Synthesis of isosteric selenium analog of the PPARβ/δ agonist GW501516 and comparison of biological activity

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 14, 2010, Pages 4050-4052

  Sharma, Arun K ^a   Sk, Ugir Hossain ^a   He, Pengfei ^b   Peters, Jeffrey M ^b   Amin, Shantu ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Agonist; Angiopoietin like protein 4; PPAR ; Selenium analog

Indexed keywords

2 METHYL 4 ((4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 1,3 SELENAZOL 5 YL)METHYLSULFANYL)PHENOXY ACETIC ACID; [2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; ANGIOPOIETIN; ANTINEOPLASTIC AGENT; SELENIUM DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG ACTIVATION; DRUG STRUCTURE; DRUG SYNTHESIS; GENE EXPRESSION; HUMAN; HUMAN CELL; KERATINOCYTE;

CELL LINE; CELL PROLIFERATION; GENE EXPRESSION; HUMANS; KERATINOCYTES; PPAR DELTA; PPAR-BETA; SELENIUM; THIAZOLES;

EID: 77954082797     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.05.094     Document Type: Article

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