Pharmacological properties of N-095, a drug containing red ginseng, polygala root, saffron, antelope horn and aloe wood

American Journal of Chinese Medicine

Volumn 33, Issue 1, 2005, Pages 49-60

  Inoue, Eiji ^a   Shimizu, Yasuharu ^a   Shoji, Masamichi ^a   Tsuchida, Haruyo ^a   Sano, Yumiko ^a   Ito, Chihiro ^a  

^a Kyushin Pharmaceutical Co Ltd   (Japan)

Author keywords

Aloe wood (Aquilariae Lignum); Antelope horn (Antelopis Cornu); General pharmacology; Polygala root (Polygalae Radix); Red ginseng (Ginseng Radix); Saffron (Crocus)

Indexed keywords

ATROPINE; CARRAGEENAN; CHINESE DRUG; EMODIN; GINSENG EXTRACT; HEXOBARBITAL; HISTAMINE; INDOMETACIN; N 095; NITRAZEPAM; PENTETRAZOLE; PENTOBARBITAL; PHENOBARBITAL; PLANT EXTRACT; POLYGALA EXTRACT; SAFFRON EXTRACT; UNCLASSIFIED DRUG;

ALOE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTELOPE; ARTICLE; CARDIOVASCULAR SYSTEM; CONTROLLED STUDY; CROCUS; DRUG SAFETY; ELECTROLYTE BALANCE; FATIGUE; FLUID BALANCE; FOOT PAD; FORCED SWIMMING TEST; HEMOLYSIS; IMMOBILIZATION STRESS; MOTOR ACTIVITY; MOUSE; NONHUMAN; NUTRIENT; POLYGALACEAE; RAT; RESPIRATORY SYSTEM; SLEEP TIME; STOMACH ULCER; STRESS ULCER; UTERUS CONTRACTILITY; WATER IMMERSION; WOOD;

ANIMALS; BEHAVIOR, ANIMAL; CARRAGEENAN; CONVULSANTS; CROCUS; DRUGS, CHINESE HERBAL; EDEMA; EPILEPSY; ERYTHROCYTES; FEMALE; HISTAMINE; MALE; MICE; PANAX; PENTYLENETETRAZOLE; PERIPHERAL NERVOUS SYSTEM; PLANT ROOTS; POLYGALA; RABBITS; RATS; RATS, WISTAR; STOMACH ULCER; SWIMMING; UTERUS; WATER-ELECTROLYTE BALANCE;

EID: 16344389225     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X05002655     Document Type: Article

References (16)

1. Aloe wood. In: Dictionary of Chinese Materia Medica (Shogakukan, eds., translated by author). Shanghai Scientific and Technical Publishing Co., Shogakukan, Tokyo, 1985, pp. 1310-1312 (in Japanese).
2. Antelope horn. In: Dictionary of Chinese Materia Medica (Shogakukan, eds., translated by author). Shanghai Scientific and Technical Publishing Co., Shogakukan, Tokyo, 1985, pp. 2738-2739 (in Japanese).
3. Chan, W.Y. and N. Kelley. A pharmacologic analysis of the significance of the chemical functional groups of oxytocin to its oxytocic activity and on the effect of magnesium on the in vitro and in vivo oxytocic activity of neurohypophysial hormones. J. Pharmacol. Exp. Ther. 156: 150-158, 1967.
4. Chang, P., C. Wang, J. Liang and W. Kuo. Studies on the pharmacological action of Zang Hong Hua (Crocus Sativus L). Yao Xue Xue Bao 11: 94-100, 1964 (abstract in English).
5. Irwin, S. Animal and Clinical Pharmacological Techniques in Drug Evaluation. J.H. Nordine and PE. Siegler (eds.) Year book Medical Publishers, Chicago, 1964.
6. Kiefer, D. and T. Pantuso. Panax ginseng. Am. Fam. Physician 15: 1539-1542, 2003.
7. Morishita, S., Y. Mishima, Y. Hirai, T. Saito and M. Shoji. Pharmacological studies of water extract of the Zizyphus seed and the Zizyphus seed containing drug. Gen. Pharmacol. 18: 637-641, 1987.
8. Okabe, S. and H. Kunimi. Effect of clebopride malate on experimental gastric ulcers in rats. Oyo Yakuri 24: 261-265, 1982.
9. Saffron. In: Dictionary of Chinese Materia Medica (Shogakukan, eds., translated by author). Shanghai Scientific and Technical Publishing Co., Shogakukan, Tokyo, 1985, pp. 1574-1575 (in Japanese).
10. Shinohara, T., H. Kamikawa and Z. Ogita. Anti-fatigue effect of traditional cardiac drug contained Epimedii herba. J. Tradit. Med. 13: 260-267, 1996 (abstract in English).
11. Shoji, M., H. Tsuchida, E. Inoue, Y. Shimizu and C. Ito. Pharmacological studies of a crude drug containing red ginseng, polygala root, saffron, antelope horn and aloe wood: Effects on the cerebral blood circulation system. Natural Medicines 58: 64-70, 2004a.
12. Shoji, M., H. Tsuchida, Y. Shimizu and C. Ito. Pharmacological studies of a crude drug containing red ginseng, polygala root, saffron, antelope horn and aloe wood. Natural Medicines 58: 1-9, 2004b.
13. Watanabe, K. Anti-ulcer agents. In: K. Tsuda and H. Nogami (eds.) Lecture for Basic Development of Drugs 5 (translated by author). Chijinshokan, Tokyo, 1971, pp. 1107-1143 (in Japanese).
14. Sugiura, M., Y. Shoyama, H. Saito and N. Nishiyama. Crocin improves the ethanol-induced impairment of learning behaviors of mice in passive avoidance tasks. Proc. Japan. Acad. 71 (Ser B): 319-324, 1995.
15. Yabe, T., S. Iizuka, Y. Komatsu and H. Yamada. Enhancements of choline acetyltransferase activity and nerve growth factor secretion by Polygalae radix-extract containing active ingredients in Kami-untan-to. Phytomedicine 4: 199-205, 1997.
16. Yen, M.H. and S.H. Lee. Effects of cyclooxygenase and lipoxygenase inhibitors on cerebral edema induced by freezing lesions in rats. Eur. J. Pharmacol. 144: 369-373, 1987.