Effects of mutations of a glutamine residue in loop D of the α7 nicotinic acetylcholine receptor on agonist profiles for neonicotinoid insecticides and related ligands

British Journal of Pharmacology

Volumn 137, Issue 2, 2002, Pages 162-169

  Shimomura, Masaru ^a   Okuda, Hiroshi ^a   Matsuda, Kazuhiko ^a   Komai, Koichiro ^a   Akamatsu, Miki ^b   Sattelle, David B ^c  

^a KINKI UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Chicken 7 subunit; Desnitro imidacloprid; Imidacloprid; Loop D; Loop F; Neonicotinoid; Nicotinic acetylcholine receptor; Nitenpyram; Two electrode voltage clamp; Xenopus laevis oocyte

Indexed keywords

BINDING PROTEIN; CHOLINERGIC RECEPTOR; GLUTAMINE; IMIDACLOPRID; INSECTICIDE; NEONICOTINOID; NICOTINE; NICOTINIC RECEPTOR; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; LIGAND BINDING; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR SENSITIVITY; SITE DIRECTED MUTAGENESIS; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANIMALS; FEMALE; GLUTAMINE; IMIDAZOLES; INSECTICIDES; MUTAGENESIS, SITE-DIRECTED; NICOTINIC AGONISTS; PROTEIN SUBUNITS; PYRIDINES; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 0036739004     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704848     Document Type: Article

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