Activation and modulation of human α4β2 nicotinic acetylcholine receptors by the neonicotinoids clothianidin and imidacloprid

Journal of Neuroscience Research

Volumn 89, Issue 8, 2011, Pages 1295-1301

  Li, Ping ^a   Ann, Jason ^a   Akk, Gustav ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Insecticide; Neonicotinoid; Nicotinic receptor

Indexed keywords

ACETYLCHOLINE; CLOTHIANIDIN; IMIDACLOPRID; INSECTICIDE; NICOTINIC RECEPTOR ALPHA4BETA2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTRIC CURRENT; HUMAN; HUMAN CELL; MODULATION; NONHUMAN; PRIORITY JOURNAL; STOICHIOMETRY;

CHOLINERGIC AGENTS; ELECTROPHYSIOLOGICAL PHENOMENA; GUANIDINES; HEK293 CELLS; HUMANS; IMIDAZOLES; NEURONS; NITRO COMPOUNDS; RECEPTORS, NICOTINIC; THIAZOLES;

EID: 79957797668     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22644     Document Type: Article

References (28)

1. Akk G, Milescu LS, Heckmann M. 2005. Activation of heteroliganded mouse muscle nicotinic receptors. J Physiol 564: 359-376.
2. Brown LA, Ihara M, Buckingham SD, Matsuda K, Sattelle DB. 2006. Neonicotinoid insecticides display partial and super agonist actions on native insect nicotinic acetylcholine receptors. J Neurochem 99: 608-615.
3. Buisson B, Gopalakrishnan M, Arneric SP, Sullivan JP, Bertrand D. 1996. Human α4β2 neuronal nicotinic acetylcholine receptor in HEK 293 cells: a patch-clamp study. J Neurosci 16: 7880-7891.
4. Carbone AL, Moroni M, Groot-Kormelink PJ, Bermudez I. 2009. Pentameric concatenated (α4)(2)(β2)(3) and (α4)(3)(β2)(2) nicotinic acetylcholine receptors: subunit arrangement determines functional expression. Br J Pharmacol 156: 970-981.
5. Craig MS, Gupta RC, Candery TD, Britton DA. 2005. Human exposure to imidacloprid from dogs treated with Advantage®. Toxicol Mech Methods 15: 287-291.
6. Ihara M, Matsuda K, Otake M, Kuwamura M, Shimomura M, Komai K, Akamatsu M, Raymond V, Sattelle DB. 2003. Diverse actions of neonicotinoids on chicken α7, α4β2 and Drosophila-chicken SADβ2 and ALSβ2 hybrid nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes. Neuropharmacology 45: 33-144.
7. Ihara M, Matsuda K, Shimomura M, Sattelle DB, Komai K. 2004. Super agonist actions of clothianidin and related compounds on the SAD β2 nicotinic acetylcholine receptor expressed in Xenopus laevis oocytes. Biosci Biotechnol Biochem 68: 761-763.
8. Jeschke P, Nauen R. 2008. Neonicotinoids-from zero to hero in insecticide chemistry. Pest Manag Sci 64: 1084-1098.
9. Li P, Steinbach JH. 2010. The neuronal nicotinic α4β2 receptor has a high probability of being open. Br J Pharmacol 160: 1906-1915.
10. Liu Z, Williamson MS, Lansdell SJ, Han Z, Denholm I, Millar NS. 2006. A nicotinic acetylcholine receptor mutation (Y151S) causes reduced agonist potency to a range of neonicotinoid insecticides. J Neurochem 99: 1273-1281.
11. Matsuda K, Buckingham SD, Freeman JC, Squire MD, Baylis HA, Sattelle DB. 1998. Effects of the α subunit on imidacloprid sensitivity of recombinant nicotinic acetylcholine receptors. Br J Pharmacol 123: 518-524.
12. Matsuda K, Shimomura M, Ihara M, Akamatsu M, Sattelle DB. 2005. Neonicotinoids show selective and diverse actions on their nicotinic receptor targets: electrophysiology, molecular biology, and receptor modeling studies. Biosci Biotechnol Biochem 69: 1442-1452.
13. Moroni M, Zwart R, Sher E, Cassels BK, Bermudez I. 2006. α4β2 Nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine. Mol Pharmacol 70: 755-768.
14. Nagata K, Song JH, Shono T, Narahashi T. 1998. Modulation of the neuronal nicotinic acetylcholine receptor-channel by the nitromethylene heterocycle imidacloprid. J Pharmacol Exp Ther 285: 731-738.
15. Nelson ME, Kuryatov A, Choi CH, Zhou Y, Lindstrom J. 2003. Alternate stoichiometries of α4β2 nicotinic acetylcholine receptors. Mol Pharmacol 63: 332-341.
16. Nishiwaki H, Nakagawa Y, Kuwamura M, Sato K, Akamatsu M, Matsuda K, Komai K, Miyagawa H. 2003. Correlations of the electrophysiological activity of neonicotinoids with their binding and insecticidal activities. Pest Manag Sci 59: 1023-1030.
17. Proenca P, Teixeira H, Castanheira F, Pinheiro J, Monsanto PV, Marques EP, Vieira DN. 2005. Two fatal intoxication cases with imidacloprid: LC/MS analysis. Forensic Sci Int 153: 75-80.
18. Salgado VL, Saar R. 2004. Desensitizing and non-desensitizing subtypes of α-bungarotoxin-sensitive nicotinic acetylcholine receptors in cockroach neurons. J Insect Physiol 50: 867-879.
19. Shadnia S, Moghaddam HH. 2008. Fatal intoxication with imidacloprid insecticide. Am J Emerg Med 26: 631-634.
20. Sheets LP. 2001. Imidacloprid: a neonicotinoid insecticide. In: Kreiger R, editor. Handbook of pesticide toxicology, 2nd ed. New York: Academic Press. p 1123-1130.
21. Shimomura M, Okuda H, Matsuda K, Komai K, Akamatsu M, Sattelle DB. 2002. Effects of mutations of a glutamine residue in loop D of the α7 nicotinic acetylcholine receptor on agonist profiles for neonicotinoid insecticides and related ligands. Br J Pharmacol 137: 162-169.
22. Steinbach JH, Chen Q. 1995. Antagonist and partial agonist actions of d-tubocurarine at mammalian muscle acetylcholine receptors. J Neurosci 15: 230-240.
23. Tan J, Galligan JJ, Hollingworth RM. 2007. Agonist actions of neonicotinoids on nicotinic acetylcholine receptors expressed by cockroach neurons. Neurotoxicology 28: 829-842.
24. Tomizawa M, Casida JE. 2005. Neonicotinoid insecticide toxicology: mechanisms of selective action. Annu Rev Pharmacol Toxicol 45: 247-268.
25. Toshima K, Ihara M, Kanaoka S, Tarumoto K, Yamada A, Sattelle DB, Matsuda K. 2008. Potentiating and blocking actions of neonicotinoids on the response to acetylcholine of the neuronal α4β2 nicotinic acetylcholine receptor. J Pestic Sci 33: 146-151.
26. Toshima K, Kanaoka S, Yamada A, Tarumoto K, Akamatsu M, Sattelle DB, Matsuda K. 2009. Combined roles of loops C and D in the interactions of a neonicotinoid insecticide imidacloprid with the α4β2 nicotinic acetylcholine receptor. Neuropharmacology 56: 264-272.
27. Zhang J, Steinbach JH. 2003. Cytisine binds with similar affinity to nicotinic α4β2 receptors on the cell surface and in homogenates. Brain Res 959: 98-102.
28. Zwart R, Vijverberg HP. 2000. Potentiation and inhibition of neuronal α4β4 nicotinic acetylcholine receptors by choline. Eur J Pharmacol 393: 209-214.