kaneko T, Veki M, Gimoto O. Endocrinologic studies of Unkei-to (TJ-106) in young females with weight loss amenorrhea with an effect on pulsatile secretion of gonadotropins. Jap J Fertil Steril 1991; 36: pp. 61-65.
38. Warren Ch, Hiyari F, Wingo PhA, Abdel-aziz AM and Morris L. Fertility and family planning in Jordan: Results from the 1985 Jordan Husband's Fertility survey studies in family planning. 1990; 21, 1:33-39.
39. WHO. Protocol MB50 A method for examining the effect of plant extracts adminsitration orally on the fertility of male rats. 1983.