Combined roles of loops C and D in the interactions of a neonicotinoid insecticide imidacloprid with the α4β2 nicotinic acetylcholine receptor

Neuropharmacology

Volumn 56, Issue 1, 2009, Pages 264-272

  Toshima, Kayoko ^a   Kanaoka, Satoshi ^b   Yamada, Atsushi ^a   Tarumoto, Kiyoshi ^a   Akamatsu, Miki ^b   Sattelle, David B ^c   Matsuda, Kazuhiko ^a  

^a KINKI UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Acetylcholine binding protein; Chicken 4 2 nicotinic receptor; Homology modeling; Imidacloprid; Ion channels; Ligand binding domain; Neonicotinoids; Nicotinic acetylcholine receptor

Indexed keywords

IMIDACLOPRID; ION CHANNEL; NICOTINIC RECEPTOR ALPHA4BETA2;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CHICKEN; COMPUTER MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; FEMALE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BINDING; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; XENOPUS LAEVIS;

ACETYLCHOLINE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; IMIDAZOLES; INSECTICIDES; MEMBRANE POTENTIALS; MICROINJECTIONS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; NITRO COMPOUNDS; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN STRUCTURE, QUATERNARY; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 58049108594     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2008.08.022     Document Type: Article

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