Podocin-green fluorescence protein allows visualization and functional analysis of podocytes

Journal of the American Society of Nephrology

Volumn 22, Issue 6, 2011, Pages 1019-1023

  He, Bing ^a   Ebarasi, Lwaki ^a   Hultenby, Kjell ^a   Tryggvason, Karl ^a   Betsholtz, Christer ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; PODOCIN;

ARTICLE; CHEMICAL ANALYSIS; GENE EXPRESSION; GENETIC ANALYSIS; GLOMERULUS; GLOMERULUS CAPILLARY; IN VIVO STUDY; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; TRANSGENIC ANIMAL; ZEBRA FISH;

EID: 79957762214     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2010121291     Document Type: Article

References (29)

1. Boute N, Gribouval O, Roselli S, Benessy F, Lee H, Fuchshuber A, Dahan K, Gubler MC, Niaudet P, Antignac C: NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Nat Genet 24: 349-354, 2000 (Pubitemid 30187431)
2. Kestilä, M, Lenkkeri U, Männikkö, M, Lamerdin J, McCready P, Putaala H, Ruotsalainen V, Morita T, Nissinen M, Herva R, Kashtan CE, Peltonen L, Holmberg C, Olsen A, Tryggvason K: Positionally cloned gene for a novel glomerular protein - nephrin - is mutated in congenital nephrotic syndrome. Mol Cell 1: 575-582, 1998 (Pubitemid 128374693)
3. Segelmark M, Hellmark T: Autoimmune kidney diseases. Autoimmun Rev 9: A366-A371, 2010
4. Sun Y, He L, Takemoto M, Patrakka J, Pikkarainen T, Genové, G, Norlin J, Truvé , K, Tryggvason K, Betsholtz C: Glomerular transcriptome changes associated with lipopolysaccharide- induced proteinuria. Am J Nephrol 29: 558-570, 2009
5. Ly J, Alexander M, Quaggin SE: A podocentric view of nephrology. Curr Opin Nephrol Hypertens 13: 299-305, 2004 (Pubitemid 38584614)
6. Tryggvason K, Patrakka J, Wartiovaara J: Hereditary proteinuria syndromes and mechanisms of proteinuria. N Engl J Med 354: 1387-1401, 2006
7. Kriz W: Progressive renal failure-inability of podocytes to replicate and the consequences for development of glomerulosclerosis. Nephrol Dial Transplant 11: 1738-1742, 1996
8. Pavenstädt H, Kriz W, Kretzler M: Cell biology of the glomerular podocyte. Physiol Rev 83: 253-307, 2003 (Pubitemid 36459882)
9. Cui S, Schwartz L, Quaggin SE: Pod1 is required in stromal cells for glomerulogenesis. Dev Dyn 226: 512-522, 2003 (Pubitemid 36278481)
10. Donoviel DB, Freed DD, Vogel H, Potter DG, Hawkins E, Barrish JP, Mathur BN, Turner CA, Geske R, Montgomery CA, Starbuck M, Brandt M, Gupta A, Ramirez-Solis R, Zambrowicz BP, Powell DR: Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN. Mol Cell Biol 21: 4829-4836, 2001 (Pubitemid 32588261)
11. Doyonnas R, Kershaw DB, Duhme C, Merkens H, Chelliah S, Graf T, McNagny KM: Anuria, omphalocele, and perinatal lethality in mice lacking the CD34-related protein podocalyxin. J Exp Med 194: 13-27, 2001 (Pubitemid 32660434)
12. Putaala H, Soininen R, Kilpeläinen P, Wartiovaara J, Tryggvason K: The murine nephrin gene is specifically expressed in kidney, brain and pancreas: Inactivation of the gene leads to massive proteinuria and neonatal death. Hum Mol Genet 10: 1-8, 2001 (Pubitemid 32051561)
13. Takemoto M, He L, Norlin J, Patrakka J, Xiao Z, Petrova T, Bondjers C, Asp J, Wallgard E, Sun Y, Samuelsson T, Mostad P, Lundin S, Miura N, Sado Y, Alitalo K, Quaggin SE, Tryggvason K, Betsholtz C: Large-scale identification of genes implicated in kidney glomerulus development and function. EMBO J 25: 1160-1174, 2006 (Pubitemid 43372128)
14. Li B, Yao J, Kawamura K, Oyanagi-Tanaka Y, Hoshiyama M, Morioka T, Gejyo F, Uchiyama M, Oite T: Real-time observation of glomerular hemodynamic changes in diabetic rats: Effects of insulin and ARB. Kidney Int 66: 1939-1948, 2004
15. Peti-Peterdi J, Toma I, Sipos A, Vargas SL: Multiphoton imaging of renal regulatory mechanisms. Physiology 24: 88-96, 2009
16. Drummond IA, Davidson AJ: Zebrafish kidney development. Methods Cell Biol 100: 233-260, 2010
17. Howland RB: On the effect of removal of the pronephros of the amphibian embryo. Proc Natl Acad Sci U S A 2: 231-234, 1916
18. Vize PD, Seufert DW, Carroll TJ, Wallingford JB: Model systems for the study of kidney development: Use of the pronephros in the analysis of organ induction and patterning. Dev Biol 188: 189-204, 1997 (Pubitemid 27394623)
19. Drummond IA, Majumdar A, Hentschel H, Elger M, Solnica-Krezel L, Schier AF, Neuhauss SC, Stemple DL, Zwartkruis F, Rangini Z, Driever W, Fishman MC: Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function. Development 125: 4655-4667, 1998 (Pubitemid 29027196)
20. Kramer-Zucker AG, Wiessner S, Jensen AM, Drummond IA: Organization of the pronephric filtration apparatus in zebrafish requires nephrin, podocin and the FERM domain protein Mosaic eyes. Dev Biol 285: 316-329, 2005 (Pubitemid 41394022)
21. Moeller MJ, Sanden SK, Soofi A, Wiggins RC, Holzman LB: Two gene fragments that direct podocyte-specific expression in transgenic mice. J Am Soc Nephrol 13: 1561-1567, 2002 (Pubitemid 34579245)
22. Zhou W, Boucher RC, Bollig F, Englert C, Hildebrandt F: Characterization of mesonephric development and regeneration using transgenic zebrafish. Am J Physiol Renal Physiol 299: F1040-F1047, 2010
23. Ebarasi L, He L, Hultenby K, Takemoto M, Betsholtz C, Tryggvason K, Majumdar A: A reverse genetic screen in the zebrafish identifies crb2b as a regulator of the glomerular filtration barrier. Dev Biol 334: 1-9, 2009
24. Perner B, Englert C, Bollig F: The Wilms tumor genes wt1a and wt1b control different steps during formation of the zebrafish pronephros. Dev Biol 309: 87-96, 2007 (Pubitemid 47302449)
25. Majumdar A, Drummond IA: The zebrafish floating head mutant demonstrates podocytes play an important role in directing glomerular differentiation. Dev Biol 222: 147-157, 2000 (Pubitemid 30387736)
26. Lee HC, Tsai JN, Liao PY, Tsai WY, Lin KY, Chuang CC, Sun CK, Chang WC, Tsai HJ: Glycogen synthase kinase 3 alpha and 3 beta have distinct functions during cardiogenesis of zebrafish embryo. BMC Dev Biol 7: 93, 2007
27. Nadauld LD, Sandoval IT, Chidester S, Yost HJ, Jones DA: Adenomatous polyposis coli control of retinoic acid biosynthesis is critical for zebrafish intestinal development and differentiation. J Biol Chem 279: 51581-51589, 2004 (Pubitemid 40017909)
28. Tang J, Hu G, Hanai J, Yadlapalli G, Lin Y, Zhang B, Galloway J, Bahary N, Sinha S, Thisse B, Thisse C, Jin JP, Zon LI, Sukhatme VP: A critical role for calponin 2 in vascular development. J Biol Chem 281: 6664-6672, 2006 (Pubitemid 43847601)
29. Kawakami K, Takeda H, Kawakami N, Kobayashi M, Matsuda N, Mishina M: A transposon-mediated gene trap approach identifies developmentally regulated genes in zebrafish. Dev Cell 7: 133-144, 2004 (Pubitemid 39172695)