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Volumn 436, Issue 3, 2011, Pages 651-660

5-HT2A receptor signalling through phospholipase D1 associated with its C-terminal tail

Author keywords

5 hydroxytryptamine 2A (5 HT2A) receptor; ADP ribosylation factor (ARF); Co immunoprecipitation; Glutathione transferase (GST) fusion protein; Phospholipase D (PLD); Schizophrenia; Signalling complex

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR; G PROTEIN COUPLED RECEPTOR; GLUTATHIONE TRANSFERASE; GLYCOSYLPHOSPHATIDYLINOSITOL PHOSPHOLIPASE D; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; HYBRID PROTEIN; PHOSPHOLIPASE D1; SEROTONIN 2A RECEPTOR; PHOSPHOLIPASE D;

EID: 79957770499     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20101844     Document Type: Article
Times cited : (16)

References (49)
  • 1
    • 0037374767 scopus 로고    scopus 로고
    • The cortical serotonin2A receptor and the pathology of schizophrenia: A likely accomplice
    • Dean, B. (2003) The cortical serotonin2A receptor and the pathology of schizophrenia: a likely accomplice. J. Neurochem. 85, 1-13
    • (2003) J. Neurochem. , vol.85 , pp. 1-13
    • Dean, B.1
  • 3
    • 0031595265 scopus 로고    scopus 로고
    • 5-Hydroxytryptamine2- family receptors (5-hydroxytryptamine2A, 5-hydroxytryptamine2B, 5-hydroxytryptamine2C): Where structure meets function
    • Roth, B. L., Willins, D. L., Kristiansen, K. and Kroeze, W. K. (1998) 5-Hydroxytryptamine2- family receptors (5-hydroxytryptamine2A, 5-hydroxytryptamine2B, 5-hydroxytryptamine2C): where structure meets function. Pharmacol. Ther. 79, 231-257
    • (1998) Pharmacol. Ther. , vol.79 , pp. 231-257
    • Roth, B.L.1    Willins, D.L.2    Kristiansen, K.3    Kroeze, W.K.4
  • 5
    • 0032748866 scopus 로고    scopus 로고
    • Mechanisms of 5-hydroxytryptamine(2A) receptor activation of the mitogen-activated protein kinase pathway in vascular smooth muscle
    • Banes, A., Florian, J. A. and Watts, S. W. (1999) Mechanisms of 5-hydroxytryptamine(2A) receptor activation of the mitogen-activated protein kinase pathway in vascular smooth muscle. J. Pharmacol. Exp. Ther. 291, 1179-1187
    • (1999) J. Pharmacol. Exp. Ther. , vol.291 , pp. 1179-1187
    • Banes, A.1    Florian, J.A.2    Watts, S.W.3
  • 6
    • 0036827963 scopus 로고    scopus 로고
    • Activation of extracellular-regulated kinase by 5-hydroxytryptamine(2A) receptors in PC12 cells is protein kinase C-independent and requires calmodulin and tyrosine kinases
    • Quinn, J. C., Johnson-Farley, N. N., Yoon, J. and Cowen, D. S. (2002) Activation of extracellular-regulated kinase by 5-hydroxytryptamine(2A) receptors in PC12 cells is protein kinase C-independent and requires calmodulin and tyrosine kinases. J. Pharmacol. Exp. Ther. 303, 746-752
    • (2002) J. Pharmacol. Exp. Ther. , vol.303 , pp. 746-752
    • Quinn, J.C.1    Johnson-Farley, N.N.2    Yoon, J.3    Cowen, D.S.4
  • 7
    • 33746328093 scopus 로고    scopus 로고
    • 5-HT2A receptor induces ERK phosphorylation and proliferation through ADAM-17 tumor necrosis factor-α-converting enzyme (TACE) activation and heparin-bound epidermal growth factor-like growth factor (HB-EGF) shedding in mesangial cells
    • Gooz, M., Gooz, P., Luttrell, L. M. and Raymond, J. R. (2006) 5-HT2A receptor induces ERK phosphorylation and proliferation through ADAM-17 tumor necrosis factor-α-converting enzyme (TACE) activation and heparin-bound epidermal growth factor-like growth factor (HB-EGF) shedding in mesangial cells. J. Biol. Chem. 281, 21004-21012
    • (2006) J. Biol. Chem. , vol.281 , pp. 21004-21012
    • Gooz, M.1    Gooz, P.2    Luttrell, L.M.3    Raymond, J.R.4
  • 8
    • 38949210817 scopus 로고    scopus 로고
    • Agonist-directed signaling of the serotonin 2A receptor depends on β-arrestin-2 interactions in vivo
    • Schmid, C. L., Raehal, K. M. and Bohn, L. M. (2008) Agonist-directed signaling of the serotonin 2A receptor depends on β-arrestin-2 interactions in vivo. Proc. Natl. Acad. Sci. U.S.A. 105, 1079-1084
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 1079-1084
    • Schmid, C.L.1    Raehal, K.M.2    Bohn, L.M.3
  • 9
    • 0031815337 scopus 로고    scopus 로고
    • Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: Evidence for agonist-directed trafficking of receptor stimulus
    • Berg, K. A., Maayani, S., Goldfarb, J., Scaramellini, C., Leff, P. and Clarke, W. P. (1998) Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: evidence for agonist-directed trafficking of receptor stimulus. Mol. Pharmacol. 54, 94-104
    • (1998) Mol. Pharmacol. , vol.54 , pp. 94-104
    • Berg, K.A.1    Maayani, S.2    Goldfarb, J.3    Scaramellini, C.4    Leff, P.5    Clarke, W.P.6
  • 10
    • 0042731683 scopus 로고    scopus 로고
    • A complex signaling cascade links the serotonin2A receptor to phospholipase A2 activation: The involvement of MAP kinases
    • Kurrasch-Orbaugh, D. M., Parrish, J. C., Watts, V. J. and Nichols, D. E. (2003) A complex signaling cascade links the serotonin2A receptor to phospholipase A2 activation: the involvement of MAP kinases. J. Neurochem. 86, 980-991
    • (2003) J. Neurochem. , vol.86 , pp. 980-991
    • Kurrasch-Orbaugh, D.M.1    Parrish, J.C.2    Watts, V.J.3    Nichols, D.E.4
  • 11
    • 0030902977 scopus 로고    scopus 로고
    • Identification and localization of a skeletal muscle serotonin 5-HT2A receptor coupled to the Jak/STAT pathway
    • Guillet-Deniau, I., Burnol, A. F. and Girard, J. (1997) Identification and localization of a skeletal muscle serotonin 5-HT2A receptor coupled to the Jak/STAT pathway. J. Biol. Chem. 272, 14825-14829
    • (1997) J. Biol. Chem. , vol.272 , pp. 14825-14829
    • Guillet-Deniau, I.1    Burnol, A.F.2    Girard, J.3
  • 12
    • 13244273871 scopus 로고    scopus 로고
    • 7A receptors in PC12 cells
    • DOI 10.1111/j.1471-4159.2004.02832.x
    • Johnson-Farley, N. N., Kertesy, S. B., Dubyak, G. R. and Cowen, D. S. (2005) Enhanced activation of Akt and extracellular-regulated kinase pathways by simultaneous occupancy of Gq-coupled 5-HT2A receptors and Gs-coupled 5-HT7A receptors in PC12 cells. J. Neurochem. 92, 72-82 (Pubitemid 40193510)
    • (2005) Journal of Neurochemistry , vol.92 , Issue.1 , pp. 72-82
    • Johnson-Farley, N.N.1    Kertesy, S.B.2    Dubyak, G.R.3    Cowen, D.S.4
  • 13
    • 66749118877 scopus 로고    scopus 로고
    • PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors
    • Abbas, A. I., Yadav, P. N., Yao, W. D., Arbuckle, M. I., Grant, S. G., Caron, M. G. and Roth, B. L. (2009) PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors. J. Neurosci. 29, 7124-7136
    • (2009) J. Neurosci. , vol.29 , pp. 7124-7136
    • Abbas, A.I.1    Yadav, P.N.2    Yao, W.D.3    Arbuckle, M.I.4    Grant, S.G.5    Caron, M.G.6    Roth, B.L.7
  • 15
  • 16
    • 33747073874 scopus 로고    scopus 로고
    • 2A receptor in determining selective interaction with isoforms of ADP-Ribosylation Factor (ARF)
    • DOI 10.1016/j.cellsig.2006.02.002, PII S0898656806000349
    • Johnson, M. S., Robertson, D. N., Holland, P. J., Lutz, E. M. and Mitchell, R. (2006) Role of the conserved NPxxY motif of the 5-HT2A receptor in determining selective interaction with isoforms of ADP-ribosylation factor (ARF). Cell. Signalling 18, 1793-1800 (Pubitemid 44216132)
    • (2006) Cellular Signalling , vol.18 , Issue.10 , pp. 1793-1800
    • Johnson, M.S.1    Robertson, D.N.2    Holland, P.J.3    Lutz, E.M.4    Mitchell, R.5
  • 17
    • 0037215643 scopus 로고    scopus 로고
    • Serotonin 5-hydroxytryptamine 2A receptor-coupled phospholipase C and phospholipase A2 signaling pathways have different receptor reserves
    • Kurrasch-Orbaugh, D. M., Watts, V. J., Barker, E. L. and Nichols, D. E. (2003) Serotonin 5-hydroxytryptamine 2A receptor-coupled phospholipase C and phospholipase A2 signaling pathways have different receptor reserves. J. Pharmacol. Exp. Ther. 304, 229-237
    • (2003) J. Pharmacol. Exp. Ther. , vol.304 , pp. 229-237
    • Kurrasch-Orbaugh, D.M.1    Watts, V.J.2    Barker, E.L.3    Nichols, D.E.4
  • 18
    • 34248583550 scopus 로고    scopus 로고
    • Functional selectivity of hallucinogenic phenethylamine and phenylisopropylamine derivatives at human 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors
    • Moya, P. R., Berg, K. A., Gutierrez-Hernandez, M. A., Saez-Briones, P., Reyes-Parada, M., Cassels, B. K. and Clarke, W. P. (2007) Functional selectivity of hallucinogenic phenethylamine and phenylisopropylamine derivatives at human 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors. J. Pharmacol. Exp. Ther. 321, 1054-1061
    • (2007) J. Pharmacol. Exp. Ther. , vol.321 , pp. 1054-1061
    • Moya, P.R.1    Berg, K.A.2    Gutierrez-Hernandez, M.A.3    Saez-Briones, P.4    Reyes-Parada, M.5    Cassels, B.K.6    Clarke, W.P.7
  • 19
    • 0032557573 scopus 로고    scopus 로고
    • ADP-ribosylation factor and Rho proteins mediate fMLP-dependent activation of phospholipase D in human neutrophils
    • Fensome, A., Whatmore, J., Morgan, C., Jones, D. and Cockcroft, S. (1998) ADP-ribosylation factor and Rho proteins mediate fMLP-dependent activation of phospholipase D in human neutrophils. J. Biol. Chem. 273, 13157-13164
    • (1998) J. Biol. Chem. , vol.273 , pp. 13157-13164
    • Fensome, A.1    Whatmore, J.2    Morgan, C.3    Jones, D.4    Cockcroft, S.5
  • 20
    • 0034456319 scopus 로고    scopus 로고
    • The activation of phospholipase D by endothelin-1, angiotensin II, and platelet-derived growth factor in vascular smooth muscle A10 cells is mediated by small G proteins of the ADP-ribosylation factor family
    • DOI 10.1210/en.141.6.2200
    • Shome, K., Rizzo, M. A., Vasudevan, C., Andresen, B. and Romero, G. (2000) The activation of phospholipase D by endothelin-1, angiotensin II, and platelet-derived growth factor in vascular smooth muscle A10 cells is mediated by small G proteins of the ADP-ribosylation factor family. Endocrinology 141, 2200-2208 (Pubitemid 32274374)
    • (2000) Endocrinology , vol.141 , Issue.6 , pp. 2200-2208
    • Shome, K.1    Rizzo, M.A.2    Vasudevan, C.3    Andresen, B.4    Romero, G.5
  • 21
    • 0034992440 scopus 로고    scopus 로고
    • ADP-ribosylation factor-dependent phospholipase D activation by VPAC receptors and a PAC(1) receptor splice variant
    • McCulloch, D. A., Lutz, E. M., Johnson, M. S., Robertson, D. N., MacKenzie, C. J., Holland, P. J. and Mitchell, R. (2001) ADP-ribosylation factor-dependent phospholipase D activation by VPAC receptors and a PAC(1) receptor splice variant. Mol. Pharmacol. 59, 1523-1532
    • (2001) Mol. Pharmacol. , vol.59 , pp. 1523-1532
    • McCulloch, D.A.1    Lutz, E.M.2    Johnson, M.S.3    Robertson, D.N.4    MacKenzie, C.J.5    Holland, P.J.6    Mitchell, R.7
  • 22
    • 0034307486 scopus 로고    scopus 로고
    • G-protein-independent signaling by G-protein-coupled receptors
    • Heuss, C. and Gerber, U. (2000) G-protein-independent signaling by G-protein-coupled receptors. Trends Neurosci. 23, 469-475
    • (2000) Trends Neurosci. , vol.23 , pp. 469-475
    • Heuss, C.1    Gerber, U.2
  • 23
    • 27644477496 scopus 로고    scopus 로고
    • When 7 transmembrane receptors are not G protein-coupled receptors
    • Rajagopal, K., Lefkowitz, R. J. and Rockman, H. A. (2005) When 7 transmembrane receptors are not G protein-coupled receptors. J. Clin. Invest. 115, 2971-2974
    • (2005) J. Clin. Invest. , vol.115 , pp. 2971-2974
    • Rajagopal, K.1    Lefkowitz, R.J.2    Rockman, H.A.3
  • 24
    • 36148944785 scopus 로고    scopus 로고
    • When a G protein-coupled receptor does not couple to a G protein
    • Sun, Y., McGarrigle, D. and Huang, X. Y. (2007) When a G protein-coupled receptor does not couple to a G protein. Mol. Biosyst. 3, 849-854
    • (2007) Mol. Biosyst. , vol.3 , pp. 849-854
    • Sun, Y.1    McGarrigle, D.2    Huang, X.Y.3
  • 25
    • 0038322031 scopus 로고    scopus 로고
    • ADP-ribosylation factor-dependent phospholipase D2 activation is required for agonist-induced mu-opioid receptor endocytosis
    • Koch, T., Brandenburg, L. O., Schulz, S., Liang, Y., Klein, J. and Hollt, V. (2003) ADP-ribosylation factor-dependent phospholipase D2 activation is required for agonist-induced mu-opioid receptor endocytosis. J. Biol. Chem. 278, 9979-9985
    • (2003) J. Biol. Chem. , vol.278 , pp. 9979-9985
    • Koch, T.1    Brandenburg, L.O.2    Schulz, S.3    Liang, Y.4    Klein, J.5    Hollt, V.6
  • 26
    • 5444265165 scopus 로고    scopus 로고
    • Ral and phospholipase D2-dependent pathway for constitutive metabotropic glutamate receptor endocytosis
    • DOI 10.1523/JNEUROSCI.3155-04.2004
    • Bhattacharya, M., Babwah, A. V., Godin, C., Anborgh, P. H., Dale, L. B., Poulter, M. O. and Ferguson, S. S. (2004) Ral and phospholipase D2-dependent pathway for constitutive metabotropic glutamate receptor endocytosis. J. Neurosci. 24, 8752-8761 (Pubitemid 39362970)
    • (2004) Journal of Neuroscience , vol.24 , Issue.40 , pp. 8752-8761
    • Bhattacharya, M.1    Babwah, A.V.2    Godin, C.3    Anborgh, P.H.4    Dale, L.B.5    Poulter, M.O.6    Ferguson, S.S.G.7
  • 27
    • 0033635117 scopus 로고    scopus 로고
    • Dual requirement for rho and protein kinase C in direct activation of phospholipase D1 through G protein-coupled receptor signaling
    • Du, G., Altshuller, Y. M., Kim, Y., Han, J. M., Ryu, S. H., Morris, A. J. and Frohman, M. A. (2000) Dual requirement for rho and protein kinase C in direct activation of phospholipase D1 through G protein-coupled receptor signaling. Mol. Biol. Cell 11, 4359-4368
    • (2000) Mol. Biol. Cell , vol.11 , pp. 4359-4368
    • Du, G.1    Altshuller, Y.M.2    Kim, Y.3    Han, J.M.4    Ryu, S.H.5    Morris, A.J.6    Frohman, M.A.7
  • 28
    • 0034614655 scopus 로고    scopus 로고
    • Inhibition of subsets of G protein-coupled receptors by empty mutants of G protein α subunits in Go, G11, and G16
    • Yu, B., Gu, L. and Simon, M. I. (2000) Inhibition of subsets of G protein-coupled receptors by empty mutants of G protein α subunits in Go, G11, and G16. J. Biol. Chem. 275, 71-76
    • (2000) J. Biol. Chem. , vol.275 , pp. 71-76
    • Yu, B.1    Gu, L.2    Simon, M.I.3
  • 29
    • 0030902426 scopus 로고    scopus 로고
    • Ontogenetic and pharmacological studies on metabotropic glutamate receptors coupled to phospholipase D activation
    • DOI 10.1016/S0028-3908(97)00024-5, PII S0028390897000245
    • Klein, J., Iovino, M., Vakil, M., Shinozaki, H. and Loffelholz, K. (1997) Ontogenetic and pharmacological studies on metabotropic glutamate receptors coupled to phospholipase D activation. Neuropharmacology 36, 305-311 (Pubitemid 27198690)
    • (1997) Neuropharmacology , vol.36 , Issue.3 , pp. 305-311
    • Klein, J.1    Iovino, M.2    Vakil, M.3    Shinozaki, H.4    Loffelholz, K.5
  • 30
    • 0018078266 scopus 로고
    • Is GABA release modulated by presynaptic receptors?
    • Mitchell, P. R. and Martin, I. L. (1978) Is GABA release modulated by presynaptic receptors? Nature 274, 904-905
    • (1978) Nature , vol.274 , pp. 904-905
    • Mitchell, P.R.1    Martin, I.L.2
  • 31
    • 0141668939 scopus 로고    scopus 로고
    • ADP-ribosylation factor-dependent phospholipase D activation by the M3 muscarinic receptor
    • Mitchell, R., Robertson, D. N., Holland, P. J., Collins, D., Lutz, E. M. and Johnson, M. S. (2003) ADP-ribosylation factor-dependent phospholipase D activation by the M3 muscarinic receptor. J. Biol. Chem. 278, 33818-33830
    • (2003) J. Biol. Chem. , vol.278 , pp. 33818-33830
    • Mitchell, R.1    Robertson, D.N.2    Holland, P.J.3    Collins, D.4    Lutz, E.M.5    Johnson, M.S.6
  • 33
    • 0028971907 scopus 로고
    • DOI, a 5-HT2A/2C receptor agonist, potentiates amphetamine-induced dopamine release in rat striatum
    • Ichikawa, J. and Meltzer, H. Y. (1995) DOI, a 5-HT2A/2C receptor agonist, potentiates amphetamine-induced dopamine release in rat striatum. Brain Res. 698, 204-208
    • (1995) Brain Res. , vol.698 , pp. 204-208
    • Ichikawa, J.1    Meltzer, H.Y.2
  • 34
    • 30944443357 scopus 로고    scopus 로고
    • Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex
    • DOI 10.1038/sj.npp.1300819, PII 1300819
    • Pehek, E. A., Nocjar, C., Roth, B. L., Byrd, T. A. and Mabrouk, O. S. (2006) Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex. Neuropsychopharmacology 31, 265-277 (Pubitemid 43113392)
    • (2006) Neuropsychopharmacology , vol.31 , Issue.2 , pp. 265-277
    • Pehek, E.A.1    Nocjar, C.2    Roth, B.L.3    Byrd, T.A.4    Mabrouk, O.S.5
  • 36
    • 63149128774 scopus 로고    scopus 로고
    • Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity
    • Lavieri, R., Scott, S. A., Lewis, J. A., Selvy, P. E., Armstrong, M. D., Brown, A. H. and Lindsley, C. W. (2009) Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity. Bioorg. Med. Chem. Lett. 19, 2240-2243
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 2240-2243
    • Lavieri, R.1    Scott, S.A.2    Lewis, J.A.3    Selvy, P.E.4    Armstrong, M.D.5    Brown, A.H.6    Lindsley, C.W.7
  • 37
    • 0028073780 scopus 로고
    • Mechanisms of phospholipase D stimulation by m3 muscarinic acetylcholine receptors. Evidence for involvement of tyrosine phosphorylation
    • Schmidt, M., Huwe, S. M., Fasselt, B., Homann, D., Rumenapp, U., Sandmann, J. and Jakobs, K. H. (1994) Mechanisms of phospholipase D stimulation by m3 muscarinic acetylcholine receptors. Evidence for involvement of tyrosine phosphorylation. Eur. J. Biochem. 225, 667-675
    • (1994) Eur. J. Biochem. , vol.225 , pp. 667-675
    • Schmidt, M.1    Huwe, S.M.2    Fasselt, B.3    Homann, D.4    Rumenapp, U.5    Sandmann, J.6    Jakobs, K.H.7
  • 38
    • 0030029143 scopus 로고    scopus 로고
    • Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and Fyn-dependent T cell activation
    • Hanke, J. H., Gardner, J. P., Dow, R. L., Changelian, P. S., Brissette, W. H., Weringer, E. J., Pollok, B. A. and Connelly, P. A. (1996) Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and Fyn-dependent T cell activation. J. Biol. Chem. 271, 695-701
    • (1996) J. Biol. Chem. , vol.271 , pp. 695-701
    • Hanke, J.H.1    Gardner, J.P.2    Dow, R.L.3    Changelian, P.S.4    Brissette, W.H.5    Weringer, E.J.6    Pollok, B.A.7    Connelly, P.A.8
  • 39
    • 0035912929 scopus 로고    scopus 로고
    • Structural determinants for potent, selective dual site inhibition of human pp60c-src by 4-anilinoquinazolines
    • Tian, G., Cory, M., Smith, A. A. and Knight, W. B. (2001) Structural determinants for potent, selective dual site inhibition of human pp60c-src by 4-anilinoquinazolines. Biochemistry 40, 7084-7091
    • (2001) Biochemistry , vol.40 , pp. 7084-7091
    • Tian, G.1    Cory, M.2    Smith, A.A.3    Knight, W.B.4
  • 40
    • 0008855384 scopus 로고    scopus 로고
    • Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-α
    • Hammond, S. M., Jenco, J. M., Nakashima, S., Cadwallader, K., Gu, Q., Cook, S., Nozawa, Y., Prestwich, G. D., Frohman, M. A. and Morris, A. J. (1997) Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-α. J. Biol. Chem. 272, 3860-3868
    • (1997) J. Biol. Chem. , vol.272 , pp. 3860-3868
    • Hammond, S.M.1    Jenco, J.M.2    Nakashima, S.3    Cadwallader, K.4    Gu, Q.5    Cook, S.6    Nozawa, Y.7    Prestwich, G.D.8    Frohman, M.A.9    Morris, A.J.10
  • 41
    • 38549110300 scopus 로고    scopus 로고
    • Small molecule disruption of G-protein βγ subunit signaling inhibits neutrophil chemotaxis and inflammation
    • Lehmann, D. M., Seneviratne, A. M. and Smrcka, A. V. (2008) Small molecule disruption of G-protein βγ subunit signaling inhibits neutrophil chemotaxis and inflammation. Mol. Pharmacol. 73, 410-418
    • (2008) Mol. Pharmacol. , vol.73 , pp. 410-418
    • Lehmann, D.M.1    Seneviratne, A.M.2    Smrcka, A.V.3
  • 44
    • 1542283816 scopus 로고    scopus 로고
    • Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis
    • Du, G., Huang, P., Liang, B. T. and Frohman, M. A. (2004) Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis. Mol. Biol. Cell 15, 1024-1030
    • (2004) Mol. Biol. Cell , vol.15 , pp. 1024-1030
    • Du, G.1    Huang, P.2    Liang, B.T.3    Frohman, M.A.4
  • 45
    • 70349771766 scopus 로고    scopus 로고
    • ADP-ribosylation factor 6 regulates mu-opioid receptor trafficking and signaling via activation of phospholipase D2
    • Rankovic, M., Jacob, L., Rankovic, V., Brandenburg, L. O., Schroder, H., Hollt, V. and Koch, T. (2009) ADP-ribosylation factor 6 regulates mu-opioid receptor trafficking and signaling via activation of phospholipase D2. Cell. Signalling 21, 1784-1793
    • (2009) Cell. Signalling , vol.21 , pp. 1784-1793
    • Rankovic, M.1    Jacob, L.2    Rankovic, V.3    Brandenburg, L.O.4    Schroder, H.5    Hollt, V.6    Koch, T.7
  • 46
    • 0036016113 scopus 로고    scopus 로고
    • Pharmacological importance of phospholipase D and phosphatidic acid in the regulation of the mitogen-activated protein kinase cascade
    • Rizzo, M. and Romero, G. (2002) Pharmacological importance of phospholipase D and phosphatidic acid in the regulation of the mitogen-activated protein kinase cascade. Pharmacol. Ther. 94, 35-50
    • (2002) Pharmacol. Ther. , vol.94 , pp. 35-50
    • Rizzo, M.1    Romero, G.2
  • 47
    • 73249131475 scopus 로고    scopus 로고
    • Role of phospholipase D in parathyroid hormone type 1 receptor signaling and trafficking
    • Garrido, J. L., Wheeler, D., Vega, L. L., Friedman, P. A. and Romero, G. (2009) Role of phospholipase D in parathyroid hormone type 1 receptor signaling and trafficking. Mol. Endocrinol. 23, 2048-2059
    • (2009) Mol. Endocrinol. , vol.23 , pp. 2048-2059
    • Garrido, J.L.1    Wheeler, D.2    Vega, L.L.3    Friedman, P.A.4    Romero, G.5
  • 48
    • 34447544274 scopus 로고    scopus 로고
    • The differential regulation of phosphatidylinositol 4-phosphate 5-kinases and phospholipase D1 by ADP-ribosylation factors 1 and 6
    • Perez-Mansilla, B., Ha, V. L., Justin, N., Wilkins, A. J., Carpenter, C. L. and Thomas, G. M. (2006) The differential regulation of phosphatidylinositol 4-phosphate 5-kinases and phospholipase D1 by ADP-ribosylation factors 1 and 6. Biochim. Biophys. Acta 1761, 1429-1442
    • (2006) Biochim. Biophys. Acta , vol.1761 , pp. 1429-1442
    • Perez-Mansilla, B.1    Ha, V.L.2    Justin, N.3    Wilkins, A.J.4    Carpenter, C.L.5    Thomas, G.M.6
  • 49
    • 68949091932 scopus 로고    scopus 로고
    • Phosphatidic acid regulation of phosphatidylinositol 4-phosphate 5-kinases
    • Cockcroft, S. (2009) Phosphatidic acid regulation of phosphatidylinositol 4-phosphate 5-kinases. Biochim. Biophys. Acta 1791, 905-912
    • (2009) Biochim. Biophys. Acta , vol.1791 , pp. 905-912
    • Cockcroft, S.1


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