Point: M cells are present in the ventricular myocardium

Heart Rhythm

Volumn 8, Issue 6, 2011, Pages 930-933

  Wilson, Lance D ^a   Jennings, Michelle M ^a   Rosenbaum, David S ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Arrhythmia; Dispersion of repolarization; M cells; Repolarization

Indexed keywords

CONNEXIN 43;

ACTION POTENTIAL; ACTION POTENTIAL DURATION; ANISOTROPY; ARRHYTHMOGENESIS; ELECTROCARDIOGRAM; HEART DEPOLARIZATION; HEART FAILURE; HEART MUSCLE CELL; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART MUSCLE PERFUSION; HEART MUSCLE POTENTIAL; HEART RATE; HEART REPOLARIZATION; HUMAN; LONG QT SYNDROME; MICROELECTRODE; MUSCLE CELL; NERVE BLOCK; NONHUMAN; PRIORITY JOURNAL; QRS COMPLEX; REVIEW; SAMPLING ERROR; SODIUM CALCIUM EXCHANGE; T WAVE; TOPOGRAPHY;

EID: 79957741557     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2011.01.026     Document Type: Article

References (17)

1. Sicouri S, Antzelevitch C. A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle: The M cell. Circ Res 1991;68:1729-1741.
2. Akar FG, Yan GX, Antzelevitch C, Rosenbaum DS. Unique topographical distribution ofMcells underlies reentrant mechanism of torsade de pointes in the long-QT syndrome. Circulation 2002;105:1247-1253. (Pubitemid 34225828)
3. Shimizu W, Antzelevitch C. Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade de pointes in LQT2 and LQT3 models of the long-QT syndrome. Circulation 1997;96:2038-2047. (Pubitemid 27400769)
4. Spach MS, Barr RC. Ventricular intramural and epicardial potential distributions during ventricular activation and repolarization in the intact dog. Circ Res 1975;37:243-257.
5. Viswanathan PC, Shaw RM, Rudy Y. Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: a simulation study. Circulation 1999;99:2466-2474. (Pubitemid 29218245)
6. Akar FG, Rosenbaum DS. Transmural electrophysiological heterogeneities underlying arrhythmogenesis in heart failure. Circ Res 2003;93:638-645. (Pubitemid 37222160)
7. Glukhov AV, Fedorov VV, Lou Q, Ravikumar VK, et al. Transmural dispersion of repolarization in failing and nonfailing human ventricle. Circ Res 2010;106:981-991.
8. Strom M, Wan X, Poelzing S, Ficker E, Rosenbaum DS. Gap junction heterogeneity as mechanism for electrophysiologically distinct properties across the ventricular wall. Am J Physiol Heart Circ Physiol 2010;298:H787-H794.
9. Anyukhovsky EP, Sosunov EA, Rosen MR. Regional differences in electrophysiological properties of epicardium, midmyocardium, and endocardium: in vitro and in vivo correlations. Circulation 1996;94:1981-1988. (Pubitemid 26349314)
10. Ueda N, Zipes DP, Wu J. Functional and transmural modulation of M cell behavior in canine ventricular wall. Am J Physiol Heart Circ Physiol 2004;287:H2569-H2575. (Pubitemid 39557126)
11. Yan GX, Shimizu W, Antzelevitch C. Characteristics and distribution of M cells in arterially perfused canine left ventricular wedge preparations. Circulation 1998;98:1921-1927. (Pubitemid 28509290)
12. Poelzing S, Roth BJ, Rosenbaum DS. Optical measurements reveal nature of intercellular coupling across ventricular wall. Am J Physiol Heart Circ Physiol 2005;289:H1428-H1435. (Pubitemid 41368983)
13. Akar FG, Laurita KR, Rosenbaum DS. Cellular basis for dispersion of repolarization underlying reentrant arrhythmias. J Electrocardiol 2000;33(Suppl):23-31. (Pubitemid 32167280)
14. El-Sherif N, Caref EB, Yin H, et al. The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome: tridimensional mapping of activation and recovery patterns. Circ Res 1996;79:474-492. (Pubitemid 26276908)
15. Chen PS, Moser KM, Dembitsky WP, et al. Epicardial activation and repolarization patterns in patients with right ventricular hypertrophy. Circulation 1991;83:104-118.
16. Millar CK, Kralios FA, Lux RL. Correlation between refractory periods and activation-recovery intervals from electrograms: effects of rate and adrenergic interventions. Circulation 1985;6:1372-1379. (Pubitemid 16126818)
17. Steinhaus BM. Estimating cardiac transmembrane activation and recovery times from unipolar and bipolar extracellular electrograms: a simulation study. Circ Res 1989;64:449-462. (Pubitemid 19073799)