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Volumn 3, Issue SUPPL. 3, 2011, Pages 22-26

Medicinal uses and pharmacological properties of Crocus sativus linn (saffron)

Author keywords

Crocetin; Crocus sativus

Indexed keywords

AMINO ACID; ANTHOCYANIN; CROCETIN; CROCIN; CROCUS SATIVUS EXTRACT; FLAVANOID; GLUCOSIDE; PENTETRAZOLE; STARCH; VITAMIN;

EID: 79957762484     PISSN: 09751491     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (83)

References (47)
  • 1
    • 79957707340 scopus 로고    scopus 로고
    • "Saffron Industrial": http://www.saffron.de/en/safron-industrial-uses/saffron.htm
    • Saffron Industrial
  • 3
    • 79957783679 scopus 로고    scopus 로고
    • Emory health care
    • "EMORY HEALTH CARE":
  • 4
    • 79957778098 scopus 로고    scopus 로고
    • http://healthlibrary.epnet.com/GetContent.aspx?Token=8482e079-8512-47c2-960c-a403c77a5e4c&chunkiid=111801.
  • 7
    • 79957765810 scopus 로고    scopus 로고
    • Zang HH. http://alternativehealing.org/hong_hua.htm.
    • Zang, H.H.1
  • 8
    • 33745216323 scopus 로고    scopus 로고
    • Biology, biotechnology and biomedicine of saffron
    • Jose-antonio. "Biology, biotechnology and biomedicine of saffron". Recent Res. Devel. Plant Sci. 2004: 2127-159.
    • (2004) Recent Res. Devel. Plant Sci. , pp. 2127-2159
    • Jose-Antonio1
  • 9
    • 0036377909 scopus 로고    scopus 로고
    • Cancer Chemopreventive and Tumoricidal Properties of Saffron (Crocus sativus L.)
    • Abdullaev FI. "Cancer Chemopreventive and Tumoricidal Properties of Saffron (Crocus sativus L.)". Exp Biol Med. 2002; 227(1): 20-25,
    • (2002) Exp Biol Med. , vol.227 , Issue.1 , pp. 20-25
    • Abdullaev, F.I.1
  • 11
    • 0000568102 scopus 로고
    • Monoterpene aldehydes and isophorone-related compounds of saffron
    • November
    • Zarghami N. S, Heinz D.E. "Monoterpene aldehydes and isophorone-related compounds of saffron". Phytochemistry. 1971 November; 10(11); 2755-2761
    • (1971) Phytochemistry , vol.10 , Issue.11 , pp. 2755-2761
    • Zarghami, N.S.1    Heinz, D.E.2
  • 12
    • 79957780881 scopus 로고    scopus 로고
    • "Saffron" http://www.saffron.de/en/safron-chemical-structure/saffron.htm
    • Saffron
  • 13
    • 33751305217 scopus 로고    scopus 로고
    • Inhibitory activity on amyloid-beta aggregation and antioxidant properties of Crocus sativus stigmas extract and its crocin constituents
    • Papandreou MA, Kanakis CD, Polissiou MG, Efthimiopoulos S, Cordopatis P, Margarity M, Lamari FN. "Inhibitory activity on amyloid-beta aggregation and antioxidant properties of Crocus sativus stigmas extract and its crocin constituents". J Agric Food Chem. 2006; 54(23): 8762-8.
    • (2006) J Agric Food Chem. , vol.54 , Issue.23 , pp. 8762-8768
    • Papandreou, M.A.1    Kanakis, C.D.2    Polissiou, M.G.3    Efthimiopoulos, S.4    Cordopatis, P.5    Margarity, M.6    Lamari, F.N.7
  • 14
    • 33748188583 scopus 로고    scopus 로고
    • Evaluation of the antitussive effect of stigma and petals of saffron (Crocus sativus) and its components, safranal and crocin in guinea pigs
    • Hosseinzadeh H, Ghenaati J. "Evaluation of the antitussive effect of stigma and petals of saffron (Crocus sativus) and its components, safranal and crocin in guinea pigs". Fitoterapia 2006; 77: 446-448.
    • (2006) Fitoterapia , vol.77 , pp. 446-448
    • Hosseinzadeh, H.1    Ghenaati, J.2
  • 15
    • 33746190618 scopus 로고    scopus 로고
    • Mechanism of hypolipidemic effect of crocin in rats: Crocin inhibits pancreatic lipase
    • Aug 14, Epub 2006 Jun 2
    • Sheng L, Qian Z, Zheng S, Xi L. "Mechanism of hypolipidemic effect of crocin in rats: crocin inhibits pancreatic lipase". Eur J Pharmacol. 2006 Aug 14; 543(1-3): 116-22. Epub 2006 Jun 2.
    • (2006) Eur J Pharmacol. , vol.543 , Issue.1-3 , pp. 116-122
    • Sheng, L.1    Qian, Z.2    Zheng, S.3    Xi, L.4
  • 16
    • 27444447828 scopus 로고    scopus 로고
    • Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice
    • Hosseinzadeh H, Talebzadeh F. "Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice". Fitoterapia 2005; 76: 722-724.
    • (2005) Fitoterapia , vol.76 , pp. 722-724
    • Hosseinzadeh, H.1    Talebzadeh, F.2
  • 17
    • 33847752592 scopus 로고    scopus 로고
    • Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: Involvement of GABAergic and opioids systems
    • Epub 2006 May 16
    • Hosseinzadeh H, Sadeghnia H.R. "Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: Involvement of GABAergic and opioids systems". Phytomedicine. 2007; 14(4): 256-62. Epub 2006 May 16
    • (2007) Phytomedicine , vol.14 , Issue.4 , pp. 256-262
    • Hosseinzadeh, H.1    Sadeghnia, H.R.2
  • 18
    • 23844446657 scopus 로고    scopus 로고
    • Emollient and antipruritic effect of Itch cream in dermatological disorders: A randomized controlled trial
    • Chatterjee S, Datta RN, Bhattacharyya D, Bandopadhyay SK. "Emollient and antipruritic effect of Itch cream in dermatological disorders: A randomized controlled trial". Research Letter 2005; 37(4): 253-254.
    • (2005) Research Letter , vol.37 , Issue.4 , pp. 253-254
    • Chatterjee, S.1    Datta, R.N.2    Bhattacharyya, D.3    Bandopadhyay, S.K.4
  • 19
    • 29244478599 scopus 로고    scopus 로고
    • Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents
    • Assimopoulou AN, Sinakos Z, Papageorgiou VP. "Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents". Phytother Res. 2005; 19(11): 997-1000.
    • (2005) Phytother Res , vol.19 , Issue.11 , pp. 997-1000
    • Assimopoulou, A.N.1    Sinakos, Z.2    Papageorgiou, V.P.3
  • 20
    • 2442604428 scopus 로고    scopus 로고
    • Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of alphatocopherol
    • Ochiai T, Ohno S, Soeda S, Tanaka H, Shoyama Y, Shimeno H. "Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of alphatocopherol". Neurosci Lett. 2004; 362(1): 61-4
    • (2004) Neurosci Lett. , vol.362 , Issue.1 , pp. 61-64
    • Ochiai, T.1    Ohno, S.2    Soeda, S.3    Tanaka, H.4    Shoyama, Y.5    Shimeno, H.6
  • 21
    • 0034788497 scopus 로고    scopus 로고
    • Inhibition of genotoxicity by saffron (Crocus sativus L.) in reply to cyclophsophamide mice
    • Premkumar K, Abraham SK, Santhiya ST, Gopinath PM, Ramesh A. "Inhibition of genotoxicity by saffron (Crocus sativus L.) in reply to cyclophsophamide mice". Drug Chem Toxicol. 2001; 24(4): 421-8
    • (2001) Drug Chem Toxicol. , vol.24 , Issue.4 , pp. 421-428
    • Premkumar, K.1    Abraham, S.K.2    Santhiya, S.T.3    Gopinath, P.M.4    Ramesh, A.5
  • 22
    • 0033399114 scopus 로고    scopus 로고
    • Saffron extract prevents acetaldehyde-induced inhibition of long-term potentiation in the rat dentate gyrus in vivo
    • Dec 18
    • Abe K, Sugiura M, Yamaguchi S, Shoyama Y, Saito H. "Saffron extract prevents acetaldehyde-induced inhibition of long-term potentiation in the rat dentate gyrus in vivo. " Brain Res. 1999 Dec 18; 851(1-2): 287-9
    • (1999) Brain Res. , vol.851 , Issue.1-2 , pp. 287-289
    • Abe, K.1    Sugiura, M.2    Yamaguchi, S.3    Shoyama, Y.4    Saito, H.5
  • 23
    • 12344251187 scopus 로고    scopus 로고
    • Protective effect of crocetin on primary culture of cardiac myocyte treated with noradrenaline in vitro
    • Oct
    • Shen XC, Qian ZY, Chen Q, Wang YJ Protective effect of crocetin on primary culture of cardiac myocyte treated with noradrenaline in vitro. Yao Xue Xue Bao. 2004 Oct; 39(10): 787-91
    • (2004) Yao Xue Xue Bao , vol.39 , Issue.10 , pp. 787-791
    • Shen, X.C.1    Qian, Z.Y.2    Chen, Q.3    Wang, Y.J.4
  • 24
    • 20444395029 scopus 로고    scopus 로고
    • Calcium antagonistic effects of Chinese crude drugs: Preliminary investigation and evaluation by 45 Ca
    • Aug
    • Liu N, Yang Y, Mo S, Liao J, Jin J. "Calcium antagonistic effects of Chinese crude drugs: preliminary investigation and evaluation by 45 Ca". Appl Radiat Isot. 2005 Aug; 63(2): 151-5.
    • (2005) Appl Radiat Isot , vol.63 , Issue.2 , pp. 151-155
    • Liu, N.1    Yang, Y.2    Mo, S.3    Liao, J.4    Jin, J.5
  • 25
    • 33645766262 scopus 로고    scopus 로고
    • Effects of crocetin on antioxidant enzymatic activities in cardiac hypertrophy induced by norepinephrine in rats
    • Apr
    • Shen XC, Qian ZY. "Effects of crocetin on antioxidant enzymatic activities in cardiac hypertrophy induced by norepinephrine in rats". Pharmazie. 2006 Apr; 61(4): 348-52.
    • (2006) Pharmazie , vol.61 , Issue.4 , pp. 348-352
    • Shen, X.C.1    Qian, Z.Y.2
  • 26
    • 34249934672 scopus 로고    scopus 로고
    • Beneficial impact of crocetin, a carotenoid from saffron, on insulin sensitivity in fructose-fed rats
    • Jan, Epub 2006 May 19
    • Xi L, Qian Z, Xu G, Zheng S, Sun S, Wen N, Sheng L, Shi Y, Zhang Y. "Beneficial impact of crocetin, a carotenoid from saffron, on insulin sensitivity in fructose-fed rats" J Nutr Biochem. 2007 Jan; 18(1): 64-72. Epub 2006 May 19.
    • (2007) J Nutr Biochem , vol.18 , Issue.1 , pp. 64-72
    • Xi, L.1    Qian, Z.2    Xu, G.3    Zheng, S.4    Sun, S.5    Wen, N.6    Sheng, L.7    Shi, Y.8    Zhang, Y.9
  • 28
    • 79957757829 scopus 로고    scopus 로고
    • "Saffron for health". http://www.babysaffron.com/saffronusage.htm.
    • Saffron for health
  • 29
    • 33750041373 scopus 로고    scopus 로고
    • Relaxant effect of Crocus sativus (saffron) on guinea-pig tracheal chains and its possible mechanisms
    • Boskabady MH, Aslani MR. "Relaxant effect of Crocus sativus (saffron) on guinea-pig tracheal chains and its possible mechanisms". J Pharm Pharmacol. 2006; 58(10): 1385-90.
    • (2006) J Pharm Pharmacol. , vol.58 , Issue.10 , pp. 1385-1390
    • Boskabady, M.H.1    Aslani, M.R.2
  • 30
    • 0032911271 scopus 로고    scopus 로고
    • Effects of crocin analogs on ocular blood flow and retinal function
    • Xuan B, Zhou YH, Li N, Min ZD, Chiou GC. "Effects of crocin analogs on ocular blood flow and retinal function". J Ocul Pharmacol Ther.1999; 15(2): 143-52.
    • (1999) J Ocul Pharmacol Ther , vol.15 , Issue.2 , pp. 143-152
    • Xuan, B.1    Zhou, Y.H.2    Li, N.3    Min, Z.D.4    Chiou, G.C.5
  • 31
    • 33745826332 scopus 로고    scopus 로고
    • Effect of Saffron (Crocus sativus) on Neurobehavioral and Neurochemical Changes in Cerebral Ischemia in Rats
    • Sofiyan S. "Effect of Saffron (Crocus sativus) on Neurobehavioral and Neurochemical Changes in Cerebral Ischemia in Rats". Journal of Medicinal Food. 2006; 9(2): 246-253
    • (2006) Journal of Medicinal Food , vol.9 , Issue.2 , pp. 246-253
    • Sofiyan, S.1
  • 33
    • 0034087334 scopus 로고    scopus 로고
    • Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation
    • May
    • Abe K, Saito H. "Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation" Phytother Res. 2000 May; 14(3): 149-52.
    • (2000) Phytother Res , vol.14 , Issue.3 , pp. 149-152
    • Abe, K.1    Saito, H.2
  • 34
    • 0035798068 scopus 로고    scopus 로고
    • Crocin suppresses tumor necrosis factor-alpha-induced cell death of neuronally differentiated PC-12 cells
    • Soeda S, Ochiai T, Paopong L, Tanaka H, Shoyama Y, Shimeno H. "Crocin suppresses tumor necrosis factor-alpha-induced cell death of neuronally differentiated PC-12 cells". Life Sci. 2001; 69(24): 2887-98.
    • (2001) Life Sci , vol.69 , Issue.24 , pp. 2887-2898
    • Soeda, S.1    Ochiai, T.2    Paopong, L.3    Tanaka, H.4    Shoyama, Y.5    Shimeno, H.6
  • 35
    • 0037296919 scopus 로고    scopus 로고
    • Effects of Crocus sativus petal's extract on rat blood pressure and on responses induced by electrical field stimulation in the rat isolated vas deferens and guinea-pig ileum
    • Fatehi M, Rashidabady T, Fatehi-Hassanabad Z. "Effects of Crocus sativus petal's extract on rat blood pressure and on responses induced by electrical field stimulation in the rat isolated vas deferens and guinea-pig ileum". J Ethnopharmacol. 2003; 84(2-3): 199-203.
    • (2003) J Ethnopharmacol. , vol.84 , Issue.2-3 , pp. 199-203
    • Fatehi, M.1    Rashidabady, T.2    Fatehi-Hassanabad, Z.3
  • 37
    • 13544274008 scopus 로고    scopus 로고
    • Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: A double blind, randomized pilot trial
    • Epub 2005 Jan 6
    • Noorbala AA, Akhondzadeh S, Tahmacebi-Pour N, Jamshidi AH. "Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: a double blind, randomized pilot trial". J Ethnopharmacol. 2005; 97(2): 281-4. Epub 2005 Jan 6
    • (2005) J Ethnopharmacol. , vol.97 , Issue.2 , pp. 281-284
    • Noorbala, A.A.1    Akhondzadeh, S.2    Tahmacebi-Pour, N.3    Jamshidi, A.H.4
  • 38
    • 33846820128 scopus 로고    scopus 로고
    • Comparison of petal of Crocus sativus L. and fluoxetine in the treatment of depressed outpatients: A pilot double-blind randomized trial
    • Epub 2006 Dec 15
    • Akhondzadeh B. A, Moshiri E, Noorbala AA, Jamshidi AH, Abbasi SH, Akhondzadeh S. "Comparison of petal of Crocus sativus L. and fluoxetine in the treatment of depressed outpatients: a pilot double-blind randomized trial. " Prog Neuropsychopharmacol Biol Psychiatry. 2007; 31(2): 439-42. Epub 2006 Dec 15
    • (2007) Prog Neuropsychopharmacol Biol Psychiatry , vol.31 , Issue.2 , pp. 439-442
    • Akhondzadeh, B.A.1    Moshiri, E.2    Noorbala, A.A.3    Jamshidi, A.H.4    Abbasi, S.H.5    Akhondzadeh, S.6
  • 39
    • 10444231865 scopus 로고    scopus 로고
    • Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: A pilot double-blind randomized trial
    • Akhondzadeh S, Fallah-Pour H, Afkham K, Jamshidi AH, Khalighi-Cigaroudi F "Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: a pilot double-blind randomized trial. " BMC Complement Altern Med. 2004; 4: 12.
    • (2004) BMC Complement Altern Med , vol.4 , pp. 12
    • Akhondzadeh, S.1    Fallah-Pour, H.2    Afkham, K.3    Jamshidi, A.H.4    Khalighi-Cigaroudi, F.5
  • 40
    • 79957754316 scopus 로고    scopus 로고
    • Herb of the month: http://www.allayurveda.com/herb_month_march2002.htm
    • Herb of the month
  • 41
    • 16344389225 scopus 로고    scopus 로고
    • Pharmacological properties of N-095, a drug containing red ginseng, polygala root, saffron, antelope horn and aloe wood
    • Inoue E, Shimizu Y, Shoji M, Tsuchida H, Sano Y, Ito C. "Pharmacological properties of N-095, a drug containing red ginseng, polygala root, saffron, antelope horn and aloe wood". Am J Chin Med. 2005; 33(1): 49-60.
    • (2005) Am J Chin Med , vol.33 , Issue.1 , pp. 49-60
    • Inoue, E.1    Shimizu, Y.2    Shoji, M.3    Tsuchida, H.4    Sano, Y.5    Ito, C.6
  • 42
    • 0028834324 scopus 로고
    • Saffron chemoprevention in biology and medicine: A review
    • Nair SC, Kurumboor SK, Hasegawa JH. "Saffron chemoprevention in biology and medicine: a review. " Cancer Biother. 1995; 10(4): 257-64
    • (1995) Cancer Biother , vol.10 , Issue.4 , pp. 257-264
    • Nair, S.C.1    Kurumboor, S.K.2    Hasegawa, J.H.3
  • 43
    • 33745953345 scopus 로고    scopus 로고
    • Antitumour activity of crocetin in accordance to tumor incidence, antioxidant status, drug metabolizing enzymes and histopathological studies
    • Magesh. "Antitumour activity of crocetin in accordance to tumor incidence, antioxidant status, drug metabolizing enzymes and histopathological studies" Mol Cell Biochem 2006; 287 (1-2): 127-135.
    • (2006) Mol Cell Biochem , vol.287 , Issue.1-2 , pp. 127-135
    • Magesh1
  • 44
    • 2542554241 scopus 로고    scopus 로고
    • Saffron can prevent chemically induced skin carcinogenesis in swiss albino mice
    • Das I, chakrabarty RN, Das S. "Saffron can prevent chemically induced skin carcinogenesis in swiss albino mice". Asian Pac J Cancer Prev 2004; 5 (1): 70-76.
    • (2004) Asian Pac J Cancer Prev , vol.5 , Issue.1 , pp. 70-76
    • Das, I.1    Chakrabarty, R.N.2    Das, S.3
  • 45
    • 0023027490 scopus 로고
    • Protection of crocin dyes on the acute hepatic damage induced by aflatoxin B1 and dimethylnitrosamine in rats
    • Lin JK, Wang CJ. "Protection of crocin dyes on the acute hepatic damage induced by aflatoxin B1 and dimethylnitrosamine in rats". Carcinogenesis 1986; 7: 595-599.
    • (1986) Carcinogenesis , vol.7 , pp. 595-599
    • Lin, J.K.1    Wang, C.J.2
  • 46
    • 39049176405 scopus 로고    scopus 로고
    • Crocetin inhibits mRNA expression for Tumour necrosis factor-α, Interleukin-1β, and inducible nitric oxide synthase in haemorrhagic shock
    • Yang R, Xia Tan, Thomas AM, Shen J, Qureshi N, Morrison D, et. al. "Crocetin inhibits mRNA expression for Tumour necrosis factor-α, Interleukin-1β, and inducible nitric oxide synthase in haemorrhagic shock". J Parent Ent Nut 2006; 30 (4): 297-301.
    • (2006) J Parent Ent Nut , vol.30 , Issue.4 , pp. 297-301
    • Yang, R.1    Xia, T.2    Thomas, A.M.3    Shen, J.4    Qureshi, N.5    Morrison, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.