Changes in spinal cord expression of fractalkine and its receptor in a rat model of disc herniation by autologous nucleus pulposus

Spine

Volumn 36, Issue 12, 2011, Pages

  Park, Hea Woon ^a   Ahn, Sang Ho ^b,e   Kim, Su Jeong ^c   Seo, Jeong Min ^c   Cho, Yun Woo ^b   Jang, Sung Ho ^b   Hwang, Se Jin ^d   Kwak, So Young ^b  

^a Catholic University of Daegu   (South Korea)

^b Chungnam National University   (South Korea)

^c Yeungnam University   (South Korea)

^d Hanyang University   (South Korea)

^e Yeungnam University College of Medicine   (South Korea)

Author keywords

autologous nucleus pulposus; CX3CR1; fractalkine; lumbar disc herniation; microglia; neuropathic pain

Indexed keywords

CHEMOKINE RECEPTOR CX3CR1; FRACTALKINE; MESSENGER RNA;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; AUTOGRAFT; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE EXPRESSION; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISK HERNIA; MALE; MICROGLIA; NERVE CELL; NERVE ROOT; NEUROPATHIC PAIN; NONHUMAN; NUCLEUS PULPOSUS; PATHOPHYSIOLOGY; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SPINAL CORD; SPINAL CORD DORSAL HORN; SPINAL GANGLION; UPREGULATION;

ANIMALS; CHEMOKINE CX3CL1; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HYPERALGESIA; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DISPLACEMENT; LUMBAR VERTEBRAE; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOKINE; RECEPTORS, HIV; SPINAL CORD; TRANSPLANTATION, AUTOLOGOUS;

EID: 79957787573     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e3181ef610b     Document Type: Article

References (54)

1. Olmarker K, Rydevik B, Nordborg C Autologous nucleus pulpo-sus induces neurophysiologic and histologic changes in porcine cauda equina nerve roots. Spine (Phila Pa 1976) 1993; 18: 1425-32. (Pubitemid 23270905)
2. Goupille P, Mulleman D, Valat JP. Radiculopathy associated with disc herniation. Ann Rheum Dis 2006; 65: 141-3. (Pubitemid 43131984)
3. Mulleman D, Mammou S, Griffoul I, et al. Pathophysiology of disk-related sciatica. I.-Evidence supporting a chemical component. Joint Bone Spine 2006; 73: 151-8.
4. Olmarker K, Larsson K. Tumor necrosis factor alpha and nucleus-pulposus-induced nerve root injury. Spine (Phila Pa 1976) 1998; 23: 2538-44. (Pubitemid 29003527)
5. Specchia N, Pagnotta A, Toesca A, et al. Cytokines and growth factors in the protruded intervertebral disc of the lumbar spine. Eur Spine J 2002; 11: 145-51. (Pubitemid 34328117)
6. Ahn SH, Cho YW, Ahn MW, et al. mRNA expression of cytokines and chemokines in herniated lumbar intervertebral discs. Spine (Phila Pa 1976) 2002; 27: 911-7.
7. Cuellar JM, Montesano PX, Carstens E. Role of TNF-alpha in sen-sitization of nociceptive dorsal horn neurons induced by applica-tion of nucleus pulposus to L5 dorsal root ganglion in rats. Pain 2004; 110: 578-87. (Pubitemid 39036789)
8. Kallakuri S, Takebayashi T, Ozaktay AC, et al. The effects of epidural application of allografted nucleus pulposus in rats on cytokine expression, limb withdrawal and nerve root discharge. Eur Spine J 2005; 14: 956-64. (Pubitemid 41798046)
9. Colburn RW, Rickman AJ, DeLeo JA. The effect of site and type of nerve injury on spinal glial activation and neuropathic pain behavior. Exp Neurol 1999; 157: 289-304. (Pubitemid 29260737)
10. Hashizume H, DeLeo JA, Colburn RW, et al. Spinal glial activation and cytokine expression after lumbar root injury in the rat. Spine (Phila Pa 1976) 2000; 25: 1206-17. (Pubitemid 30322310)
11. Ledeboer A, Sloane EM, Milligan ED, et al. Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation. Pain 2005; 115: 71-83.
12. Marchand F, Perretti M, McMahon SB. Role of the immune system in chronic pain. Nat Rev Neurosci 2005; 6: 521-32. (Pubitemid 40942819)
13. McMahon SB, Cafferty WB, Marchand F. Immune and glial cell factors as pain mediators and modulators. Exp Neurol 2005; 192: 444-62. (Pubitemid 40341688)
14. Twining CM, Sloane EM, Schoeniger DK, et al. Activation of the spinal cord complement cascade might contribute to mechanical al-lodynia induced by three animal models of spinal sensitization. J Pain 2005; 6: 174-83. (Pubitemid 40365021)
15. Watkins LR, Milligan ED, Maier SF. Glial activation: a driving force for pathological pain. Trends Neurosci 2001; 24: 450-5. (Pubitemid 32695356)
16. Watkins LR, Maier SF. Glia: a novel drug discovery target for clini-cal pain. Nat Rev Drug Discov 2003; 2: 973-85. (Pubitemid 37540579)
17. Watkins LR, Milligan ED, Maier SF. Spinal cord glia: new players in pain. Pain 2001; 93: 201-5. (Pubitemid 32763176)
18. Milligan ED, Twining C, Chacur M, et al. Spinal glia and proin-flammatory cytokines mediate mirror-image neuropathic pain in rats. J Neurosci 2003; 23: 1026-40. (Pubitemid 36206195)
19. Abbadie C Chemokines, chemokine receptors and pain. Trends Immunol 2005; 26: 529-34.
20. Tsuda M, Inoue K, Salter MW. Neuropathic pain and spinal mi-croglia: a big problem from molecules in small glia. Trends Neuro-sci 2005; 28: 101-7. (Pubitemid 40178927)
21. Milligan ED, Zapata V, Chacur M, et al. Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilita-tion in rats. Eur J Neurosci 2004; 20: 2294-302. (Pubitemid 39472392)
22. Tanaka T, Minami M, Nakagawa T, et al. Enhanced production of monocyte chemoattractant protein-1 in the dorsal root ganglia in a rat model of neuropathic pain: possible involvement in the develop-ment of neuropathic pain. Neurosci Res 2004; 48: 463-9. (Pubitemid 38369344)
23. Lindia JA, McGowan E, Jochnowitz N, et al. Induction of CX3CL1 expression in astrocytes and CX3CR1 in microglia in the spinal cord of a rat model of neuropathic pain. J Pain 2005; 6: 434-8. (Pubitemid 40922694)
24. Verge GM, Milligan ED, Maier SF, et al. Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions. Eur J Neurosci 2004; 20: 1150-60. (Pubitemid 39233569)
25. Zhuang ZY, Kawasaki Y, Tan PH, et al. Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuro-pathic pain following nerve injury-induced cleavage of fractalkine. Brain Behav Immun 2007; 21: 642-51. (Pubitemid 46830963)
26. Johnston IN, Milligan ED, Wieseler-Frank J, et al. A role for pro-inflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal mor-phine. J Neurosci 2004; 24: 7353-65. (Pubitemid 39100704)
27. Milligan E, Zapata V, Schoeniger D, et al. An initial investiga-tion of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine. Eur J Neurosci 2005; 22: 2775-82. (Pubitemid 41811274)
28. Owolabi SA, Saab CY Fractalkine and minocycline alter neuronal activity in the spinal cord dorsal horn. FEBS Lett 2006; 580: 4306-10. (Pubitemid 44118244)
29. Ito T, Ohtori S, Inoue G, et al. Glial phosphorylated p38 MAP ki-nase mediates pain in a rat model of lumbar disc herniation and induces motor dysfunction in a rat model of lumbar spinal canal stenosis. Spine (Phila Pa 1976) 2007; 32: 159-67. (Pubitemid 46105802)
30. Hargreaves K, Dubner R, Brown F, et al. A new and sensitive meth-od for measuring thermal nociception in cutaneous hyperalgesia. Pain 1988; 32: 77-88.
31. Dirig DM, Salami A, Rathbun ML, et al. Characterization of vari-ables defining hindpaw withdrawal latency evoked by radiant ther-mal stimuli. J Neurosci Methods 1997; 76: 183-91. (Pubitemid 27428253)
32. Chaplan SR, Bach FW, Pogrel JW, et al. Quantitative assessment of tactile allodynia in the rat paw J Neurosci Methods 1994; 53: 55-63. (Pubitemid 24238751)
33. Imai Y, Kohsaka S. Intracellular signaling in M-CSF-induced mi-croglia activation: role of Iba1. Glia 2002; 40: 164-74. (Pubitemid 35337374)
34. Ito D, Tanaka K, Suzuki S, et al. Enhanced expression of Iba1, ion-ized calcium-binding adapter molecule 1, after transient focal cere-bral ischemia in rat brain. Stroke 2001; 32: 1208-15. (Pubitemid 32825812)
35. Obata H, Eisenach JC, Hussain H, et al. Spinal glial activation con-tributes to postoperative mechanical hypersensitivity in the rat. J Pain 2006; 7: 816-22. (Pubitemid 44636363)
36. Pekny M, Pekna M. Astrocyte intermediate filaments in CNS pa-thologies and regeneration. J Pathol 2004; 204: 428-37. (Pubitemid 39468154)
37. Hou SX, Tang JG, Chen HS, et al. Chronic inflammation and com-pression of the dorsal root contribute to sciatica induced by the intervertebral disc herniation in rats. Pain 2003; 105: 255-64.
38. Kawakami M, Tamaki T, Hayashi N, et al. Possible mechanism of painful radiculopathy in lumbar disc herniation. Clin Orthop Relat Res 1998: 241-51. (Pubitemid 28275409)
39. Omarker K, Myers RR. Pathogenesis of sciatic pain: role of herni-ated nucleus pulposus and deformation of spinal nerve root and dorsal root ganglion. Pain 1998; 78: 99-105. (Pubitemid 28517947)
40. Kim SH, Chung JM. An experimental model for peripheral neu-ropathy produced by segmental spinal nerve ligation in the rat Pain 1992; 50: 355-63.
41. Seltzer Z, Dubner R, Shir Y A novel behavioral model of neuro-pathic pain disorders produced in rats by partial sciatic nerve injury Pain 1990; 43: 205-18. (Pubitemid 20385185)
42. Zhang JM, Li H, Brull SJ. Perfusion of the mechanically compressed lumbar ganglion with lidocaine reduces mechanical hyperalgesia and allodynia in the rat J Neurophysiol 2000; 84: 798-805. (Pubitemid 30655602)
43. Koltzenburg M, Wall PD, McMahon SB. Does the right side know what the left is doing? Trends Neurosci 1999; 22: 122-7. (Pubitemid 29151805)
44. Hatashita S, Sekiguchi M, Kobayashi H, et al. Contralateral neu-ropathic pain and neuropathology in dorsal root ganglion and spi-nal cord following hemilateral nerve injury in rats. Spine (Phila Pa 1976) 2008; 33: 1344-51.
45. Sun S, Cao H, Han M, et al. New evidence for the involvement of spinal fractalkine receptor in pain facilitation and spinal glial acti-vation in rat model of monoarthritis. Pain 2007; 129: 64-75.
46. Igarashi T, Kikuchi S, Shubayev V, et al. 2000 Volvo Award win-ner in basic science studies: Exogenous tumor necrosis factor-alpha mimics nucleus pulposus-induced neuropathology. Molecular, his-tologic, and behavioral comparisons in rats. Spine (Phila Pa 1976) 2000; 25: 2975-80.
47. Kawakami M, Tamaki T, Weinstein JN, et al. Pathomechanism of pain-related behavior produced by allografts of intervertebral disc in the rat Spine (Phila Pa 1976) 1996; 21: 2101-7. (Pubitemid 26330595)
48. Ohtori S, Takahashi K, Aoki Y, et al. Spinal neural cyclooxygen-ase-2 mediates pain caused in a rat model of lumbar disk hernia-tion. J Pain 2004; 5: 385-91. (Pubitemid 39410107)
49. Rand N, Reichert F, Floman Y, et al. Murine nucleus pulposus-de-rived cells secrete interleukins-1-beta,-6, and-10 and granulocyte-macrophage colony-stimulating factor in cell culture. Spine (Phila Pa 1976) 1997; 22: 2598-601; discussion 602.
50. Takahashi H, Suguro T, Okazima Y, et al. Inflammatory cytokines in the herniated disc of the lumbar spine. Spine (Phila Pa 1976) 1996; 21: 218-24. (Pubitemid 26041220)
51. Obata K, Tsujino H, Yamanaka H, et al. Expression of neurotroph-ic factors in the dorsal root ganglion in a rat model of lumbar disc herniation. Pain 2002; 99: 121-32. (Pubitemid 35251869)
52. Onda A, Murata Y, Rydevik B, et al. Nerve growth factor content in dorsal root ganglion as related to changes in pain behavior in a rat model of experimental lumbar disc herniation. Spine (Phila Pa 1976) 2005; 30: 188-93. (Pubitemid 40348207)
53. Clark AK, Yip PK, Grist J, et al. Inhibition of spinal microglial ca-thepsin S for the reversal of neuropathic pain. Proc Natl Acad Sci USA 2007; 104: 10655-60. (Pubitemid 47185720)
54. Clark AK, Yip PK, Malcangio M. The liberation of fractalkine in the dorsal horn requires microglial cathepsin S. J Neurosci 2009; 29: 6945-54.