Comparative thermodynamic studies on substrate and product binding of O-Acetylserine Sulfhydrylase reveals two different ligand recognition modes

BMC Biochemistry

Volumn 12, Issue 1, 2011, Pages

  Banerjee, Shrijita ^a   Ekka, Mary K ^a   Kumaran, Sangaralingam ^a  

^a INSTITUTE OF MICROBIAL TECHNOLOGY   (India)

Author keywords

Enthalpy; Entropy; Fluorescence; Isothermal Titration Calorimetry; Ligand Binding

Indexed keywords

CYSTEINE; CYSTEINE SYNTHASE; METHIONINE; DRUG DERIVATIVE; LIGAND; O ACETYLSERINE; O-ACETYLSERINE; SERINE; SODIUM CHLORIDE;

ARTICLE; BINDING AFFINITY; ENTHALPY; ENTROPY; ENZYME BINDING; HAEMOPHILUS INFLUENZAE; LIGAND BINDING; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; SALMONELLA TYPHIMURIUM; TEMPERATURE; THERMODYNAMICS; CALORIMETRY; CHEMISTRY; ENZYMOLOGY; METABOLISM; METHODOLOGY; SPECTROFLUOROMETRY;

HAEMOPHILUS INFLUENZAE; MYCOBACTERIUM TUBERCULOSIS; SALMONELLA TYPHIMURIUM;

CALORIMETRY; CYSTEINE; CYSTEINE SYNTHASE; ENTROPY; HAEMOPHILUS INFLUENZAE; LIGANDS; METHIONINE; MYCOBACTERIUM TUBERCULOSIS; SALMONELLA TYPHIMURIUM; SERINE; SODIUM CHLORIDE; SPECTROMETRY, FLUORESCENCE; TEMPERATURE; THERMODYNAMICS;

EID: 79957793364     PISSN: None     EISSN: 14712091     Source Type: Journal    
DOI: 10.1186/1471-2091-12-31     Document Type: Article

References (36)

1. Purification and characterization of cysteine synthetase, a bifunctional protein complex, from Salmonella typhimurium. NM Kredich MA Becker GM Tomkins, J Biol Chem 1969 244 2428 2439 4977445
2. Initial kinetic characterization of the multienzyme complex, cysteine synthetase. PF Cook RT Wedding, Arch Biochem Biophys 1977 178 293 302 10.1016/0003-9861(77)90194-1 319757 (Pubitemid 8035442)
3. Assembly of the cysteine synthase complex and the regulatory role of protein-protein interactions. S Kumaran H Yi HB Krishnan JM Jez, J Biol Chem 2009 284 10268 10275 10.1074/jbc.M900154200 19213732
4. Structure and mechanism of O-acetylserine Sulfhydrylase. WM Rabeh PF Cook, J Biol Chem 2004 279 26803 26806 10.1074/jbc.R400001200 15073190 (Pubitemid 38812512)
5. Molecular basis of cysteine biosynthesis in plants: structural and functional analysis of O-acetylserine sulfhydrylase from Arabidopsis thaliana. ER Bonner RE Cahoon SM Knapke JM Jez, J Biol Chem 2005 280 38803 38813 10.1074/jbc.M505313200 16166087 (Pubitemid 43853783)
6. Kinetic mechanisms of the A and B isozymes of O-acetylserine sulfhydrylase from Salmonella typhimurium LT-2 using the natural and alternative reactants. CH Tai SR Nalabolu TM Jacobson DE Minter PF Cook, Biochemistry 1993 32 6433 6442 10.1021/bi00076a017 8518286 (Pubitemid 23208827)
7. Plant concepts for mineral acquisition and allocation. R Hell H Hillebrand, Curr Opin Biotech 2001 12 161 168 10.1016/S0958-1669(00)00193-2 11287231 (Pubitemid 32247402)
8. Sulfur metabolism in Escherichia coli and related bacteria: facts and fiction. A Sekowska HF Kung A Danchin, J Mol Microbiol Biotechnol 2000 2 145 177 10939241 (Pubitemid 30218817)
9. Biochemistry of sulfur-containing amino acids. AJ Cooper, Annu Rev Biochem 1983 53 187 222
10. Non replicating persistence of Mycobacterium tuberculosis. LG Wayne CD Schoskey, Annu Rev Microbiol 2001 55 139 163 10.1146/annurev.micro.55.1.139 11544352 (Pubitemid 32978103)
11. Functional genomics reveals the sole sulphate transporter of the Mycobacterium tuberculosis complex and its relevance to the acquisition of sulphur in vivo. E Wooff SL Michell SV Gordon MA Chambers S Bardarov WR Jacobs Jr RG Hewinson PR Wheeler, Mol Microbiol 2002 43 653 663 10.1046/j.1365-2958. 2002.02771.x 11929522 (Pubitemid 34597260)
12. L-Cysteine is required for induced antibiotic resistance in actively swarming S. enterica serovar typhimurium. AL Turbull MG Survette, Microbiology 2008 154 3410 3415 10.1099/mic.0.2008/020347-0 18957594
13. Design of O-acetyl serine sulfhydrylase inhibitors by mimicking nature. E Salsi AS Bayden F Spyrakis A Amadasi B Campanini S Bettati T Dodatko P Cozzini GE Kellogg PF Cook SL Roderick A Mozzarelli, J Med Chem 2010 53 345 356 10.1021/jm901325e 19928859
14. Three-dimensional structure of O-acetylserine sulfhydrylase from Salmonella typhimurium. P Burkhard GS Rao E Hohenester KD Schnackerz PF Cook JN Jansonius, J Mol Biol 1998 283 121 133 10.1006/jmbi.1998.2037 9761678 (Pubitemid 28466644)
15. Ligand binding induces a large conformational change in O-acetylserine sulfhydrylase from Salmonella typhimurium. P Burkhard CH Tai CM Ristroph PF Cook JN Jansonius, J Mol Biol 1999 291 941 953 10.1006/jmbi.1999.3002 10452898 (Pubitemid 29403622)
16. The active site of O-acetylserine sulfhydrylase is the anchor point for bienzyme complex formation with serine acetyltransferase. B Huang MW Vetting, J Bacteriol 2005 187 3201 3205 10.1128/JB.187.9.3201-3205.2005 15838047 (Pubitemid 40571613)
17. Identification and spectral characterization of the external aldimine of the O-acetylserine sulfhydrylase reaction. KD Schnackerz CH Tai JW Simmons TM Jacobson GS Rao PF Cook, Biochemistry 1995 34 12152 12160 10.1021/bi00038a008 7547955
18. Crystal structure of native O-acetyl-serine sulfhydrylase from Entamoeba histolytica and its complex with cysteine: structural evidence for cysteine binding and lack of interactions with serine acetyl transferase. K Chinthalapudi M Kumar S Kumar S Jain N Alam S Gourinath, Proteins; Struc Funct Bioinform 2008 72 1222 1232 10.1002/prot.22013 21644255
19. Structural insights into catalysis and inhibition of O-acetylserine sulfhydrylase from Mycobacterium tuberculosis: crystal structures of the enzyme -aminoacrylate intermediate and an enzyme-inhibitor complex. R Schnell W Oehlmann M Singh G Schneider, J Biol Chem 2007 282 23473 23481 10.1074/jbc.M703518200 17567578 (Pubitemid 47311931)
20. A reaction mechanism from steady state kinetic studies for O-acetylserine sulfhydrylase from Salmonella typhimurium LT-2. PF Cook RT Wedding, J Biol Chem 1976 251 2023 2029 773932
21. Overall mechanism and rate equation for O-acetylserine sulfhydrylase. PF Cook RT Wedding, J Biol Chem 1977 252 3459 863890 (Pubitemid 8113937)
22. Overcoming road blocks in lead optimization: A thermodynamic perpective. AJ Ruben Y Kiso E Frierie, Chem Biol Drug Design 2006 67 2 4 10.1111/j.1747-0285.2005.00314.x (Pubitemid 43881382)
23. Rapid measurement of binding constants and heats of binding using a new titration calorimeter. T Wiseman S Williston JF Brandts LN Lin, Anal Biochem 1989 179 131 137 10.1016/0003-2697(89)90213-3 2757186 (Pubitemid 19149635)
24. Interaction of serine acetyltransferase with O-acetylserine sulfhydrylase active site: Evidence from fluorescence spectroscopy. B Campanini F Speroni E Salsi PF Cook SL Roderick B Huang S Bettati A Mozzarelli, Protein Sci 2005 14 2115 2124 10.1110/ps.051492805 15987896 (Pubitemid 41132377)
25. Role of pyridoxal 5'-phosphate in the structural stabilization of O-acetylserine sulfhydrylase. S Bettati S Benci B Campanini S Raboni G Chirico S Beretta KD Schnackerz TL Hazlett E Gratton A Mozzarelli, J Biol Chem 2000 275 40244 40251 10.1074/jbc.M007015200 10995767 (Pubitemid 32064655)
26. A change in internal aldimine lysine (K42) in O-acetylserine sulfhydrylase to alanine indicates its importance in transimination and as a general base catalyst. VD Rege NM Kredich CH Tai WE Karsten KD Schnackerz PF Cook, Biochemistry 1996 35 13485 13495 10.1021/bi961517j 8873618
27. Formation of the -aminoacrylate intermediate limits the overall reaction catalyzed by O-acetyl serine sulfhydrylase. EU Woehl CH Tai MF Dunn PF Cook, Biochemistry 1996 35 4776 4783 10.1021/bi952938o 8664267 (Pubitemid 26126695)
28. Structure of the complex between a cap analogue and mRNA guanyl transferase demonstrates the structural chemistry of RNA-capping. K Hakansson DB Wigley, Proc Natl Acad Sci USA 1998 95 1505 1510 10.1073/pnas.95.4.1505 9465045 (Pubitemid 28103422)
29. TROSY-NMR studies of the 91 kDa protein reveal allosteric control of a gene regulatory protein by ligand-altered flexibility. C McElroy A Manfredo A Wendt P Gollnick M Foster, J Mol Biol 2002 323 463 473 10.1016/S0022-2836(02) 00940-3 12381302 (Pubitemid 35291050)
30. Contribution of ligand desolvation to binding thermodynamics in a ligand-protein interaction. N Shimokhina A Bronowska SW Homans, Angrew Chem Int Ed 2006 45 6374 6376 10.1002/anie.200602227 (Pubitemid 44483868)
31. Experimentally determined hydrophobicity scale for proteins at membrane interfaces. WC Wimley SH White, Nat Struct Biol 1996 10 842 848 (Pubitemid 26330634)
32. Rates of bimolecular substitution reaction. AJ Parker, Adv Phys Org Chem 1967 5 173 175
33. On the detection of multiple-binding modes of ligands to proteins from biological, structural, and modeling data. PJ Lewi M de Jonge F Daeyaert L Koymans M Vinkers J Heeres PA Janssen E Arnold K Das AD Clark Jr SH Hughes PL Boyer MP de Béthune R Pauwels K Andries M Kukla D Ludovici B De Corte R Kavash C Ho, J Comput Aided Mol Des 2003 17 129 134 10.1023/A:1025313705564 13677481 (Pubitemid 37062776)
34. Active site of -chymotrypsin activation by association-desolvation. SG Cohen VM Vaidya RM Schultz, Proc Natl Acad Sci USA 1970 66 249 256 10.1073/pnas.66.2.249 16591836
35. Interactions between serine acetyl tranferase and O-acetylserine (thiol) lyase in higher plants-structural and kinetic properties of the free enzyme and bound enzymes. M Droux ML Ruffet R Douce D Job, E J Biochem 1998 255 235 245 10.1046/j.1432-1327.1998.2550235.x (Pubitemid 28316858)
36. High levels of intracellular cysteine promote oxidative DNA damage by driving the fenton reaction. S Park JA Imlay, J Bactriol 2003 185 1942 1950 10.1128/JB.185.6.1942-1950.2003 (Pubitemid 36297894)