Lipophilicity of acidic compounds: Impact of ion pair partitioning on drug design

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 12, 2011, Pages 3550-3556

  Wenlock, Mark C ^a   Barton, Patrick ^a   Luker, Tim ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Acidic compounds; Distribution coefficient; Drug design; Ion pair partitioning; Log D 5.5

Indexed keywords

[2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; ACETOHEXAMIDE; ACID; BENAZEPRIL; BUMETANIDE; CERIVASTATIN; CHLORAMBUCIL; ENALAPRIL; ETODOLAC; FUROSEMIDE; GLIBENCLAMIDE; GLIPIZIDE; INDOMETACIN; IRBESARTAN; KETOROLAC; LOSARTAN; OXAPROZIN; PIROXICAM; RAMATROBAN; RAMIPRIL; REPAGLINIDE; SULFAMETHIZOLE; TOLAZAMIDE; TOLMETIN;

ACIDITY; ARTICLE; CHEMICAL PROCEDURES; DATA ANALYSIS; DRUG DESIGN; DRUG SOLUBILITY; ION PAIR PARTITIONING; LIPOPHILICITY; MATHEMATICAL MODEL; PH; RISK FACTOR;

ACIDS; ALBUMINS; DRUG DESIGN; HUMANS; HYDROGEN-ION CONCENTRATION; LIPIDS; MOLECULAR STRUCTURE; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING;

EID: 79957800770     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.04.133     Document Type: Article

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